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Scopus Author ID: 55458141700
Loop profile: 1107763

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Employment (4)

Indian Institute of Technology Guwahati: Guwahati, Assam, IN

2021-09-25 to present | Professor (Department of Biosciences and Bioengineering)
Employment
Source: Self-asserted source
MANISH KUMAR

Indian Institute of Technology Guwahati: Guwahati, Assam, IN

2017-01-27 to 2021-09-24 | Associate Professor (Department of Biosciences and Bioengineering)
Employment
Source: Self-asserted source
MANISH KUMAR

Indian Institute of Technology Guwahati: Guwahati, Assam, IN

2012-07-22 to 2017-01-26 | Assistant Professor (Department of Biosciences and Bioengineering)
Employment
Source: Self-asserted source
MANISH KUMAR

Johns Hopkins School of Medicine: Baltimore, MD, US

2011-01-01 to 2012-04-30 | Post doctoral fellow/ Research fellow (Division of Rheumatology)
Employment
Source: Self-asserted source
MANISH KUMAR

Education and qualifications (3)

University of Maryland at College Park: College Park, MD, US

2006-08-16 to 2010-11-17 | PhD (Veterinary Medical Sciences)
Education
Source: Self-asserted source
MANISH KUMAR

Indian Veterinary Research Institute: Izatnagar, Uttar Pradesh, IN

2004-07-15 to 2006-07-15 | MVSc (Veterinary Public Health)
Education
Source: Self-asserted source
MANISH KUMAR

Govind Ballabh Pant University of Agriculture & Technology: Pantnagar, Uttarakhand, IN

1999-06-01 to 2004-06-01 | BVSc and AH (College of Veterinary Sciences)
Qualification
Source: Self-asserted source
MANISH KUMAR

Professional activities (9)

American Society for Microbiology: Washington, DC, US

subscribed membership (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

American Chemical Society: Washington, DC, US

2019-11-01 to present | One year (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

Society for Biosafety: Bhopal, Madhya Pradesh, IN

2017-01-01 to present | Life membership (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

Indian Science Congress Association: Kolkata, West Bengal, IN

2015-01-27 to present | Life membership (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

Bihar Veterinary Council: Patna, Bihar, IN

2006-01-01 to present | Registered practitioner (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

Veterinary Council of India: New Delhi, Delhi, IN

2004-07-01 to present | Registered practitioner (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

Indian Association of Veterinary Public Health Specialists: Izatnagar, Uttar Pradesh, IN

2004-06-01 to present | Life membership (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

Indian Society of Veterinary Medicine: Bareilly, Uttar Pradesh, IN

2004-05-01 to present | Life membership (BSBE)
Membership
Source: Self-asserted source
MANISH KUMAR

Govind Ballabh Pant University of Agriculture & Technology: Pantnagar, Uttarakhand, IN

2004-07-01 | BVSc and AH (College of Veterinary Sciences)
Distinction
Source: Self-asserted source
MANISH KUMAR

Works (42)

Unveiling the impact of Leptospira TolC efflux protein on host tissue adherence, complement evasion, and diagnostic potential

Infection and Immunity
2024-11-12 | Journal article
DOI: 10.1128/iai.00419-24
Contributors: Saswat Hota; Manish Kumar; Guy H. Palmer
Source: check_circle
Crossref

ErpY-like Protein Interaction with Host Thrombin and Fibrinogen Intervenes the Plasma Coagulation through Extrinsic and Intrinsic Pathways

ACS Infectious Diseases
2024-09-13 | Journal article
DOI: 10.1021/acsinfecdis.4c00266
Contributors: Saswat Hota; Manish Kumar
Source: check_circle
Crossref

Nucleotide-induced ClpC oligomerization and its non-preferential association with ClpP isoforms of pathogenic Leptospira

International Journal of Biological Macromolecules
2024-05 | Journal article
DOI: 10.1016/j.ijbiomac.2024.131371
Part of ISSN: 0141-8130
Contributors: Surbhi Kumari; Arfan Ali; Manish Kumar
Source: Self-asserted source
MANISH KUMAR

