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HKUMed_School of Clinical Medicine_Department of Microbiology

Other IDs

Scopus Author ID: 56711746100
Loop profile: 1990850

Keywords

Emerging infectious disease, coronavirus, animal model, virus-host interactions, molecular virology

Countries

Hong Kong SAR China

Activities

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Employment (2)

The University of Hong Kong: Hong Kong, HK

2022-07-01 to present | Research Assistant Professor (Microbiology)
Employment
Source: Self-asserted source
Shuai H.

The University of Hong Kong: Hong Kong, HK

2018-05-01 to 2022-06-30 | Post-doctoral fellow (Microbiology)
Employment
Source: Self-asserted source
Shuai H.

Education and qualifications (2)

University of Hong Kong: Hong Kong, HK

2013-08-01 to 2018-02-09 | PhD (Microbiology)
Education
Source: Self-asserted source
Shuai H.

Sun Yat-sen University: Guangzhou, Guangdong, CN

2008-09-01 to 2013-06-30 | Bachelor of Medicine (School of Public Health)
Qualification
Source: Self-asserted source
Shuai H.

Works (40)

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

2024-11-21 | Preprint
DOI: 10.21203/rs.3.rs-5454588/v1
Contributors: Hin Chu; Huiping Shuai; Jingxin Qiao; Chaemin Yoon; Guo Zhang; Yuxin Hou; Xiaoyan Xia; Lei Wang; Xinyue Deng; Yifei Wang et al.
Source: check_circle
Crossref

Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3

Nature Communications
2024-10-09 | Journal article
DOI: 10.1038/s41467-024-53033-7
Contributors: Yuanchen Liu; Xiaoyu Zhao; Jialu Shi; Yajie Wang; Huan Liu; Ye-Fan Hu; Bingjie Hu; Huiping Shuai; Terrence Tsz-Tai Yuen; Yue Chai et al.
Source: check_circle
Crossref

A new generation M<sup>pro</sup> inhibitor with potent activity against SARS-CoV-2 Omicron variants

Signal Transduction and Targeted Therapy
2023 | Journal article
DOI: 10.1038/s41392-023-01392-w
EID:

2-s2.0-85150666069

Part of ISSN: 20593635 20959907
Contributors: Huang, C.; Shuai, H.; Qiao, J.; Hou, Y.; Zeng, R.; Xia, A.; Xie, L.; Fang, Z.; Li, Y.; Yoon, C. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Altered host protease determinants for SARS-CoV- 2 Omicron

Science Advances
2023 | Journal article
DOI: 10.1126/sciadv.add3867
EID:

2-s2.0-85147045304

Part of ISSN: 23752548
Contributors: Chan, J.F.W.; Huang, X.; Hu, B.; Chai, Y.; Shi, H.; Zhu, T.; Yuen, T.T.T.; Liu, Y.; Liu, H.; Shi, J. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo

Cell Reports Medicine
2022 | Journal article
DOI: 10.1016/j.xcrm.2022.100774
EID:

2-s2.0-85139246293

Part of ISSN: 26663791
Contributors: Chan, J.F.-W.; Oh, Y.J.; Yuan, S.; Chu, H.; Yeung, M.-L.; Canena, D.; Chan, C.C.-S.; Poon, V.K.-M.; Chan, C.C.-Y.; Zhang, A.J. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier
grade
Preferred source (of 3)‎

Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

Emerging Microbes and Infections
2022 | Journal article
DOI: 10.1080/22221751.2022.2026741
EID:

2-s2.0-85123570015

Part of ISSN: 22221751
Contributors: Chen, Y.; Li, C.; Liu, F.; Ye, Z.; Song, W.; Lee, A.C.Y.; Shuai, H.; Lu, L.; To, K.K.-W.; Chan, J.F.-W. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs

Emerging Microbes and Infections
2022 | Journal article
DOI: 10.1080/22221751.2022.2032372
EID:

2-s2.0-85124439491

Part of ISSN: 22221751
Contributors: Zhang, X.; Chu, H.; Chik, K.K.-H.; Wen, L.; Shuai, H.; Yang, D.; Wang, Y.; Hou, Y.; Yuen, T.T.-T.; Cai, J.-P. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters

Clinical Infectious Diseases
2022 | Journal article
DOI: 10.1093/cid/ciab817
EID:

2-s2.0-85123625192

Part of ISSN: 15376591 10584838
Contributors: Chan, J.F.W.; Poon, V.K.M.; Chan, C.C.S.; Chik, K.K.H.; Tsang, J.O.L.; Zou, Z.; Chan, C.C.Y.; Lee, A.C.Y.; Li, C.; Liang, R. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2

