Personal information

Other IDs

Loop profile: 30708

Keywords

telomere, yeast, DNA damage, pef1, cdk5

Countries

United States

Activities

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Employment (2)

Cleveland Clinic Foundation: OH, OH, US

1993-10-11 to present | Staff (Immunology)
Employment
Source: Self-asserted source
Kurt Runge

Fred Hutchinson Cancer Research Center: Seattle, WA, US

1980-02-27 to 1993-10-10 | Postdoctoral Fellow (Genetics)
Employment
Source: Self-asserted source
Kurt Runge

Education and qualifications (2)

Massachusetts Institute of Technology: Cambridge, MA, US

1980-09-01 to 1985-02-27 | Ph.D. (Biology)
Education
Source: Self-asserted source
Kurt Runge

California Institute of Technology: Pasadena, California, US

1977-09-15 to 1980-06-14 | B.S. (Biology and Chemistry)
Education
Source: Self-asserted source
Kurt Runge

Funding (8)

Impact of gamma-glutamyl carboxylase processivity on vitamin K-dependent protein modification and function in human health and disease

2021-08-01 to 2025-05-31 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.9845736
GRANT_NUMBER: R01HL152678
Source: Self-asserted source
Kurt Runge via DimensionsWizard

Mechanisms controlling the efficiency of hemostatic vitamin K-dependent protein activation

2021-04-01 to 2025-03-31 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.9644231
GRANT_NUMBER: R01HL158007
Source: Self-asserted source
Kurt Runge via DimensionsWizard

The Telomere Anti-Checkpoint Activity

2019-08-01 to 2023-07-31 | Grant
Directorate for Biological Sciences (Alexandria, US)
URL: https://app.dimensions.ai/details/grant/grant.8523212
GRANT_NUMBER: 1908875
Source: Self-asserted source
Kurt Runge via DimensionsWizard

Regulation of Lifespan

2016-05 to 2021-04 | Grant
National Institute on Aging (MD, MD, US)
GRANT_NUMBER:

R01AG051601
Source: Self-asserted source
Kurt Runge

Epigenetic Control and the Checkpoint-Exempt Status of Telomeres

2015-08-01 to 2018-07-31 | Grant
National Science Foundation - Directorate for Biological Sciences (Arlington, US)
URL: https://grants.uberresearch.com/100000076/1516220/Epigenetic-Control-and-the-Checkpoint-Exempt-Status-of-Telomeres
GRANT_NUMBER: 1516220
Source: Self-asserted source
Kurt Runge via DimensionsWizard

Control of Yeast Life Span

2001-09-30 to 2016-01-31 | Grant
National Institute on Aging (Bethesda, US)
URL: https://grants.uberresearch.com/100000049/R01AG019960/Control-of-Yeast-Life-Span
GRANT_NUMBER: 3R01AG019960-10S1
Source: Self-asserted source
Kurt Runge via DimensionsWizard

Regulation of telomere length

1994-05-01 to 2013-08-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://grants.uberresearch.com/100000057/R01GM050752/Regulation-of-telomere-length
GRANT_NUMBER: 5R01GM050752-15
Source: Self-asserted source
Kurt Runge via DimensionsWizard

TELOMERE REPLICATION AND RESOLUTION IN YEAST

1986-02-28 to present | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://grants.uberresearch.com/100000057/F32GM010472/TELOMERE-REPLICATION-AND-RESOLUTION-IN-YEAST
GRANT_NUMBER: 5F32GM010472-03
Source: Self-asserted source
Kurt Runge via DimensionsWizard

Works (50 of 54)

Items per page:
Page 1 of 2

Cellular and biochemical approaches to define GGCX carboxylation of vitamin K-dependent proteins

2024 | Book chapter
DOI: 10.1016/bs.mie.2024.10.023
Contributors: Kathleen L. Berkner; Kevin W. Hallgren; Mark A. Rishavy; Kurt W. Runge
Source: check_circle
Crossref

Ccq1 restrains Mre11-mediated degradation of telomere-repeat capped ends.