Differential processing of CRISPR RNA by LinCas5c and LinCas6 of Leptospira

Biochimica et Biophysica Acta (BBA) - General Subjects
2023-12 | Journal article
DOI: 10.1016/j.bbagen.2023.130469
Part of ISSN: 0304-4165
Contributors: Vineet Anand; Harshini Sheeja Prabhakaran; Aman Prakash; Md Saddam Hussain; Manish Kumar
Source: Self-asserted source
MANISH KUMAR

Epidemiological Status of Leptospirosis in India

Journal of Pure and Applied Microbiology
2023-12-01 | Journal article
DOI: 10.22207/JPAM.17.4.44
Contributors: Shanti Choudhary; Ratan Kumar Choudhary; Manish Kumar; Satparkash Singh; Yashpal Singh Malik
Source: check_circle
Crossref

Leptospira ClpP mutant variants in association with the ClpX, acyldepsipeptide, and the trigger factor displays unprecedented gain-of-function

International Journal of Biological Macromolecules
2023-10 | Journal article
DOI: 10.1016/j.ijbiomac.2023.127753
Part of ISSN: 0141-8130
Contributors: Surbhi Kumari; Anusua Dhara; Manish Kumar
Source: Self-asserted source
MANISH KUMAR

Functional PAM sequence for DNA interference by CRISPR-Cas I-B system of Leptospira interrogans and the role of LinCas11b encoded within lincas8b.

International journal of biological macromolecules
2023-03-20 | Journal article
DOI: 10.1016/j.ijbiomac.2023.124086
PMID: 36940764
Contributors: Hussain MS; Anand V; Kumar M
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Structural and functional characterization of Cas2 of CRISPR-Cas subtype I-C lacking the CRISPR component

Frontiers in Molecular Biosciences
2022-09-12 | Journal article
DOI: 10.3389/fmolb.2022.988569
Part of ISSN: 2296-889X
Contributors: Vineet Anand; Harshini Sheeja Prabhakaran; Prerana Gogoi; Shankar Prasad Kanaujia; Manish Kumar
Source: Self-asserted source
MANISH KUMAR

Transcriptional analysis of CRISPR I-B arrays of Leptospira interrogans serovar Lai and its processing by Cas6

Frontiers in Microbiology
2022-07-29 | Journal article
DOI: 10.3389/fmicb.2022.960559
Part of ISSN: 1664-302X
Contributors: Aman Prakash; Manish Kumar
Source: Self-asserted source
MANISH KUMAR

ErpY-like Lipoprotein of Leptospira Outsmarts Host Complement Regulation by Acquiring Complement Regulators, Activating Alternative Pathways, and Intervening in the Membrane Attack Complex

ACS Infectious Diseases
2022-05-13 | Journal article
DOI: 10.1021/acsinfecdis.1c00602
Contributors: Saswat Hota; Md Saddam Hussain; Manish Kumar
Source: check_circle
Crossref

Assembly of Cas7 subunits of Leptospira on the mature crRNA of CRISPR-Cas I-B is modulated by divalent ions

Gene
2022-04 | Journal article
DOI: 10.1016/j.gene.2022.146244
Part of ISSN: 0378-1119
Source: Self-asserted source
MANISH KUMAR

The core Cas1 protein of CRISPR-Cas I-B in Leptospira shows metal-tunable nuclease activity

Current Research in Microbial Sciences
2021-12 | Journal article
DOI: 10.1016/j.crmicr.2021.100059
Part of ISSN: 2666-5174
Source: Self-asserted source
MANISH KUMAR

The CRISPR-associated Cas4 protein from Leptospira interrogans demonstrate versatile nuclease activity

Current Research in Microbial Sciences
2021-12 | Journal article
DOI: 10.1016/j.crmicr.2021.100040
Part of ISSN: 2666-5174
Source: Self-asserted source
MANISH KUMAR

Characterizing the transcripts of Leptospira CRISPR I-B array and its processing with endoribonuclease LinCas6

International Journal of Biological Macromolecules
2021-07 | Journal article
DOI: 10.1016/j.ijbiomac.2021.04.066
Part of ISSN: 0141-8130
Source: Self-asserted source
MANISH KUMAR

