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Activities

Employment (4)

St. Jude Children's Research Hospital: Memphis, TN, US

2018-09 to present | Member (Immunology)
Employment
Source: Self-asserted source
Paul G. Thomas

St. Jude Children's Research Hospital: Memphis, TN, US

2014 to 2018-09 | Associate Member (Immunology)
Employment
Source: Self-asserted source
Paul G. Thomas

St. Jude Children's Research Hospital: Memphis, TN, US

2009 to 2014 | Assistant Member (Immunology)
Employment
Source: Self-asserted source
Paul G. Thomas

St. Jude Children's Research Hospital: Memphis, TN, US

2004 to 2009 | Postdoctoral Research Associate (Immunology)
Employment
Source: Self-asserted source
Paul G. Thomas

Education and qualifications (2)

Harvard University: Cambridge, MA, US

1999 to 2003 | PhD (Immunology and Infectious Diseases)
Education
Source: Self-asserted source
Paul G. Thomas

Wake Forest University: Winston-Salem, NC, US

1995 to 1999 | BS (Biology and Philosophy)
Education
Source: Self-asserted source
Paul G. Thomas

Funding (4)

DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSES

2020-06-29 to 2025-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: U01AI150747
Source: Self-asserted source
Paul G. Thomas via DimensionsWizard

DIVINCI: Dissection of Influenza Vaccination and Infection for Childhood Immunity

2019-05-02 to 2026-04-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: U01AI144616
Source: Self-asserted source
Paul G. Thomas via DimensionsWizard

Decoding the interactions between T cell receptors and peptide-MHC

2018-06-20 to 2023-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI136514
Source: Self-asserted source
Paul G. Thomas via DimensionsWizard

A protective role for gamma delta T cells in respiratory infection

2016-03-01 to 2021-02-28 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI121832
Source: Self-asserted source
Paul G. Thomas via DimensionsWizard

Works (50 of 263)

Items per page:
Page 1 of 6

High-Dose Inactivated Influenza Vaccine Inconsistently Improves Heterologous Antibody Responses in an Older Human Cohort

The Journal of Infectious Diseases
2025-01-08 | Journal article
Contributors: W Zane Billings; Yang Ge; Jessica H Knight; Hayley Hemme; Savannah M Hammerton; Amanda L Skarlupka; Wangnan Cao; Ye Shen; Justin Bahl; Paul G Thomas et al.
Source: check_circle
Crossref

TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing

2024-09-21 | Preprint
Contributors: Mikhail V. Pogorelyy; Allison M. Kirk; Samir Adhikari; Anastasia A. Minervina; Balaji Sundararaman; Kasi Vegesana; David C. Brice; Zachary B. Scott; Paul G. Thomas
Source: check_circle
Crossref

Immune Cell Profiles of Patients with Sickle Cell Disease during Parvovirus B19–Induced Transient Red Cell Aplasia

Vaccines
2024-08 | Journal article | Author
Contributors: E. Kaitlynn Allen; Rhiannon R. Penkert; Jane S Hankins; Sherri L. Surman; Lee-Ann Van de Velde; Alyssa Cotton; Randall Hayden; Li Tang; Xiaomeng Yuan; Ying Zheng et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Biologic and clinical analysis of childhood gamma delta T-ALL identifies LMO2/STAG2 rearrangements as extremely high-risk.

Cancer discovery
2024-06-25 | Journal article
Contributors: Shunsuke Kimura; Chun Shik Park; Lindsey Montefiori; Ilaria Iacobucci; Petri Pölönen; Qingsong Gao; Elizabeth Arnold; Andishe Attarbaschi; Anthony Brown; BARBARA BULDINI et al.
Source: Self-asserted source
Paul G. Thomas

Lack of memory recall in human CD4 T cells elicited by the first encounter with SARS-CoV-2.

iScience
2024-05-17 | Journal article
Contributors: Richards KA; Changrob S; Thomas PG; Wilson PC; Sant AJ; Paul G. Thomas
Source: Self-asserted source
Paul G. Thomas

Diet-induced obesity affects influenza disease severity and transmission dynamics in ferrets.