2022-11-03 | Preprint
DOI: 10.21203/rs.3.rs-1456395/v2
Contributors: Julien Audry; Kurt Runge
Source: check_circle
Crossref

GGCX mutants that impair hemostasis reveal the importance of processivity and full carboxylation to VKD protein function

Blood
2022-10-13 | Journal article
DOI: 10.1182/blood.2021014275
Contributors: Mark A. Rishavy; Kevin W. Hallgren; Lee A. Wilson; James M. Hiznay; Kurt W. Runge; Kathleen L. Berkner
Source: check_circle
Crossref

Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease

International Journal of Molecular Sciences
2022-05-20 | Journal article
DOI: 10.3390/ijms23105759
Contributors: Kathleen L. Berkner; Kurt W. Runge
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Ccq1 restrains Mre11-mediated degradation of short telomeres

2022-03-24 | Preprint
DOI: 10.21203/rs.3.rs-1456395/v1
Contributors: Julien Audry; Kurt Runge
Source: check_circle
Crossref

Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast

PLOS Genetics
2019-08-27 | Journal article
DOI: 10.1371/journal.pgen.1008335
Contributors: Hiroyuki Irie; Bas van Steensel; Io Yamamoto; Yusuke Tarumoto; Sanki Tashiro; Kurt W. Runge; Fuyuki Ishikawa
Source: check_circle
Crossref

Compound heterozygosity of the gamma-glutamyl carboxylase mutants V255M and S300F causes pseudoxanthoma elasticum-like disease through impaired processivity

2019-06-12 | Other
DOI: 10.1101/668574
Contributors: Mark A. Rishavy; Kevin W. Hallgren; Kurt W. Runge; Kathleen L. Berkner
Source: check_circle
Crossref

The inhibition of checkpoint activation by telomeres does not involve exclusion of dimethylation of histone H4 lysine 20 (H4K20me2)

F1000Research
2018-10-09 | Journal article
DOI: 10.12688/f1000research.15166.2
Contributors: Julien Audry; Jinyu Wang; Jessica R. Eisenstatt; Kathleen L. Berkner; Kurt W. Runge
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The inhibition of checkpoint activation by telomeres does not involve exclusion of dimethylation of histone H4 lysine 20 (H4K20me2)

F1000Research
2018-07-09 | Journal article
DOI: 10.12688/f1000research.15166.1
Contributors: Julien Audry; Jinyu Wang; Jessica R. Eisenstatt; Kathleen L. Berkner; Kurt W. Runge
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase

Blood
2018-06-21 | Journal article
DOI: 10.1182/blood-2017-09-804666
Contributors: Mark A. Rishavy; Kevin W. Hallgren; Lee Wilson; Savita Singh; Kurt W. Runge; Kathleen L. Berkner
Source: check_circle
Crossref

A heterochromatin domain forms gradually at a new telomere and is dynamic at stable telomeres.

Molecular and cellular biology
2018-05 | Journal article
DOI: 10.1128/mcb.00393-17
PMID: 29784772
Contributors: Wang J; Eisenstatt JR; Audry J; Cornelius K; Shaughnessy M; Berkner KL; Runge KW
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Rif1 phosphorylation site analysis in telomere length regulation and the response to damaged telomeres

DNA Repair
2018-05 | Journal article
DOI: 10.1016/j.dnarep.2018.03.001
Contributors: Jinyu Wang; Haitao Zhang; Mohammed Al Shibar; Belinda Willard; Alo Ray; Kurt W. Runge
Source: check_circle
Crossref

A curious new role for MRN in Schizosaccharomyces pombe non-homologous end-joining

Current Genetics
2018-04-10 | Journal article
DOI: 10.1007/s00294-017-0760-1
Contributors: Kurt W. Runge; Yanhui Li
Source: check_circle
Crossref

How Do Telomeres Block Checkpoint Activation?

2018-01-22 | Other
DOI: 10.1101/251389
Contributors: Julien Audry; Jinyu Wang; Jessica R. Eisenstatt; Steven L. Sanders; Kathleen L. Berkner; Kurt W. Runge
Source: check_circle
Crossref

Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe

Genetics
2017-05 | Journal article
DOI: 10.1534/genetics.117.200972
Contributors: Yanhui Li; Jinyu Wang; Gang Zhou; Michael Lajeunesse; Nga Le; Brittany N. Stawicki; Yalitza Lopez Corcino; Kathleen L. Berkner; Kurt W. Runge
Source: check_circle
Crossref

The Evolving Telomeres

Frontiers Research Topics
2016 | Book
DOI: 10.3389/978-2-88919-881-8
Contributors: Arthur J. Lustig; Kurt Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

2016-08 | Journal article
DOI: 10.1091/mbc.e16-03-0156
PMID: 27385337
PMC: PMC4985255
Contributors: Liu Y; Lee IJ; Sun M; Lower CA; Runge KW; Ma J; Wu JQ
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Editorial: The Evolving Telomeres

Front. Genet.
2016-04-06 | Journal article
DOI: 10.3389/fgene.2016.00050
Contributors: Kurt W. Runge; Arthur J. Lustig
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation.

