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Cornell University: Ithaca, NY, US

2014-07-01 to present | Assistant Professor (Biological Statistics and Computational Biology)
Employment
Source: Self-asserted source
Philipp Messer

Works (50 of 77)

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Page 1 of 2

Gaussian Process Emulation for Modeling Dengue Outbreak Dynamics

2024-11-29 | Preprint
DOI: 10.1101/2024.11.28.24318136
Contributors: Anna M. Langmüller; Kiran A. Chandrasekher; Benjamin C. Haller; Samuel E. Champer; Courtney C. Murdock; Philipp W. Messer
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Crossref

Signatures of selective sweeps in continuous-space populations

2024-07-26 | Preprint
DOI: 10.1101/2024.07.26.605365
Contributors: Meera Chotai; Xinzhu Wei; Philipp W. Messer
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Population genetics meets ecology: a guide to individual-based simulations in continuous landscapes

2024-07-24 | Preprint
DOI: 10.1101/2024.07.24.604988
Contributors: Elizabeth T. Chevy; Jiseon Min; Victoria Caudill; Samuel E. Champer; Benjamin C. Haller; Clara T. Rehmann; Chris C. R. Smith; Silas Tittes; Philipp W. Messer; Andrew D. Kern et al.
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Germline Cas9 promoters with improved performance for homing gene drive

Nature Communications
2024-05-29 | Journal article
DOI: 10.1038/s41467-024-48874-1
Contributors: Jie Du; Weizhe Chen; Xihua Jia; Xuejiao Xu; Emily Yang; Ruizhi Zhou; Yuqi Zhang; Matt Metzloff; Philipp W. Messer; Jackson Champer
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Incorporating ecology into gene drive modelling

Ecology Letters
2023-09 | Journal article
DOI: 10.1111/ele.14194
Contributors: Jaehee Kim; Keith D. Harris; Isabel K. Kim; Shahar Shemesh; Philipp W. Messer; Gili Greenbaum
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Catching a wave: on the suitability of traveling-wave solutions in epidemiological modeling

2023-06-26 | Preprint
DOI: 10.1101/2023.06.23.546298
Contributors: Anna M. Langmüller; Joachim Hermisson; Courtney C. Murdock; Philipp W. Messer
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A framework for identifying fertility gene targets for mammalian pest control

2023-06-01 | Preprint
DOI: 10.1101/2023.05.30.542751
Contributors: Anna C Clark; Alana Alexander; Rey Edison; Kevin Esvelt; Sebastian Kamau; Ludovic Dutoit; Jackson Champer; Samuel E Champer; Philipp W Messer; Neil J Gemmell
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Crossref

Deep cis-regulatory homology of the butterfly wing pattern ground plan

Science
2022-10-21 | Journal article
DOI: 10.1126/science.abi9407
Contributors: Anyi Mazo-Vargas; Anna M. Langmüller; Alexis Wilder; Karin R. L. van der Burg; James J. Lewis; Philipp W. Messer; Linlin Zhang; Arnaud Martin; Robert D. Reed
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Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure

eLife
2022-10-14 | Journal article
DOI: 10.7554/eLife.79121
Contributors: Samuel E Champer; Isabel K Kim; Andrew G Clark; Philipp W Messer; Jackson Champer
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Crossref

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

G3 Genes|Genomes|Genetics
2022-05-30 | Journal article
DOI: 10.1093/g3journal/jkac081
Contributors: Emily Yang; Matthew Metzloff; Anna M Langmüller; Xuejiao Xu; Andrew G Clark; Philipp W Messer; Jackson Champer; M Ramaswami
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Crossref

Predicting the genomic resolution of bulk segregant analysis

G3 Genes|Genomes|Genetics
2022-03-04 | Journal article
DOI: 10.1093/g3journal/jkac012
Contributors: Runxi Shen; Philipp W Messer; A E Lipka
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A model of functionally buffered deleterious mutations can lead to signatures of positive selection

2022-02-16 | Preprint
DOI: 10.1101/2022.02.14.480440
Contributors: Runxi Shen; Miwa Wenzel; Philipp W Messer; Charles F. Aquadro
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Crossref

Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations

2021-05-14 | Other
DOI: 10.1101/2021.05.13.444039
Contributors: Anna M. Langmüller; Jackson Champer; Sandra Lapinska; Lin Xie; Matthew Metzloff; Jingxian Liu; Yineng Xu; Andrew G. Clark; Philipp W. Messer
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Crossref

Design and analysis of CRISPR‐based underdominance toxin‐antidote gene drives

Evolutionary Applications
2021-04 | Journal article
DOI: 10.1111/eva.13180
Contributors: Jackson Champer; Samuel E. Champer; Isabel K. Kim; Andrew G. Clark; Philipp W. Messer
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Crossref

Predicting the Genomic Resolution of Bulk Segregant Analysis

2021-04-17 | Preprint
DOI: 10.1101/2021.04.16.440220
Contributors: Runxi Shen; Philipp W. Messer
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Detection of hard and soft selective sweeps from Drosophila melanogaster population genomic data

