Personal information

Emails & domains

Verified email domains

Websites & social links

https://pure.qub.ac.uk/en/persons/alerie-guzman-de-la-fuente
http://www.neuroscience.cam.ac.uk/directory/profile.php?ag636

Other IDs

Loop profile: 333641
Loop profile: 736855
Scopus Author ID: 35810088500

Keywords

Oligodendrocyte, Stem Cells, Myelin, Multiple Sclerosis, Inflammation, Ageing, Immune System

Countries

United Kingdom, Spain

Activities

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Employment (6)

Queen's University Belfast: Belfast, GB

2022-04-19 to present | Visiting Scholar (Wellcome-Wolfson Institute for Experimental Medicine)
Employment
Source: Self-asserted source
Alerie Guzman de la Fuente

Instituto de Neurociencias de Alicante: San Juan de Alicante, ES

2022-04-19 to present | Miguel Servet Investigator
Employment
Source: Self-asserted source
Alerie Guzman de la Fuente

Health and Biomedical Resaerch Institute of Alicante (ISABIAL): Alicante, ES

2022-04-19 to present | Miguel Servet Investigator
Employment
Source: Self-asserted source
Alerie Guzman de la Fuente

Queen's University Belfast: Belfast, Belfast, GB

2018-07 to 2022-04-15 | Research Fellow (Centre for Experimental Medicine)
Employment
Source: Self-asserted source
Alerie Guzman de la Fuente

University of Cambridge: Cambridge, Cambridgeshire, GB

2015-04-07 to 2018-06 | Postdoctoral Research Associate (Clinical Neuroscience- Stem Cell Neurobiology)
Employment
Source: Self-asserted source
Alerie Guzman de la Fuente

Universita degli Studi di Milano Facolta di Scienze e Tecnologie: Milano, Lombardia, IT

2010-01 to 2010-07 | Research assistant (Department of Pharmacology)
Employment
Source: Self-asserted source
Alerie Guzman de la Fuente

Education and qualifications (3)

University of Cambridge: Cambridge, Cambridgeshire, GB

2011-01-05 to 2015-05-18 | PhD in Clinical Neurosciences (Clinical Neurosciences- Stem Cell Neurobiology)
Education
Source: Self-asserted source
Alerie Guzman de la Fuente

Universidad de Navarra: Pamplona, Navarra, ES

2004-09 to 2009-06 | Licentiate in Biology (Sciences)
Education
Source: Self-asserted source
Alerie Guzman de la Fuente

Universidad de Navarra: Pamplona, Navarra, ES

2004-09 to 2009-06 | Licentiate in Biochemistry (Sciences)
Education
Source: Self-asserted source
Alerie Guzman de la Fuente

Funding (8)

Oligodendrocyte progenitor cells and inflammation in Multiple Sclerosis

2022-04 to 2027-04 | Salary award
Instituto de Salud Carlos III (Madrid, ES)
Source: Self-asserted source
Alerie Guzman de la Fuente

Understanding the effect of ageing in the immune-modulatory role of OPCs

2020-07 to 2022-06 | Salary award
Wellcome Trust (London, GB)
GRANT_NUMBER:

Wellcome Trust ISSF QUB fellowship
Source: Self-asserted source
Alerie Guzman de la Fuente

High Parameter Flow Cytometry suite to study the role of immune and neural cells in health and disease

2020-04 to 2025-05 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
Alerie Guzman de la Fuente

Determine the role of aged oligodendrocyte progenitor cells in the interaction with adaptive immune system

2018-07 to 2020-06 | Salary award
ECTRIMS (Basel, CH)
Source: Self-asserted source
Alerie Guzman de la Fuente

Understanding changes in the aged OPC proteome

2015-04 to 2018-05 | Contract
MedImmune/ AstraZeneca (Cambridge, GB)
Source: Self-asserted source
Alerie Guzman de la Fuente

RXR signaling in oligodendrocyte lineage cells

2014-01 to 2014-12 | Salary award
Obra social la caixa (Barcelona, ES)
Source: Self-asserted source
Alerie Guzman de la Fuente

Endocytosis of ADAM10 in Alzheimer's disease

2010-03 to 2010-06 | Salary award
International Brain Research Organization (Paris, FR)
Source: Self-asserted source
Alerie Guzman de la Fuente

Endocytosis of ADAM10 in Alzheimer's disease

2010-01 to 2010-03 | Salary award
Universidad de Navarra (Pamplona, ES)
Source: Self-asserted source
Alerie Guzman de la Fuente

Works (30)

Glial cell alterations in diabetes-induced neurodegeneration

Cellular and Molecular Life Sciences
2024-12 | Journal article
DOI: 10.1007/s00018-023-05024-y
Contributors: María Llorián-Salvador; Sonia Cabeza-Fernández; Jose A. Gomez-Sanchez; Alerie G. de la Fuente
Source: check_circle
Crossref

Schwann cell JUN expression worsens motor performance in an amyotrophic lateral sclerosis mouse model

Glia
2024-12 | Journal article
DOI: 10.1002/glia.24604
Contributors: Sonia Cabeza‐Fernández; Rubí Hernández‐Rojas; Angeles Casillas‐Bajo; Nikiben Patel; Alerie G. de la Fuente; Hugo Cabedo; Jose A. Gomez‐Sanchez
Source: check_circle
Crossref

Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes.

