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Sixth Affiliated Hospital of Sun Yat-sen University
Sun Yat-sen University

Other IDs

ResearcherID: AAH-8379-2021
Scopus Author ID: 56535592400
Loop profile: 845536

Keywords

Genomics, Epigenetics, Cancer, Machine learning

Countries

China

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Employment (3)

The Sixth Affiliated Hospital, Sun Yat-sen University: Guangzhou, Guangdong, CN

2021-12-01 to present | Associate Professor (Guangdong Institute of Gastroenterology)
Employment
Source: Self-asserted source
Huichuan Yu

The Sixth Affiliated Hospital, Sun Yat-sen University: Guangzhou, Guangdong, CN

2015-12-01 to 2021-12-01 | Assistant Professor (Guangdong Institute of Gastroenterology)
Employment
Source: Self-asserted source
Huichuan Yu

The Sixth Affiliated Hospital, Sun Yat-sen University: Guangzhou, Guangdong, CN

2014-06-20 to 2015-12-01 | Resident (Department of Colorectal Surgery)
Employment
Source: Self-asserted source
Huichuan Yu

Education and qualifications (1)

Sun Yat-Sen University: Guangzhou, Guangdong, CN

2006-09-01 to 2014-06-20 | MD, PhD (Zhongshan School of Medicine/The Sixth Affiliated Hospital)
Education
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Huichuan Yu

Professional activities (1)

American Association for Cancer Research: PA, PA, US

Active Membership
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Huichuan Yu

Works (50 of 67)

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Page 1 of 2

Deep learning model targeting cancer surrounding tissues for accurate cancer diagnosis based on histopathological images

Journal of Translational Medicine
2025 | Journal article
DOI: 10.1186/S12967-024-06017-6
WOSUID: WOS:001405656600002
Contributors: Li, Lanlan; Geng, Yi; Chen, Tao; Lin, Kaixin; Xie, Chengjie; Qi, Jing; Wei, Hongan; Wang, Jianping; Wang, Dabiao; Yuan, Ze et al.
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Disrupting EDEM3-induced M2-like macrophage trafficking by glucose restriction overcomes resistance to PD-1/PD-L1 blockade

Clinical and Translational Medicine
2025 | Journal article
DOI: 10.1002/CTM2.70161
WOSUID: WOS:001388950700001
Contributors: Peng, Shaoyong; Wu, Minshan; Yan, Qian; Xu, Gaopo; Xie, Yumo; Tang, Guannan; Lin, Jinxin; Yuan, Zixu; Liang, Xiaoxia; Yuan, Ze et al.
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Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity

Cell & Bioscience
2025 | Journal article
DOI: 10.1186/S13578-024-01337-Y
WOSUID: WOS:001402136200001
Contributors: Liu, Binbin; Xie, Yumo; Zhang, Yu; Tang, Guannan; Lin, Jinxin; Yuan, Ze; Liu, Xiaoxia; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin et al.
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Enlarged metastasis-free tumor-draining lymph node is a marker of tumor invasion in local tissues with an active NK cell-mediated immunity

Cancer Research
2024 | Journal article
DOI: 10.1158/1538-7445.AM2024-5519
WOSUID: WOS:001253000903055
Contributors: Wan, Zixiao; Yu, Huichuan
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Fasting-mimicking diet plus 2-DG drives antitumor immunity by targeting EDEM3-induced PD-L1 glycosylation

Cancer Research
2024 | Journal article
DOI: 10.1158/1538-7445.AM2024-3719
WOSUID: WOS:001252656306388
Contributors: Liu, Xiaoxia; Peng, Shaoyong; Wang, Xiaolin; Yu, Huichuan; Luo, Yanxin
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Global DNA methylation level is associated with the sensitivity of cytotoxic and senotherapeutic drugs in gastrointestinal tumors

Cancer Research
2024 | Journal article
DOI: 10.1158/1538-7445.AM2024-3485
WOSUID: WOS:001252656306185
Contributors: Lin, Kaixin; Wang, Xiaolin; Luo, Yanxin; Yu, Huichuan
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N6AMT1-mediated DNA 6mA modification in DNA repetitive elements LINE-1 dynamically regulates the IFN signal pathway in colorectal cancer

