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ResearcherID: F-5117-2013
Scopus Author ID: 6603439191

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Employment (4)

Lund University: Lund, SE

2021-06-01 to present | Professor (Experimental Medical Science)
Employment
Source: Self-asserted source
Tomas Bjorklund

Lund University: Lund, SE

2018-11-01 to 2021-05-31 | Tenured Senior lecturer (Lektor) (Experimental Medical Science )
Employment
Source: Self-asserted source
Tomas Bjorklund

Lund University: Lund, SE

2011-08-01 to 2018-10-31 | Assistant professor (Experimental Medical Science)
Employment
Source: Self-asserted source
Tomas Bjorklund

Lund University: Lund, SE

2009-12-05 to 2011-07-31 | Postdoctoral scientist (Experimental Medical Science)
Employment
Source: Self-asserted source
Tomas Bjorklund

Education and qualifications (2)

Lund University: Lund, SE

2016-08-12 to present | Docent (Reader) (Experimental Medical Science)
Qualification
Source: Self-asserted source
Tomas Bjorklund

Lund University: Lund, SE

2005-09-01 to 2009-12-04 | PhD (Experimental Medical Science)
Education
Source: Self-asserted source
Tomas Bjorklund

Works (50 of 61)

Items per page:
Page 1 of 2

Lineage tracing of stem cell–derived dopamine grafts in a Parkinson’s model reveals shared origin of all graft-derived cells

Science Advances
2024-10-18 | Journal article
DOI: 10.1126/sciadv.adn3057
Contributors: Petter Storm; Yu Zhang; Fredrik Nilsson; Alessandro Fiorenzano; Niklas Krausse; Malin Åkerblom; Marcus Davidsson; Joan Yuan; Agnete Kirkeby; Tomas Björklund et al.
Source: check_circle
Crossref

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Stem Cell Reports
2022-01 | Journal article
DOI: 10.1016/j.stemcr.2021.11.014
Contributors: Patrick Aldrin-Kirk; Malin Åkerblom; Tiago Cardoso; Sara Nolbrant; Andrew F. Adler; Xiaohe Liu; Andreas Heuer; Marcus Davidsson; Malin Parmar; Tomas Björklund
Source: check_circle
Crossref

In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?

Current Opinion in Genetics & Development
2021-10 | Journal article
DOI: 10.1016/j.gde.2021.06.002
Contributors: Malin Parmar; Anders Björklund; Tomas Björklund
Source: check_circle
Crossref

AAV Production Everywhere: A Simple, Fast, and Reliable Protocol for In-house AAV Vector Production Based on Chloroform Extraction

Current Protocols in Neuroscience
2020 | Journal article
DOI: 10.1002/cpns.103
EID:

2-s2.0-85090106089

Part of ISSN: 19348576 19348584
Contributors: Negrini, M.; Wang, G.; Heuer, A.; Björklund, T.; Davidsson, M.
Source: Self-asserted source
Tomas Bjorklund via Scopus - Elsevier

Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy

Movement Disorders
2019 | Journal article
DOI: 10.1002/mds.27810
EID:

2-s2.0-85071099228

Part of ISSN: 15318257 08853185
Contributors: Espa, E.; Clemensson, E.K.H.; Luk, K.C.; Heuer, A.; Björklund, T.; Cenci, M.A.
Source: Self-asserted source
Tomas Bjorklund via Scopus - Elsevier

Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

Brain
2019 | Journal article
DOI: 10.1093/brain/awz176
EID:

2-s2.0-85070660425

Part of ISSN: 14602156 00068950
Contributors: Rosenblad, C.; Li, Q.; Pioli, E.Y.; Dovero, S.; Antunes, A.S.L.M.; Agúndez, L.; Bardelli, M.; Linden, R.M.; Henckaerts, E.; Björklund, A. et al.
Source: Self-asserted source
Tomas Bjorklund via Scopus - Elsevier

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Proceedings of the National Academy of Sciences
2019-12-26 | Journal article
DOI: 10.1073/pnas.1910061116
Contributors: Marcus Davidsson; Gang Wang; Patrick Aldrin-Kirk; Tiago Cardoso; Sara Nolbrant; Morgan Hartnor; Janitha Mudannayake; Malin Parmar; Tomas Björklund
Source: check_circle
Crossref
grade
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Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain.

