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Employment (5)

University of Georgia: Athens, US

Employment
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UGA Elements

United States Food and Drug Administration: Silver Spring, US

2024-01 to present | Senior Staff Fellow
Employment
Source: Self-asserted source
Ross Marklein

University of Georgia: Athens, GA, US

2018-10-02 to present
Employment
Source: Self-asserted source
Ross Marklein

U.S. Food and Drug Administration: Silver Spring, MD, US

2015-08 to 2018-09 | Staff Fellow
Employment
Source: Self-asserted source
Ross Marklein

U.S. Food and Drug Administration: Silver Spring, Md., US

2012-10 to 2015-08 | ORISE Post-Doctoral Fellow
Employment
Source: Self-asserted source
Ross Marklein

Works (29)

High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory function.

Stem Cell Research and Therapy
2025-03-07 | Journal article
DOI: 10.1186/s13287-025-04206-8
SOURCE-WORK-ID:

2318791

PMC: PMC11889916
PMID: 40055728
Part of ISSN: 1757-6512
Contributors: Thomas M Spoerer; Andrew M Larey; Winifred Asigri; Kanupriya R Daga; Ross Marklein
Source: check_circle
UGA Elements

High throughput screening of mesenchymal stromal cell morphological response to inflammatory signals for bioreactor-based manufacturing of extracellular vesicles that modulate microglia.

Bioactive Materials
2024-07 | Journal article
DOI: 10.1016/j.bioactmat.2024.03.009
SOURCE-WORK-ID:

2206032

PMC: PMC10972802
PMID: 38549769
Part of ISSN: 2452-199X
Contributors: Andrew M Larey; Thomas M Spoerer; Kanupriya R Daga; Maria G Morfin; Hannah M Hynds; Jana Carpenter; Kelly M. Hines; Ross Marklein
Source: check_circle
UGA Elements

Microglia Morphological Response to Mesenchymal Stromal Cell Extracellular Vesicles Demonstrates EV Therapeutic Potential for Modulating Neuroinflammation.

bioRxiv
2024-07-03 | Journal article
DOI: 10.1101/2024.07.01.601612
SOURCE-WORK-ID:

2227280

PMC: PMC11245023
Contributors: Kanupriya R Daga; Andrew M Larey; Maria G Morfin; Kailin Chen; Sara Bitarafan; Jana M Carpenter; Hannah M Hynds; Kelly M. Hines; Levi B Wood; Ross Marklein
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UGA Elements

Development of a Robust Consensus Modeling Approach for Identifying Cellular and Media Metabolites Predictive of Mesenchymal Stromal Cell Potency.

Stem Cells
2023-08-16 | Journal article
DOI: 10.1093/stmcls/sxad039
SOURCE-WORK-ID:

2107002

PMC: PMC10427967
PMID: 37279550
Part of ISSN: 1066-5099
Contributors: Alexandria Van Grouw; Maxwell B Colonna; Ty S Maughon; Xunan Shen; Andrew M Larey; Samuel G Moore; Carolyn Yeago; Facundo M Fernández; Arthur Edison; XIAN WU et al.
Source: check_circle
UGA Elements

Metabolomics and cytokine profiling of mesenchymal stromal cells identify markers predictive of T-cell suppression

Cytotherapy
2022-02-01 | Journal article
DOI: 10.1016/j.jcyt.2021.08.002
SOURCE-WORK-ID:

1867463

PMID: 34696960
Part of ISSN: 1465-3249
WOSUID:

WOS:000747204800005
Contributors: Ty S Maughon; Xunan Shen; Danning Huang; Adeola O Adebayo Michael; W Andrew Shockey; Seth H Andrews; Jon M McRae; Manu O Platt; Facundo M Fernandez; Arthur Edison et al.
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UGA Elements

Human pluripotent stem cell-derived functional sympathetic neurons express ACE2 and RAAS components: a framework for studying the effect of COVID-19 on sympathetic responsiveness

Clinical Autonomic Research
2022-01-29 | Journal article
DOI: 10.1007/s10286-021-00850-1
SOURCE-WORK-ID:

1912521

PMID: 35091835
PMC: PMC8799422
Part of ISSN: 0959-9851
WOSUID:

WOS:000749050900001
Contributors: Hsueh-Fu Wu; Chia-Wei Huang; Kanupriya R Daga; Ross Marklein; Natalia Ivanova; Nadja Zeltner
Source: check_circle
UGA Elements

Morphological landscapes from high content imaging reveal cytokine priming strategies that enhance mesenchymal stromal cell immunosuppression

Biotechnology and Bioengineering
2021-11-17 | Journal article
DOI: 10.1002/bit.27974
SOURCE-WORK-ID:

1867683

PMID: 34716713
Part of ISSN: 0006-3592
WOSUID:

WOS:000719644800001
Contributors: Seth H Andrews; Matthew W Klinker; Steven R Bauer; Ross Marklein
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UGA Elements

Shape up before you ship out: morphology as a potential critical quality attribute for cellular therapies

Current Opinion in Biomedical Engineering
2021-10-28 | Journal article
DOI: 10.1016/j.cobme.2021.100352
SOURCE-WORK-ID:

1873848

Part of ISSN: 2468-4511
WOSUID:

WOS:000719915800003
Contributors: Kanupriya R Daga; Priyanka Priyadarshani; Andrew M Larey; Kejie Rui; Luke Mortensen; Ross Marklein
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UGA Elements

DEVELOPMENT OF A MORPHOLOGY-BASED MICROGLIA POTENCY ASSAY TO ASSESS THE THERAPEUTIC POTENTIAL OF MSCS FOR NEURODEGENERATIVE DISEASES

Cytotherapy
2021-05-01 | Conference paper
SOURCE-WORK-ID:

1809674

Part of ISSN: 1465-3249
WOSUID:

WOS:000650965900037
Contributors: K R Daga; K Chen; Ross Marklein
Source: check_circle
UGA Elements

Priming of MSCs with inflammation-relevant signals affects extracellular vesicle biogenesis, surface markers, and modulation of T cell subsets

2020 | Journal article
DOI: 10.1101/2020.04.30.066456
SOURCE-WORK-ID:

1760138
Contributors: Seth Andrews; Ty Maughon; Ross Marklein; XIAN WU
Source: check_circle
UGA Elements

High Throughput Image-Based Assessment of iPSC Morphology to Optimize Post-Thaw Recovery

2020-10-17 | Conference poster
SOURCE-WORK-ID:

1765748
Contributors: Ross Marklein; Karen Mancera Azamar; Kelly Scheulin
Source: check_circle
UGA Elements

Tracking Morphological Features of Mesenchymal Stromal Cells to Evaluate Immunosuppressive Potential

2020-10-17 | Conference poster
SOURCE-WORK-ID:

1765751
Contributors: Ross Marklein; Gianna Busch; Kanupriya Daga
Source: check_circle
UGA Elements

Creation of Morphological Landscapes Using High Content Imaging to Identify Optimal Priming Strategies that Enhance MSC Immunosuppression

Biomedical Engineering Society
2020-10-15 | Conference paper
SOURCE-WORK-ID:

1765755
Contributors: Ross Marklein; Seth Andrew; Matthew Klinker; Steven Bauer
Source: check_circle
UGA Elements

Multi-omics Approach for the Identification of MSC CAndidate Critical Quality Attributes

2020-10-15 | Conference poster
SOURCE-WORK-ID:

1765753
Contributors: Ross Marklein; Timothy Maughon; Seth Andrews; Sara Shen; Xunan Shen; Danning Huang; Andrew Shockey; Adeola Michael; Facundo Fernandez; Manu Platt et al.
Source: check_circle
UGA Elements

Development of a high-throughput imaging approach to assess microglia activation

2019-10-19 | Conference poster
SOURCE-WORK-ID:

1435996
Contributors: Ross Marklein; Lauren Jennings; Sam Spellicy
Source: check_circle
UGA Elements

Identification of MSC Priming Conditions that Enhance Immunosuppression Using High Content Imaging

2019-10-19 | Conference poster
SOURCE-WORK-ID:

1436001
Contributors: Ross Marklein; Andrew Larey; Timothy Maughon
Source: check_circle
UGA Elements

Towards Development of a Reference Standard Curve for Assessing MSC Potency and Comparability

2019-10-19 | Conference poster
SOURCE-WORK-ID:

1436003
Contributors: Ross Marklein; Arafat Fasuyi; Seth Andrews; Timothy Maughon
Source: check_circle
UGA Elements

Immunomodulation of Preconditioned Mesenchymal Stem Cells and Isolated Extracellular Vesicles.

