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malaria, metabolism, drug development

Biography

Professor, Departments of Pediatrics and Microbiology
Perelman School of Medicine
University of Pennsylvania
Division Chief, Infectious Diseases
Children's Hospital of Philadelphia
Philadelphia PA

Division website: https://www.chop.edu/centers-programs/division-infectious-diseases/our-team
Lab website: https://www.research.chop.edu/people/audrey-r-odom-john

Activities

Employment (5)

University of Pennsylvania: Philadelphia, PA, US

Sponsor
Employment
Source: check_circle
University of Pennsylvania via ORCID Member Portal

Children's Hospital of Philadelphia: Philadelphia, PA, US

2019-08-01 to present | Chief/Infectious Diseases (Pediatrics)
Employment
Source: Self-asserted source
Audrey R. Odom John

Washington University School of Medicine: Saint Louis, MO, US

2016-07-01 to 2019-07-31 | Associate Professor (Pediatrics and Molecular Microbiology)
Employment
Source: Self-asserted source
Audrey R. Odom John

Washington University in Saint Louis School of Medicine: Saint Louis, MO, US

2010-08-01 to 2016-07-01 | Assistant Professor (Pediatrics and Molecular Microbiology)
Employment
Source: Self-asserted source
Audrey R. Odom John

Washington University in Saint Louis School of Medicine: Saint Louis, MO, US

2008-08-01 to 2010-07-01 | Instructor (Pediatrics)
Employment
Source: Self-asserted source
Audrey R. Odom John

Education and qualifications (5)

University of Washington Medical Center: Seattle, WA, US

2005-07-01 to 2008-07-31 | Pediatrics Infectious Diseases Fellowship (Pediatrics)
Education
Source: Self-asserted source
Audrey R. Odom John

University of Washington Medical Center: Seattle, WA, US

2003-07-01 to 2005-06-30 | Pediatrics residency (Pediatrics)
Education
Source: Self-asserted source
Audrey R. Odom John

Duke University School of Medicine: Durham, NC, US

1996-07-01 to 2003-05-01 | MD/combined MD-PhD (MSTP) degree program
Education
Source: Self-asserted source
Audrey R. Odom John

Duke University School of Medicine: Durham, NC, US

1998-07-01 to 2002-12-01 | PhD (Biochemistry)
Education
Source: Self-asserted source
Audrey R. Odom John

Duke University: Durham, NC, US

1992-07-01 to 1996-05-01 | B.S./Biology, minor chemistry
Education
Source: Self-asserted source
Audrey R. Odom John

Funding (10)

Diagnosis of MIS-C in febrile children

2021-01-01 to 2022-11-30 | Grant
Eunice Kennedy Shriver National Institute of Child Health and Human Development (Bethesda, US)
GRANT_NUMBER: R61HD105594
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

Microbial Origin of Breath Volatile Metabolites

2020-06-01 to 2022-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI154370
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

Towards noninvasive diagnosis of malaria

2019-01-18 to 2020-12-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI144472
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

TARGETING ISPC TO TREAT MALARIA

2016-03-15 to 2018-02-28 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 1R21AI123808-01
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

TARGETING ISPC TO TREAT MALARIA

2016-03-15 to 2018-02-28 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI123808
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUM

2012-12-01 to 2022-11-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI103280
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUM

2012-12-01 to 2017-11-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5R01AI103280-03
GRANT_NUMBER: 5R01AI103280-03
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUM

2012-12-01 to 2017-11-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 4R01AI103280-04
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard

GE AKTAEXPLORER CHROMOTOGRAPHY SYSTEM

2010-04-08 to 2011-04-07 | Grant
National Center for Research Resources (Bethesda, US)
GRANT_NUMBER: 1S10RR026891-01
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard
grade
Preferred source (of 2)‎

Targeting isoprenoid biosynthesis in Plasmodium falciparum

2008-09-15 to 2012-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5K08AI079010-04
Source: Self-asserted source
Audrey R. Odom John via DimensionsWizard
grade
Preferred source (of 2)‎

Works (50 of 76)

