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Biography

I obtained my PhD in Neonatal Gastrointestinal Development at the Dunn Nutrition Unit, Cambridge University. I then undertook a number of postdoc research roles with the WHO, Great Almond Street hospital and Cambridge university, investigating the nutritional status of infants. I then undertook postdoctoral work at Newcastle University in the Department of Physiological Sciences, on a number of in vivo and clinical studies looking at the role of mucins in gastrointestinal pathology and disease, and also spent some time at Upsala University in Sweden. I undertook my first lectureship at Bradford University in the Department of Biomedical Sciences and then move to Sheffield Hallam where I have progressed from Lecturer to Senior Lecturer, and then to Principal lecturer over the last 20 years. I have also taken on a number of roles of responsibility, including being the Chair of the Research Ethics Committee for the College of Health and Wellbeing and life Sciences for the last 18 years and have been involved in policy and process development and implication across the College and the wider University. I have been the course leader for five different degree programs, and I am currently the BSc/MSci Biochemistry course leader.
I would describe myself as a highly skilled scientist with expertise in cancer cell biology and tissue engineering, with experience in clinical, in vivo and in vitro work. My current research focuses on (1) Cancer cell biology, therapies, and nutraceuticals, and (2) Tissue engineering and regenerative medicine. I work on the biochemical mechanisms of disease, and I have specific expertise in gastrointestinal dysfunction and disease, including, oesophageal, gastric, colorectal cancer, and leukaemia. I am also very interested in the role of immunomodulators and inflammation in the mechanisms of disease and cancer, be this inflammatory driven bowel disease or degenerative disc disease. My tissue engineering work has focused on the use of hydrogels in the creation of tissue patches that could be used for the investigation of disease processes and regeneration in the gastrointestinal and urinary tract.
My current work focuses on the use of 2D and 3D cell culture models and the use of tissue engineering scaffolds to recapitulate the disease tissue microenvironment and its response to treatments and novel pharmaceutical agents. This work has included the study of the use of bioactive nutraceuticals' such as polyphenols and how they work alone and in combination with standard and novel chemotherapy agents. I am also interested in the use of novel drug delivery systems including the use of gold nanoparticles, dendrimers, and nano-emulsions, which can be used for the delivery of chemotherapy, nutraceuticals, and bioactive compounds within the cancer tumour microenvironment. My research has been funded by university studentships, and funding calls, charities, and commercial grants. This work has led to over 40 publications and seven successful PhD completions, with more publications and PhD completions in the pipeline.
I am very enthusiastic about my research, and I am a great advocate of research informed teaching. My research informs every part of my job, it informs my course design, my teaching, and assessments at all levels, from first year undergraduate essay topics to final year master’s and MSci research projects. I aim to inspire and encourage my students to embrace research to not only transform their lives, but the lives of others, and I encourage them to push the envelope of scientific discovery. I am delighted to say I have graduates and postdocs who have gone on to undertake study and research at the best pharmaceutical industries and universities in the World.

Activities

Employment (4)

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

1998-11-05 to present | Principal Lecturer in Cellular and Molecular Biology (Biosciences and Chemistry )
Employment
Source: Self-asserted source
Nicola Jordan-Mahy

University of Bradford: Bradford, West Yorkshire,, GB

1998-11-05 to 1999-11-05 | Lectuer (Biomedical Sciences )
Employment
Source: Self-asserted source
Nicola Jordan-Mahy

Newcastle University: Newcastle upon Tyne, Tyeside, GB

1995-11 to 1998-11 | BBSRC Postdoctoral Associate (Department of Physiological Sciences)
Employment
Source: Self-asserted source
Nicola Jordan-Mahy

University of Cambridge: Cambridge, Cambridgeshire, GB

1991 to 1995 | MRC PhD Student (The MRC Dunn Nutrition Unit)
Employment
Source: Self-asserted source
Nicola Jordan-Mahy

Education and qualifications (6)

Sheffield Hallam University: Sheffield, GB

2018-05 to present | Senior Fellow of the HEA. (Department of Education)
Education
Source: Self-asserted source
Nicola Jordan-Mahy

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

2016 to present | Fellowship of the Higher Education Academy (Biosciences and Chemistry )
Qualification
Source: Self-asserted source
Nicola Jordan-Mahy