Science advances
2024-05-10 | Journal article | Author
Contributors: Victoria Meliopoulos; Rebekah Honce; Livingston B; Hargest V; Pamela Freiden; Lauren Lazure; Pamela H Brigleb; Erik Karlsson; Heather Sheppard; E. Kaitlynn Allen et al.
Source: Self-asserted source
Paul G. Thomas

Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice.

Nature microbiology
2024-04-18 | Journal article | Author
Contributors: Rebekah Honce; Ana Vazquez-Pagan; Livingston B; Mandarano AH; Benjamin Wilander; Cherry S; Virginia Hargest; Sharp B; Pamela H Brigleb; Kirkpatrick Roubidoux E et al.
Source: Self-asserted source
Paul G. Thomas

Necroptosis blockade prevents lung injury in severe influenza.

Nature
2024-04-10 | Journal article | Author
Contributors: Gautam A; Boyd DF; Sameer Nikhar; Zhang T; Siokas I; Lee-Ann Van De Velde; Jessica Gaevert; Victoria Meliopoulos; Thapa B; Diego A. Rodriguez et al.
Source: Self-asserted source
Paul G. Thomas

Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation.

Cell reports
2024-04-07 | Journal article
Contributors: Boeren M; Nicky de Vrij; Ha MK; Valkiers S; Souquette A; Gielis S; Maria Kuznetsova; Schippers J; Bartholomeus E; Van den Bergh J et al.
Source: Self-asserted source
Paul G. Thomas

Principles and therapeutic applications of adaptive immunity.

Cell
2024-04-01 | Journal article
Contributors: Chi H; Pepper M; Thomas PG
Source: Self-asserted source
Paul G. Thomas

Secondary bone marrow graft loss after third-party virus-specific T cell infusion: Case report of a rare complication.

Nature communications
2024-03-29 | Journal article | Author
Contributors: Michael Keller; Stefan A Schattgen; shanmuganathan chandrakasan; E. Kaitlynn Allen; Jensen-Wachspress MA; Christopher A. Lazarski; Qayed M; Lang H; Hanley PJ; Tanna J et al.
Source: Self-asserted source
Paul G. Thomas

Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer.

Human gene therapy
2024-03-28 | Journal article
Contributors: Mark A Brimble; Morton CL; Winston SM; Reeves IL; Spence Y; Cheng PH; Zhou J; Nathwani AC; Thomas PG; Aisha Souquette et al.
Source: Self-asserted source
Paul G. Thomas

DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma.

Cell reports. Medicine
2024-03-01 | Journal article
Contributors: Kirk AM; Crawford JC; Chou CH; Guy C; Pandey K; Kozlik T; Ravi Shah; Chung S; Nguyen P; Zhang X et al.
Source: Self-asserted source
Paul G. Thomas

Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma.

Cell reports. Medicine
2024-03-01 | Journal article
Contributors: Abu-Zaid A; Fang J; Jin H; Singh S; Pichavaram P; Wu Q; Tillman H; Janke L; Rosikiewicz W; Xu B et al.
Source: Self-asserted source
Paul G. Thomas

Impact of the COVID-19 related border restrictions on influenza and other common respiratory viral infections in New Zealand.

Influenza and other respiratory viruses
2024-02-01 | Journal article
Contributors: Q. Sue Huang; Turner N; Wood T; Anglemyer A; McIntyre P; Aminisani N; Dowell T; Trenholme A; Byrnes C; Balm M et al.
Source: Self-asserted source
Paul G. Thomas

Variation in the basal immune state and implications for disease

eLife
2024-01-26 | Journal article
Contributors: Aisha Souquette; Paul G Thomas
Source: check_circle
Crossref

Comparisons of Pediatric and Adult SARS-CoV-2-Specific Antibodies up to 6 Months after Infection, Vaccination, or Hybrid Immunity.