Items per page:
Page 1 of 2

Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling

2025-01-20 | Preprint
Contributors: Amalia Z Berna; Tzvi Pollock; Yang Liu; Michelle Gibison; Amritha Mallikarjun; Joey Logan; Cynthia Otto; Audrey John
Source: check_circle
Crossref

Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs

RSC Medicinal Chemistry
2024 | Journal article
Contributors: Darean Bague; Ruiqin Wang; Dana Hodge; Marwa O. Mikati; Jose S. Roma; Helena I. Boshoff; Allyson L. Dailey; Misgina Girma; Robin D. Couch; Audrey R. Odom John et al.
Source: check_circle
Crossref

Essential role for HSP40 in asexual replication and thermotolerance of malaria parasites

2024-11-05 | Preprint
Contributors: Brianne Roper; Deepika Kannan; Emily S. Mathews; Audrey R. Odom John
Source: check_circle
Crossref

Breath Biomarkers of Pediatric Malaria: Reproducibility and Response to Antimalarial Therapy

The Journal of Infectious Diseases
2024-06-17 | Journal article
Contributors: Amalia Z Berna; X Rosalind Wang; Lucy B Bollinger; Josephine Banda; Patricia Mawindo; Tasha Evanoff; Diana L Culbertson; Karl Seydel; Audrey R Odom John
Source: check_circle
Crossref

Oops, the Microbes Did It Again: Gut Dysbiosis Precedes Late-Onset Meningitis

The Journal of Infectious Diseases
2024-05-23 | Journal article
Contributors: Samantha A Whiteside; Audrey R Odom John
Source: check_circle
Crossref

Thinking Small, Stinking Big: The World of Microbial Odors

The Journal of Infectious Diseases
2024-05-15 | Journal article
Contributors: Tzvi Y Pollock; Audrey R Odom John
Source: check_circle
Crossref

Volatile profiling distinguishes Streptococcus pyogenes from other respiratory streptococcal species

mSphere
2023-10-24 | Journal article
Contributors: Amalia Z. Berna; Joseph A. Merriman; Leah Mellett; Danealle K. Parchment; Michael G. Caparon; Audrey R. Odom John; Jacqueline M. Achkar
Source: check_circle
Crossref

Volatile profiling distinguishesStreptococcus pyogenesfrom other respiratory streptococcal species

2023-04-13 | Preprint
Contributors: Amalia Z. Berna; Joseph A. Merriman; Leah Mellet; Danealle K. Parchment; Michael G. Caparon; Audrey R. Odom John
Source: check_circle
Crossref

Tale of the Titers: Serologic Testing for SARS-CoV-2—Yes, No, and Maybe, With Clinical Examples From the IDSA Diagnostics Committee

Open Forum Infectious Diseases
2023-01-04 | Journal article
Contributors: Robert Colgrove; Lou Ann Bruno-Murtha; Cody A Chastain; Kimberly E Hanson; Francesca Lee; Audrey R Odom John; Romney Humphries
Source: check_circle
Crossref

GAPDH mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites

PLOS Pathogens
2022-09-14 | Journal article
Contributors: Andrew J. Jezewski; Sean T. Prigge; Ann M. Guggisberg; Dana M. Hodge; Naomi Ghebremichael; Gavin Nicholas John; Lisa K. McLellan; Audrey Ragan Odom John
Source: check_circle
Crossref

Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causing parasites

Journal of Biological Chemistry
2022-02 | Journal article
Contributors: Philip M. Frasse; Justin J. Miller; Alexander J. Polino; Ebrahim Soleimani; Jian-She Zhu; David L. Jakeman; Joseph M. Jez; Daniel E. Goldberg; Audrey R. Odom John
Source: check_circle
Crossref

In situ structure and priming mechanism of the rhoptry secretion system in Plasmodium revealed by cryo-electron tomography

2022-01-11 | Preprint
Contributors: Matthew Martinez; William David Chen; Marta Mendonça Cova; Petra Molnár; Shrawan Kumar Mageswaran; Amandine Guérin; Audrey R. Odom John; Maryse Lebrun; Yi-Wei Chang
Source: check_circle
Crossref