Newcastle University: Newcastle upon Tyne, GB

1998 to present | PgCert in Teaching and Learning (Department of Physiological Sciences)
Education
Source: Self-asserted source
Nicola Jordan-Mahy

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

1998-10 to 1999-10 | PgCert in Person-Centred Counselling (Biosciences and Chemistry )
Education
Source: Self-asserted source
Nicola Jordan-Mahy

University of Cambridge: Cambridge, Cambridgeshire, GB

1990-10-10 to 1995-11-05 | PhD Student (The Dunn Nutrition Unit)
Qualification
Source: Self-asserted source
Nicola Jordan-Mahy

Royal Holloway University of London: Egham, GB

1987-09 to 1990-05 | Physiology & Zoology (Department of Physiological and Zoology )
Education
Source: Self-asserted source
Nicola Jordan-Mahy

Professional activities (7)

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

2021 | Inspirational Student Support 2021. (Biosciences and Chemistry )
Distinction
Source: Self-asserted source
Nicola Jordan-Mahy

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

2020 | Inspiration Academic Advisor 2020 (Biosciences and Chemistry )
Distinction
Source: Self-asserted source
Nicola Jordan-Mahy

Leeds Beckett University: Leeds, West Yorkshire,, GB

2017 to 2020 | External Examiner (Biomedical Sciences )
Invited position
Source: Self-asserted source
Nicola Jordan-Mahy

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

2016 | Vice Chancellors Inspirational Teaching Award in 2016 (Biosciences and Chemistry )
Distinction
Source: Self-asserted source
Nicola Jordan-Mahy

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

2015 | Inspirational Teaching Award in 2015 (Biosciences and Chemistry )
Distinction
Source: Self-asserted source
Nicola Jordan-Mahy

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

2014 | Inspirational Teaching Award in 2014 (Biosciences and Chemistry )
Distinction
Source: Self-asserted source
Nicola Jordan-Mahy

Sheffield Hallam University: Sheffield, South Yorkshire,, GB

2013 | Inspirational Teaching Award in 2013 (Biosciences and Chemistry )
Distinction
Source: Self-asserted source
Nicola Jordan-Mahy

Funding (13)

Synthesis of Polyphenol Coinage Metal Complexes and Study of their Anti-Cancer Potential

2023 to 2024 | Award
Royal Society (London, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Investigating the Intrinsic Role of Programmed Death-Ligand 1 in Human Cancers.

2019-10 to 2023-01 | Grant
Sheffield Hallam University (Sheffield, South Yorkshire,, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Epithelial Regenerative Medicine Research.

2019 to 2023 | Grant
Funded by Pioneer, SCH and SHU (Sheffield, South Yorkshire,, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

The Molecular Mechanisms of Action of Polyphenols and Polyacetylenes in Leukaemia Cell Lines

Source: Self-asserted source
Nicola Jordan-Mahy

Grow MedTech Proof of Feasibility Grant (£30K)

2019 to 2020 | Grant
Grow MedTech (Sheffield, South Yorkshire,, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

UKIP grant investigating the anti-inflammatory action of tart cherry in osteoarthritis

2019 to 2020 | Grant
Sheffield Hallam University (Sheffield, South Yorkshire,, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Tissue Loading Equipment Grant

2019 to 2019 | Grant
Sheffield Hallam University (Sheffield, South Yorkshire,, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Development of novel immunotherapy in the treatment of cancer

2018-06 to 2018-08 | Grant
The Immunological Society funded a summer internship (London, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Corn Seed Funding to Run a Polyphenol Anti-Inflammatory and Bioavailability Study

2018 to 2019 | Grant
Sheffield Hallam University (Sheffield, South Yorkshire,, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Regenerative Gastrointestinal Medicine Research

2017 to 2019 | Grant
Iraqi Cultural Attaché in London (London, IQ)
Source: Self-asserted source
Nicola Jordan-Mahy

Epithelial Regenerative Medicine Research.