Emerging Microbes and Infections
2022 | Journal article
DOI: 10.1080/22221751.2022.2117098
EID:

2-s2.0-85139147634

Part of ISSN: 22221751
Contributors: Hu, B.; Chan, J.F.-W.; Liu, H.; Liu, Y.; Chai, Y.; Shi, J.; Shuai, H.; Hou, Y.; Huang, X.; Yuen, T.T.-T. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Targeting ACLY efficiently inhibits SARS-CoV-2 replication

International Journal of Biological Sciences
2022 | Journal article
DOI: 10.7150/ijbs.72709
EID:

2-s2.0-85134152870

Part of ISSN: 14492288
Contributors: Yuen, T.T.-T.; Chan, J.F.-W.; Yan, B.; Shum, C.C.-Y.; Liu, Y.; Shuai, H.; Hou, Y.; Huang, X.; Hu, B.; Chai, Y. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2

Cell Reports Medicine
2022 | Journal article
DOI: 10.1016/j.xcrm.2022.100743
EID:

2-s2.0-85137711958

Part of ISSN: 26663791
Contributors: Chan, J.F.-W.; Hu, B.; Chai, Y.; Shuai, H.; Liu, H.; Shi, J.; Liu, Y.; Yoon, C.; Zhang, J.; Hu, J.-C. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

IFN-γ mediated-cellular immunity is essential to the vaccine-induced protection against SARS-CoV-2

2022-09-20 | Preprint
DOI: 10.21203/rs.3.rs-2035535/v1
Contributors: Xiao-lei Wang; Terrence Tsz-Tai Yuen; Ying Dou; Jingchu Hu; Renhao Li; Zheng Zeng; Xuansheng Lin; Hua-Rui Gong; Chaemin Yoon; Huiping Shuai et al.
Source: check_circle
Crossref
grade
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Coronaviruses exploit a host cysteine-aspartic protease for replication

Nature
2022-08-03 | Journal article
DOI: 10.1038/s41586-022-05148-4
Contributors: Hin Chu; Yuxin Hou; Dong Yang; Lei Wen; Huiping Shuai; Chaemin Yoon; Jialu Shi; Yue Chai; Terrence Tsz-Tai Yuen; Bingjie Hu et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice

JCI Insight
2022-06-08 | Journal article
DOI: 10.1172/jci.insight.157393
Contributors: Bao-Zhong Zhang; Huiping Shuai; Hua-rui Gong; Jing-Chu Hu; Bingpeng Yan; Terrence Tsz-Tai Yuen; Ye-Fan Hu; Chaemin Yoon; Xiao-Lei Wang; Yuxin Hou et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Nature Microbiology
2022-04-27 | Journal article
DOI: 10.1038/s41564-022-01119-7
Contributors: Bao-Xue Quan; Huiping Shuai; An-Jie Xia; Yuxin Hou; Rui Zeng; Xin-Lei Liu; Gui-Feng Lin; Jing-Xin Qiao; Wen-Pei Li; Fa-Lu Wang et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

Nature
2022-03-24 | Journal article
DOI: 10.1038/s41586-022-04442-5
Contributors: Huiping Shuai; Jasper Fuk-Woo Chan; Bingjie Hu; Yue Chai; Terrence Tsz-Tai Yuen; Feifei Yin; Xiner Huang; Chaemin Yoon; Jing-Chu Hu; Huan Liu et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Coronaviruses exploit a host cysteine-aspartic protease for efficient replication

ResearchSquare
2021 | Other
DOI: 10.21203/rs.3.rs-354943
EID:

2-s2.0-85145811313
Contributors: Yuen, K.-Y.; Chu, H.; Hou, Y.; Yang, D.; Wen, L.; Shuai, H.; Yuen, T.T.-T.; Li, C.; Zhao, X.; Wang, Y. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Emerging SARS-CoV-2 variants expand species tropism to murines

EBioMedicine
2021 | Journal article
DOI: 10.1016/j.ebiom.2021.103643
EID:

2-s2.0-85118752425

Part of ISSN: 23523964
Contributors: Shuai, H.; Chan, J.F.-W.; Yuen, T.T.-T.; Yoon, C.; Hu, J.-C.; Wen, L.; Hu, B.; Yang, D.; Wang, Y.; Hou, Y. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Emerging SARS-CoV-2 variants expand species tropism to rodents

ResearchSquare
2021 | Other
DOI: 10.21203/rs.3.rs-676992
EID:

2-s2.0-85132763776
Contributors: Shuai, H.; Chan, J.F.-W.; Yuen, T.T.-T.; Yoon, C.; Hu, J.-C.; Wen, L.; Hu, B.; Yang, D.; Wang, Y.; Hou, Y. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Nature Communications
2021 | Journal article
DOI: 10.1038/s41467-020-20457-w
EID:

2-s2.0-85098952672

Part of ISSN: 20411723
Contributors: Chu, H.; Hu, B.; Huang, X.; Chai, Y.; Zhou, D.; Wang, Y.; Shuai, H.; Yang, D.; Hou, Y.; Zhang, X. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19

Cellular and Molecular Gastroenterology and Hepatology
2021 | Journal article
DOI: 10.1016/j.jcmgh.2020.09.017
EID:

2-s2.0-85100051853

Part of ISSN: 2352345X
Contributors: Chu, H.; Chan, J.F.-W.; Wang, Y.; Yuen, T.T.-T.; Chai, Y.; Shuai, H.; Yang, D.; Hu, B.; Huang, X.; Zhang, X. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells

Emerging Microbes and Infections
2021 | Journal article
DOI: 10.1080/22221751.2021.1929503
EID:

2-s2.0-85107792243

Part of ISSN: 22221751
Contributors: Yang, D.; Chu, H.; Lu, G.; Shuai, H.; Wang, Y.; Hou, Y.; Zhang, X.; Huang, X.; Hu, B.; Chai, Y. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

Science Advances
2021 | Journal article
DOI: 10.1126/sciadv.abf8577
EID:

2-s2.0-85108024168

Part of ISSN: 23752548
Contributors: Chu, H.; Shuai, H.; Hou, Y.; Zhang, X.; Wen, L.; Huang, X.; Hu, B.; Yang, D.; Wang, Y.; Yoon, C. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier
grade
Preferred source (of 2)‎

Attenuated interferon and proinflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation

Journal of Infectious Diseases
2020 | Journal article
DOI: 10.1093/infdis/jiaa356
EID:

2-s2.0-85089129573

Part of ISSN: 15376613 00221899
Contributors: Yang, D.; Chu, H.; Hou, Y.; Chai, Y.; Shuai, H.; Lee, A.C.-Y.; Zhang, X.; Wang, Y.; Hu, B.; Huang, X. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation

Emerging Microbes and Infections
2020 | Journal article
DOI: 10.1080/22221751.2020.1738277
EID:

2-s2.0-85082566940

Part of ISSN: 22221751
Contributors: Zhang, X.; Chu, H.; Wen, L.; Shuai, H.; Yang, D.; Wang, Y.; Hou, Y.; Zhu, Z.; Yuan, S.; Yin, F. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target

Emerging Microbes and Infections
2020 | Journal article
DOI: 10.1080/22221751.2020.1850183
EID:

2-s2.0-85097660904

Part of ISSN: 22221751
Contributors: Li, C.; Chu, H.; Liu, X.; Chiu, M.C.; Zhao, X.; Wang, D.; Wei, Y.; Hou, Y.; Shuai, H.; Cai, J. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Targeting the Inositol-Requiring Enzyme-1 Pathway Efficiently Reverts Zika Virus-Induced Neurogenesis and Spermatogenesis Marker Perturbations

ACS Infectious Diseases
2020 | Journal article
DOI: 10.1021/acsinfecdis.9b00526
EID:

2-s2.0-85088485913

Part of ISSN: 23738227
Contributors: Chu, H.; Yuen, T.T.T.; Chik, K.K.H.; Yuan, S.; Shuai, H.; Zou, Z.; Wang, Y.; Zhu, Z.; Yang, D.; Poon, V.K.M. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2020-09-01 | Journal article
DOI: 10.1093/cid/ciaa410
PMID: 32270184
PMC: PMC7184390
Source: Self-asserted source
Shuai H.
grade
Preferred source (of 2)‎

SARS-CoV-2 infects human neural progenitor cells and brain organoids.

Cell research
2020-08-04 | Journal article
DOI: 10.1038/s41422-020-0390-x
PMID: 32753756
PMC: PMC7399356
Source: Self-asserted source
Shuai H.
grade
Preferred source (of 2)‎

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer.

The Journal of infection
2020-07-21 | Journal article
DOI: 10.1016/j.jinf.2020.07.016
PMID: 32707230
PMC: PMC7373021
Source: Self-asserted source
Shuai H.
grade
Preferred source (of 2)‎

Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study

The Lancet Microbe
2020-05 | Journal article
DOI: 10.1016/s2666-5247(20)30004-5
Part of ISSN: 2666-5247
Source: Self-asserted source
Shuai H.

