Personal information

No personal information available

Activities

Collapse all

Works (34)

Is Lyophilization Key for Transportation and Storage of Biopharmaceutical Drug Products in Space?

Journal of Pharmaceutical Sciences
2024-07 | Journal article
DOI: 10.1016/j.xphs.2024.04.030
Contributors: Tim Menzen
Source: check_circle
Crossref

Three-Dimensional Homodyne Light Detection (3D-HLD) for High-Throughput Submicron Particle Analysis in (Highly Concentrated) Protein Biopharmaceuticals, Viral Vectors, and LNPs

Journal of Pharmaceutical Sciences
2024-04 | Journal article
DOI: 10.1016/j.xphs.2023.10.042
Contributors: Dominik Brandstetter; Constanze Helbig; Kentaro Osawa; Hiroyuki Minemura; Yumiko Anzai; Tetsuo Torisu; Susumu Uchiyama; Tim Menzen; Wolfgang Friess; Andrea Hawe
Source: check_circle
Crossref

Genome length determination in adeno-associated virus vectors with mass photometry

Molecular Therapy - Methods & Clinical Development
2023-12 | Journal article
DOI: 10.1016/j.omtm.2023.101162
Contributors: Cornelia Hiemenz; Nadine Baumeister; Constanze Helbig; Andrea Hawe; Sabrina Babutzka; Stylianos Michalakis; Wolfgang Friess; Tim Menzen
Source: check_circle
Crossref

Osmotic properties of T cells determined by flow imaging microscopy in comparison to electrical sensing zone analysis

Cryobiology
2023-12 | Journal article
DOI: 10.1016/j.cryobiol.2023.104587
Contributors: Alexandra Roesch; Roland Windisch; Christian Wichmann; Willem F. Wolkers; Gideon Kersten; Tim Menzen
Source: check_circle
Crossref

Possibilities and limitations of α-relaxation data of amorphous freeze-dried cakes to predict long term IgG1 antibody stability

International Journal of Pharmaceutics
2023-11 | Journal article
DOI: 10.1016/j.ijpharm.2023.123445
Contributors: Sebastian Groël; Tim Menzen; Gerhard Winter
Source: check_circle
Crossref

Characterization of Virus Particles and Submicron-Sized Particulate Impurities in Recombinant Adeno-Associated Virus Drug Product

Journal of Pharmaceutical Sciences
2023-08 | Journal article
DOI: 10.1016/j.xphs.2023.05.009
Contributors: Cornelia Hiemenz; Anabel Pacios-Michelena; Constanze Helbig; Valerija Vezočnik; Michael Strebl; Felix Nikels; Andrea Hawe; Patrick Garidel; Tim Menzen
Source: check_circle
Crossref

Prediction of Unwanted Crystallization of Freeze-Dried Protein Formulations Using α-Relaxation Measurements

Pharmaceutics
2023-02-20 | Journal article
DOI: 10.3390/pharmaceutics15020703
Contributors: Sebastian Groël; Tim Menzen; Gerhard Winter
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals

Journal of Pharmaceutical Sciences
2022-11 | Journal article
DOI: 10.1016/j.xphs.2022.08.006
Contributors: Haruka Nishiumi; Natalie Deiringer; Nils Krause; Saki Yoneda; Tetsuo Torisu; Tim Menzen; Wolfgang Friess; Susumu Uchiyama
Source: check_circle
Crossref

Combining Machine Learning and Backgrounded Membrane Imaging: A Case Study in Comparing and Classifying Different Types of Biopharmaceutically Relevant Particles

Journal of Pharmaceutical Sciences
2022-09 | Journal article
DOI: 10.1016/j.xphs.2022.05.022
Contributors: Christopher P. Calderon; Ana Krhač Levačić; Constanze Helbig; Klaus Wuchner; Tim Menzen
Source: check_circle
Crossref

Imaging Flow Cytometry for Sizing and Counting of Subvisible Particles in Biotherapeutics

Journal of Pharmaceutical Sciences
2022-09 | Journal article
DOI: 10.1016/j.xphs.2022.06.019
Contributors: C. Helbig; T. Menzen; K. Wuchner; A. Hawe
Source: check_circle
Crossref

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

Journal of Pharmaceutical Sciences
2022-08 | Journal article
DOI: 10.1016/j.xphs.2022.03.004
Contributors: Ruth Rieser; Tim Menzen; Martin Biel; Stylianos Michalakis; Gerhard Winter
Source: check_circle
Crossref

