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South Africa

Biography

Snakebite envenoming has been classified by the World Health Organization (WHO) as a neglected tropical disease that is responsible for tremendous suffering, disability and mortality around the globe. The typical encounter between human and snake is usually unpleasant and frightening for both parties, which may end in devastation for both, driven by mutual fear. Humans often sustain a snakebite by accidently stepping on it in the field, or by threating it by trying to corner and catch it. Due to the lack of fast and reliable snake identification at hospital level, most cases of snakebite appropriate clinical management require reliable identification of a distinctive clinical syndrome based on epidemiological, clinical and laboratory data. It is interesting to note that all venomous snakebites will affect blood coagulation to some or other degree, implicating a haemotoxic profile for all venomous snakes at various grades of intensities. This gives us the opportunity for a more in-depth investigation of this common ground phenomenon, which may give us better insights into possible species specific differences by assessing their effects on human blood. This has the potential to bring us closer to snake identification on a biochemical level.

Our research team study the effects of snake venom on blood cell ultrastructure and coagulation in humans, with special reference to diagnostic markers and toxicology, by incorporating various techniques including haematology analysers, thromboelastography (TEG), flow cytometry, turbidimetry, microscopy (light, confocal and scanning electron), proteomics and metabolomics. The aim of our research is to investigate the effects of venom from various Southern African snake species which are known to deliver a clinical significant bite and envenomation, to profile and compare its effects on blood cell ultrastructure and coagulation, in order to access whether the results could be of diagnostic value to confirm envenomation and potentially snake identification in future.

Activities

Employment (7)

University of Pretoria: Pretoria, Gauteng, ZA

2024-01-01 to present | Extraordinary Lecturer | Clinical Pharmacologist (Pharmacology)
Employment
Source: Self-asserted source
Morné Strydom

Intercare: Pretoria, ZA

2015 to present | Medical practitioner (Private Clinical Practice)
Employment
Source: Self-asserted source
Morné Strydom

University of Pretoria: Pretoria, ZA

2021-02-01 to 2023-12-31 | Senior Lecturer | Clinical Pharmacologist (Pharmacology)
Employment
Source: Self-asserted source
Morné Strydom

Synexus Clinical Research Ltd: South Africa, ZA

2015 to 2018 | Feasibility & Research Physician
Employment
Source: Self-asserted source
Morné Strydom

University of Pretoria: Pretoria, ZA

2013 to 2014 | Registrar in Clinical Pharmacology & Lecturer (Pharmacology)
Employment
Source: Self-asserted source
Morné Strydom

National Department of Health: Pretoria, ZA

2013 to 2013 | Community Service Medical Officer (Family Medicine)
Employment
Source: Self-asserted source
Morné Strydom

National Department of Health: Pretoria, ZA

2011 to 2012 | Internship (Steve Biko Academic Hospital)
Employment
Source: Self-asserted source
Morné Strydom

Education and qualifications (5)

Colleges of Medicine of South Africa: Rondebosch, ZA

2018 to present | Associate of the College of Clinical Pharmacologists (SA)
Education
Source: Self-asserted source
Morné Strydom

University of Pretoria Faculty of Health Sciences: Pretoria, Gauteng, ZA

2015 to 2018 | PhD (Snake Venom Research)
Education
Source: Self-asserted source
Morné Strydom

University of Pretoria Faculty of Health Sciences: Pretoria, Gauteng, ZA

2013 to 2014 | MPharmMed (Master in Medical Pharmacology) (Pharmacology)
Education
Source: Self-asserted source
Morné Strydom

University of Pretoria Faculty of Health Sciences: Pretoria, Gauteng, ZA

2005 to 2010 | MBChB (Bachelor in Medicine and Surgery)
Education
Source: Self-asserted source
Morné Strydom

University of Pretoria: Pretoria, ZA

2003 to 2005 | BSc (Medical Sciences) (Pharmacology)
Education
Source: Self-asserted source
Morné Strydom

Funding (1)

NRF Thuthuka Grant (TTK2204072413)

2023-01 to 2025-12 | Grant
National Research Foundation (Pretoria, ZA)
Source: Self-asserted source
Morné Strydom

Works (14)

Mapping evidence on the regulations affecting accessibility, availability and management of snake antivenom globally: a scoping review protocol

BMJ Open
2024-12 | Journal article
Contributors: Ramsha Majeed; Janette Bester; Kabelo Kgarosi; Morné Strydom
Source: check_circle
Crossref

The role of flavonoids in the pharmacological treatment of haemorrhoids

South African General Practitioner
2024-03 | Journal article
Contributors: SS Singh; MA Strydom; M Balmith; C Megaw; MJ Nell
Source: check_circle
Crossref

Exploring the ex vivo effects of Naja mossambica venom on the ultrastructure and viscoelastic properties of human blood

Research and Practice in Thrombosis and Haemostasis
2024-01 | Journal article
Part of ISSN: 2475-0379
Contributors: Tanyaradzwa Chamboko; Jenna Love; Morné A. Strydom; Janette Bester
Source: Self-asserted source
Morné Strydom

Unravelling the complexities of the human microbiome: current trends in microbiome research for medical practitioners

South African General Practitioner
2023-06 | Journal article
Contributors: Morné A Strydom
Source: check_circle
Crossref

Augmented Reality Technology: A Systematic Review on Gaming Strategy for Medication Adherence

2022 | Book chapter
Contributors: R. O. Adetunji; M. A. Strydom; M. E. Herselman; A. Botha
Source: check_circle
Crossref

Social Media and COVID-19—Perceptions and Public Deceptions of Ivermectin, Colchicine and Hydroxychloroquine: Lessons for Future Pandemics

Antibiotics
2022-03-25 | Journal article
Contributors: Natalie Schellack; Morné Strydom; Michael S. Pepper; Candice L. Herd; Candice Laverne Hendricks; Elmien Bronkhorst; Johanna C. Meyer; Neelaveni Padayachee; Varsha Bangalee; Ilse Truter et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Scoping Review: Adherence in TB journey, its challenges, and Sustainability.

International Conference on Emerging Technology and Interdisciplinary Science (ICETIS 2021)
2021-12-04 | Conference paper
Source: Self-asserted source
Morné Strydom

The potential role of bromhexine in COVID-19 – Has a possible new candidate been “coughed” up?

South African General Practitioner
2021-10-25 | Journal article
Source: Self-asserted source
Morné Strydom

A Brief Updated Review of Advances to Enhance Resveratrol’s Bioavailability

Molecules
2021-07-20 | Journal article
Part of ISSN: 1420-3049
Source: Self-asserted source
Morné Strydom

The potential role of bromhexine in COVID-19 – Has a possible new candidate been “coughed” up?

South African General Practitioner
2021-01 | Journal article
Contributors: T Pillay; M Strydom
Source: check_circle
Crossref

Bioavailability of resveratrol: Possibilities for enhancement

Journal of Herbal Medicine
2018-03 | Journal article
Part of ISSN: 2210-8033
Source: Self-asserted source
Morné Strydom

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting

Toxins
2017-03-13 | Journal article
Part of ISSN: 2072-6651
Source: Self-asserted source
Morné Strydom

The effect of physiological levels of South African puff adder (Bitis arietans) snake venom on blood cells: an in vitro model

Scientific Reports
2016-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Morné Strydom

The anatomical basis of venographic filling defects of the transverse sinus

Clinical Anatomy
2009 | Journal article
Part of ISSN: 0897-3806
Part of ISSN: 1098-2353
Source: Self-asserted source
Morné Strydom