PLOS Genetics
2021-02-26 | Journal article
DOI: 10.1371/journal.pgen.1009373
Contributors: Nandita R. Garud; Michael W. Nachman; Philipp W. Messer; Dmitri A. Petrov
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Modeling CRISPR gene drives for suppression of invasive rodents

2020-11-06 | Preprint
DOI: 10.1101/2020.11.05.369942
Contributors: Samuel E. Champer; Nathan Oakes; Ronin Sharma; Pablo García-Díaz; Jackson Champer; Philipp W. Messer
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The Effects of Quantitative Trait Architecture on Detection Power in Short-Term Artificial Selection Experiments

G3: Genes|Genomes|Genetics
2020-09 | Journal article
DOI: 10.1534/g3.120.401287
Contributors: R. Nicolas Lou; Nina O. Therkildsen; Philipp W. Messer
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A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population

Proceedings of the National Academy of Sciences
2020-09-29 | Journal article
DOI: 10.1073/pnas.2004373117
Contributors: Jackson Champer; Emily Yang; Esther Lee; Jingxian Liu; Andrew G. Clark; Philipp W. Messer
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Crossref

Detection of hard and soft selective sweeps fromDrosophila melanogasterpopulation genomic data

2020-06-21 | Preprint
DOI: 10.1101/2020.06.20.163261
Contributors: Nandita Garud; Philipp W. Messer; Dmitri Petrov
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Crossref

Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs

Science Advances
2020-03-06 | Journal article
DOI: 10.1126/sciadv.aaz0525
Contributors: Samuel E. Champer; Suh Yeon Oh; Chen Liu; Zhaoxin Wen; Andrew G. Clark; Philipp W. Messer; Jackson Champer
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Crossref

A toxin-antidote CRISPR gene drive system for regional population modification

Nature Communications
2020-02-27 | Journal article
DOI: 10.1038/s41467-020-14960-3
Contributors: Jackson Champer; Esther Lee; Emily Yang; Chen Liu; Andrew G. Clark; Philipp W. Messer
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Crossref

Design and analysis of CRISPR-based underdominance toxin-antidote gene drives

2019-12-02 | Other
DOI: 10.1101/861435
Contributors: Jackson Champer; Samuel E. Champer; Isabel Kim; Andrew G. Clark; Philipp W. Messer
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Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles

2019-09-14 | Other
DOI: 10.1101/769810
Contributors: Jackson Champer; Isabel Kim; Samuel E. Champer; Andrew G. Clark; Philipp W. Messer
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Crossref

Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs

2019-06-23 | Other
DOI: 10.1101/679902
Contributors: Samuel E. Champer; Suh Yeon Oh; Chen Liu; Zhaoxin Wen; Andrew G. Clark; Philipp W. Messer; Jackson Champer
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Crossref

The Effects of Quantitative Trait Architecture on Detection Power in Artificial Selection Experiments

2019-06-15 | Other
DOI: 10.1101/672683
Contributors: R. Nicolas Lou; Nina O. Therkildsen; Philipp W. Messer
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Crossref

CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect

Genetics
2019-05 | Journal article
DOI: 10.1534/genetics.119.302037
Contributors: Jackson Champer; Zhaoxin Wen; Anisha Luthra; Riona Reeves; Joan Chung; Chen Liu; Yoo Lim Lee; Jingxian Liu; Emily Yang; Philipp W. Messer et al.
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Crossref

Resistance is futile: A CRISPR homing gene drive targeting a haplolethal gene

2019-05-27 | Other
DOI: 10.1101/651737
Contributors: Jackson Champer; Emily Yang; Yoo Lim Lee; Jingxian Liu; Andrew G. Clark; Philipp W. Messer
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Crossref

A toxin-antidote CRISPR gene drive system for regional population modification

2019-05-05 | Other
DOI: 10.1101/628354
Contributors: Jackson Champer; Yoo Lim Lee; Emily Yang; Chen Liu; Andrew G. Clark; Philipp W. Messer
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Crossref

Performance analysis of novel toxin-antidote CRISPR gene drive systems

2019-05-05 | Other
DOI: 10.1101/628362
Contributors: Jackson Champer; Isabel Kim; Samuel E. Champer; Andrew G. Clark; Philipp W. Messer
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Evolutionary Modeling in SLiM 3 for Beginners

Molecular Biology and Evolution
2019-05-01 | Journal article
DOI: 10.1093/molbev/msy237
Part of ISSN: 0737-4038
Part of ISSN: 1537-1719
Source: Self-asserted source
Philipp Messer

Maximum Likelihood Estimation of Fitness Components in Experimental Evolution

Genetics
2019-03 | Journal article
DOI: 10.1534/genetics.118.301893
Part of ISSN: 0016-6731
Part of ISSN: 1943-2631
Source: Self-asserted source
Philipp Messer

Tree‐sequence recording in SLiM opens new horizons for forward‐time simulation of whole genomes

Molecular Ecology Resources
2019-03 | Journal article
DOI: 10.1111/1755-0998.12968
Contributors: Benjamin C. Haller; Jared Galloway; Jerome Kelleher; Philipp W. Messer; Peter L. Ralph
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SLiM 3: Forward Genetic Simulations Beyond the Wright–Fisher Model