Proceedings of the Biomedical Engineering Society 2019 Annual Meeting
2019-10-01 | Other
SOURCE-WORK-ID:

1416533
Contributors: S Andrews; T Maughon; Ross Marklein; XIAN WU
Source: check_circle
UGA Elements

Development of a High-Throughput Imaging Approach to Assess Microglia Activation

2019-08-08 | Conference poster
SOURCE-WORK-ID:

1436011
Contributors: Ross Marklein; Lauren Jennings; Sam Spellicy
Source: check_circle
UGA Elements

Towards Development of a Reference Standard Curve for Assessing MSC Potency and Comparability

2019-08-08 | Conference poster
SOURCE-WORK-ID:

1436016
Contributors: Ross Marklein; Arafat Fasuyi; Seth Andrews; Timothy Maughon
Source: check_circle
UGA Elements

Multivariate analysis reveals differential effects of priming on MSC extracellular vesicle secretion.

Proceedings of 2019 Cell Manufacturing Technologies Annual Retreat
2019-08-01 | Other
SOURCE-WORK-ID:

1416524
Contributors: S Andrews; T Maughon; Ross Marklein; XIAN WU
Source: check_circle
UGA Elements

Standardization of a High-Throughput Semi-Automated Image-Based Microglia Screen (HITS AIMS).

NSF Engineering and Research Center for Cellular Manufacturing and Technologies (CMaT)
2019-08-01 | Other
SOURCE-WORK-ID:

1416521
Contributors: S Spellicy; L Jennings; C Hu; M Kandel; Ross Marklein; G Popescu; XIAN WU
Source: check_circle
UGA Elements

Label-free quantitative phase imaging reveals intracellular transport alterations following extracellular vesicle addition.

NSF Science and Technology Center Emergent Behaviors of Integrated Cellular Systems (EBICS) Annual Retreat
2019-07-01 | Other
SOURCE-WORK-ID:

1416310
Contributors: Samantha Spellicy; L Jennings; C Hu; M Kandel; Ross Marklein; G Popescu; XIAN WU
Source: check_circle
UGA Elements

Creation of morphological landscapes using high content imaging to identify optimal preconditioning strategies that enhance MSC immunosuppression

2019-03-23 | Lecture
SOURCE-WORK-ID:

1436026
Contributors: Ross Marklein
Source: check_circle
UGA Elements

Morphological profiling using machine learning reveals emergent subpopulations of interferon-gamma-stimulated mesenchymal stromal cells that predict immunosuppression

Cytotherapy
2019-01-01 | Journal article
DOI: 10.1016/j.jcyt.2018.10.008
SOURCE-WORK-ID:

1297631

PMID: 30503100
Part of ISSN: 1465-3249
WOSUID:

WOS:000455478000003
Contributors: Ross Marklein; Matthew W Klinker; Katherine A Drake; Hannah G Polikowsky; Elizabeth C Lessey-Morillon; Steven R Bauer
Source: check_circle
UGA Elements

Cyclical priming as an approach to increase mesenchymal stromal cell extracellular vesicle yield and reproducibility

Other
SOURCE-WORK-ID:

2125728
Source: check_circle
UGA Elements

Defined culture media for mesenchymal stromal cell expansion

Other
SOURCE-WORK-ID:

2128233
Source: check_circle
UGA Elements

Microparticle Hydrogels for Cell Manufacturing

Other
SOURCE-WORK-ID:

2320037
Source: check_circle
UGA Elements

MSC exosomes increase T cell differentiation towards T regulatory cells

Other
SOURCE-WORK-ID:

1931942
Source: check_circle
UGA Elements

Peer review (6 reviews for 4 publications/grants)

Review activity for Acta biomaterialia. (1)
Review activity for Annals of biomedical engineering. (1)
Review activity for Cytotherapy. (3)
Review activity for Macromolecular bioscience. (1)
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