Journal of neuroinflammation
2024-12-23 | Journal article
DOI: 10.1186/s12974-024-03323-0
PMID: 39716335
PMC: PMC11668053
Contributors: María Llorián-Salvador; Pérez-Martínez D; Tang M; Anna Duarri; García-Ramirez M; Deàs-Just A; Álvarez-Guaita A; Ramos-Pérez L; Bogdanov P; Gomez-Sanchez JA et al.
Source: Self-asserted source
Alerie Guzman de la Fuente

Navigating the transition to Principal Investigator

Immunology & Cell Biology
2024-10 | Journal article
DOI: 10.1111/imcb.12821
Contributors: Alerie G de la Fuente
Source: check_circle
Crossref

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

Molecular Neurodegeneration
2024-04-05 | Journal article
DOI: 10.1186/s13024-024-00724-w
Contributors: María Llorián-Salvador; Alerie G. de la Fuente; Christopher E. McMurran; Amy Dashwood; James Dooley; Adrian Liston; Rosana Penalva; Yvonne Dombrowski; Alan W. Stitt; Denise C. Fitzgerald
Source: check_circle
Crossref

Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination

Nature Communications
2024-03-11 | Journal article
DOI: 10.1038/s41467-024-45742-w
Contributors: Alerie Guzman de la Fuente; Marie Dittmer; Elise J. Heesbeen; Nira de la Vega Gallardo; Jessica A. White; Andrew Young; Tiree McColgan; Amy Dashwood; Katie Mayne; Sonia Cabeza-Fernández et al.
Source: check_circle
Crossref

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

2023-10-14 | Preprint
DOI: 10.1101/2023.10.11.561874
Contributors: María Llorián-Salvador; Alerie G de Fuente; Christopher E. McMurran; Rosana Penalva; Yvonne Dombrowski; Alan W. Stitt; Denise C Fitzgerald
Source: check_circle
Crossref

Brain-specific regulatory T cell expansion limits cognitive decline

Trends in Molecular Medicine
2023-07 | Journal article
DOI: 10.1016/j.molmed.2023.05.001
Contributors: Maria Llorián-Salvador; Alerie G. de la Fuente
Source: check_circle
Crossref

Novel therapeutic approaches to target neurodegeneration

British Journal of Pharmacology
2023-07 | Journal article
DOI: 10.1111/bph.16078
Contributors: Alerie G. de la Fuente; Silvia Pelucchi; Jerome Mertens; Monica Di Luca; Daniela Mauceri; Elena Marcello
Source: check_circle
Crossref

Immune–stem cell crosstalk in the central nervous system: how oligodendrocyte progenitor cells interact with immune cells

Immunology & Cell Biology
2023-01 | Journal article
DOI: 10.1111/imcb.12610
Contributors: Sonia Cabeza‐Fernández; Jessica A White; Christopher E McMurran; José A Gómez‐Sánchez; Alerie G de la Fuente
Source: check_circle
Crossref

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

2023-01-25 | Preprint
DOI: 10.1101/2023.01.25.525562
Contributors: Alerie Guzman de la Fuente; Marie Dittmer; Elise Heesbeen; Nira de la Vega Gallardo; Jessica White; Andrew Young; Tiree McColgan; Amy Dashwood; Katie Mayne; Sonia Cabeza-Fernández et al.
Source: check_circle
Crossref

Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non‐cell‐autonomous neuronal damage

Clinical and Translational Medicine
2022-05 | Journal article
DOI: 10.1002/ctm2.837
Contributors: Clara Matute‐Blanch; Verónica Brito; Luciana Midaglia; Luisa M Villar; Gerardo Garcia‐Diaz Barriga; Alerie Guzman de la Fuente; Eva Borrás; Sara Fernández‐García; Laura Calvo‐Barreiro; Andrés Miguez et al.
Source: check_circle
Crossref

Autoantibodies and microglia: boon or bane?

Brain
2021-08-11 | Journal article
DOI: 10.1093/brain/awab269
Contributors: Michelle Naughton; Alerie G de la Fuente
Source: check_circle
Crossref

Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders

Nanoscale
2020 | Journal article
DOI: 10.1039/C9NR06187H
Contributors: I. Conejos-Sánchez; E. Gallon; A. Niño-Pariente; J. A. Smith; A. G. De la Fuente; L. Di Canio; S. Pluchino; R. J. M. Franklin; M. J. Vicent
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.