2013-11 | Journal article
DOI: 10.1074/jbc.m113.497297
PMID: 23918929
PMC: PMC3814752
Contributors: Rishavy MA; Hallgren KW; Wilson LA; Usubalieva A; Runge KW; Berkner KL
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Zinc finger protein Loz1 is required for zinc-responsive regulation of gene expression in fission yeast.

2013-09 | Journal article
DOI: 10.1073/pnas.1300853110
PMID: 24003116
PMC: PMC3780850
Contributors: Corkins ME; May M; Ehrensberger KM; Hu YM; Liu YH; Bloor SD; Jenkins B; Runge KW; Bird AJ
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Identification of a Lifespan Extending Mutation in the Schizosaccharomyces pombe Cyclin Gene clg1+ by Direct Selection of Long-Lived Mutants

PLoS ONE
2013-07-09 | Journal article
DOI: 10.1371/journal.pone.0069084
Contributors: Bo-Ruei Chen; Yanhui Li; Jessica R. Eisenstatt; Kurt W. Runge; Simon Whitehall
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Generation and analysis of a barcode-tagged insertion mutant library in the fission yeast Schizosaccharomyces pombe

BMC Genomics
2012 | Journal article
DOI: 10.1186/1471-2164-13-161
Contributors: Bo-Ruei Chen; Devin C Hale; Peter J Ciolek; Kurt W Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

A new method to efficiently induce a site-specific double-strand break in the fission yeast Schizosaccharomyces pombe

Yeast
2012-06-06 | Journal article
DOI: 10.1002/yea.2908
Contributors: Sham Sunder; Nikole T. Greeson-Lott; Kurt W. Runge; Steven L. Sanders
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.

2012-04 | Journal article
DOI: 10.1091/mbc.e11-09-0800
PMID: 22298427
PMC: PMC3315812
Contributors: Ye Y; Lee IJ; Runge KW; Wu JQ
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Mec1p associates with functionally compromised telomeres

Chromosoma
2012-01 | Journal article
DOI: 10.1007/s00412-011-0359-0
Contributors: Ronald E. Hector; Alo Ray; Bo-Ruei Chen; Rebecca Shtofman; Kathleen L. Berkner; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Genetic Approaches to Aging in Budding and Fission Yeasts: New Connections and New Opportunities

Aging Research in Yeast
2011 | Other
DOI: 10.1007/978-94-007-2561-4_13
Contributors: Bo-Ruei Chen; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

A two-step model for senescence triggered by a single critically short telomere

Nat Cell Biol
2010-05 | Journal article
DOI: 10.1038/ncb0510-520b
Contributors: Pauline Abdallah; Pierre Luciano; Kurt W. Runge; Michael Lisby; Vincent Géli; Eric Gilson; M. Teresa Teixeira
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity

Experimental Gerontology
2009-08 | Journal article
DOI: 10.1016/j.exger.2009.04.004
Contributors: Bo-Ruei Chen; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

A two-step model for senescence triggered by a single critically short telomere

Nat Cell Biol
2009-07 | Journal article
DOI: 10.1038/ncb1911
Contributors: Pauline Abdallah; Pierre Luciano; Kurt W. Runge; Michael Lisby; Vincent Géli; Eric Gilson; M. Teresa Teixeira
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Tel1p Preferentially Associates with Short Telomeres to Stimulate Their Elongation

Molecular Cell
2007-09 | Journal article
DOI: 10.1016/j.molcel.2007.08.007
Contributors: Ronald E. Hector; Rebecca L. Shtofman; Alo Ray; Bo-Ruei Chen; Thihan Nyun; Kathleen L. Berkner; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Telomeres and Aging in the Yeast Model System

Handbook of Models for Human Aging
2006 | Other
DOI: 10.1016/b978-012369391-4/50018-7
Contributors: Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Brønsted Analysis Reveals Lys218 as the Carboxylase Active Site Base That Deprotonates Vitamin K Hydroquinone To Initiate Vitamin K-Dependent Protein Carboxylation †

Biochemistry
2006-11 | Journal article
DOI: 10.1021/bi0609523
Contributors: Mark A. Rishavy; Kevin W. Hallgren; Anna V. Yakubenko; Rebecca L. Shtofman; Kurt W. Runge; Kathleen L. Berkner
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

r-VKORC1 Expression in Factor IX BHK Cells Increases the Extent of Factor IX Carboxylation but Is Limited by Saturation of Another Carboxylation Component or by a Shift in the Rate-Limiting Step †

Biochemistry
2006-05 | Journal article
DOI: 10.1021/bi051986y
Contributors: Kevin W. Hallgren; Wen Qian; Anna V. Yakubenko; Kurt W. Runge; Kathleen L. Berkner
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation.

