Personal information

United Kingdom

Activities

Employment (5)

Cardiff University: Cardiff, GB

2023-08-01 to present | Senior Lecturer (School of Biosciences)
Employment
Source: Self-asserted source
Florian Siebzehnrubl

Cardiff University: Cardiff, GB

2021-09-01 to 2023-07-31 | Lecturer (Biosciences)
Employment
Source: Self-asserted source
Florian Siebzehnrubl

Cardiff University: Cardiff, Cardiff, GB

2014-07-01 to 2021-08-31 | Research Fellow (European Cancer Stem Cell Research Institute)
Employment
Source: Self-asserted source
Florian Siebzehnrubl

University of Florida: Gainesville, FL, US

2011-06-01 to 2014-05-31 | Research assistant professor (Neurosurgery)
Employment
Source: Self-asserted source
Florian Siebzehnrubl

University of Florida: Gainesville, FL, US

2007-11-01 to 2011-05-31 | Postdoc (Neuroscience)
Employment
Source: Self-asserted source
Florian Siebzehnrubl

Education and qualifications (1)

Friedrich-Alexander-Universität Erlangen-Nürnberg: Erlangen, Bayern, DE

2004-06-01 to 2007-10-07 | PhD (Neuropathology)
Education
Source: Self-asserted source
Florian Siebzehnrubl

Funding (10)

Proteostatic regulation of glioblastoma stemness

2023-05-31 to 2027-05-30 | Grant
Medical Research Council (London, GB)
GRANT_NUMBER: MR/X018318/1
Source: Self-asserted source
Florian Siebzehnrubl via DimensionsWizard

Defining the roles of fibroblast growth factor receptors on glioblastoma stem-like and non-stem cell populations

2019-04-30 to 2022-09-29 | Grant
Medical Research Council (London, GB)
GRANT_NUMBER: MR/S007709/1
Source: Self-asserted source
Florian Siebzehnrubl via DimensionsWizard

Investigating biodistribution of therapeutic exosomes

2019-02 to 2021-02 | Grant
Innovate UK (London, GB)
Source: Self-asserted source
Florian Siebzehnrubl

Targeting the ubiquitin-proteasome system in glioblastoma

2018-10 to 2021-10 | Grant
Medical Research Council (Bath, GB)
Source: Self-asserted source
Florian Siebzehnrubl

Narciclasine, an accessible natural product as a lead compound for the treatment of gliomas

2017-10 to 2020-10 | Grant
European Social Fund (Bangor, GB)
Source: Self-asserted source
Florian Siebzehnrubl

Radiolabelling of exosomes for in vivo tracking in murine glioma

2017-02 to 2017-08 | Grant
Medical Research Council (Cardiff, GB)
Source: Self-asserted source
Florian Siebzehnrubl

Developing human glioma OrganDot cultures

2016-10 to 2019-10 | Grant
National Centre for the Replacement, Refinement and Reduction of Animals in Research (London, GB)
Source: Self-asserted source
Florian Siebzehnrubl

Functions of MIF in glioblastoma tumour progression

2015-10-01 to 2019-09-01 | Grant
Tenovus Cancer Care (Cardiff, GB)
GRANT_NUMBER:

PHD2015/L19

Source: Self-asserted source
Florian Siebzehnrubl via DimensionsWizard

Cell-cell interactions during early transformation events in brain cancer

2015-10 to 2018-10 | Grant
Cancer Research UK (Cardiff, GB)
Source: Self-asserted source
Florian Siebzehnrubl

ZEB1 target profiling in glioblastoma

2015-01 to 2016-12 | Grant
Cancer Research UK (Cardiff, GB)
Source: Self-asserted source
Florian Siebzehnrubl

Works (48)

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

Cancer Letters
2023-09 | Journal article
Contributors: Nawal Alshahrany; Ayesha Begum; Dorit Siebzehnrubl; Ana Jimenez-Pascual; Florian A. Siebzehnrubl
Source: check_circle
Crossref