Cancer Research
2024 | Journal article
DOI: 10.1158/1538-7445.AM2024-2629
WOSUID: WOS:001252656304385
Contributors: Yuan, Ze; Liu, Xiaoxia; Wang, Xiaolin; Luo, Yanxin; Yu, Huichuan
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Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial

British Journal of Cancer
2024 | Journal article
DOI: 10.1038/S41416-024-02652-4
WOSUID: WOS:001183638300001
Contributors: Cai, Jinlin; Lin, Kaixin; Luo, Tongfeng; Weng, Jingrong; Liu, Haotian; Yuan, Ze; Wan, Zixiao; Han, Junyi; Lin, Jinxin; Liu, Xiaoxia et al.
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Primer Guide for phenotype-specific profiling of DNA

STAR Protocols
2024 | Journal article
DOI: 10.1016/J.XPRO.2023.102820
WOSUID: WOS:001154776500001
Contributors: Zhao, Zhuoyan; Wang, Jianru; Yu, Huichuan; Wang, Xiaolin
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Radiogenomic profiling of global DNA methylation associated with molecular phenotypes and immune features in glioma

BMC Medicine
2024 | Journal article
DOI: 10.1186/S12916-024-03573-Y
WOSUID: WOS:001302583300008
Contributors: Zhuang, Zhuokai; Lin, Jinxin; Wan, Zixiao; Weng, Jingrong; Yuan, Ze; Xie, Yumo; Liu, Zongchao; Xie, Peiyi; Mao, Siyue; Wang, Zongming et al.
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Replenishment of mitochondrial Na<SUP>+</SUP> and H<SUP>+</SUP> by ionophores potentiates cutaneous wound healing in diabetes

Materials Today Bio
2024 | Journal article
DOI: 10.1016/J.MTBIO.2024.101056
WOSUID: WOS:001231940300001
Contributors: Bai, Liangliang; Wu, Linping; Zhang, Changsheng; Liu, Zhiwen; Ma, Liang; Ni, Jing; He, Dezhen; Zhu, Mingxuan; Peng, Shaoyong; Liu, Xiaoxia et al.
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Reply to Qiao et al

British Journal of Cancer
2024 | Journal article
DOI: 10.1038/S41416-024-02716-5
WOSUID: WOS:001229342200001
Contributors: Chen, Zibin; Lin, Kaixin; Yu, Huichuan
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Senescent cancer-associated fibroblast drives colorectal cancer progression in a METTL1-dependent manner

Cancer Research
2024 | Journal article
DOI: 10.1158/1538-7445.AM2024-1728
WOSUID: WOS:001252656303089
Contributors: Weng, Jingrong; Wang, Xiaolin; Liu, Xiaoxia; Luo, Yanxin; Yu, Huichuan
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Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity

Cell Death and Disease
2024 | Journal article
DOI: 10.1038/S41419-024-07215-2
WOSUID: WOS:001352425000003
Contributors: Li, Peisi; Zhou, Dawang; Xie, Yumo; Yuan, Ze; Huang, Mingzhe; Xu, Gaopo; Huang, Junfeng; Zhuang, Zhuokai; Luo, Yanxin; Yu, Huichuan et al.
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Aberrant methylation in neurofunctional gene serves as a hallmark of tumorigenesis and progression in colorectal cancer

BMC Cancer
2023 | Journal article
DOI: 10.1186/S12885-023-10765-X
WOSUID: WOS:000963291100001
Contributors: Li, Xuan; Cai, Du; Huang, Yaoyi; Xie, Yumo; Shen, Dingcheng; Yuan, Ze; Liu, Xiaoxia; Huang, Meijin; Luo, Yanxin; Yu, Huichuan et al.
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Activated pyroptosis prior to treatment marks a potential response to immunotherapy in cancers

Cancer Research
2023 | Journal article
DOI: 10.1158/1538-7445.AM2023-4147
WOSUID: WOS:001008499102088
Contributors: Xie, Yumo; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Automatic treatment outcome prediction with DeepInteg based on multimodal radiological images in rectal cancer

