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Scopus Author ID: 6506138815
Loop profile: 435957

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Employment (4)

Niederösterreichische Landeskliniken-Holding: Sankt Polten, Lower Austria, AT

2022-06-01 to present | Neuropathologist (Universitätsklinikum St. Pölten)
Employment
Source: Self-asserted source
Mario Dorostkar

Ludwig-Maximilians-Universität München: Munich, DE

2010-09-15 to 2022-05-31 | Neuropathologist (Center for Neuropathology)
Employment
Source: Self-asserted source
Mario Dorostkar

MRC Laboratory of Molecular Biology: Cambridge, Cambridgeshire, GB

2007-09-01 to 2010-08-31 | Postdoc
Employment
Source: Self-asserted source
Mario Dorostkar

Medizinische Universität Wien: Vienna, AT

2003-03-01 to 2007-08-31 | PhD (Pharmacology)
Employment
Source: Self-asserted source
Mario Dorostkar

Funding (3)

C3: The role of TSPO on dendritic spine structural plasticity in health and neurodegenerative diseases

2019-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.8576451
GRANT_NUMBER: 422181340
Source: Self-asserted source
Mario Dorostkar via DimensionsWizard

Elucidating the role of astrocytes in structural plasticity of dendritic spines in vivo

2015-01-01 to 2018-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4841769
GRANT_NUMBER: 285728806
Source: Self-asserted source
Mario Dorostkar via DimensionsWizard

Synaptic function in the optic tectum

2008-06-01 to 2010-05-31 | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.6192275
GRANT_NUMBER: J 2788
Source: Self-asserted source
Mario Dorostkar via DimensionsWizard

Works (47)

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

2023-01-09 | Preprint
DOI: 10.1101/2023.01.09.523234
Contributors: Hannah Voß; Shweta Godbole; Simon Schlumbohm; Yannis Schumann; Bojia Peng; Martin Mynarek; Stefan Rutkowski; Matthias Dottermusch; Mario M. Dorostkar; Andrey Koshunov et al.
Source: check_circle
Crossref

Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

Molecular Psychiatry
2022-07 | Journal article
DOI: 10.1038/s41380-022-01561-3
Contributors: Rainer Rupprecht; Christian H. Wetzel; Mario Dorostkar; Jochen Herms; Nathalie L. Albert; Jens Schwarzbach; Michael Schumacher; Inga D. Neumann
Source: check_circle
Crossref

Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

Nature Neuroscience
2022-02 | Journal article
DOI: 10.1038/s41593-022-01013-9
Part of ISSN: 1097-6256
Contributors: Yuan Shi; Mochen Cui; Katharina Ochs; Matthias Brendel; Felix L. Strübing; Nils Briel; Florian Eckenweber; Chengyu Zou; Richard B. Banati; Guo-Jun Liu et al.
Source: Self-asserted source
Mario Dorostkar via Crossref Metadata Search

Anaplastic pleomorphic xanthoastrocytoma with epithelioid morphology misdiagnosed and treated as melanoma

Neuro-Oncology Advances
2022-01-01 | Journal article
DOI: 10.1093/noajnl/vdac009
Contributors: Mario M Dorostkar; Dinah Konnerth; Maximilian Niyazi; Niklas Thon; Max Schlaak; Kinan Hayani; Anne Guertler
Source: check_circle
Crossref

Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations.

Acta neuropathologica
2021-01-12 | Journal article
DOI: 10.1007/s00401-020-02259-y
PMID: 33433639
Source: Self-asserted source
Mario Dorostkar

Extent and prognostic value of MGMT promotor methylation in glioma WHO grade II.

Scientific reports
2020-11-12 | Journal article
DOI: 10.1038/s41598-020-76312-x
PMID: 33184319
PMC: PMC7661705
Source: Self-asserted source
Mario Dorostkar

Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy

Acta Neuropathologica
2019-12-26 | Journal article
DOI: 10.1007/s00401-019-02063-3
Contributors: Sonja Blumenstock; Maria Florencia Angelo; Finn Peters; Mario M. Dorostkar; Viktoria C. Ruf; Manja Luckner; Sophie Crux; Lenka Slapakova; Thomas Arzberger; Stéphane Claverol et al.
Source: check_circle
Crossref

Molecular characterization of histopathological ependymoma variants.