Journal of the Pediatric Infectious Diseases Society
2024-01-01 | Journal article | Author
Contributors: Minjun Kim; Wesley A. Cheng; Zion Congrave-Wilson; Marentes Ruiz CJ; Turner L; Shirley Mendieta; Jaycee Jumarang; Del Valle J; Lee Y; Thomas Fabrizio et al.
Source: Self-asserted source
Paul G. Thomas

Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer.

Science advances
2023-12-22 | Journal article | Author
Contributors: Mehdi Chaib; Jeremiah Holt; Emilie L Fisher-Gupta; Laura Sipe; Margaret S Bohm; Sydney C. Joseph; Emily W. Grey; Simon, SE; Johnathan Yarbro; Ubaid Tanveer et al.
Source: Self-asserted source
Paul G. Thomas

Multi-variate model of T cell clonotype competition and homeostasis.

Scientific reports
2023-12-11 | Journal article
Contributors: Daniel Luque Duque; Gaevert JA; Thomas PG; López-García M; Lythe G; Molina-París C
Source: Self-asserted source
Paul G. Thomas

CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity.

Cancer research communications
2023-12-01 | Journal article | Author
Contributors: Dalia Haydar; Jorge Ibanez; Jeremy Chase Crawford; Chingheng Chou; Cliff Guy; Michaela Meehl; Zhongzhen Yi; Scott Perry; Jonathan Laxton; Trevor Cunningahm et al.
Source: Self-asserted source
Paul G. Thomas

Digital PCR to Measure SARS-CoV-2 RNA, Variants, and Outcomes in Youth.

Journal of the Pediatric Infectious Diseases Society
2023-12-01 | Journal article
Contributors: Hijano, DR; Ferrolino JA; Gu Z; Brazelton JN; Zhu H; Suganda S; Heather Glasgow; Dallas RH; Allison KJ; Maron G et al.
Source: Self-asserted source
Paul G. Thomas

copepodTCR: Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling

2023-11-29 | Preprint
Contributors: Vasilisa A. Kovaleva; David J. Pattinson; Carl Barton; Sarah R. Chapin; Anastasia A. Minervina; Katherine A. Richards; Andrea J. Sant; Paul G. Thomas; Mikhail V. Pogorelyy; Hannah V. Meyer
Source: check_circle
Crossref

Latent human herpesvirus 6 is reactivated in CAR T cells.

Nature
2023-11-08 | Journal article | Author
Contributors: Caleb Lareau; Yajie Yin; Alexandria Maurer; Katalin Sandor; Bence Daniel; Yagnik G; José Peña; Jeremy Chase Crawford; Anne Mea Spanjaart; Gutierrez JC et al.
Source: Self-asserted source
Paul G. Thomas

Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan.

Nature immunology
2023-09-25 | Journal article | Author
Contributors: Carolien van de Sandt; THI HOANG OANH NGUYEN; Nicholas Gherardin; Jeremy Chase Crawford; Jerome Samir; Minervina AA; Pogorelyy MV; Simone Rizzetto; Christopher Szeto; Kaur J et al.
Source: Self-asserted source
Paul G. Thomas

Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside

Journal of Clinical Investigation
2023-09-01 | Journal article
Contributors: Mohamed A. Ghonim; David F. Boyd; Tim Flerlage; Paul G. Thomas
Source: check_circle
Crossref

Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2

2023-07-13 | Preprint
Contributors: Ericka Kirkpatrick Roubidoux; Pamela H. Brigleb; Kasi Vegesana; Aisha Souquette; Kendall Whitt; Pamela Freiden; Amanda Green; Paul G. Thomas; Maureen A. McGargill; Joshua Wolf et al.
Source: check_circle
Crossref

Modeling Antigen-Specific T Cell Dynamics Following Hepatitis B Vaccination indicates differences between conventional and regulatory T cell dynamics

2023-05-28 | Preprint
Contributors: Hajar Besbassi; George Elias; Pieter Meysman; Hilde Jansens; Kris Laukens; Pierre Van Damme; Paul Thomas; Niel Hens; Philippe Beutels; Benson Ogunjimi
Source: check_circle
Crossref

