Personal information

Biomineralization, bone, teeth, extracellular matrix, pathologic calcification, eggshells
Canada

Biography

McKee is Full Professor (and Canada Research Chair in Biomineralization) in the Faculty of Dentistry at McGill University in Montreal, with a joint appointment in the Dept. of Anatomy & Cell Biology in the Faculty of Medicine and Health Sciences. McKee obtained his Ph.D. from McGill University, and completed a postdoctoral fellowship at Harvard University/Children’s Hospital (Orthopedic Surgery) in Boston. Following appointments at the Forsyth Institute in Boston and the University of Montreal, he joined McGill University in 1998.

McKee’s research program focuses on the mechanisms regulating biomineralization in bones, teeth and other biomineralizing systems such as otoconia and eggshells, and more specifically, on the role of proteins in controlling the growth of calcium-phosphate and calcium-carbonate crystals in extracellular matrices. He also studies pathologic calcification in tissues that do not normally mineralize. His research is relevant to bone and tooth diseases affecting mineralization (the osteomalacias), and to debilitating calcification pathologies seen in, for example, cardiovascular disease and urolithiasis/kidney stones. McKee has 250 scientific articles published in books/journals, and a Google Scholar h-index of 89 for his publications with over 36,000 citations of his research. He has received two Distinguished Scientist Awards, their highest research honor (the 1996 Young Investigator Award, and the 2003 Biological Mineralization Award) from the International Association for Dental Research, the 2018 C.P. Leblond Award honoring a Quebec scientist for exceptional involvement in bone research, and the 2019 Adele L. Boskey Award from the American Society of Bone and Mineral Research (their highest research honor as one of their Esteemed Awards).

Activities

Employment (1)

McGill University: Montreal, Quebec, CA

Professor (Faculty of Dentistry)
Employment
Source: Self-asserted source
McKee MD

Education and qualifications (1)

McGill University: Montreal, Quebec, CA

PhD (Anatomy and Cell Biology)
Education
Source: Self-asserted source
McKee MD

Professional activities (1)

Canada Research Chairs: Ottawa, Ontario, CA

2018 | Canada Research Chair in Biomineralization (Tier 1)
Distinction
Source: Self-asserted source
McKee MD

Funding (28)

Mineralization mechanisms and osteopontin in bones and teeth

2021-04-01 to 2026-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

6f7d01a831df0a0673194bc65dae7053

Source: Self-asserted source
McKee MD via DimensionsWizard

Correlative 3D nanoimaging and molecular mapping in situ of mineralized tissues

2019-06-18 to present | Grant
Canada Foundation for Innovation (Ottawa, CA)
GRANT_NUMBER:

CFI8192

Source: Self-asserted source
McKee MD via DimensionsWizard

Protein-mineral interactions at the organic-inorganic interface in biominerals

2019-04-01 to 2020-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: 684951
Source: Self-asserted source
McKee MD via DimensionsWizard

Thirteenth International Conference on the Chemistry and Biology of Mineralized Tissues

2018-12-01 to 2019-11-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

a11d7e9cd3bd310fae9166335554ec2f

Source: Self-asserted source
McKee MD via DimensionsWizard

Canada Research Chair Tier 1

2018-10-01 to 2025-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

c596ceea296ed700ca33b84f82061e6b

Source: Self-asserted source
McKee MD via DimensionsWizard

Regulation of biomineralization by osteopontin

2015-07-01 to 2020-06-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

f1300c485abd3bcd87530f40147dfb41

Source: Self-asserted source
McKee MD via DimensionsWizard

2014 Biomineralization Gordon Research Conference & Gordon Research Seminar

2014-08-01 to 2015-07-31 | Grant
National Institute of Arthritis and Musculoskeletal and Skin Diseases (Bethesda, US)
GRANT_NUMBER: R13AR066913
Source: Self-asserted source
McKee MD via DimensionsWizard

2014 Gordon Research Conference/Seminar on Biomineralization

2014-07-01 to 2015-06-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

7c1d48942611f730bdb243a9be5835d1

Source: Self-asserted source
McKee MD via DimensionsWizard

Infrastructure for analysis of extracellular matrix assembly and mineralization

2014-03-18 to present | Grant
Canada Foundation for Innovation (Ottawa, CA)
GRANT_NUMBER:

CFI8193

Source: Self-asserted source
McKee MD via DimensionsWizard

Multiscale Imaging and Analysis of Biological Systems and Biomaterials in Nanomedicine

