Personal information

Other IDs

Scopus Author ID: 55687422100

Activities

Collapse all

Works (50 of 138)

Items per page:
Page 1 of 3

A patent review of small molecular inhibitors targeting EGFR exon 20 insertion (Ex20ins) (2019-present)

Expert Opinion on Therapeutic Patents
2025 | Journal article
DOI: 10.1080/13543776.2024.2446220
EID:

2-s2.0-85213227277

Part of ISSN: 17447674 13543776
Contributors: Zhu, W.; Pei, J.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Cell-Active, Arginine-Targeting Irreversible Covalent Inhibitors for Non-Kinases and Kinases

Angewandte Chemie - International Edition
2025 | Journal article
DOI: 10.1002/anie.202422372
EID:

2-s2.0-85214796064

Part of ISSN: 15213773 14337851
Contributors: Chen, P.; Wang, L.; Wang, X.; Sun, J.; Miao, F.; Wang, Z.; Yang, F.; Xiang, M.; Gu, M.; Li, S. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Design, synthesis and evaluation of diarylidenyl piperidone-ligated platinum (IV) complexes as chemoimmunotherapeutic agents

European Journal of Medicinal Chemistry
2025 | Journal article
DOI: 10.1016/j.ejmech.2025.117338
EID:

2-s2.0-85216756814

Part of ISSN: 17683254 02235234
Contributors: Mao, Z.-C.; Chen, L.; Chen, X.-M.; Lu, X.-Y.; Mo, Z.-Y.; Gou, Y.; Wei, J.-H.; Huang, R.-Z.; Zhang, Y.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Optimization of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors for Wild-Type and Mutant Fgfr4

SSRN
2025 | Other
DOI: 10.2139/ssrn.5096059
EID:

2-s2.0-85216135075

Part of ISSN: 15565068
Contributors: Guo, J.; Chen, X.; Li, X.; Shao, M.; Song, X.; Zhang, L.; Huang, S.; Patterson, A.V.; Smaill, J.B.; Zhou, Y. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H<sub>2</sub>O<sub>2</sub>-Triggered Targeted Protein Degradation in Cancer Therapy

Journal of the American Chemical Society
2024 | Journal article
DOI: 10.1021/jacs.4c11003
EID:

2-s2.0-85212755940

Part of ISSN: 15205126 00027863
Contributors: Sun, J.; Gu, M.; Peng, L.; Guo, J.; Chen, P.; Wen, Y.; Feng, F.; Chen, X.; Liu, T.; Chen, Y. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Advances in Small-Molecule C-KIT/PDGFRα Inhibitors for the Treatment of Gastrointestinal Stromal Tumors

Pharmaceutical Fronts
2024 | Journal article
DOI: 10.1055/s-0044-1791541
EID:

2-s2.0-85207360760

Part of ISSN: 26285096 26285088
Contributors: Zheng, X.; Liang, H.; Zhou, Y.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Deciphering Molecular Specificity in MCL-1/BAK Interaction and Its Implications for Designing Potent MCL-1 Inhibitors

Research Square
2024 | Other
DOI: 10.21203/rs.3.rs-4708498/v1
EID:

2-s2.0-85204410543
Contributors: Chen, Y.; Wei, H.; Wang, H.; Xiang, S.; Wang, J.; Qu, L.; Chen, X.; Guo, M.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors

European Journal of Medicinal Chemistry
2024 | Journal article
DOI: 10.1016/j.ejmech.2024.116558
EID:

2-s2.0-85195584671

Part of ISSN: 17683254 02235234
Contributors: Deng, W.; Chen, X.; Liang, H.; Song, X.; Xiang, S.; Guo, J.; Tu, Z.; Zhou, Y.; Chen, Y.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Design, Synthesis and Biological Evaluation of 5-Amino-1h-Pyrazole-4-Carboxamide Derivatives as Pan-Fgfr Covalent Inhibitors

SSRN
2024 | Other
DOI: 10.2139/ssrn.4798510
EID:

2-s2.0-85191275568

Part of ISSN: 15565068
Contributors: Deng, W.; Chen, X.; Liang, H.; Song, X.; Xiang, S.; Guo, J.; Tu, Z.; Zhou, Y.; Chen, Y.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation

Journal of Medicinal Chemistry
2024 | Journal article
DOI: 10.1021/acs.jmedchem.4c01975
EID:

2-s2.0-85210069764

Part of ISSN: 15204804 00222623
Contributors: Hu, S.; Tong, L.; Qin, Q.; Wen, J.; Li, Y.; Feng, F.; Wu, K.; Zhou, Y.; Shang, J.; Wang, J. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity

Journal of Medicinal Chemistry
2024 | Journal article
DOI: 10.1021/acs.jmedchem.3c01810
EID:

2-s2.0-85185614076

Part of ISSN: 15204804 00222623
Contributors: Yang, F.; Lin, Q.; Song, X.; Huang, H.; Chen, X.; Tan, J.; Li, Y.; Zhou, Y.; Tu, Z.; Du, H. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Dynamics Playing a Key Role in the Covalent Binding of Inhibitors to Focal Adhesion Kinase

Journal of Chemical Information and Modeling
2024 | Journal article
DOI: 10.1021/acs.jcim.4c00418
EID:

2-s2.0-85199528457

Part of ISSN: 1549960X 15499596
Contributors: Liu, Y.; Tan, J.; Hu, S.; Hussain, M.; Qiao, C.; Tu, Y.; Lu, X.; Zhou, Y.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Kinase modulators approved by FDA in 2022

Yaoxue Xuebao
2024 | Journal article
DOI: 10.16438/j.0513-4870.2023-0472
EID:

2-s2.0-85185256088

Part of ISSN: 05134870
Contributors: Zheng, X.; Lu, X.-Y.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Macrocyclization strategy in kinase drug discovery

Drug Discovery Stories: From Bench to Bedside
2024 | Book chapter
Part of DOI: 10.1016/B978-0-443-23932-8.00005-4
EID:

2-s2.0-85213194549

Part of ISBN: 9780443239328 9780443239335
Contributors: Zhou, Y.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Multidisciplinary Training for Fostering Next-Generation Medicinal Chemists

Journal of Medicinal Chemistry
2024 | Journal article
DOI: 10.1021/acs.jmedchem.4c02316
EID:

2-s2.0-85205866015

Part of ISSN: 15204804 00222623
Contributors: Yu, B.; Lu, X.; Chang, J.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

NeoaPred: a deep-learning framework for predicting immunogenic neoantigen based on surface and structural features of peptide–human leukocyte antigen complexes

Bioinformatics
2024 | Journal article
DOI: 10.1093/bioinformatics/btae547
EID:

2-s2.0-85204819669

Part of ISSN: 13674811 13674803
Contributors: Jiang, D.; Xi, B.; Tan, W.; Chen, Z.; Wei, J.; Hu, M.; Lu, X.; Chen, D.; Cai, H.; Du, H.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma

Nature Communications
2024 | Journal article
DOI: 10.1038/s41467-024-54140-1
EID:

2-s2.0-85209755394

Part of ISSN: 20411723
Contributors: Wen, Y.; Wang, H.; Yang, X.; Zhu, Y.; Li, M.; Ma, X.; Huang, L.; Wan, R.; Zhang, C.; Li, S. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib

Acta Pharmaceutica Sinica B
2024 | Journal article
DOI: 10.1016/j.apsb.2023.11.010
EID:

2-s2.0-85178104873

Part of ISSN: 22113843 22113835
Contributors: Xiang, S.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Small Molecule-Induced Post-Translational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells

Journal of the American Chemical Society
2024 | Journal article
DOI: 10.1021/jacs.4c07181
EID:

2-s2.0-85201666390

Part of ISSN: 15205126 00027863
Contributors: Tang, G.; Wang, X.; Huang, H.; Xu, M.; Ma, X.; Miao, F.; Lu, X.; Zhang, C.-J.; Gao, L.; Zhang, Z.-M. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer

Journal of Medicinal Chemistry
2024 | Journal article
DOI: 10.1021/acs.jmedchem.4c01458
EID:

2-s2.0-85201708093

Part of ISSN: 15204804 00222623
Contributors: Wang, C.; Fang, Y.; Zhou, Z.; Liu, Z.; Feng, F.; Wan, X.; Li, Y.; Liu, S.; Ding, J.; Zhang, Z.-M. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Structure-Based Optimization of Pyrazinamide-Containing Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors to Overcome Clinical Mutations

ACS Pharmacology and Translational Science
2024 | Journal article
DOI: 10.1021/acsptsci.4c00071
EID:

2-s2.0-85190282989

Part of ISSN: 25759108
Contributors: Zheng, X.; Chen, Z.; Guo, M.; Liang, H.; Song, X.; Liu, Y.; Liao, Z.; Zhang, Y.; Guo, J.; Zhou, Y. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Targeting Solvent-Front Mutations for Kinase Drug Discovery: From Structural Basis to Design Strategies

Journal of Medicinal Chemistry
2024 | Journal article
DOI: 10.1021/acs.jmedchem.4c00361
EID:

2-s2.0-85201519331

Part of ISSN: 15204804 00222623
Contributors: Zhou, Y.; Kang, J.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer

EMBO Molecular Medicine
2024 | Journal article
DOI: 10.1038/s44321-024-00108-z
EID:

2-s2.0-85200137896

Part of ISSN: 17574684 17574676
Contributors: Wang, H.; Sun, H.; Huang, J.; Zhang, Z.; Cai, G.; Wang, C.; Xiao, K.; Xiong, X.; Zhang, J.; Liu, P. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

2-Aminopyrimidine: a privileged scaffold in kinase drug discovery

Privileged Scaffolds in Drug Discovery
2023 | Book chapter
Part of DOI: 10.1016/B978-0-443-18611-0.00012-7
EID:

2-s2.0-85176818069

Part of ISBN: 9780443186110 9780443186127
Contributors: Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Advances in protein kinase drug discovery through targeting gatekeeper mutations

Expert Opinion on Drug Discovery
2023 | Journal article
DOI: 10.1080/17460441.2023.2265303
EID:

2-s2.0-85173964174

Part of ISSN: 1746045X 17460441
Contributors: Guo, J.; Zhou, Y.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors

European Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1016/j.ejmech.2022.115034
EID:

2-s2.0-85145690046

Part of ISSN: 17683254 02235234
Contributors: Song, S.; Tang, H.; Ran, T.; Fang, F.; Tong, L.; Chen, H.; Xie, H.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry

European Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1016/j.ejmech.2023.115671
EID:

2-s2.0-85165576085

Part of ISSN: 17683254 02235234
Contributors: Tang, G.; Wang, W.; Wang, X.; Ding, K.; Ngan, S.C.; Chen, J.-Y.; Sze, S.K.; Gao, L.; Yuan, P.; Lu, X. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3- d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor

Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1021/acs.jmedchem.3c00319
EID:

2-s2.0-85159618160

Part of ISSN: 15204804 00222623
Contributors: Li, Q.; Zhang, T.; Song, P.; Tong, L.; Feng, F.; Guo, J.; Zhou, Y.; Xie, H.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of 1-hydroxy-2-methylquinolin-4(1H)-one derivatives as new cytochrome bd oxidase inhibitors for tuberculosis therapy

European Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1016/j.ejmech.2022.114896
EID:

2-s2.0-85141511480

Part of ISSN: 17683254 02235234
Contributors: Zhou, Y.; Shao, M.; Wang, W.; Cheung, C.-Y.; Wu, Y.; Yu, H.; Hu, X.; Cook, G.M.; Gong, H.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)

Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1021/acs.jmedchem.3c00088
EID:

2-s2.0-85162207657

Part of ISSN: 15204804 00222623
Contributors: Zhou, Y.; Yu, H.; Vind, A.C.; Kong, L.; Liu, Y.; Song, X.; Tu, Z.; Yun, C.; Smaill, J.B.; Zhang, Q.-W. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations

Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1021/acs.jmedchem.3c00875
EID:

2-s2.0-85171309461

Part of ISSN: 15204804 00222623
Contributors: Chen, H.; Hu, S.; Patterson, A.V.; Smaill, J.B.; Ding, K.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations

Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1021/acs.jmedchem.3c00899
EID:

2-s2.0-85172739945

Part of ISSN: 15204804 00222623
Contributors: Wang, Z.; Wang, J.; Wang, Y.; Xiang, S.; Zhou, H.; Song, S.; Song, X.; Tu, Z.; Zhou, Y.; Ding, K. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy

European Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1016/j.ejmech.2022.114899
EID:

2-s2.0-85142187656

Part of ISSN: 17683254 02235234
Contributors: Xiang, S.; Wang, J.; Huang, H.; Wang, Z.; Song, X.; Zhou, Y.; Jin, F.; He, X.; Zhang, Z.-M.; Tu, Z. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy

Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1021/acs.jmedchem.3c00028
EID:

2-s2.0-85163428926

Part of ISSN: 15204804 00222623
Contributors: Wang, C.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria

Nature Communications
2022 | Journal article
DOI: 10.1038/s41467-022-34034-w
EID:

2-s2.0-85140791694

Part of ISSN: 20411723
Contributors: Wang, Y.; Zhou, Y.; Shi, C.; Liu, J.; Lv, G.; Huang, H.; Li, S.; Duan, L.; Zheng, X.; Liu, Y. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Application of Deep Generative Model for Design of Pyrrolo[2,3-d] Pyrimidine Derivatives as New Selective TANK Binding Kinase 1 (TBK1) Inhibitors

SSRN
2022 | Other
DOI: 10.2139/ssrn.4263815
EID:

2-s2.0-85179575129

Part of ISSN: 15565068
Contributors: Song, S.; Tang, H.; Ran, T.; Fang, F.; Tong, L.; Chen, H.; Xie, H.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/acs.jmedchem.2c00168
EID:

2-s2.0-85129287688

Part of ISSN: 15204804 00222623
Contributors: Chen, H.; Lai, M.; Zhang, T.; Chen, Y.; Tong, L.; Zhu, S.; Zhou, Y.; Ren, X.; Ding, J.; Xie, H. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/acs.jmedchem.2c01319
EID:

2-s2.0-85141014054

Part of ISSN: 15204804 00222623
Contributors: Yang, F.; Chen, X.; Song, X.; Ortega, R.; Lin, X.; Deng, W.; Guo, J.; Tu, Z.; Patterson, A.V.; Smaill, J.B. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/acs.jmedchem.2c00096
EID:

2-s2.0-85126613283

Part of ISSN: 15204804 00222623
Contributors: Shao, M.; Chen, X.; Yang, F.; Song, X.; Zhou, Y.; Lin, Q.; Fu, Y.; Ortega, R.; Lin, X.; Tu, Z. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of 1-Hydroxy-2-Methylquinolin-4(1H)-One Derivatives as New Cytochrome bd Oxidase Inhibitors for Tuberculosis Therapy

SSRN
2022 | Other
DOI: 10.2139/ssrn.4215666
EID:

2-s2.0-85143260805

Part of ISSN: 15565068
Contributors: Zhou, Y.; Shao, M.; Wang, W.; Cheung, C.-Y.; Wu, Y.; Yu, H.; Hu, X.; Cook, G.M.; Gong, H.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/acs.jmedchem.1c01719
EID:

2-s2.0-85122376832

Part of ISSN: 15204804 00222623
Contributors: Lu, X.; Smaill, J.B.; Patterson, A.V.; Ding, K.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/acs.jmedchem.2c00981
EID:

2-s2.0-85141995152

Part of ISSN: 15204804 00222623
Contributors: Wang, C.; Li, J.; Qu, L.; Tang, X.; Song, X.; Yang, F.; Chen, X.; Lin, Q.; Lin, W.; Zhou, Y. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies

European Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1016/j.ejmech.2021.114022
EID:

2-s2.0-85120494615

Part of ISSN: 17683254 02235234
Contributors: Guo, J.; Xiang, S.; Wang, J.; Zhou, Y.; Wang, Z.; Zhang, Z.; Ding, K.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/acs.jmedchem.1c01768
EID:

2-s2.0-85123979307

Part of ISSN: 15204804 00222623
Contributors: Lu, J.; Huang, Y.; Huang, J.; He, R.; Huang, M.; Lu, X.; Xu, Y.; Zhou, F.; Zhang, Z.; Ding, K.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance

Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1021/acs.jmedchem.2c00308
EID:

2-s2.0-85128845455

Part of ISSN: 15204804 00222623
Contributors: Wang, Z.; Wang, J.; Wang, Y.; Xiang, S.; Song, X.; Tu, Z.; Zhou, Y.; Zhang, Z.-M.; Zhang, Z.; Ding, K. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Efficient targeted oncogenic KRAS<sup>G12C</sup> degradation via first reversible-covalent PROTAC

European Journal of Medicinal Chemistry
2022 | Journal article
DOI: 10.1016/j.ejmech.2021.114088
EID:

2-s2.0-85122330200

Part of ISSN: 17683254 02235234
Contributors: Yang, F.; Wen, Y.; Wang, C.; Zhou, Y.; Zhou, Y.; Zhang, Z.-M.; Liu, T.; Lu, X.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo

Molecules
2022 | Journal article
DOI: 10.3390/molecules27196500
EID:

2-s2.0-85139854538

Part of ISSN: 14203049
Contributors: Wang, J.; Zhou, Y.; Tang, X.; Yu, X.; Wang, Y.; Chan, S.; Song, X.; Tu, Z.; Zhang, Z.; Lu, X. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo

Cancer Science
2022 | Journal article
DOI: 10.1111/cas.15229
EID:

2-s2.0-85121401063

Part of ISSN: 13497006 13479032
Contributors: Liu, Y.; Lai, M.; Li, S.; Wang, Y.; Feng, F.; Zhang, T.; Tong, L.; Zhang, M.; Chen, H.; Chen, Y. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR<sup>T790M/C797S</sup>Mutants

ACS Medicinal Chemistry Letters
2022 | Journal article
DOI: 10.1021/acsmedchemlett.1c00555
EID:

2-s2.0-85123918997

Part of ISSN: 19485875
Contributors: Li, S.; Zhang, T.; Zhu, S.-J.; Lei, C.; Lai, M.; Peng, L.; Tong, L.; Pang, Z.; Lu, X.; Ding, J. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier

Targeted inhibition of ZAK ameliorates renal interstitial fibrosis

Translational Research
2022 | Journal article
DOI: 10.1016/j.trsl.2022.03.002
EID:

2-s2.0-85127747651

Part of ISSN: 18781810 19315244
Contributors: Shu, S.; Liu, H.; Yang, J.; Tang, H.; Li, H.; Liu, Z.; Zhou, M.; Zhu, F.; Hu, Z.; Ding, K. et al.
Source: Self-asserted source
xiaoyun Lu via Scopus - Elsevier
Items per page:
Page 1 of 3

Peer review (123 reviews for 14 publications/grants)

Review activity for ACS chemical neuroscience. (1)
Review activity for ACS medicinal chemistry letters. (3)
Review activity for Acta pharmaceutica sinica B. (2)
Review activity for Advanced science. (2)
Review activity for Angewandte Chemie. (1)
Review activity for Bioorganic & medicinal chemistry. (1)
Review activity for ChemMedChem. (1)
Review activity for Communications chemistry. (1)
Review activity for European journal of medicinal chemistry. (19)
Review activity for Heliyon. (1)
Review activity for Journal of chemical information and modeling. (1)
Review activity for Journal of medicinal chemistry. (87)
Review activity for Journal of the American Chemical Society. (1)
Review activity for The Innovation. (2)
How many people are using ORCID?