Methods in molecular biology (Clifton, N.J.)
2019-01-01 | Journal article
DOI: 10.1007/978-1-4939-9065-8_4
PMID: 30706390
Source: Self-asserted source
Tomas Bjorklund
grade
Preferred source (of 2)‎

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Brain : a journal of neurology
2018-07-01 | Journal article
DOI: 10.1093/brain/awy126
PMID: 29788236
PMC: PMC6037107
Source: Self-asserted source
Tomas Bjorklund
grade
Preferred source (of 2)‎

Barcoded Rational AAV Vector Evolution enables systematic in vivo mapping of peptide binding motifs

2018-05-31 | Other
DOI: 10.1101/335372
Contributors: Marcus Davidsson; Gang Wang; Patrick Aldrin-Kirk; Tiago Cardoso; Sara Nolbrant; Morgan Hartnor; Malin Parmar; Tomas Björklund
Source: check_circle
Crossref

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

RNA
2018-05-31 | Journal article
DOI: 10.1261/rna.063925.117
Contributors: Marcus Davidsson; Paula Díaz-Fernández; Marcos Torroba; Oliver D. Schwich; Patrick Aldrin-Kirk; Luis Quintino; Andreas Heuer; Gang Wang; Cecilia Lundberg; Tomas Björklund
Source: check_circle
Crossref
grade
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Repairing the Brain: Gene Therapy.

Journal of Parkinson's disease
2018-01-01 | Journal article
DOI: 10.3233/JPD-181485
PMID: 30584164
PMC: PMC6311375
Source: Self-asserted source
Tomas Bjorklund
grade
Preferred source (of 2)‎

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum.

Neurobiology of disease
2017-10 | Journal article
DOI: 10.1016/j.nbd.2017.10.010
PMID: 29037828
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 2)‎

Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

2016 | Journal article
DOI: 10.1007/978-1-4939-3271-9_3
PMID: 26611577
Contributors: Björklund T
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 2)‎

Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson's Disease.

2016 | Journal article
DOI: 10.1038/srep31701
PMID: 27550741
Contributors: Kurowska Z; Jewett M; Brattås PL; Jimenez-Ferrer I; Kenéz X; Björklund T; Nordström U; Brundin P; Swanberg M
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 2)‎

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing.

Scientific Reports
2016-11 | Journal article
DOI: 10.1038/srep37563
PMID: 27874090
PMC: PMC5118689
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 2)‎

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.

2016-08 | Journal article
DOI: 10.1016/j.immuni.2016.07.014
PMID: 27533015
Contributors: Kristiansen TA; Jaensson Gyllenbäck E; Zriwil A; Björklund T; Daniel JA; Sitnicka E; Soneji S; Bryder D; Yuan J
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 2)‎

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor.

2016-06 | Journal article
DOI: 10.1016/j.neuron.2016.04.017
PMID: 27161524
PMC: PMC4893163
Contributors: Aldrin-Kirk P; Heuer A; Wang G; Mattsson B; Lundblad M; Parmar M; Björklund T
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 2)‎

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.

2014 | Journal article
DOI:

10.1371/journal.pone.0100869

PMID:

24999658

PMC:

PMC4085060
Contributors: Aldrin-Kirk P; Davidsson M; Holmqvist S; Li JY; Björklund T
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 3)‎

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

2014-12 | Journal article
DOI:

10.1007/s00401-014-1343-6

PMID:

25296989
Contributors: Holmqvist S; Chutna O; Bousset L; Aldrin-Kirk P; Li W; Björklund T; Wang ZY; Roybon L; Melki R; Li JY
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 3)‎

A novel alpha-synuclein-GFP mouse model displays progressive motor impairment and age-dependent alpha-synuclein accumulation

Society for Neuroscience Abstract Viewer and Itinerary Planner
2013 | Journal article
Contributors: Li, J. -Y. J. -Y.; Bjorklund, T.; Petit, G. H.; Lundblad, M.; Murmu, R. P.; Brundin, P.; Hansen, C.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

A novel alpha-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of alpha-synuclein-GFP

Neurobiology of Disease
2013 | Journal article
Contributors: Hansen, Christian; Bjoerklund, Tomas; Petit, Geraldine H.; Lundblad, Martin; Murmu, Reena Prity; Brundin, Patrik; Li, Jia-Yi
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

A novel alpha-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of alpha-synuclein-GFP

Movement Disorders
2013 | Journal article
Contributors: Hansen, C.; Bjorklund, T.; Petit, G. H.; Lundblad, M.; Murmu, R. P.; Brundin, P.; Li, J. Y.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

An unbiased screening assay of trans-splicing efficiency by randomized intron fragmentation

Society for Neuroscience Abstract Viewer and Itinerary Planner
2013 | Journal article
Contributors: Davidsson, M.; Torroba, M.; Aldrin, P.; Lundberg, C.; Bjorklund, T.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