Breath Metabolites to Diagnose Infection

Clinical Chemistry
2021-12-30 | Journal article
Contributors: Amalia Z Berna; Audrey R Odom John
Source: check_circle
Crossref

GAPDH cooperativity mediates drug resistance and metabolism in Plasmodium fal-ciparum malaria parasites

2021-11-06 | Other
Contributors: Andrew J. Jezewski; Ann M. Guggisberg; Dana M. Hodge; Naomi Ghebremichael; Lisa K. McLellan; Audrey R. Odom John
Source: check_circle
Crossref

Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection

ACS Infectious Diseases
2021-09-10 | Journal article
Contributors: Amalia Z. Berna; Elikplim H. Akaho; Rebecca M. Harris; Morgan Congdon; Emilie Korn; Samuel Neher; Mirna M’Farrej; Julianne Burns; Audrey R. Odom John
Source: check_circle
Crossref

Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria parasites

2021-07-04 | Other
Contributors: Philip M Frasse; Justin J Miller; Ebrahim Soleimani; Jian-She Zhu; David L Jakeman; Joseph M Jez; Daniel E Goldberg; Audrey R Odom John
Source: check_circle
Crossref

Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites

mBio
2021-06-29 | Journal article
Contributors: Emily S. Mathews; Andrew J. Jezewski; Audrey R. Odom John; L. David Sibley
Source: check_circle
Crossref

Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics

Molecular Systems Biology
2021-04 | Journal article
Contributors: Simon A Cobbold; Madel V Tutor; Philip Frasse; Emma McHugh; Markus Karnthaler; Darren J Creek; Audrey Odom John; Leann Tilley; Stuart A Ralph; Malcolm J McConville
Source: check_circle
Crossref

Cutaneous Findings in SARS-CoV-2-Associated Multisystem Inflammatory Disease in Children

Open Forum Infectious Diseases
2021-03-01 | Journal article
Contributors: Allison M Blatz; Michelle Oboite; Kathleen Chiotos; Leslie Castelo-Soccio; Audrey R Odom John; Hamid Bassiri; Edward M Behrens; Caroline Diorio; Julie C Fitzgerald; Therese Giglia et al.
Source: check_circle
Crossref

Crystal structure of hydroxyacyl glutathione hydrolase (GloB) from Staphylococcus aureus, apoenzyme

2020 | Other
Contributors: J.J. Miller; J.M. Jez; A.R. Odom John
Source: Self-asserted source
Audrey R. Odom John via Crossref Metadata Search

Crystal structure of s-formylglutathione hydrolase (FrmB) from Staphylococcus aureus, apoenzyme

2020 | Other
Contributors: J.J. Miller; J.M. Jez; A.R. Odom John
Source: Self-asserted source
Audrey R. Odom John via Crossref Metadata Search

Reproducible breath metabolite changes in children with SARS-CoV-2 infection

2020-12-07 | Other
Contributors: Amalia Z. Berna; Elikplim H. Akaho; Rebecca M. Harris; Morgan Congdon; Emilie Korn; Samuel Neher; Mirna M’Farrej; Julianne Burns; Audrey R. Odom John
Source: check_circle
Crossref

Editorial overview: Paths of least resistance: surveillance, discovery, and innovation to address the other (antimicrobial resistance) pandemic

Current Opinion in Microbiology
2020-10 | Journal article
Contributors: Iruka N Okeke; Audrey R Odom John
Source: check_circle
Crossref

Targeting host glycolysis as a strategy for antimalarial development

2020-10-10 | Preprint
Contributors: Andrew J. Jezewski; Yu-Hsi Lin; Julie A. Reisz; Rachel Culp-Hill; Yasaman Barekatain; Victoria C. Yan; Angelo D’Alessandro; Florian L. Muller; Audrey R. Odom John
Source: check_circle
Crossref

The Malaria Metabolite HMBPP Does Not Trigger Erythrocyte Terpene Release

ACS Infectious Diseases
2020-10-09 | Journal article
Contributors: Justin J. Miller; Audrey R. Odom John
Source: check_circle
Crossref