Evaluation of sporozoite and macroschizont antigen (Spm2) of Theileria annulata for its diagnostic potential

Ticks and Tick-borne Diseases
2021-07 | Journal article
DOI: 10.1016/j.ttbdis.2021.101691
Part of ISSN: 1877-959X
Source: Self-asserted source
MANISH KUMAR

Development Of Novel Multiplex PCR For Rapid Diagnosis Of Coinfected Hemo-Parasites In Cattle

2021-06-14 | Other
DOI: 10.1101/2021.06.14.448329
Contributors: Pankaj Kumar; Abhay Kumar; Kamal Sarma; Paresh Sharma; Rashmi Rekha Kumari; Manish Kumar
Source: check_circle
Crossref

Mixed Infection of Tick-borne Haemo-parasites in Water Buffalo and Associated Pathological Responses and Treatment

Indian Journal of Animal Research
2021-06-03 | Journal article
DOI: 10.18805/ijar.b-4450
Part of ISSN: 0976-0555
Part of ISSN: 0367-6722
Source: Self-asserted source
MANISH KUMAR

ErpY-like lipoprotein of Leptospira outsmart host complement regulation by acquiring complement regulators, activating alternate pathway, and intervening membrane attack complex

2021-05-28 | Other
DOI: 10.1101/2021.05.27.446086
Contributors: Saswat Hota; Md Saddam Hussain; Manish Kumar
Source: check_circle
Crossref

Acyldepsipeptide activated ClpP1P2 macromolecule of Leptospira, an ideal Achilles’ heel to hamper the cell survival and deregulate ClpP proteolytic activity

Research in Microbiology
2021-03 | Journal article
DOI: 10.1016/j.resmic.2021.103797
Part of ISSN: 0923-2508
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Trigger Factor in Association with the ClpP1P2 Heterocomplex of Leptospira Promotes Protease/Peptidase Activity

ACS Omega
2021-01-19 | Journal article
DOI: 10.1021/acsomega.0c05057
Contributors: Madhurima Choudhury; Anusua Dhara; Manish Kumar
Source: check_circle
Crossref

Status of Subclinical Mastitis in Crossbred Cattle of Peri-urban Unorganized Herd of Middle Indo-gangetic Plains

Indian Journal of Animal Research
2020-11-12 | Journal article
DOI: 10.18805/ijar.b-4241
Part of ISSN: 0976-0555
Part of ISSN: 0367-6722
Source: Self-asserted source
MANISH KUMAR

ADEP1 activated ClpP1P2 macromolecule ofLeptospira, an ideal Achilles’ heel to deregulate proteostasis and hamper the cell survival

2020-08-05 | Preprint
DOI: 10.1101/2020.08.05.237438
Contributors: Anusua Dhara; Md Saddam Hussain; Shankar Prasad Kanaujia; Manish Kumar
Source: check_circle
Crossref

Emergence and Variations in Disease Ecology of Tick-Borne Bovine Theileriosis in East India

International Journal of Livestock Research
2019 | Journal article
DOI: 10.5455/ijlr.20190920061236
Part of ISSN: 2277-1964
Source: Self-asserted source
MANISH KUMAR

BLIMP-1 Plays Important Role in the Regulation of Macrophage Pyroptosis for the Growth and Multiplication of Leishmania donovani

ACS Infectious Diseases
2019-12-13 | Journal article
DOI: 10.1021/acsinfecdis.9b00186
Contributors: Gundappa Saha; Bakulesh M. Khamar; Kumari Prerna; Manish Kumar; Vikash Kumar Dubey
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Role of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its Diagnostic Potential

Infection and Immunity
2019-09-23 | Journal article
DOI: 10.1128/iai.00536-19
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Insights to the Assembly of a Functionally Active Leptospiral ClpP1P2 Protease Complex along with Its ATPase Chaperone ClpX

ACS Omega
2019-07-31 | Journal article
DOI: 10.1021/acsomega.9b00399
Contributors: Anusua Dhara; Md Saddam Hussain; Debika Datta; Manish Kumar
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The effects of PPR on the reproductive health of Black Bengal goats and the possible role played by oxidative stress

Tropical Animal Health and Production
2018-10 | Journal article
DOI: 10.1007/s11250-018-1578-7
Part of ISSN: 0049-4747
Part of ISSN: 1573-7438
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Evaluation of a novel outer membrane surface-exposed protein, LIC13341 of Leptospira, as an adhesin and serodiagnostic candidate marker for leptospirosis.