2013 | Journal article
DOI:

10.1038/srep02157

PMID:

23831692

PMC:

PMC3703607
Contributors: Cederfjäll E; Nilsson N; Sahin G; Chu Y; Nikitidou E; Björklund T; Kordower JH; Kirik D
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 3)‎

Novel DLB rat model based on AAV vector mediated expression of alpha-synuclein localized to the cerebral cortices, display significant neuronal degeneration and pathology

Society for Neuroscience Abstract Viewer and Itinerary Planner
2013 | Journal article
Contributors: Aldrin, P.; Holmqvist, S.; Davidsson, M.; Bjorklund, A.; Li, J. -Y.; Bjorklund, T.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

2013-08 | Journal article
DOI:

10.1016/j.nbd.2013.04.017

PMID:

23643841
Contributors: Hansen C; Björklund T; Petit GH; Lundblad M; Murmu RP; Brundin P; Li JY
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
Preferred source (of 2)‎

Dose-Response Study of Continuous DOPA Delivery with AAV Gene Therapy Reveals Threshold and Kinetics for Restoration of Motor Function in a Rodent Model of Parkinson's Disease

Molecular Therapy
2012 | Journal article
Contributors: Cederfjall, Erik; Bjorklund, Tomas; Nilsson, Nathalie; Kirik, Deniz
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Dose-response study on the continuous DOPA delivery with expression of the TH and GCH1 genes by a single AAV-vector in the striatum

Society for Neuroscience Abstract Viewer and Itinerary Planner
2012 | Journal article
Contributors: Cederfjall, E.; Nilsson, N.; Bjorklund, T.; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Development of a novel rat model of forebrain synucleinopathy using neonatal AAV mediated over-expression of human alpha-synuclein

Society for Neuroscience Abstract Viewer and Itinerary Planner
2011 | Journal article
Contributors: Bjorklund, T.; Gabery, S.; Petersen, A.; Li, J. -Y.; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Gene Therapy for Parkinson's Disease Shows Promise

Science Translational Medicine
2011 | Journal article
DOI:

10.1126/scitranslmed.3002430
Contributors: Bjorklund, Anders; Bjorklund, Tomas
Source: Self-asserted source
Tomas Bjorklund via ResearcherID
grade
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Development of a new rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using AAV vectors

Society for Neuroscience Abstract Viewer and Itinerary Planner
2010 | Journal article
Contributors: Schultz, K.; Gabery, S.; Hult, S.; Bjorklund, T.; Kirik, D.; Petersen, A.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Development of a rat model of forebrain synucleinopathy using neonatal AAV-vector mediated over-expression of human alpha-synuclein

Society for Neuroscience Abstract Viewer and Itinerary Planner
2010 | Journal article
Contributors: Bjorklund, T.; Schultz, K.; Petersen, A.; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Expression of mutant huntingtin in the hypothalamus causes metabolic disturbances in mice

Society for Neuroscience Abstract Viewer and Itinerary Planner
2010 | Journal article
Contributors: Soylu, R.; Hult, S.; Bjorklund, T.; Belgardt, B. F.; Mauer, J.; Bruening, J.; Kirik, D.; Petersen, A.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Gene therapy for dopamine replacement.

2010 | Journal article
DOI:

10.1016/S0079-6123(10)84012-9

PMID:

20887878
Contributors: Björklund T; Cederfjäll EA; Kirik D
Source: Self-asserted source
Tomas Bjorklund via Europe PubMed Central
grade
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Grafted serotonin neurons aggravate L-dopa induced dyskinesias: In vivo evidence by microdialysis and [18F]fallypride PET imaging

Society for Neuroscience Abstract Viewer and Itinerary Planner
2010 | Journal article
Contributors: Sahin, G.; Lavisse, S.; Thompson, L.; Rbah, L.; Bjorklund, T.; Carta, M.; Hantraye, P.; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

HYPOTHALAMIC EXPRESSION OF MUTANT HUNTINGTIN CAUSES METABOLIC DISTURBANCES IN MICE

Journal of Neurology Neurosurgery and Psychiatry
2010 | Journal article
DOI:

10.1136/jnnp.2010.222570.24
Contributors: Soylu, R.; Hult, S.; Bjorklund, T.; Belgardt, B. F.; Mauer, J.; Bruening, J. C.; Kirik, D.; Petersen, A.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Novel Gene-Based Therapeutics Targeting the Dopaminergic System in Parkinson's Disease