Acta neuropathologica
2019-11-02 | Journal article
DOI: 10.1007/s00401-019-02090-0
PMID: 31679042
Source: Self-asserted source
Mario Dorostkar

Tcf4 regulates dendritic spine density and morphology in the adult brain

2018 | Other
OTHER-ID:

S-BSST131
Source: check_circle
EMBL-EBI

Tcf4 regulates dendritic spine density and morphology in the adult brain

PLOS ONE
2018-06-22 | Journal article
DOI: 10.1371/journal.pone.0199359
Contributors: Sophie Crux; Brian R Christie; Jochen Herms; Mario M. Dorostkar
Source: check_circle
Crossref

High plasticity of axonal pathology in Alzheimer's disease mouse models.

2017-02 | Journal article
DOI: 10.1186/s40478-017-0415-y
PMID: 28173876
PMC: PMC5296955
Contributors: Blazquez-Llorca L; Valero-Freitag S; Rodrigues EF; Merchán-Pérez Á; Rodríguez JR; Dorostkar MM; DeFelipe J; Herms J
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

2016-12 | Journal article
DOI: 10.1016/j.biopsych.2016.12.023
PMID: 28129943
Contributors: Zhu K; Xiang X; Filser S; Marinković P; Dorostkar MM; Crux S; Neumann U; Shimshek DR; Rammes G; Haass C et al.
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

K27M midline gliomas display malignant progression by imaging and histology.

2016-12 | Journal article
DOI: 10.1111/nan.12371
PMID: 27997032
Contributors: Vettermann FJ; Neumann JE; Suchorska B; Bartenstein P; Giese A; Dorostkar MM; Albert NL; Schüller U
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis.

2016-10 | Journal article
PMID: 27572463
PMC: PMC5069548
Contributors: Zou C; Crux S; Marinesco S; Montagna E; Sgobio C; Shi Y; Shi S; Zhu K; Dorostkar MM; Müller UC et al.
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Dendritic Spine Pathology in Neurodegenerative Diseases.

2016-05 | Journal article
DOI: 10.1146/annurev-pathol-012615-044216
PMID: 26907528
Contributors: Herms J; Dorostkar MM
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Distinct Histomorphology in Molecular Subgroups of Glioblastomas in Young Patients.

2016-05 | Journal article
DOI: 10.1093/jnen/nlw015
PMID: 26975364
Contributors: Neumann JE; Dorostkar MM; Korshunov A; Mawrin C; Koch A; Giese A; Schüller U
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease.

2016-02 | Journal article
DOI: 10.1007/s00401-015-1527-8
PMID: 26724934
PMC: PMC4713725
Contributors: Zou C; Shi Y; Ohli J; Schüller U; Dorostkar MM; Herms J
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Miliary pattern of brain metastases - a case report of a hyperacute onset in a patient with malignant melanoma documented by magnetic resonance imaging.

2015 | Journal article
DOI: 10.1186/s13014-015-0459-8
PMID: 26187589
PMC: PMC4506569
Contributors: Reiter FP; Giessen-Jung C; Dorostkar MM; Ertl-Wagner B; Denk GU; Heck S; Rieger CT; Pfister HW; op den Winkel M
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities.

2015-07 | Journal article
DOI: 10.1007/s00401-015-1449-5
PMID: 26063233
PMC: PMC4469300
Contributors: Dorostkar MM; Zou C; Blazquez-Llorca L; Herms J
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

δ subunit-containing GABA-A receptors are preferred targets for the centrally acting analgesic flupirtine.

2015-07 | Journal article
DOI: 10.1111/bph.13262
PMID: 26211808
Contributors: Klinger F; Bajric M; Salzer I; Dorostkar MM; Khan D; Pollak DD; Kubista H; Boehm S; Koenig X
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease.

2015-06 | Journal article
DOI: 10.1007/s00401-015-1421-4
PMID: 25862638
PMC: PMC4436699
Contributors: Zou C; Montagna E; Shi Y; Peters F; Blazquez-Llorca L; Shi S; Filser S; Dorostkar MM; Herms J
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques

2014 | Journal article
DOI: 10.1186/2051-5960-2-30
EID:

2-s2.0-84921929489
Contributors: Herms, J.; Filser, S.; Dorostkar, M.M.; Schmidt, B.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin

2014 | Journal article
DOI: 10.1038/mp.2014.55
EID:

2-s2.0-84901903183
Contributors: Ochs, S.M.; Dorostkar, M.M.; Aramuni, G.; Schön, C.; Filser, S.; Pöschl, J.; Kremer, A.; Van Leuven, F.; Ovsepian, S.V.; Herms, J.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier
grade
Preferred source (of 2)‎

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

2014 | Journal article
DOI: 10.1038/ncomms4915
EID:

2-s2.0-84901715819
Contributors: Neuner, J.; Ovsepian, S.V.; Dorostkar, M.; Filser, S.; Gupta, A.; Michalakis, S.; Biel, M.; Herms, J.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model.