Heliyon
2023 | Journal article
DOI: 10.1016/J.HELIYON.2023.E13094
WOSUID: WOS:000972997900001
Contributors: Hu, Yihuang; Li, Juan; Zhuang, Zhuokai; Xu, Bin; Wang, Dabiao; Yu, Huichuan; Li, Lanlan
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Clinical atlas of rectal cancer highlights the barriers and insufficient interventions underlying the unfavorable outcomes in older patients

Heliyon
2023 | Journal article
DOI: 10.1016/J.HELIYON.2023.E15966
WOSUID: WOS:001029204800001
Contributors: Zhao, Zhuoyang; Lin, Jinxin; Chen, Shunlun; Wang, Xiaolin; Wang, Heng; Xu, Gaopo; Wang, Jianru; Zhou, Ruwen; Huang, Zenghong; Li, Yingjie et al.
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Clinical spectrum of rectal cancer identifies hallmarks of early-onset patients and next-generation treatment strategies

Cancer Medicine
2023 | Journal article
DOI: 10.1002/CAM4.5120
WOSUID: WOS:000836297900001
Contributors: Shen, Dingcheng; Wang, Puning; Xie, Yumo; Zhuang, Zhuokai; Zhu, Mingxuan; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancer

Journal of the National Cancer Institute
2023 | Journal article
DOI: 10.1093/JNCI/DJAC183
WOSUID: WOS:000875759900001
Contributors: Yu, Huichuan; Wang, Xiaolin; Bai, Liangliang; Tang, Guannan; Carter, Kelly T.; Cui, Ji; Huang, Pinzhu; Liang, Li; Ding, Yanqing; Cai, Muyan et al.
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Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells

EBioMedicine
2023 | Journal article
DOI: 10.1016/J.EBIOM.2023.104496
WOSUID: WOS:000953476100001
Contributors: Liu, Xiaoxia; Peng, Shaoyong; Tang, Guannan; Xu, Gaopo; Xie, Yumo; Shen, Dingcheng; Zhu, Mingxuan; Huang, Yaoyi; Wang, Xiaolin; Yu, Huichuan et al.
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Pan-cancer investigation of C-to-U editing reveals its important role in cancer development and new targets for cancer treatment

Frontiers in Oncology
2023 | Journal article
DOI: 10.3389/FONC.2023.1097667
WOSUID: WOS:000951338900001
Contributors: Guo, Mengbiao; Li, Feng; Zhao, Linghao; Fang, Zhengwen; Yu, Huichuan; Songyang, Zhou; Xiong, Yuanyan
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Prevalent Pseudoprogression and Pseudoresidue in Patients With Rectal Cancer Treated With Neoadjuvant Immune Checkpoint Inhibitors

JNCCN–Journal of the National Comprehensive Cancer Network
2023 | Journal article
DOI: 10.6004/JNCCN.2022.7071
WOSUID: WOS:000946526600006
Contributors: Xie, Yumo; Lin, Jinxin; Zhang, Ning; Wang, Xiaolin; Wang, Puning; Peng, Shaoyong; Li, Juan; Wu, Yuanhui; Huang, Yaoyi; Zhuang, Zhuokai et al.
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Radiological lymph-node size improves the prognostic value of systemic inflammation index in rectal cancer with pathologically negative nodes

Cancer Medicine
2023 | Journal article
DOI: 10.1002/CAM4.5761
WOSUID: WOS:000956007100001
Contributors: Peng, Shaoyong; Liu, Xiaoxia; Li, Yingjie; Yu, Huichuan; Xie, Yumo; Wang, Xiaolin; Zhou, Jiaming; Zhu, Mingxuan; Luo, Yanxin; Huang, Meijin
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RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner

Clinical and Translational Medicine
2023 | Journal article
DOI: 10.1002/CTM2.1279
WOSUID: WOS:000990431300001
Contributors: Shen, Dingcheng; Lin, Jinxin; Xie, Yumo; Zhuang, Zhuokai; Xu, Gaopo; Peng, Shaoyong; Tang, Guannan; Bai, Liangliang; Zhu, Mingxuan; Zhang, Yu et al.
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RNA m6A methylation relay the oncogenic flow from DNA methylationto gene expression of ANKRD13B