Engineering Adenoviral Vectors with Improved GBM Selectivity

Viruses
2023-04-28 | Journal article
Contributors: Emily A. Bates; Charlotte Lovatt; Alice R. Plein; James A. Davies; Florian A. Siebzehnrubl; Alan L. Parker
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Engineering Adenoviral Vectors With Improved GBM Selectivity

2023-04-03 | Preprint
Contributors: Emily A Bates; Charlotte Lovatt; Alice R Plein; James A Davies; Florian A. Siebzehnrubl; Alan L Parker
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

HECTD1 is both a positive regulator and substrate of caspase-3 activity during apoptotic cell death

2023-02-18 | Preprint
Contributors: Nico Scholz; Florian Siebzehnrubl; Julien D. F Licchesi
Source: check_circle
Crossref

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

2023-01-10 | Preprint
Contributors: Nawal Alshahrany; Ana Jimenez-Pascual; Florian A Siebzehnrubl
Source: check_circle
Crossref

A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance

2022-10-23 | Preprint
Contributors: J Brown; M Zaben; C Ormonde; F Sharouf; R Spencer; H Bhatt; FA Siebzehnrubl; WP Gray
Source: check_circle
Crossref

Singular Adult Neural Stem Cells Do Not Exist

Cells
2022-02-18 | Journal article
Contributors: David Petrik; Sara Jörgensen; Vasileios Eftychidis; Florian A. Siebzehnrubl
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Identifying subpopulations in multicellular systems by quantitative chemical imaging using label-free hyperspectral CARS microscopy

The Analyst
2021 | Journal article
Contributors: Iestyn Pope; Francesco Masia; Kenneth Ewan; Ana Jimenez-Pascual; Trevor C. Dale; Florian A. Siebzehnrubl; Paola Borri; Wolfgang Langbein
Source: check_circle
Crossref

The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus

Cell Reports
2021-08 | Journal article
Contributors: Bhavana Gupta; Adam C. Errington; Ana Jimenez-Pascual; Vasileios Eftychidis; Simone Brabletz; Marc P. Stemmler; Thomas Brabletz; David Petrik; Florian A. Siebzehnrubl
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

FGF2: a novel druggable target for glioblastoma?

Expert Opinion on Therapeutic Targets
2020-04-02 | Journal article
Contributors: Ana Jimenez-Pascual; Kelly Mitchell; Florian A Siebzehnrubl; Justin D Lathia
Source: check_circle
Crossref

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Molecular & Cellular Oncology
2020-01-02 | Journal article
Contributors: Ana Jimenez-Pascual; Justin D. Lathia; Florian A. Siebzehnrubl
Source: check_circle
Crossref

ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

Cancer Discovery
2019-11 | Journal article
Part of ISSN: 2159-8274
Part of ISSN: 2159-8290
Source: Self-asserted source
Florian Siebzehnrubl

Fibroblast Growth Factor Receptor Functions in Glioblastoma

Cells
2019-07-13 | Journal article
Contributors: Ana Jimenez-Pascual; Florian A. Siebzehnrubl
Source: check_circle
Crossref

Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma

2018-12-03 | Journal article
Source: Self-asserted source
Florian Siebzehnrubl

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

Proceedings of the National Academy of Sciences
2018-09-11 | Journal article
Contributors: Florian A. Siebzehnrübl; Kerstin A. Raber; Yvonne K. Urbach; Anja Schulze-Krebs; Fabio Canneva; Sandra Moceri; Johanna Habermeyer; Dalila Achoui; Bhavana Gupta; Dennis A. Steindler et al.
Source: check_circle
Crossref

Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression.