2014-12 | Journal article
DOI: 10.1093/brain/awu280
PMID: 25281869
PMC: PMC4240293
Contributors: Dorostkar MM; Burgold S; Filser S; Barghorn S; Schmidt B; Anumala UR; Hillen H; Klein C; Herms J
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin.

2014-06 | Journal article
PMID: 24912492
Contributors: Ochs SM; Dorostkar MM; Aramuni G; Schön C; Filser S; Pöschl J; Kremer A; Van Leuven F; Ovsepian SV; Herms J
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Constitutive activation of Β-Catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system

2013 | Journal article
DOI: 10.1016/j.ydbio.2012.12.001
Part of ISSN: 00121606 1095564X
EID:

2-s2.0-84872923971
Contributors: Pöschl, J.; Grammel, D.; Dorostkar, M.M.; Kretzschmar, H.A.; Schüller, U.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.

2013 | Journal article
DOI: 10.1186/2051-5960-1-82
PMID: 24344647
PMC: PMC3880070
Contributors: Hoffmann NA; Dorostkar MM; Blumenstock S; Goedert M; Herms J
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Amyloid plaque formation precedes dendritic spine loss

2012 | Journal article
DOI: 10.1007/s00401-012-1047-8
Part of ISSN: 00016322 14320533
EID:

2-s2.0-84878351215
Contributors: Bittner, T.; Burgold, S.; Dorostkar, M.M.; Fuhrmann, M.; Wegenast-Braun, B.M.; Schmidt, B.; Kretzschmar, H.; Herms, J.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Arc illuminates Alzheimer's pathophysiology

2012 | Journal article
DOI: 10.1038/nn.3226
Part of ISSN: 10976256 15461726
EID:

2-s2.0-84866682719
Contributors: Dorostkar, M.M.; Herms, J.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Concomitant facilitation of GABA A receptors and K V7 channels by the non-opioid analgesic flupirtine

2012 | Journal article
DOI: 10.1111/j.1476-5381.2011.01821.x
Part of ISSN: 00071188 14765381
EID:

2-s2.0-84862738335
Contributors: Klinger, F.; Geier, P.; Dorostkar, M.M.; Chandaka, G.K.; Yousuf, A.; Salzer, I.; Kubista, H.; Boehm, S.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

4D in in vivo 2-photon laser scanning fluorescence microscopy with sample motion in 6 degrees of freedom

2011 | Journal article
DOI: 10.1016/j.jneumeth.2011.06.013
Part of ISSN: 01650270 1872678X
EID:

2-s2.0-79960892379
Contributors: Scheibe, S.; Dorostkar, M.M.; Seebacher, C.; Uhl, R.; Lison, F.; Herms, J.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks

2011 | Journal article
DOI: 10.1007/s00401-010-0787-6
Part of ISSN: 00016322
EID:

2-s2.0-79954449798
Contributors: Burgold, S.; Bittner, T.; Dorostkar, M.M.; Kieser, D.; Fuhrmann, M.; Mitteregger, G.; Kretzschmar, H.; Schmidt, B.; Herms, J.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Computational processing of optical measurements of neuronal and synaptic activity in networks

2010 | Journal article
DOI: 10.1016/j.jneumeth.2010.01.033
Part of ISSN: 01650270
EID:

2-s2.0-77950459016
Contributors: Dorostkar, M.M.; Dreosti, E.; Odermatt, B.; Lagnado, L.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

A genetically encoded reporter of synaptic activity in vivo

2009 | Journal article
DOI: 10.1038/nmeth.1399
Part of ISSN: 15487091 15491676
EID:

2-s2.0-73349141171
Contributors: Dreosti, E.; Odermatt, B.; Dorostkar, M.M.; Lagnado, L.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3

2009 | Journal article
DOI: 10.1523/JNEUROSCI.4559-08.2009
Part of ISSN: 02706474 15292401
EID:

2-s2.0-65549089736
Contributors: Egaña, L.A.; Cuevas, R.A.; Baust, T.B.; Parra, L.A.; Leak, R.K.; Hochendoner, S.; Peña, K.; Quiroz, M.; Hong, W.C.; Dorostkar, M.M. et al.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Modulation of transmitter release via presynaptic ligand-gated ion channels.