Microbiology (Reading, England)
2018-07-03 | Journal article
DOI: 10.1099/mic.0.000685
PMID: 29969088
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Catecholamine-Modulated Novel Surface-Exposed Adhesin LIC20035 of Leptospira spp. Binds Host Extracellular Matrix Components and Is Recognized by the Host during Infection.

Applied and environmental microbiology
2018-03-01 | Journal article
DOI: 10.1128/AEM.02360-17
PMID: 29269501
PMC: PMC5835738
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Borrelia burgdorferi BBI39 Paralogs, Targets of Protective Immunity, Reduce Pathogen Persistence Either in Hosts or in the Vector.

The Journal of infectious diseases
2017-03-01 | Journal article
DOI: 10.1093/infdis/jix036
PMID: 28453837
PMC: PMC5407057
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Dual nuclease activity of a Cas2 protein in CRISPR-Cas subtype I-B of Leptospira interrogans.

FEBS letters
2016-03-21 | Journal article
DOI: 10.1002/1873-3468.12124
PMID: 26950513
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Current practices and research updates on diabetes mellitus in canine

Veterinary World
2014 | Journal article
DOI: 10.14202/vetworld.2014.952-959
EID:

2-s2.0-84911477014

Part of ISBN:

22310916 09728988
Contributors: Kumar, P.; Kumari, R.R.; Kumar, M.; Kumar, S.; Chakrabarti, A.
Source: Self-asserted source
MANISH KUMAR via Scopus - Elsevier

Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi.

BMC microbiology
2012-03-23 | Journal article
DOI: 10.1186/1471-2180-12-44
PMID: 22443136
PMC: PMC3320556
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Prevalence and characterization of rotavirus from faecal samples of children and animals

Indian Journal of Animal Sciences
2011 | Journal article
EID:

2-s2.0-80054757225

Part of ISBN:

03678318
Contributors: Kumar, M.; Bhilegaonkar, K.N.; Agarwal, R.K.
Source: Self-asserted source
MANISH KUMAR via Scopus - Elsevier

Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccine.

Vaccine
2011-09-21 | Journal article
DOI: 10.1016/j.vaccine.2011.09.035
PMID: 21945261
PMC: PMC3202674
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

A host-restricted viral vector for antigen-specific immunization against Lyme disease pathogen.

Vaccine
2011-05-19 | Journal article
DOI: 10.1016/j.vaccine.2011.05.010
PMID: 21600949
PMC: PMC3138909
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts.

The Journal of infectious diseases
2010-04-01 | Journal article
DOI: 10.1086/651172
PMID: 20170377
PMC: PMC2832101
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

BosR (BB0647) governs virulence expression in Borrelia burgdorferi.

Molecular microbiology
2009-11-02 | Journal article
DOI: 10.1111/j.1365-2958.2009.06945.x
PMID: 19889086
PMC: PMC2831293
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle.

The Journal of infectious diseases
2009-10-01 | Journal article
DOI: 10.1086/605846
PMID: 19754308
PMC: PMC2896499
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice.

Molecular microbiology
2009-08-24 | Journal article
DOI: 10.1111/j.1365-2958.2009.06853.x
PMID: 19703109
PMC: PMC2754595
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity.

PloS one
2008-08-20 | Journal article
DOI: 10.1371/journal.pone.0003010
PMID: 18714378
PMC: PMC2526170
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks.

The Journal of infectious diseases
2008-01-01 | Journal article
DOI: 10.1086/523764
PMID: 18171298
Source: Self-asserted source
MANISH KUMAR
grade
Preferred source (of 2)‎

Peer review (5 reviews for 3 publications/grants)

Review activity for BMC veterinary research (1)
Review activity for Communications biology. (1)
Review activity for Microbes and infection. (3)
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