Comparison of Submicron Particle Counting Methods with a Heat Stressed Monoclonal Antibody: Effect of Electrolytes and Implications on Sample Preparation

Journal of Pharmaceutical Sciences
2022-07 | Journal article
DOI: 10.1016/j.xphs.2022.01.012
Contributors: Andreas Stelzl; Adam Grabarek; Stefan Schneid; Wim Jiskoot; Tim Menzen; Gerhard Winter
Source: check_circle
Crossref

Particles in Biopharmaceutical Formulations, Part 2: An Update on Analytical Techniques and Applications for Therapeutic Proteins, Viruses, Vaccines and Cells

Journal of Pharmaceutical Sciences
2022-04 | Journal article
DOI: 10.1016/j.xphs.2021.12.011
Contributors: Alexandra Roesch; Sarah Zölls; Daniela Stadler; Constanze Helbig; Klaus Wuchner; Gideon Kersten; Andrea Hawe; Wim Jiskoot; Tim Menzen
Source: check_circle
Crossref

Ongoing challenges to develop high concentration monoclonal antibody-based formulations for subcutaneous administration: Quo Vadis?

Journal of Pharmaceutical Sciences
2021-11 | Journal article
DOI: 10.1016/j.xphs.2021.11.008
Contributors: Wim Jiskoot; Andrea Hawe; Tim Menzen; David B. Volkin; Daan J.A. Crommelin
Source: check_circle
Crossref

Calorimetric Investigation of the Relaxation Phenomena in Amorphous Lyophilized Solids

Pharmaceutics
2021-10-19 | Journal article
DOI: 10.3390/pharmaceutics13101735
Contributors: Sebastian Groёl; Tim Menzen; Gerhard Winter
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Minimizing Oxidation of Freeze-Dried Monoclonal Antibodies in Polymeric Vials Using a Smart Packaging Approach

Pharmaceutics
2021-10-15 | Journal article
DOI: 10.3390/pharmaceutics13101695
Contributors: Nicole Härdter; Tim Menzen; Gerhard Winter
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Towards quantification and differentiation of protein aggregates and silicone oil droplets in the low micrometer and submicrometer size range by using oil-immersion flow imaging microscopy and convolutional neural networks.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
2021-09 | Journal article
DOI: 10.1016/j.ejpb.2021.09.010
PMID: 34597817
Contributors: Umar M; Krause N; Hawe A; Simmel F; Menzen T
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Forced degradation of cell-based medicinal products guided by flow imaging microscopy: Explorative studies with Jurkat cells.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
2021-07 | Journal article
DOI: 10.1016/j.ejpb.2021.07.004
PMID: 34274457
Contributors: Grabarek AD; Jiskoot W; Hawe A; Pike-Overzet K; Menzen T
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

Pharmaceutics
2021-05 | Journal article | Author
DOI: 10.3390/pharmaceutics13050748
Contributors: Ruth Rieser; Johanna Koch; Greta Faccioli; Klaus Richter; Tim Menzen; Martin Biel; Gerhard Winter; Stylianos Michalakis
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Combining Unfolding Reversibility Studies and Molecular Dynamics Simulations to Select Aggregation-Resistant Antibodies.

Molecular pharmaceutics
2021-04 | Journal article
DOI: 10.1021/acs.molpharmaceut.1c00017
PMID: 33928776
Contributors: Berner C; Menzen T; Winter G; Svilenov HL
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Oil-Immersion Flow Imaging Microscopy for Quantification and Morphological Characterization of Submicron Particles in Biopharmaceuticals.

The AAPS journal
2021-01 | Journal article
DOI: 10.1208/s12248-020-00547-9
PMID: 33398482
Contributors: Krause N; Kuhn S; Frotscher E; Nikels F; Hawe A; Garidel P; Menzen T
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Micelle Driven Oxidation Mechansim and Novel Oxidation Markers for Different Grades of Polysorbate 20 and 80.

Journal of pharmaceutical sciences
2020-07 | Journal article
DOI: 10.1016/j.xphs.2020.06.028
PMID: 32653599
Contributors: Kranz W; Wuchner K; Corradini E; Menzen T; Hawe A
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Particulate impurities in cell-based medicinal products traced by flow imaging microscopy combined with deep learning for image analysis.