Characterization of the lipidomic profile of human coronavirus-infected cells: Implications for lipid metabolism remodeling upon coronavirus replication

Viruses
2019 | Journal article
DOI: 10.3390/v11010073
EID:

2-s2.0-85060147134

Part of ISSN: 19994915
Contributors: Yan, B.; Chu, H.; Yang, D.; Sze, K.-H.; Lai, P.-M.; Yuan, S.; Shuai, H.; Wang, Y.; Kao, R.Y.-T.; Chan, J.F.-W. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Establishment of a lethal aged mouse model of human respiratory syncytial virus infection

Antiviral Research
2019 | Journal article
DOI: 10.1016/j.antiviral.2018.11.015
EID:

2-s2.0-85057775335

Part of ISSN: 18729096 01663542
Contributors: Zhang, K.; Li, C.; Luo, Y.-S.; Wen, L.; Yuan, S.; Wang, D.; Ho-Yin Wong, B.; Zhao, X.; Chiu, M.C.; Ye, Z.-W. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-04792-7
EID:

2-s2.0-85048727537

Part of ISSN: 20411723
Contributors: Zhao, H.; To, K.K.W.; Chu, H.; Ding, Q.; Zhao, X.; Li, C.; Shuai, H.; Yuan, S.; Zhou, J.; Kok, K.-H. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

Journal of Biological Chemistry
2018 | Journal article
DOI: 10.1074/jbc.RA118.001897
EID:

2-s2.0-85050779327

Part of ISSN: 1083351X 00219258
Contributors: Chu, H.; Chan, C.-M.; Zhang, X.; Wang, Y.; Yuan, S.; Zhou, J.; Au-Yeung, R.K.-H.; Sze, K.-H.; Yang, D.; Shuai, H. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy

Antiviral Research
2018 | Journal article
DOI: 10.1016/j.antiviral.2018.10.007
EID:

2-s2.0-85055254013

Part of ISSN: 18729096 01663542
Contributors: Chan, J.F.-W.; Zhu, Z.; Chu, H.; Yuan, S.; Chik, K.K.-H.; Chan, C.C.-S.; Poon, V.K.-M.; Yip, C.C.-Y.; Zhang, X.; Tsang, J.O.-L. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Antibody-dependent cell-mediated cytotoxicity epitopes on the hemagglutinin head region of pandemic H1N1 influenza virus play detrimental roles in H1N1-infected mice

Frontiers in Immunology
2017 | Journal article
DOI: 10.3389/fimmu.2017.00317
EID:

2-s2.0-85017191342

Part of ISSN: 16643224
Contributors: Ye, Z.-W.; Yuan, S.; Poon, K.-M.; Wen, L.; Yang, D.; Sun, Z.; Li, C.; Hu, M.; Shuai, H.; Zhou, J. et al.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

PA<inf>n</inf>substitutions A37s, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza a virus by impairing the polymerase and endonuclease activities

Journal of General Virology
2017 | Journal article
DOI: 10.1099/jgv.0.000717
EID:

2-s2.0-85017011014

Part of ISSN: 14652099 00221317
Contributors: Hu, M.; Yuan, S.; Ye, Z.-W.; Singh, K.; Li, C.; Shuai, H.; Fai, N.; Chow, B.K.C.; Chu, H.; Zheng, B.-J.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts

Virology
2016 | Journal article
DOI: 10.1016/j.virol.2016.08.004
EID:

2-s2.0-84981555954

Part of ISSN: 10960341 00426822
Contributors: Zhao, H.; Chu, H.; Zhao, X.; Shuai, H.; Wong, B.H.-Y.; Wen, L.; Yuan, S.; Zheng, B.-J.; Zhou, J.; Yuen, K.-Y.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Cross-protection of influenza A virus infection by a DNA aptamer targeting the PA endonuclease domain

Antimicrobial Agents and Chemotherapy
2015 | Journal article
DOI: 10.1128/AAC.00306-15
EID:

2-s2.0-84935856083

Part of ISSN: 10986596 00664804
Contributors: Yuan, S.; Zhang, N.; Singh, K.; Shuai, H.; Chu, H.; Zhou, J.; Chow, B.K.C.; Zheng, B.-J.
Source: Self-asserted source
Shuai H. via Scopus - Elsevier

Peer review (1 review for 1 publication/grant)

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