2017 to 2018 | Grant
Funded by Pioneer, SCH and SHU. (Sheffield, South Yorkshire,, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

The Anti-Cancer Potential of Polyphenols in the Treatment of Leukaemia

2012 to 2015 | Grant
Saudi Arabian and Libyan Education Ministries (London, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Effect of Pomegranate Extracts on Apoptosis and Cell Cycle in Haematological Malignancies

2010 to 2013 | Grant
Saudi Arabian Education Ministries (London, GB)
Source: Self-asserted source
Nicola Jordan-Mahy

Works (41)

Enhancement of Breast Cancer Chemotherapy and Radiotherapy Responses by Modulation of Ferroptosis

2023 | Dissertation or Thesis | Supervision
Contributors: Nicola Jordan-Mahy; Neil Cross
Source: Self-asserted source
Nicola Jordan-Mahy

Synthesis of Gold (I) Complexes with Bioactive Ligands as Dual-Action Anticancer Agents.

Unwin, B., Cross, N., Jordan-Mahy, N., Johnson A. Synthesis of Gold (I) Complexes Royal Society of Chemistry Conference 2023 Sheffield UK.
2023-12 | Conference poster | Supervision
Contributors: Nicola Jordan-Mahy; Alice Johnson; Neil Cross
Source: Self-asserted source
Nicola Jordan-Mahy

Assessment of ferroptosis inducers and Nrf2 inhibitors as radiosensitisers in 2D and 3D breast cancer cell cultures

2023-12-08 | Preprint | Supervision
Contributors: AA Alzufairi; C Souilhol; Neil Cross; Nicola Jordan-Mahy
Source: Self-asserted source
Nicola Jordan-Mahy

Molecular Mechanisms of Action of Polyphenols and Polyacetylenes in Leukaemia Cell Lines

2023-10 | Dissertation or Thesis | Supervision
Contributors: Nicola Jordan-Mahy; Christine Le Maitre; Hamza Alaswad
Source: Self-asserted source
Nicola Jordan-Mahy

Programmed death-ligand 1 expression in human cancer three-dimensional cell culture models

2022-11-01 | Preprint | Author
Contributors: Katie Hudson; Neil Cross; Nicola Jordan-Mahy; Rebecca Leyland
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines.

Scientific reports
2022-05-25 | Journal article
Contributors: Mahbub AA; Le Maitre CL; Cross NA; Jordan-Mahy N
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Investigating the tumour-intrinsic role of programmed death-ligand 1 in 2D and 3D cell culture models of human breast cancer.

British Society for Immunology Congress, Edinburgh, UK, 2021
2021 | Conference poster | Supervision
Contributors: Nicola Jordan-Mahy; Hudson, K., ; Cross, N., ; Leyland, R.
Source: Self-asserted source
Nicola Jordan-Mahy

Characterization of 3D models of human breast, prostate and colorectal cancer

Cancer Research
2021 | Conference poster | Supervision
Contributors: Nicola Jordan-Mahy; Hudson, K.; Cross, N.,; Leyland, R.
Source: Self-asserted source
Nicola Jordan-Mahy

Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential

International Journal of Molecular Sciences
2021-03-17 | Journal article | Author
Part of ISSN: 1422-0067
Contributors: Hamza A. Alaswad; Amani A. Mahbub; Christine L. Le Maitre; Nicola Jordan-Mahy
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 4)‎

Blockade of Programmed Death-Ligand 1 with Atezolizumab in Human Breast Cancer 3D Spheroid Colonies Induces Changes in Cell Viability.

Tumour Microenvironment, Lisbon, Portugal, 2020
2020 | Conference poster | Supervision
Contributors: Nicola Jordan-Mahy; Leyland, R.; Cross N; Hudson K
Source: Self-asserted source
Nicola Jordan-Mahy

The use of auxetic materials in tissue engineering

Biomaterials Science
2020 | Journal article | Author
Part of ISSN: 2047-4830
Part of ISSN: 2047-4849
Contributors: Paul Mardling; Andrew Alderson; Nicola Jordan-Mahy; Christine Le Maitre
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 3)‎

The Extrinsic and Intrinsic Roles of PD-L1 and Its Receptor PD-1: Implications for Immunotherapy Treatment

Frontiers in Immunology
2020-10-21 | Journal article
Part of ISSN: 1664-3224
Contributors: Katie Hudson; Neil Cross; Nicola Jordan-Mahy; Rebecca Leyland
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Programmed death-ligand 1 expression in human cancer cell lines in two-dimensional and three-dimensional cell culture systems, 2019