2012-11-20 to present | Grant
Canada Foundation for Innovation (Ottawa, CA)
GRANT_NUMBER:

CFI8486

Source: Self-asserted source
McKee MD via DimensionsWizard

The Role of Pigment Epithelium Derived Factor During Skeletal Development

2012-03-01 to 2013-02-28 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

cdf6e4e1c026d22b9b4e421d5bf20faf

Source: Self-asserted source
McKee MD via DimensionsWizard

The Role of Pigment Epithelium Derived Factor During Skeletal Development

2012-01-01 to 2013-12-31 | Grant
Shriners Hospitals for Children (Tampa, US)
GRANT_NUMBER:

85500-CAN

Source: Self-asserted source
McKee MD via DimensionsWizard

10th International Conference on the Chemistry and Biology of Mineralized Tissues

2010-01-01 to 2010-12-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

60fefc115f21889e425f0142f1ecb527

Source: Self-asserted source
McKee MD via DimensionsWizard

Regulation of biomineralization by osteopontin

2009-10-01 to 2014-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

59c2968c677c16025925e325199befa1

Source: Self-asserted source
McKee MD via DimensionsWizard

Critical role for alpha-v-beta-6 integrin in enamel biomineralization

2009-10-01 to 2013-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

1edf663c25834c03037e469bed39b8d1

Source: Self-asserted source
McKee MD via DimensionsWizard

Critical role for alpha-v-beta-6 integrin in enamel biomineralization

2009-01-01 to 2009-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

67753aac7e1d4e1144545cf9014ec3bd

Source: Self-asserted source
McKee MD via DimensionsWizard

Biogenesis and function of extracellular matrix assemblies in health and disease

2007-10-23 to present | Grant
Canada Foundation for Innovation (Ottawa, CA)
GRANT_NUMBER:

CFI8191

Source: Self-asserted source
McKee MD via DimensionsWizard

Multi-user Maintenance and Development Grant for the McGill Facility for Electron Microscopy Research

2007-04-01 to 2012-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

4cd700e1b63e3bea8ec067cbdf1895f7

Source: Self-asserted source
McKee MD via DimensionsWizard

CIHR training program in applied Oral Health Research

2004-07-01 to 2010-06-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

3bc3e7ae0adec128ff2f2d2ab71e55a4

Source: Self-asserted source
McKee MD via DimensionsWizard

Multi-user EM facility equipment grant

2004-03-01 to 2005-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

8f33e34f080ae1d4851c2d02e5297755

Source: Self-asserted source
McKee MD via DimensionsWizard

Mechanisms of mineral oss in medial arterial calcifiation: Specific therapeutic opportunity for isolated systolic hypertension

2003-04-01 to 2006-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

b1f6ad55d88e350b230ac86f3d13989a

Source: Self-asserted source
McKee MD via DimensionsWizard

Training program in skeletal health research

2002-03-01 to 2009-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

8bcd0acdd5f3340de5ea2242ca08b7cf

Source: Self-asserted source
McKee MD via DimensionsWizard

Regulation of mineralization and bone formation

2000-04-01 to 2001-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

b6c0629c0e21685f5deb0f5d61b2a344

Source: Self-asserted source
McKee MD via DimensionsWizard

Multi-user EM facility development grant

2000-01-01 to 2000-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

d555851cb15755c55294942308debe26

Source: Self-asserted source
McKee MD via DimensionsWizard

Transgenic mice as models of osteoarthritis and pathological calcification

1999-09-01 to 2002-04-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

f8c1a24a1b8034028dd2605f34f14e88

Source: Self-asserted source
McKee MD via DimensionsWizard

Multi-User EM facility maintenance and development grant

1997-04-01 to 2007-03-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

923ce9872306d7b1972c527a48678867

Source: Self-asserted source
McKee MD via DimensionsWizard

Protein regulation of biomineralization

1991-07-01 to 2008-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

5b4ed6e3a33939188a37577be5e5faf4

Source: Self-asserted source
McKee MD via DimensionsWizard

CIHR Group in periodontal physiology

1988-07-01 to 2001-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

b3fdfc25f85407ff834f5b8fbb29e2d2

Source: Self-asserted source
McKee MD via DimensionsWizard

Peer review (4 reviews for 3 publications/grants)

Review activity for ACS biomaterials science & engineering. (2)
Review activity for ACS nano. (1)
Review activity for Crystal growth & design. (1)