A Small Molecule RIG-I Agonist Serves as an Adjuvant to Induce Broad Multifaceted Influenza Virus Vaccine Immunity

The Journal of Immunology
2023-05-01 | Journal article
Contributors: Emily A Hemann; Megan L Knoll; Courtney R Wilkins; Caroline Subra; Richard Green; Adolfo García-Sastre; Paul G Thomas; Lydie Trautmann; Renee C Ireton; Yueh-Ming Loo et al.
Source: check_circle
Crossref

How Estrogen, Testosterone, and Sex Differences Influence Serum Immunoglobulin Isotype Patterns in Mice and Humans

Viruses
2023-02-09 | Journal article
Contributors: Sherri L. Surman; Bart G. Jones; Rhiannon R. Penkert; Robert E. Sealy; Tony Marion; Paul G. Thomas; Geoffrey Neale; Beisi Xu; Julia L. Hurwitz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

NIAID workshop on T cell technologies

Nature Immunology
2023-01 | Journal article
Contributors: Timothy A. Gondré-Lewis; Chao Jiang; Mandy L. Ford; David M. Koelle; Alessandro Sette; Alex K. Shalek; Paul G. Thomas
Source: check_circle
Crossref

Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology

2023-01-06 | Preprint
Contributors: Paul Thomas; Robert Mettelman; Aisha Souquette; Lee-Ann Van De Velde; Kasi Vegesana; Emma Allen; Taylor Wilson; Christina Kackos; Jennifer DeBeauchamp; Sanja Trifkovic et al.
Source: check_circle
Crossref

Comparing T cell receptor repertoires using optimal transport

PLOS Computational Biology
2022-12-07 | Journal article
Contributors: Branden J. Olson; Andrew J. Yates; Stefan A. Schattgen; Paul G. Thomas; Philip Bradley; Frederick A. Matsen IV
Source: check_circle
Crossref

Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes

Biomedicines
2022-11-23 | Journal article
Contributors: Sherri L. Surman; Jeremy Crawford; Pradyot Dash; Susan L. Tonkonogy; Paul G. Thomas; Julia L. Hurwitz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2

Nature Methods
2022-09 | Journal article
Contributors: Mikhail Goncharov; Dmitry Bagaev; Dmitrii Shcherbinin; Ivan Zvyagin; Dmitry Bolotin; Paul G. Thomas; Anastasia A. Minervina; Mikhail V. Pogorelyy; Kristin Ladell; James E. McLaren et al.
Source: check_circle
Crossref

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity

2022-09-20 | Preprint
Contributors: Emily A. Hemann; Megan L. Knoll; Courtney R. Wilkins; Caroline Subra; Richard Green; Adolfo García-Sastre; Paul G. Thomas; Lydie Trautmann; Renee Ireton; Yueh-Ming Loo et al.
Source: check_circle
Crossref

Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery

Cell Reports Medicine
2022-08 | Journal article
Contributors: Mikhail V. Pogorelyy; Elisa Rosati; Anastasia A. Minervina; Robert C. Mettelman; Alexander Scheffold; Andre Franke; Petra Bacher; Paul G. Thomas
Source: check_circle
Crossref

(E1)levating COVID-19 vaccine efficiency with adenoviral E1 proteins

Science Advances
2022-08-26 | Journal article
Contributors: Douglas R. Green; Paul G. Thomas
Source: check_circle
Crossref

Mucosal immune responses to infection and vaccination in the respiratory tract

Immunity
2022-05 | Journal article
Contributors: Robert C. Mettelman; E. Kaitlynn Allen; Paul G. Thomas
Source: check_circle
Crossref

Twelve-Month Longitudinal Serology in SARS-CoV-2 Naïve and Experienced Vaccine Recipients and Unvaccinated COVID-19-Infected Individuals

Vaccines
2022-05 | Journal article | Author
Contributors: Zion Congrave-Wilson; Wesley A. Cheng; Yesun Lee; Stephanie Perez; Lauren Turner; Carolyn Jennifer Marentes Ruiz; Shirley Mendieta; Adam Skura; Jaycee Jumarang; Jennifer Del Valle et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Improved metabolic syndrome and timing of weight loss is crucial for influenza vaccine-induced immunity in obese mice