BACR: Tumour Microenvironment meeting, Nottingham, UK, 2019
2019 | Conference poster | Supervision
Contributors: Nicola Jordan-Mahy; Katie Hudson; Neil Cross; Rebecca Leyland
Source: Self-asserted source
Nicola Jordan-Mahy

Use of poly-pNIPAM hydrogel as a 3D-scaffold for intestinal crypts and stem cell tissue engineering

Biomaterials Science
2019 | Journal article
Part of ISSN: 2047-4830
Part of ISSN: 2047-4849
Contributors: Rasha H. Dosh; Nicola Jordan-Mahy; Chris Sammon; Christine Le Maitre
Source: Self-asserted source
Nicola Jordan-Mahy

Polyphenols enhance the activity of alkylating agents in leukaemia cell lines

Oncotarget
2019-07-16 | Journal article
Part of ISSN: 1949-2553
Contributors: Amani A. Mahbub; Christine L. Le Maitre; Sarah Haywood-Small; Neil A. Cross; Nicola Jordan-Mahy
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Interleukin 1 is a key driver of inflammatory bowel disease-demonstration in a murine IL-1Ra knockout model

Oncotarget
2019-05-28 | Journal article
Part of ISSN: 1949-2553
Contributors: Rasha H. Dosh; Nicola Jordan-Mahy; Christopher Sammon; Christine Le Maitre
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease

Scientific Reports
2019-02-12 | Journal article
Part of ISSN: 2045-2322
Contributors: Rasha H. Dosh; Nicola Jordan-Mahy; Christopher Sammon; Christine Le Maitre
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Tissue Engineering Laboratory Models of the Small Intestine.

Tissue engineering. Part B, Reviews
2017-12-05 | Journal article
Contributors: Rasha Dosh; Jordan-Mahy N; Chris Sammon; Le Maitre CL
Source: Self-asserted source
Nicola Jordan-Mahy

Use of hydrogel scaffolds to develop an in vitro 3D culture model of human intestinal epithelium.

Acta biomaterialia
2017-08-30 | Journal article
Contributors: Rasha Dosh; Essa A; Jordan-Mahy N; Chris Sammon; Le Maitre CL
Source: Self-asserted source
Nicola Jordan-Mahy

Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines.

Oncotarget
2017-08-24 | Journal article
Contributors: Amani A. Mahbub; Le Maitre C; Haywood-Small S; Neil Cross; Jordan-Mahy N
Source: Self-asserted source
Nicola Jordan-Mahy

Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines.

Cell death & disease
2015-12-31 | Journal article
Contributors: Amani A. Mahbub; Christine Le Maitre; Haywood-Small SL; Neil Cross; Jordan-Mahy N
Source: Self-asserted source
Nicola Jordan-Mahy

Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines.

Cell death discovery
2015-11-23 | Journal article
Contributors: Mahbub AA; Christine Le Maitre; Haywood-Small SL; Neil Cross; Jordan-Mahy N
Source: Self-asserted source
Nicola Jordan-Mahy

Dahlawi, H. (2013). Effect of pomegranate extracts on apoptosis and cell cycle in haematological malignancies. (Doctoral thesis). Supervised by Le Maitre, C., & Jordan-Mahy, N.

2013 | Dissertation or Thesis | Supervision
Contributors: Nicola Jordan-Mahy; Christine Le Maitre; Haytham Dahlawi
Source: Self-asserted source
Nicola Jordan-Mahy

Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.

Anti-cancer agents in medicinal chemistry
2013-12-01 | Journal article
Contributors: Amani A. Mahbub; Christine Le Maitre; Haywood-Small SL; McDougall GJ; Neil Cross; Jordan-Mahy N
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines.

Food science & nutrition
2013-02-20 | Journal article
Contributors: Dahlawi H; Jordan-Mahy N; Clench M; McDougall GJ; Maitre CL
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration.

Annals of the rheumatic diseases
2013-02-09 | Journal article
Contributors: Kate Phillips; Jordan-Mahy N; Martin Nicklin; Christine Le Maitre
Source: Self-asserted source
Nicola Jordan-Mahy

Extracts From Red and White Cabbage Contains Bio-Active Compounds Which Induce Apoptosis in Myeloid and Lymphoid Leukaemia Cell Lines

Journal of Pathology
2012 | Conference poster
Contributors: Nicola Jordan-Mahy; Le Maitre, C; Wilson, A.; Haywood-Small, S; Cross, N.A.
Source: Self-asserted source
Nicola Jordan-Mahy

The Anti-cancerous Potential of Polyphenols in the Treatment of Human Myeloid and Lymphoid Leukaemia.