2005-10 | Journal article
DOI: 10.1074/jbc.m504345200
PMID: 16061481
Contributors: Rishavy MA; Hallgren KW; Yakubenko AV; Zuerner RL; Runge KW; Berkner KL
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis.

2004-12 | Journal article
DOI: 10.1111/j.1538-7836.2004.00968.x
PMID: 15613016
Contributors: Berkner KL; Runge KW
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.

2004-09 | Journal article
DOI: 10.1073/pnas.0404989101
PMID: 15365175
PMC: PMC518825
Contributors: Rishavy MA; Pudota BN; Hallgren KW; Qian W; Yakubenko AV; Song JH; Runge KW; Berkner KL
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan

Nat Genet
2003-03 | Journal article
DOI: 10.1038/ng1132
Contributors: Alo Ray; Ronald E. Hector; Nilanjan Roy; Jee-Hyeon Song; Kathleen L. Berkner; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Yeast telomerase appears to frequently copy the entire template in vivo.

2001-06 | Journal article
DOI: 10.1093/nar/29.11.2382
PMID: 11376157
PMC: PMC55706
Contributors: Ray A; Runge KW
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Two paralogs involved in transcriptional silencing that antagonistically control yeast life span

Current Biology
2000-01 | Journal article
DOI: 10.1016/s0960-9822(00)00298-0
Contributors: Nilanjan Roy; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells.

1999-12 | Journal article
DOI: 10.1073/pnas.96.26.15044
PMID: 10611335
PMC: PMC24770
Contributors: Ray A; Runge KW
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Tel2p, a regulator of yeast telomeric length in vivo, binds to single-stranded telomeric DNA in vitro

Chromosoma
1999-09 | Journal article
DOI: 10.1007/s004120050379
Contributors: Rama S. Kota; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids

Chromosoma
1999-07-05 | Journal article
DOI: 10.1007/s004120050364
Contributors: Nilanjan Roy; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

The Yeast Telomere Length Counting Machinery Is Sensitive to Sequences at the Telomere-Nontelomere Junction

Mol. Cell. Biol.
1999-01-01 | Journal article
DOI: 10.1128/mcb.19.1.31
Contributors: Alo Ray; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

The yeast telomere length regulator TEL2 encodes a protein that binds to telomeric DNA.

1998-03 | Journal article
DOI: 10.1093/nar/26.6.1528
PMID: 9490802
PMC: PMC147422
Contributors: Kota RS; Runge KW
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

The C Terminus of the Major Yeast Telomere Binding Protein Rap1p Enhances Telomere Formation

Mol. Cell. Biol.
1998-03-01 | Journal article
DOI: 10.1128/mcb.18.3.1284
Contributors: Alo Ray; Kurt W. Runge
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae.

1996-06 | Journal article
DOI: 10.1128/mcb.16.6.3094
PMID: 8649421
PMC: PMC231304
Contributors: Runge KW; Zakian VA
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

Saccharomyces cerevisiae linear chromosome stability (lcs) mutants increase the loss rate of artificial and natural linear chromosomes

Chromosoma
1993-02 | Journal article
DOI: 10.1007/bf00387735
Contributors: Kurt W. Runge; Virginia A. Zakian
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Effects of excess centromeres and excess telomeres on chromosome loss rates.

1991-06 | Journal article
DOI: 10.1128/mcb.11.6.2919
PMID: 2038311
PMC: PMC360116
Contributors: Runge KW; Wellinger RJ; Zakian VA
Source: Self-asserted source
Kurt Runge via Europe PubMed Central

How does the end begin?

Trends in Genetics
1990 | Journal article
DOI: 10.1016/0168-9525(90)90043-6
Contributors: Virginia A. Zakian; Kurt Runge; Sy-Shi Wang
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search

Properties of the transcriptional enhancer in Saccharomyces cerevisiae telomeres

Nucl Acids Res
1990 | Journal article
DOI: 10.1093/nar/18.7.1783
Contributors: Kurt W. Runge; Virginia A. Zakian
Source: Self-asserted source
Kurt Runge via Crossref Metadata Search
Items per page:
Page 1 of 2

Peer review (2 reviews for 2 publications/grants)

Review activity for Life science alliance. (1)
Review activity for PloS one. (1)
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