Cytotherapy
2020-06 | Journal article
DOI: 10.1016/j.jcyt.2020.04.093
PMID: 32507606
Contributors: Grabarek AD; Senel E; Menzen T; Hoogendoorn KH; Pike-Overzet K; Hawe A; Jiskoot W
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Modulated Scanning Fluorimetry Can Quickly Assess Thermal Protein Unfolding Reversibility in Microvolume Samples.

Molecular pharmaceutics
2020-05 | Journal article
DOI: 10.1021/acs.molpharmaceut.0c00330
PMID: 32401526
Contributors: Svilenov HL; Menzen T; Richter K; Winter G
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Exploring Chemical Space for New Substances to Stabilize a Therapeutic Monoclonal Antibody.

Journal of pharmaceutical sciences
2019-11 | Journal article
DOI: 10.1016/j.xphs.2019.10.057
PMID: 31697947
Contributors: Tosstorff A; Menzen T; Winter G
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Taking Subvisible Particle Quantitation to the Limit: Uncertainties and Statistical Challenges With Ophthalmic Products for Intravitreal Injection.

Journal of pharmaceutical sciences
2019-11 | Journal article
DOI: 10.1016/j.xphs.2019.10.061
PMID: 31682829
Contributors: Gühlke M; Hecht J; Böhrer A; Hawe A; Nikels F; Garidel P; Menzen T
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes.

Journal of pharmaceutical sciences
2019-10 | Journal article
DOI: 10.1016/j.xphs.2019.10.031
PMID: 31639391
Contributors: Rieser R; Penaud-Budloo M; Bouzelha M; Rossi A; Menzen T; Biel M; Büning H; Ayuso E; Winter G; Michalakis S
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Novel High-Throughput Assay for Polysorbate Quantification in Biopharmaceutical Products by Using the Fluorescent Dye DiI.

Journal of pharmaceutical sciences
2019-10 | Journal article
DOI: 10.1016/j.xphs.2019.10.013
PMID: 31606542
Contributors: Martos A; Berger M; Kranz W; Spanopoulou A; Menzen T; Friess W; Wuchner K; Hawe A
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy.

Journal of pharmaceutical sciences
2019-10 | Journal article
DOI: 10.1016/j.xphs.2019.09.023
PMID: 31593689
Contributors: Das TK; Narhi LO; Sreedhara A; Menzen T; Grapentin C; Chou DK; Antochshuk V; Filipe V
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

What Makes Polysorbate Functional? Impact of Polysorbate 80 Grade and Quality on IgG Stability During Mechanical Stress.

Journal of pharmaceutical sciences
2019-10 | Journal article
DOI: 10.1016/j.xphs.2019.10.015
PMID: 31614127
Contributors: Grabarek AD; Bozic U; Rousel J; Menzen T; Kranz W; Wuchner K; Jiskoot W; Hawe A
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Backgrounded Membrane Imaging (BMI) for High-Throughput Characterization of Subvisible Particles During Biopharmaceutical Drug Product Development.

Journal of pharmaceutical sciences
2019-03 | Journal article
DOI: 10.1016/j.xphs.2019.03.024
PMID: 30914272
Contributors: Helbig C; Ammann G; Menzen T; Friess W; Wuchner K; Hawe A
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Laser-induced breakdown detection of temperature-ramp generated aggregates of therapeutic monoclonal antibody.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
2015-07 | Journal article
DOI: 10.1016/j.ejpb.2015.07.001
PMID: 26158409
Contributors: Menzen T; Friess W; Niessner R; Haisch C
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

Temperature-ramped studies on the aggregation, unfolding, and interaction of a therapeutic monoclonal antibody.

Journal of pharmaceutical sciences
2013-12 | Journal article
DOI: 10.1002/jps.23827
PMID: 24382634
Contributors: Menzen T; Friess W
Source: Self-asserted source
Tim Menzen via Europe PubMed Central

High-throughput melting-temperature analysis of a monoclonal antibody by differential scanning fluorimetry in the presence of surfactants.

Journal of pharmaceutical sciences
2012-12 | Journal article
DOI: 10.1002/jps.23405
PMID: 23212746
Contributors: Menzen T; Friess W
Source: Self-asserted source
Tim Menzen via Europe PubMed Central
How many people are using ORCID?