2017-04 | Journal article
Contributors: Roy A; Attarha S; Weishaupt H; Edqvist PH; Swartling FJ; Bergqvist M; Siebzehnrubl FA; Smits A; Pontén F; Tchougounova E
Source: Self-asserted source
Florian Siebzehnrubl via Europe PubMed Central

Application of an RNA amplification method for reliable single-cell transcriptome analysis

BioTechniques
2015 | Journal article
EID:

2-s2.0-84941072567

Contributors: Suslov, O.; Silver, D.J.; Siebzehnrubl, F.A.; Orjalo, A.; Ptitsyn, A.; Steindler, D.A.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres

Brain Pathology
2015 | Journal article
EID:

2-s2.0-84946221385

Contributors: Kahlert, U.D.; Suwala, A.K.; Raabe, E.H.; Siebzehnrubl, F.A.; Suarez, M.J.; Orr, B.A.; Bar, E.E.; Maciaczyk, J.; Eberhart, C.G.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

PO01DISPARATE RADIATION RESPONSE OF SLOW PROLIFERATING CANCER STEM CELLS.

2015-11 | Journal article
Contributors: Siebzehnrubl FA; Nabilsi N; Pasternack N; Rohaus M; Griffith BG; Dajac K; Patel J; Harding A; Kladde MP; Steindler DA et al.
Source: Self-asserted source
Florian Siebzehnrubl via Europe PubMed Central

Detection of primary cilia in human glioblastoma

Journal of Neuro-Oncology
2014 | Journal article
EID:

2-s2.0-84901634102

Contributors: Sarkisian, M.R.; Siebzehnrubl, D.; Hoang-Minh, L.; Deleyrolle, L.; Silver, D.J.; Siebzehnrubl, F.A.; Guadiana, S.M.; Srivinasan, G.; Semple-Rowland, S.; Harrison, J.K. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Increased precursor cell proliferation after deep brain stimulation for Parkinson's disease: A human study

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84897049631

Contributors: Vedam-Mai, V.; Gardner, B.; Okun, M.S.; Siebzehnrubl, F.A.; Kam, M.; Aponso, P.; Steindler, D.A.; Yachnis, A.T.; Neal, D.; Oliver, B.U. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

CB-07DISTINCT RADIATION RESPONSE OF SLOW-DIVIDING CANCER STEM CELLS.

2014-11 | Journal article
Contributors: Deleyrolle L; Nabilsi N; Griffith B; Pasternack N; Dajac K; Patel J; Rohaus M; Harding A; Kladde M; Steindler D et al.
Source: Self-asserted source
Florian Siebzehnrubl via Europe PubMed Central

Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment

Journal of Neuroscience
2013 | Journal article
EID:

2-s2.0-84884579346

Contributors: Silver, D.J.; Siebzehnrubl, F.A.; Schildts, M.J.; Yachnis, A.T.; Smith, G.M.; Smith, A.A.; Scheffler, B.; Reynolds, B.A.; Silver, J.; Steindler, D.A.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Isolating and culturing of precursor cells from the adult human brain

Methods in Molecular Biology
2013 | Book
EID:

2-s2.0-84934437046

Contributors: Siebzehnrubl, F.A.; Steindler, D.A.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

EMBO Molecular Medicine
2013 | Journal article
EID:

2-s2.0-84881540768

Contributors: Siebzehnrubl, F.A.; Silver, D.J.; Tugertimur, B.; Deleyrolle, L.P.; Siebzehnrubl, D.; Sarkisian, M.R.; Devers, K.G.; Yachnis, A.T.; Kupper, M.D.; Neal, D. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains

Brain Research
2012 | Journal article
EID:

2-s2.0-84862015595

Contributors: Wang, S.; Okun, M.S.; Suslov, O.; Zheng, T.; McFarland, N.R.; Vedam-Mai, V.; Foote, K.D.; Roper, S.N.; Yachnis, A.T.; Siebzehnrubl, F.A. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Evidence for label-retaining tumour-initiating cells in human glioblastoma

Brain
2011 | Journal article
EID:

2-s2.0-79957472391

Contributors: Deleyrolle, L.P.; Harding, A.; Cato, K.; Siebzehnrubl, F.A.; Rahman, M.; Azari, H.; Olson, S.; Gabrielli, B.; Osborne, G.; Vescovi, A. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Identity, Fate and Potential of Cells Grown as Neurospheres: Species Matters

Stem Cell Reviews and Reports
2011 | Journal article
EID:

2-s2.0-82355190811

Contributors: Steffenhagen, C.; Kraus, S.; Dechant, F.-X.; Kandasamy, M.; Lehner, B.; Poehler, A.-M.; Furtner, T.; Siebzehnrubl, F.A.; Couillard-Despres, S.; Strauss, O. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Isolation and characterization of adult neural stem cells.

Methods in molecular biology (Clifton, N.J.)
2011 | Journal article
EID:

2-s2.0-80052630478

Contributors: Siebzehnrubl, F.A.; Vedam-Mai, V.; Azari, H.; Reynolds, B.A.; Deleyrolle, L.P.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

The origins of glioma: E Pluribus Unum?

GLIA
2011 | Journal article
EID:

2-s2.0-79957922064

Contributors: Siebzehnrubl, F.A.; Reynolds, B.A.; Vescovi, A.; Steindler, D.A.; Deleyrolle, L.P.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans

Brain
2010 | Journal article
EID:

2-s2.0-78049467264

Contributors: Coras, R.; Siebzehnrubl, F.A.; Pauli, E.; Huttner, H.B.; Njunting, M.; Kobow, K.; Villmann, C.; Hahnen, E.; Neuhuber, W.; Weigel, D. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Evidence for a progenitor cell population in the human pituitary

Clinical Neuropathology
2009 | Journal article
EID:

2-s2.0-69249095844

Contributors: Weiss, S.; Siebzehnrübl, F.A.; Kreutzer, J.; Blümcke, I.; Buslei, R.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Evidence for a progenitor cell population in the human pituitary.

2009 | Journal article
Contributors: Weiss S; Siebzehnrübl FA; Kreutzer J; Blümcke I; Buslei R
Source: Self-asserted source
Florian Siebzehnrubl via Europe PubMed Central

Mesenchymal stem cells promote Oligodendroglial differentiation in Hippocampal Slice cultures

Cellular Physiology and Biochemistry
2009 | Journal article
EID:

2-s2.0-68349152717

Contributors: Rivera, F.J.; Siebzehnrubl, F.A.; Kandasamy, M.; Couillard-Despres, S.; Caioni, M.; Poehler, A.-M.; Berninger, B.; Sandner, B.; Bogdahn, U.; Goetz, M. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells

Brain Pathology
2009 | Journal article
EID:

2-s2.0-66949152828

Contributors: Siebzehnrubl, F.A.; Jeske, I.; Müller, D.; Buslei, R.; Coras, R.; Hahnen, E.; Huttner, H.B.; Corbeil, D.; Kaesbauer, J.; Appl, T. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Neurogenesis in the human hippocampus and its relevance to temporal lobe epilepsies

Epilepsia
2008 | Journal article
EID:

2-s2.0-44649103527

Contributors: Siebzehnrubl, F.A.; Blumcke, I.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease

Stem Cells
2008 | Journal article
EID:

2-s2.0-43049120703

Contributors: Huttner, H.B.; Janich, P.; Köhrmann, M.; Jászai, J.; Siebzehnrubl, F.; Blümcke, I.; Suttorp, M.; Gahr, M.; Kuhnt, D.; Nimsky, C. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells

Experimental Brain Research
2007 | Journal article
EID:

2-s2.0-33846632355

Contributors: Siebzehnrubl, F.A.; Buslei, R.; Eyupoglu, I.Y.; Seufert, S.; Hahnen, E.; Blumcke, I.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Nuclear β-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas

Acta Neuropathologica
2007 | Journal article
EID:

2-s2.0-34247635028

Contributors: Buslei, R.; Hölsken, A.; Hofmann, B.; Kreutzer, J.; Siebzehnrubl, F.; Hans, V.; Oppel, F.; Buchfelder, M.; Fahlbusch, R.; Blüumcke, I.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

The peroxisome proliferator-activated receptor-γ agonist troglitazone inhibits transforming growth factor-β-mediated glioma cell migration and brain invasion

Molecular Cancer Therapeutics
2007 | Journal article
EID:

2-s2.0-34250758162

Contributors: Coras, R.; Hölsken, A.; Seufert, S.; Hauke, J.; Eyüpoglu, I.Y.; Reichel, M.; Tränkle, C.; Siebzehnrübl, F.A.; Buslei, R.; Blümcke, I. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases.

Acta neuropathologica
2006 | Journal article
EID:

2-s2.0-37349022318

Contributors: Hölsken, A.; Eyüpoglu, I.Y.; Lueders, M.; Tränkle, C.; Dieckmann, D.; Buslei, R.; Hahnen, E.; Blümcke, I.; Siebzehnrübl, F.A.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275

Molecular Cancer Therapeutics
2006 | Journal article
EID:

2-s2.0-33745073751

Contributors: Eyüpoglu, I.Y.; Hahnen, E.; Tränkle, C.; Savaskan, N.E.; Siebzehnrübl, F.A.; Buslei, R.; Lemke, D.; Wick, W.; Fahlbusch, R.; Blümcke, I.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy

Journal of Neurochemistry
2006 | Journal article
EID:

2-s2.0-33745079980

Contributors: Hahnen, E.; Eyüpoglu, I.Y.; Brichta, L.; Haastert, K.; Tränkle, C.; Siebzehnrübl, F.A.; Riessland, M.; Hölker, I.; Claus, P.; Romstöck, J. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas.

2006-03 | Journal article
Contributors: Buslei R; Kreutzer J; Hofmann B; Schmidt V; Siebzehnrübl F; Hahnen E; Eyupoglu IY; Fahlbusch R; Blümcke I
Source: Self-asserted source
Florian Siebzehnrubl via Europe PubMed Central

Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region

Acta Neuropathologica
2005 | Journal article
EID:

2-s2.0-22144442760

Contributors: Buslei, R.; Nolde, M.; Hofmann, B.; Meissner, S.; Eyupoglu, I.Y.; Siebzehnrübl, F.; Hahnen, E.; Kreutzer, J.; Fahlbusch, R.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model: Technical note

Journal of Neurosurgery
2005 | Journal article
EID:

2-s2.0-18744412664

Contributors: Eyüpoglu, I.Y.; Hahnen, E.; Heckel, A.; Siebzehnrübl, F.A.; Buslei, R.; Fahlbusch, R.; Blümcke, I.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo

Journal of Neurochemistry
2005 | Journal article
EID:

2-s2.0-21044449385

Contributors: Eyüpoglu, I.Y.; Hahnen, E.; Buslei, R.; Siebzehnrübl, F.A.; Savaskan, N.E.; Lüders, M.; Tränkle, C.; Wick, W.; Weller, M.; Fahlbusch, R. et al.
Source: Self-asserted source
Florian Siebzehnrubl via Scopus - Elsevier

Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy.

2003-10 | Journal article
Contributors: Brichta L; Hofmann Y; Hahnen E; Siebzehnrubl FA; Raschke H; Blumcke I; Eyupoglu IY; Wirth B
Source: Self-asserted source
Florian Siebzehnrubl via Europe PubMed Central

Peer review (9 reviews for 9 publications/grants)

Review activity for Acta neuropathologica communications. (1)
Review activity for Advanced science. (1)
Review activity for Cancer gene therapy. (1)
Review activity for Cell death and differentiation. (1)
Review activity for Cell death and disease. (1)
Review activity for Cell death discovery. (1)
Review activity for Cellular & Molecular Biology Letters. (1)
Review activity for eLife (1)
Review activity for Oncogene. (1)