Journal of neurology, neurosurgery, and psychiatry
2020-11-12 | Journal article
DOI: 10.1136/jnnp-2020-324286
PMID: 33184094
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 3)‎

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Frontiers in aging neuroscience
2020-09-23 | Journal article
DOI: 10.3389/fnagi.2020.572090
PMID: 33173502
PMC: PMC7538701
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 3)‎

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

Proceedings of the National Academy of Sciences
2020-07-28 | Journal article
DOI: 10.1073/pnas.1922089117
Contributors: Nira de la Vega Gallardo; Rosana Penalva; Marie Dittmer; Michelle Naughton; John Falconer; Jill Moffat; Alerie G. de la Fuente; José R. Hombrebueno; Zhiyong Lin; Bernard Perbal et al.
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.

Cell
2020-07-20 | Journal article
DOI: 10.1016/j.cell.2020.06.026
PMID: 32702313
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 3)‎

Changes in the oligodendrocyte progenitor cell proteome with ageing

Molecular & Cellular Proteomics
2020-05-20 | Journal article
DOI: 10.1074/mcp.ra120.002102
Part of ISSN: 1535-9476
Part of ISSN: 1535-9484
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 3)‎

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

Glia
2020-02 | Journal article
DOI: 10.1002/glia.23789
PMID: 32017258
Contributors: Foerster S; Guzman de la Fuente A; Kagawa Y; Bartels T; Owada Y; Franklin RJM
Source: Self-asserted source
Alerie Guzman de la Fuente via Europe PubMed Central
grade
Preferred source (of 3)‎

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

Proceedings of the National Academy of Sciences of the United States of America
2019-11-18 | Journal article
DOI: 10.1073/pnas.1905787116
PMID: 31740610
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 3)‎

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders.

Frontiers in immunology
2019-09-12 | Journal article
DOI: 10.3389/fimmu.2019.02171
PMID: 31572381
PMC: PMC6751344
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 3)‎

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Glia
2019-04-30 | Journal article
DOI: 10.1002/glia.23624
PMID: 31038798
PMC: PMC6618006
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 4)‎

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells.

Frontiers in Cellular Neuroscience
2019-03-27 | Journal article
DOI: 10.3389/fncel.2019.00085
PMID: 30971893
PMC: PMC6446960
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 3)‎

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

Cell reports
2017-08-01 | Journal article
DOI: 10.1016/j.celrep.2017.08.007
PMID: 28834740
PMC: PMC5574064
Source: Self-asserted source
Alerie Guzman de la Fuente
grade
Preferred source (of 5)‎

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Brain
2015 | Journal article
DOI: 10.1093/brain/awv289
EID:

2-s2.0-84951172662

Part of ISBN:

14602156 00068950
Contributors: Natrajan, M.S.; De La Fuente, A.G.; Crawford, A.H.; Linehan, E.; Nuñez, V.; Johnson, K.R.; Wu, T.; Fitzgerald, D.C.; Ricote, M.; Bielekova, B. et al.
Source: Self-asserted source
Alerie Guzman de la Fuente via Scopus - Elsevier
grade
Preferred source (of 2)‎

Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.

2015-12 | Journal article
DOI: 10.1083/jcb.201505119
PMID: 26644513
Contributors: de la Fuente AG; Errea O; van Wijngaarden P; Gonzalez GA; Kerninon C; Jarjour AA; Lewis HJ; Jones CA; Nait-Oumesmar B; Zhao C et al.
Source: Self-asserted source
Alerie Guzman de la Fuente via Europe PubMed Central
grade
Preferred source (of 3)‎

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

2015-10 | Journal article
PMID: 26463675
Contributors: Natrajan MS; de la Fuente AG; Crawford AH; Linehan E; Nuñez V; Johnson KR; Wu T; Fitzgerald DC; Ricote M; Bielekova B et al.
Source: Self-asserted source
Alerie Guzman de la Fuente via Europe PubMed Central

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

2013-06 | Journal article
DOI: 10.1172/JCI65401
PMID: 23676497
PMC: PMC3668814
Contributors: Marcello E; Saraceno C; Musardo S; Vara H; de la Fuente AG; Pelucchi S; Di Marino D; Borroni B; Tramontano A; Pérez-Otaño I et al.
Source: Self-asserted source
Alerie Guzman de la Fuente via Europe PubMed Central
grade
Preferred source (of 3)‎

Masking of transmembrane-based retention signals controls ER export of gamma-secretase.

2010-02 | Journal article
DOI: 10.1111/j.1600-0854.2009.01014.x
PMID: 19958468
Contributors: Fassler M; Zocher M; Klare S; de la Fuente AG; Scheuermann J; Capell A; Haass C; Valkova C; Veerappan A; Schneider D et al.
Source: Self-asserted source
Alerie Guzman de la Fuente via Europe PubMed Central
grade
Preferred source (of 3)‎

Peer review (3 reviews for 2 publications/grants)

Review activity for Journal of neuroinflammation (2)
Review activity for Nature communications (1)
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