The malaria metabolite HMBPP does not trigger erythrocyte terpene production

2020-07-30 | Other
Contributors: Justin J. Miller; Audrey R. Odom John
Source: check_circle
Crossref

Comparison of breath sampling methods: a post hoc analysis from observational cohort studies

The Analyst
2019 | Journal article
Contributors: Amalia Z. Berna; Chad L. Schaber; Lucy B. Bollinger; Mwawi Mwale; Rachel Mlotha-Mitole; Indi Trehan; Audrey R. Odom John
Source: check_circle
Crossref

Protein prenylation and Hsp40 in thermotolerance of Plasmodium falciparum malaria parasites

2019-11-14 | Other
Contributors: Emily S. Mathews; Andrew J. Jezewski; Audrey R. Odom John
Source: check_circle
Crossref

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

PLOS ONE
2019-05-09 | Journal article
Contributors: Monique R. Heitmeier; Stuart Alexander Ralph; Richard C. Hresko; Rachel L. Edwards; Michael J. Prinsen; Ma Xenia G. Ilagan; Audrey R. Odom John; Paul W. Hruz
Source: check_circle
Crossref

Pediatric tropical medicine: The neglected diseases of children

PLOS Neglected Tropical Diseases
2019-05-09 | Journal article
Contributors: Peter J. Hotez; Jennifer A. Downs; Audrey R. Odom John; A. Desiree LaBeaud
Source: check_circle
Crossref

Breath Collection from Children for Disease Biomarker Discovery

Journal of Visualized Experiments
2019-02-14 | Journal article
Source: Self-asserted source
Audrey R. Odom John
grade
Preferred source (of 2)‎

Haloacid Dehalogenase Proteins: Novel Mediators of Metabolic Plasticity in Plasmodium falciparum

Microbiology Insights
2019-01 | Journal article
Contributors: Philip M Frasse; Audrey R Odom John
Source: check_circle
Crossref

Malaria in Children

Infectious Disease Clinics of North America
2018 | Journal article
EID:

2-s2.0-85038395117

Contributors: Kafai, N.M.; Odom John, A.R.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier

Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites

mBio
2018-12-21 | Journal article
Contributors: Ann M. Guggisberg; Philip M. Frasse; Andrew J. Jezewski; Natasha M. Kafai; Aakash Y. Gandhi; Samuel J. Erlinger; Audrey R. Odom John; Thomas E. Wellems
Source: check_circle
Crossref

MEPicides: α,β-Unsaturated Fosmidomycin Analogs as DXR inhibitors against Malaria.

Journal of medicinal chemistry
2018-09 | Journal article
Contributors: Wang X; Edwards RL; Ball H; Johnson C; Haymond A; Girma M; Manikkam M; Brothers RC; McKay K; Arnett S et al.
Source: Self-asserted source
Audrey R. Odom John via Europe PubMed Central

Tackling resistance: emerging antimalarials and new parasite targets in the era of elimination.

F1000Research
2018-08 | Journal article
Contributors: Mathews ES; Odom John AR
Source: Self-asserted source
Audrey R. Odom John via Europe PubMed Central

Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants.

The Journal of Infectious Diseases
2018-04 | Journal article
Contributors: Schaber CL; Katta N; Bollinger LB; Mwale M; Mlotha-Mitole R; Trehan I; Raman B; Odom John AR
Source: Self-asserted source
Audrey R. Odom John via Europe PubMed Central

Natural History of Plasmodium odocoilei Malaria Infection in Farmed White-Tailed Deer

mSphere
2018-04-25 | Journal article
Contributors: Ann M. Guggisberg; Katherine A. Sayler; Samantha M. Wisely; Audrey R. Odom John; Ira J. Blader
Source: check_circle
Crossref

Inositol phosphate multikinase dependent transcriptional control

Advances in Biological Regulation
2017 | Book
EID:

2-s2.0-85016010169

Contributors: Hatch, A.J.; Odom, A.R.; York, J.D.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier

Infectious complications of pediatric cochlear implants are highly influenced by otitis media

International Journal of Pediatric Otorhinolaryngology
2017-06 | Journal article
Contributors: Peter M. Vila; Nsangou T. Ghogomu; Audrey R. Odom-John; Timothy E. Hullar; Keiko Hirose
Source: check_circle
Crossref

Suppression of drug resistance reveals a genetic mechanism of metabolic plasticity in malaria parasites

2017-06-26 | Preprint
Contributors: Ann M. Guggisberg; Philip M. Frasse; Andrew J. Jezewski; Natasha M. Kafai; Aakash Y. Gandhi; Samuel J. Erlinger; Audrey R. Odom John
Source: check_circle
Crossref

A novel fluorescence resonance energy transfer-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters

Antimicrobial Agents and Chemotherapy
2016 | Journal article
EID:

2-s2.0-84996567248

Contributors: Kraft, T.E.; Heitmeier, M.R.; Putanko, M.; Edwards, R.L.; Ilagan, M.X.G.; Payne, M.A.; Autry, J.M.; Thomas, D.D.; Odom, A.R.; Hruz, P.W.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier

Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue

Scientific Reports
2016 | Journal article
Contributors: Kiall F. Suazo; Chad Schaber; Charuta C. Palsuledesai; Audrey R. Odom John; Mark D. Distefano
Source: Self-asserted source
Audrey R. Odom John via Crossref Metadata Search

Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis

ACS Infectious Diseases
2016 | Journal article
EID:

2-s2.0-85003443605

Contributors: San Jose, G.; Jackson, E.R.; Haymond, A.; Johny, C.; Edwards, R.L.; Wang, X.; Brothers, R.C.; Edelstein, E.K.; Odom, A.R.; Boshoff, H.I. et al.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier

Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure with Fosmidomycin-Clindamycin

Journal of Infectious Diseases
2016 | Journal article
EID:

2-s2.0-84994175661

Contributors: Guggisberg, A.M.; Sundararaman, S.A.; Lanaspa, M.; Moraleda, C.; González, R.; Mayor, A.; Cisteró, P.; Hutchinson, D.; Kremsner, P.G.; Hahn, B.H. et al.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier

Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD.

Scientific reports
2016-11 | Journal article
Contributors: Price KE; Armstrong CM; Imlay LS; Hodge DM; Pidathala C; Roberts NJ; Park J; Mikati M; Sharma R; Lawrenson AS et al.
Source: Self-asserted source
Audrey R. Odom John via Europe PubMed Central

Muddled mechanisms: recent progress towards antimalarial target identification

F1000Research
2016-10 | Journal article
Contributors: Rachel L. Edwards; Audrey R. Odom John
Source: Self-asserted source
Audrey R. Odom John via Crossref Metadata Search

Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1

Acta Crystallographica Section D: Biological Crystallography
2015 | Journal article
EID:

2-s2.0-84940843918

Contributors: Park, J.; Guggisberg, A.M.; Odom, A.R.; Tolia, N.H.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier

Determinants of anemia and hemoglobin concentration in haitian school-aged children

American Journal of Tropical Medicine and Hygiene
2015 | Journal article
EID:

2-s2.0-84946811287

Contributors: Iannotti, L.L.; Delnatus, J.R.; Odom, A.R.; Eaton, J.C.; Griggs, J.J.; Brown, S.; Wolff, P.B.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier

Malaria parasites produce volatile mosquito attractants

mBio
2015 | Journal article
EID:

2-s2.0-84928779340

Contributors: Kelly, M.; Su, C.-Y.; Schaber, C.; Crowley, J.R.; Hsu, F.-F.; Carlson, J.R.; Odom, A.R.
Source: Self-asserted source
Audrey R. Odom John via Scopus - Elsevier
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2

Peer review (42 reviews for 5 publications/grants)

Review activity for ACS infectious diseases. (13)
Review activity for ACS synthetic biology. (1)
Review activity for Faculty Opinions (26)
Review activity for Journal of infectious diseases. (1)
Review activity for PLOS pathogens : (1)