Molecular Biology and Evolution
2019-03-01 | Journal article
DOI: 10.1093/molbev/msy228
Part of ISSN: 0737-4038
Part of ISSN: 1537-1719
Source: Self-asserted source
Philipp Messer

Molecular safeguarding of CRISPR gene drive experiments

eLife
2019-01-22 | Journal article
DOI: 10.7554/eLife.41439
Contributors: Jackson Champer; Joan Chung; Yoo Lim Lee; Chen Liu; Emily Yang; Zhaoxin Wen; Andrew G Clark; Philipp W Messer
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Narrow thermal tolerance and low dispersal drive higher speciation in tropical mountains

Proceedings of the National Academy of Sciences
2018-12-04 | Journal article
DOI: 10.1073/pnas.1809326115
Contributors: Nicholas R. Polato; Brian A. Gill; Alisha A. Shah; Miranda M. Gray; Kayce L. Casner; Antoine Barthelet; Philipp W. Messer; Mark P. Simmons; Juan M. Guayasamin; Andrea C. Encalada et al.
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Signatures of Insecticide Selection in the Genome of Drosophila melanogaster

G3: Genes|Genomes|Genetics
2018-11 | Journal article
DOI: 10.1534/g3.118.200537
Part of ISSN: 2160-1836
Source: Self-asserted source
Philipp Messer

Population dynamics of underdominance gene drive systems in continuous space

2018-10-22 | Other
DOI: 10.1101/449355
Contributors: Jackson Champer; Joanna Zhao; Joanna Zhao; Samuel E. Champer; Jingxian Liu; Philipp W. Messer
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Crossref

Reducing resistance allele formation in CRISPR gene drive

Proceedings of the National Academy of Sciences
2018-05-22 | Journal article
DOI: 10.1073/pnas.1720354115
Contributors: Jackson Champer; Jingxian Liu; Suh Yeon Oh; Riona Reeves; Anisha Luthra; Nathan Oakes; Andrew G. Clark; Philipp W. Messer
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Crossref

The role of the vaginal microbiome in gynaecological cancer

BJOG: An International Journal of Obstetrics & Gynaecology
2018-02 | Journal article
DOI: 10.1111/1471-0528.14631
Part of ISSN: 1470-0328
Source: Self-asserted source
Philipp Messer

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

PLOS Genetics
2017-07-20 | Journal article
DOI: 10.1371/journal.pgen.1006796
Contributors: Jackson Champer; Harmit S. Malik; Riona Reeves; Suh Yeon Oh; Chen Liu; Jingxian Liu; Andrew G. Clark; Philipp W. Messer
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Crossref

Reducing resistance allele formation in CRISPR gene drives

2017-06-14 | Preprint
DOI: 10.1101/150276
Contributors: Jackson Champer; Jingxian Liu; Suh Yeon Oh; Riona Reeves; Anisha Luthra; Nathan Oakes; Andrew G. Clark; Philipp W. Messer
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Crossref

asymptoticMK: A Web-Based Tool for the Asymptotic McDonald–Kreitman Test

G3: Genes|Genomes|Genetics
2017-05 | Journal article
DOI: 10.1534/g3.117.039693
Contributors: Benjamin C. Haller; Philipp W. Messer
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Crossref

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

Genetics
2017-02 | Journal article
DOI: 10.1534/genetics.116.197285
Contributors: Robert L. Unckless; Andrew G. Clark; Philipp W. Messer
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Crossref

SLiM 2: Flexible, Interactive Forward Genetic Simulations

Molecular Biology and Evolution
2017-01 | Journal article
DOI: 10.1093/molbev/msw211
Part of ISSN: 0737-4038
Part of ISSN: 1537-1719
Source: Self-asserted source
Philipp Messer

asymptoticMK: A web-based tool for the asymptotic McDonald–Kreitman test

2017-01-20 | Preprint
DOI: 10.1101/101808
Contributors: Benjamin C. Haller; Philipp W. Messer
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Crossref

Neutral Models of Genetic Drift and Mutation

Encyclopedia of Evolutionary Biology
2016 | Book chapter
DOI: 10.1016/b978-0-12-800049-6.00031-7
Part of ISBN: 9780128004265
Source: Self-asserted source
Philipp Messer

Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans

Genome Biology
2016-12 | Journal article
DOI: 10.1186/s13059-016-1098-6
Part of ISSN: 1474-760X
Source: Self-asserted source
Philipp Messer

Plumage Genes and Little Else Distinguish the Genomes of Hybridizing Warblers

Current Biology
2016-09 | Journal article
DOI: 10.1016/j.cub.2016.06.034
Part of ISSN: 0960-9822
Source: Self-asserted source
Philipp Messer

Can Population Genetics Adapt to Rapid Evolution?

Trends in Genetics
2016-07 | Journal article
DOI: 10.1016/j.tig.2016.04.005
Part of ISSN: 0168-9525
Source: Self-asserted source
Philipp Messer
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