2008 | Journal article
Part of ISSN: 18744702
EID:

2-s2.0-77449137869
Contributors: Schicker, K.W.; Dorostkar, M.M.; Boehm, S.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Presynaptic lonotropic Receptors

2008 | Book
DOI: 10.1007/978-3-540-74805-2-15
ISSN: 01712004 18650325
EID:

2-s2.0-39349104519
Contributors: Dorostkar, M.M.; Boehm, S.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Presynaptic lonotropic receptors.

2008 | Journal article
PMID: 18064423
Contributors: Dorostkar MM; Boehm S
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

The non-opioid analgesic flupirtine is a modulator of GABAA receptors involved in pain sensation.

2008 | Journal article
PMC: PMC3313202
Contributors: Popovici F; Dorostkar M; Boehm S
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Modulation of transmitter release via presynaptic ligand-gated ion channels.

2008-06 | Journal article
PMID: 20021427
Contributors: Schicker KW; Dorostkar MM; Boehm S
Source: Self-asserted source
Mario Dorostkar via Europe PubMed Central

Opposite effects of presynaptic 5-HT3 receptor activation on spontaneous and action potential-evoked GABA release at hippocampal synapses

2007 | Journal article
DOI: 10.1111/j.1471-4159.2006.04218.x
Part of ISSN: 00223042 14714159
EID:

2-s2.0-33845799759
Contributors: Dorostkar, M.M.; Boehm, S.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

The brain-specific double-stranded RNA-binding protein Staufen2 is required for dendritic spine morphogenesis

2006 | Journal article
DOI: 10.1083/jcb.200509035
Part of ISSN: 00219525 00219525
EID:

2-s2.0-30944446019
Contributors: Goetze, B.; Tuebing, F.; Xie, Y.; Dorostkar, M.M.; Thomas, S.; Pehl, U.; Boehm, S.; Macchi, P.; Kiebler, M.A.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2a receptor

2006 | Journal article
DOI: 10.1124/mol.105.015818
Part of ISSN: 0026895X 15210111
EID:

2-s2.0-33645099042
Contributors: Milojević, T.; Reiterer, V.; Stefan, E.; Korkhov, V.M.; Dorostkar, M.M.; Ducza, E.; Ogris, E.; Boehm, S.; Freissmuth, M.; Nanoff, C.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Serotonin-transporter mediated efflux: A pharmacological analysis of amphetamines and non-amphetamines

2005 | Journal article
DOI: 10.1016/j.neuropharm.2005.08.008
Part of ISSN: 00283908
EID:

2-s2.0-26944489620
Contributors: Hilber, B.; Scholze, P.; Dorostkar, M.M.; Sandtner, W.; Holy, M.; Boehm, S.; Singer, E.A.; Sitte, H.H.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y12 receptor-mediated inhibition of voltage-gated Ca2+ channels

2004 | Journal article
DOI: 10.1111/j.1460-9568.2004.03760.x
Part of ISSN: 0953816X
EID:

2-s2.0-10844229396
Contributors: Lechner, S.G.; Dorostkar, M.M.; Mayer, M.; Edelbauer, H.; Pankevych, H.; Boehm, S.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat γ-aminobutyric acid transporter-1 (GAT1)

2004 | Journal article
DOI: 10.1074/jbc.M307325200
Part of ISSN: 00219258
EID:

2-s2.0-3142655360
Contributors: Farhan, H.; Korkhov, V.M.; Paulitschke, V.; Dorostkar, M.M.; Scholze, P.; Kudlacek, O.; Freissmuth, M.; Sitte, H.H.
Source: Self-asserted source
Mario Dorostkar via Scopus - Elsevier

Peer review (7 reviews for 5 publications/grants)

Review activity for Acta neuropathologica. (1)
Review activity for BMC neuroscience. (1)
Review activity for Brain disorders. (1)
Review activity for Communications biology. (1)
Review activity for Heliyon. (3)
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