2022-04-17 | Preprint
Contributors: Rebekah Honce; Ana Vazquez-Pagan; Brandi Livingston; Sean Cherry; Virginia Hargest; Bridgett Sharp; Lee-Ann Van de Velde; R. Chris Skinner; Paul G. Thomas; Stacey Schultz-Cherry
Source: check_circle
Crossref

Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer

2022-03-31 | Preprint
Contributors: Mehdi Chaib; Jeremiah Holt; Laura M. Sipe; Margaret S. Bohm; Sydney J. Clarice; Johnathan R. Yarbro; Ubaid Tanveer; T.J. Hollingsworth; QingQing Wei; Paul G. Thomas et al.
Source: check_circle
Crossref

Immunology of SARS-CoV-2 infection in children

Nature Immunology
2022-02 | Journal article
Contributors: Janet Chou; Paul G. Thomas; Adrienne G. Randolph
Source: check_circle
Crossref

Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph analysis (CoNGA)

Nature Biotechnology
2022-01 | Journal article
Contributors: Stefan A. Schattgen; Kate Guion; Jeremy Chase Crawford; Aisha Souquette; Alvaro Martinez Barrio; Michael J. T. Stubbington; Paul G. Thomas; Philip Bradley
Source: check_circle
Crossref

Characterization of SARS-CoV-2 public CD4+ αβ T cell clonotypes through reverse epitope discovery

2021-11-22 | Other
Contributors: Elisa Rosati; Mikhail V. Pogorelyy; Anastasia A. Minervina; Alexander Scheffold; Andre Franke; Petra Bacher; Paul G. Thomas
Source: check_circle
Crossref

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

2021-09-20 | Other
Contributors: Magdalena L Russell; Aisha Souquette; David M Levine; E Kaitlynn Allen; Guillermina Kuan; Noah Simon; Angel Balmaseda; Aubree Gordon; Paul G Thomas; Frederick A Matsen, IV et al.
Source: check_circle
Crossref

Quantifying T Cell Cross-Reactivity: Influenza and Coronaviruses

Viruses
2021-09-07 | Journal article
Contributors: Jessica Ann Gaevert; Daniel Luque Duque; Grant Lythe; Carmen Molina-París; Paul Glyndwr Thomas
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

Nature Reviews Microbiology
2021-07-06 | Journal article
Contributors: Tim Flerlage; David F. Boyd; Victoria Meliopoulos; Paul G. Thomas; Stacey Schultz-Cherry
Source: check_circle
Crossref

T RH cells, helpers making an impact in their local community

Science Immunology
2021-01-08 | Journal article
Contributors: Stefan A. Schattgen; Paul G. Thomas
Source: check_circle
Crossref

A population of proinflammatory T cells coexpresses $α$$β$ and $γ$$δ$ T cell receptors in mice and humans

Journal of Experimental Medicine
2020 | Journal article
Source: Self-asserted source
Paul G. Thomas

Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier

Nature Communications
2020 | Journal article
Source: Self-asserted source
Paul G. Thomas
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Peer review (84 reviews for 21 publications/grants)

Review activity for Cell reports medicine. (5)
Review activity for Cell reports. (3)
Review activity for Cell. (5)
Review activity for Genome medicine. (1)
Review activity for Immunity. (7)
Review activity for Leukemia (2)
Review activity for Nature (21)
Review activity for Nature aging. (2)
Review activity for Nature cancer. (1)
Review activity for Nature communications (5)
Review activity for Nature genetics. (1)
Review activity for Nature immunology. (11)
Review activity for Nature machine intelligence. (1)
Review activity for Nature medicine. (6)
Review activity for Nature methods. (2)
Review activity for Nature microbiology. (1)
Review activity for PLOS pathogens : (4)
Review activity for Science immunology. (1)
Review activity for Science. (2)
Review activity for The Journal of experimental medicine. (2)
Review activity for The Lancet microbe. (1)