Journal of Pathology
2012-09 | Conference paper | Supervision
Contributors: Nicola Jordan-Mahy
Source: Self-asserted source
Nicola Jordan-Mahy

Impact of Anthocyanin Chemical Structure Found in Pomegranate Juice on Leukaemia Treatment

Journal of Pathology
2012-09 | Conference paper
Contributors: Nicola Jordan-Mahy
Source: Self-asserted source
Nicola Jordan-Mahy

Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia.

Nutrition and cancer
2011-11-18 | Journal article
Contributors: Dahlawi H; Jordan-Mahy N; Malcolm Clench; Christine Le Maitre
Source: Self-asserted source
Nicola Jordan-Mahy

Effect of different cooking regimes on rhubarb polyphenols

Food Chemistry
2010-03-15 | Journal article
Contributors: Nicola Jordan-Mahy
Source: Self-asserted source
Nicola Jordan-Mahy

Use of mucin-overproducing cell line HT29-MTX to study the interaction between Campylobacter jejuni and commensal micro-organisms at the mucin interface of the gastrointestinal tract.

ZOONOSES AND PUBLIC HEALTH, 54, 102.
2007 | Journal article
Contributors: Nicola Jordan-Mahy
Source: Self-asserted source
Nicola Jordan-Mahy

The bladder does not appear to have a dynamic secreted continuous mucous gel layer.

The Journal of urology
2005-06-01 | Journal article
Contributors: N'Dow J; Jordan N; Robson CN; David Neal; Pearson JP
Source: Self-asserted source
Nicola Jordan-Mahy

Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats.

Gut
2002-10-01 | Journal article
Contributors: Sherwood PV; Wibawa JI; 0000-0001-6180-0042; Jordan N; Jenkins D; David Barrett; Paul Nicholas Shaw; robin spiller
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

The Adherent Gastric Antral and Duodenal Mucus Gel Layer Thins with Advancing Age in Subjects Infected with <i>Helicobacter pylori</i>

Gerontology
2000 | Journal article
Part of ISSN: 0304-324X
Part of ISSN: 1423-0003
Contributors: Julia L. Newton; Nicola Jordan; Jeff Pearson; Gareth V. Williams; Adrian Allen; Oliver F.W. James
Source: Self-asserted source
Nicola Jordan-Mahy

Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised.

Gut
1998-10-01 | Journal article
PMID: 9824571
Contributors: Julia Newton; Jordan N; Oliver L; Strugala V; Pearson J; James OF; Allen A
Source: Self-asserted source
Nicola Jordan-Mahy

A novel method for the visualization of the in situ mucus layer in rat and man.

Clinical science (London, England : 1979)
1998-07-01 | Journal article
PMID: 9662491
Contributors: Jordan N; Julia Newton; Pearson J; Allen A
Source: Self-asserted source
Nicola Jordan-Mahy

Mucus and H. pylori.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
1997-09-01 | Journal article
PMID: 9376612
Contributors: Allen A; Newton J; Oliver L; Jordan N; Strugala V; Pearson JP; Dettmar PW
Source: Self-asserted source
Nicola Jordan-Mahy
grade
Preferred source (of 2)‎

Effects of Helicobacter pylori colonisation on the adherent gastric mucus barrier.

Biochemical Society transactions
1997-05-01 | Journal article
PMID: 9191416
Contributors: Oliver L; Julia Newton; Jordan N; Goddard P; Dettmar P; Pearson JP; Allen A
Source: Self-asserted source
Nicola Jordan-Mahy

Developing models of the small intestine

Dissertation or Thesis
Contributors: Rasha Dosh
Source: Self-asserted source
Nicola Jordan-Mahy

Investigating the Intrinsic Role of Programmed Death-Ligand 1 in Human Cancers.

Dissertation or Thesis
Contributors: ; Katie Victoria Hudson
Source: Self-asserted source
Nicola Jordan-Mahy