Dopamine Handbook
2010 | Book chapter
Part of DOI: 10.1093/acprof:oso/9780195373035.003.0034
EID:

2-s2.0-84918878883
Contributors: Kirik, D.; Björklund, M.T.; Ramaswamy, S.; Kordower, J.
Source: Self-asserted source
Tomas Bjorklund via Scopus - Elsevier

Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease

Brain
2010 | Journal article
DOI:

10.1093/brain/awp314
Contributors: Bjorklund, Tomas; Carlsson, Thomas; Cederfjall, Erik Ahlm; Carta, Manolo; Kirik, Deniz
Source: Self-asserted source
Tomas Bjorklund via ResearcherID
grade
Preferred source (of 2)‎

Gene Therapy for Dopamine Replacement in Parkinson's Disease

Science Translational Medicine
2009 | Journal article
DOI:

10.1126/scitranslmed.3000350
Contributors: Bjorklund, Anders; Bjorklund, Tomas; Kirik, Deniz
Source: Self-asserted source
Tomas Bjorklund via ResearcherID
grade
Preferred source (of 2)‎

Long-term rAAV-mediated tyrosine hydroxylase knockdown in the nigrostriatal projection neurons

Society for Neuroscience Abstract Viewer and Itinerary Planner
2009 | Journal article
Contributors: Ulusoy, A.; Sahin, G.; Bjorklund, T.; Aebischer, P.; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

Journal of Neuroscience
2009 | Journal article
DOI:

10.1523/jneurosci.4491-08.2009
Contributors: Leriche, L.; Bjorklund, T.; Breysse, N.; Besret, L.; Gregoire, M. C.; Carlsson, T.; Dolle, F.; Mandel, R. J.; Deglon, N.; Hantraye, P. et al.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID
grade
Preferred source (of 2)‎

Rapid and robust recovery of motor functions in rodents with complete dopamine denervation after optimized rAAV5-mediated continuous DOPA delivery

Society for Neuroscience Abstract Viewer and Itinerary Planner
2009 | Journal article
Contributors: Bjorklund, T.; Cederfjall, E. Ahlm; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

[11C]raclopride PET imaging demonstrates correlation between correction of dopamine neurotransmission and behavioral recovery following gene therapy

Movement Disorders
2008 | Journal article
Contributors: Bjorklund, T.; Leriche, L.; Breysse, N.; Gregoire, M. -C.; Carlsson, T.; Dolle, F.; Mandel, R. J.; Deglon, N.; Hantraye, P.; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Future Cell-and Gene-Based Therapies for Parkinson's Disease

Therapeutics of Parkinson's Disease and Other Movement Disorders
2008 | Book chapter
Part of DOI: 10.1002/9780470713990.ch8
EID:

2-s2.0-84891017545
Contributors: Björklund, T.; Morizane, A.; Kirik, D.; Brundin, P.
Source: Self-asserted source
Tomas Bjorklund via Scopus - Elsevier

PET imaging demonstrates correlation between correction of dopamine neurotransmission and behavioral recovery following gene therapy

Society for Neuroscience Abstract Viewer and Itinerary Planner
2008 | Journal article
Contributors: Bjorklund, T.; Leriche, L.; Breysse, N.; Besret, L.; Gregoire, M. -C.; Carlsson, T.; Dolle, F.; Mandel, R. J.; Deglon, N.; Hantraye, P. et al.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain

Brain
2007 | Journal article
DOI:

10.1093/brain/awl382
Contributors: Eslamboli, A.; Romero-Ramos, M.; Burger, C.; Bjorklund, T.; Muzyczka, N.; Mandel, R. J.; Baker, H.; Ridley, R. M.; Kirik, D.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID
grade
Preferred source (of 2)‎

Morphometric and psychometric comparisons between non-substance- abusing patients with posttraumatic stress disorder and normal controls

Psychotherapy and Psychosomatics
2006 | Journal article
DOI:

10.1159/000090897
Contributors: Emdad, R.; Bonekamp, D.; Sondergaard, H. P.; Bjorklund, T. B.; Agartz, I.; Ingvar, M.; Theorell, T. R.
Source: Self-asserted source
Tomas Bjorklund via ResearcherID
grade
Preferred source (of 2)‎

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

Journal article
DOI:

10.1016/j.chembiol.2010.07.009
Source: Self-asserted source
Tomas Bjorklund
grade
Preferred source (of 3)‎

Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders

Journal article
DOI:

10.2174/156652308786847996
Source: Self-asserted source
Tomas Bjorklund
grade
Preferred source (of 3)‎
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