Cancer Research
2023 | Journal article
DOI: 10.1158/1538-7445.AM2023-6006
WOSUID: WOS:001008499105313
Contributors: Weng, JingRong; Lin, JinXin; Xie, YuMo; Tang, GuanNan; Bai, LiangLiang; Chen, JinHua; Huang, ZengHong; Zhuang, ZhuoKai; Peng, ShaoYong; Wang, Heng et al.
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Aberrant DNA 5mC and 6mA methylations increase ACE2 expression in intestinal cancer cells susceptible to SARS-CoV-2 infection

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509500491
Contributors: Wang, Heng; Xie, Yumo; Xu, Gaopo; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Aberrant DNA 5mC and 6mA methylations increase ACE2 expression in intestinal cancer cells susceptible to SARS-CoV-2 infection

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509502543
Contributors: Wang, Heng; Xie, Yumo; Xu, Gaopo; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Comprehensive characterization of rectal cancer reveals less cancer treatment with worse nutritional status and more comorbidities in the older patients

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509502437
Contributors: Zhao, Zhuoyang; Wang, Jianru; Lin, Jinxin; Chen, Shunlun; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Comprehensive characterization of rectal cancer reveals less cancer treatment with worse nutritional status and more comorbidities in the older patients

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509500385
Contributors: Zhao, Zhuoyang; Wang, Jianru; Lin, Jinxin; Chen, Shunlun; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases

IScience
2022 | Journal article
DOI: 10.1016/J.ISCI.2022.105312
WOSUID: WOS:001084010700001
Contributors: Wang, Xiaolin; Chen, Shunlun; Zhao, Zhuoyang; Chen, Fan; Huang, Yuming; Guo, Xingyu; Lei, Linchuan; Wang, Wantao; Luo, Yanxin; Yu, Huichuan et al.
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Inflamed lymph nodes mark active tumor immune response in colorectal cancer patients

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509503147
Contributors: Shen, Dingcheng; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Inflamed lymph nodes mark active tumor immune response in colorectal cancer patients

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509501084
Contributors: Shen, Dingcheng; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages

Journal for ImmunoTherapy of Cancer
2022 | Journal article
DOI: 10.1136/JITC-2022-005610
WOSUID: WOS:000894850800004
Contributors: Zhu, Mingxuan; Bai, Liangliang; Liu, Xiaoxia; Peng, Shaoyong; Xie, Yumo; Bai, Hong; Yu, Huichuan; Wang, Xiaolin; Yuan, Ping; Ma, Rui et al.
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Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509501679
Contributors: Xie, Yumo; Zhang, Yu; Tang, Guannan; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity

Cancer Research
2022 | Journal article
WOSUID: WOS:000892509504021
Contributors: Xie, Yumo; Zhang, Yu; Tang, Guannan; Wang, Xiaolin; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Systemic Inflammation Status Relates to Anti-Inflammatory Drug Benefit and Survival in Rectal Cancer

Journal of Surgical Research
2022 | Journal article
DOI: 10.1016/J.JSS.2021.08.028
WOSUID: WOS:000709723100011
Contributors: Cao, Xue; Wang, Xiaolin; Wang, Heng; Xu, Gaopo; Yu, Huichuan
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Accelerated biological aging in COVID-19 patients.

Nature communications
2022-04-19 | Journal article
DOI: 10.1038/s41467-022-29801-8
PMID: 35440567
Source: Self-asserted source
Huichuan Yu

Current Surveillance After Treatment is Not Sufficient for Patients With Rectal Cancer With Negative Baseline CEA.

Journal of the National Comprehensive Cancer Network : JNCCN
2022-03-01 | Journal article
DOI: 10.6004/jnccn.2021.7101
PMID: 35231901
Source: Self-asserted source
Huichuan Yu

Current treatment and surveillance modalities are not sufficient for advanced stage III colon cancer: Result from a multicenter cohort analysis

Cancer Medicine
2021 | Journal article
DOI: 10.1002/CAM4.4417
WOSUID: WOS:000719133400001
Contributors: Li, Juan; Xie, Yumo; Huang, Ziying; Shen, Dingcheng; Zhuang, Zhuokai; Zhu, Mingxuan; Huang, Yaoyi; He, Rongzhao; Wang, Xiaolin; Huang, Meijin et al.
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DNA methylation-based signature of CD8+tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer

Journal for ImmunoTherapy of Cancer
2021 | Journal article
DOI: 10.1136/JITC-2021-002671
WOSUID: WOS:000698428600001
Contributors: Zou, Qi; Wang, Xiaolin; Ren, Donglin; Hu, Bang; Tang, Guannan; Zhang, Yu; Huang, Meijin; Pai, Rish K.; Buchanan, Daniel D.; Win, Aung Ko et al.
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Radiomic signature of the FOWARC trial predicts pathological response to neoadjuvant treatment in rectal cancer

Journal of Translational Medicine
2021 | Journal article
DOI: 10.1186/S12967-021-02919-X
WOSUID: WOS:000662963200001
Contributors: Zhuang, Zhuokai; Liu, Zongchao; Li, Juan; Wang, Xiaolin; Xie, Peiyi; Xiong, Fei; Hu, Jiancong; Meng, Xiaochun; Huang, Meijin; Deng, Yanhong et al.
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The Addition of Preoperative Radiation Is Insufficient for Lateral Pelvic Control in a Subgroup of Patients with Low Locally Advanced Rectal Cancer: A Post-Hoc Study of a Randomized Controlled Trial.

Diseases of the colon and rectum
2021-05-13 | Journal article
DOI: 10.1097/dcr.0000000000001935
PMID: 33990500
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Huichuan Yu
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Serum calcium improved systemic inflammation marker for predicting survival outcome in rectal cancer.

Journal of gastrointestinal oncology
2021-04-01 | Journal article
DOI: 10.21037/jgo-20-479
PMID: 34012650
PMC: PMC8107585
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Huichuan Yu
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Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer.

Journal of translational medicine
2021-02-16 | Journal article
DOI: 10.1186/s12967-021-02740-6
PMID: 33593392
PMC: PMC7885252
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Huichuan Yu
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Decreased expression of SorCS1 in colorectal cancer: An independent predictor of poor prognosis

Neoplasma
2020 | Journal article
DOI: 10.4149/neo_2019_190221N146
EID:

2-s2.0-85078691979

Part of ISSN: 13384317 00282685
Contributors: Huang, P.Z.; Peng, S.Y.; Yu, H.C.; Huang, L.; Yao, Q.; Wang, X.L.; Tan, S.Y.; Zhou, J.M.; Wang, P.N.; Huang, A.P. et al.
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Epigenetic Inactivation of alpha-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer

Cancer Research
2020 | Journal article
DOI: 10.1158/0008-5472.CAN-20-1590
WOSUID: WOS:000596730000007
Contributors: Li, Yingjie; Bai, Liangliang; Yu, Huichuan; Cai, Du; Wang, Xiaolin; Huang, Baoyuan; Peng, Shaoyong; Huang, Meijin; Cao, Guangwen; Kaz, Andrew M. et al.
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High platelet-to-lymphocyte ratio predicts improved survival outcome for perioperative NSAID use in patients with rectal cancer

International Journal of Colorectal Disease
2020 | Journal article
DOI: 10.1007/S00384-020-03528-8
WOSUID: WOS:000516004100001
Contributors: Huang, Zenghong; Wang, Xiaolin; Zou, Qi; Zhuang, Zhuokai; Xie, Yumo; Cai, Du; Bai, Liangliang; Tang, Guannan; Huang, Meijin; Luo, Yanxin et al.
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Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer

Gastroenterology Research and Practice
2020 | Journal article
DOI: 10.1155/2020/5045142
WOSUID: WOS:000601115000001
Contributors: Zou, Qi; Ren, Donglin; Wang, Xiaolin; Bai, Liangliang; Tang, Guannan; Huang, Meijin; Luo, Yanxin; Yu, Huichuan
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Nomograms for Prediction of Molecular Phenotypes in Colorectal Cancer

OncoTargets and Therapy
2020 | Journal article
DOI: 10.2147/OTT.S234495
WOSUID: WOS:000507388500001
Contributors: Yu, Zhuojun; Yu, Huichuan; Zou, Qi; Huang, Zenghong; Wang, Xiaolin; Tang, Guannan; Bai, Liangliang; Zhou, Chuanhai; Zhuang, Zhuokai; Xie, Yumo et al.
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