Personal information

Activities

Employment (5)

MONASH UNIVERSITY: Clayton, AU

Employment
Source: check_circle
Monash University

University of Queensland: Brisbane, Queensland, AU

2021-08-11 to present | Future Fellow / Senior Research Fellow (School of Biomedical Sciences)
Employment
Source: Self-asserted source
Sebastian George Barton Furness

Monash Institute of Pharmaceutical Sciences: Parkville, VIC, AU

2019-01-01 to present | Future Fellow (Drug Discovery Biology)
Employment
Source: Self-asserted source
Sebastian George Barton Furness

Monash Institute of Pharmaceutical Sciences: Parkville, VIC, AU

2007-02 to present | Research Officer (Drug Discovery Biology)
Employment
Source: Self-asserted source
Sebastian George Barton Furness

UBC Biomedical Research Centre: Vancouver, BC, CA

2004-02 to 2007-02 | Post doctoral fellow
Employment
Source: Self-asserted source
Sebastian George Barton Furness

Education and qualifications (3)

University of Adelaide: Adelaide, SA, AU

1999-01 to 2004-02 | PhD (Biochemistry)
Education
Source: Self-asserted source
Sebastian George Barton Furness

University of Adelaide: Adelaide, SA, AU

1998-02 to 1998-11 | Honours (Biochemistry)
Education
Source: Self-asserted source
Sebastian George Barton Furness

University of Adelaide: Adelaide, SA, AU

1990-02 to 1997-11 | BSc (Biochemistry)
Education
Source: Self-asserted source
Sebastian George Barton Furness

Professional activities (7)

Frontiers in Endocrinology: Lausanne , CH

2019-10-03 to present | Associate Editor
Invited position
Source: Self-asserted source
Sebastian George Barton Furness

Australian Society for Medical Research: Sydney, NSW, AU

2019-10-02 to present
Membership
Source: Self-asserted source
Sebastian George Barton Furness

Endocrine Society of Australia: Sydney, NSW, AU

2018-10-24 to present
Membership
Source: Self-asserted source
Sebastian George Barton Furness

Biochemical Pharmacology: Kansas City, US

2018-10-18 to present | Editorial Advisory Board Member
Invited position
Source: Self-asserted source
Sebastian George Barton Furness

Faculty Opinions: London, GB

2012-02-13 to present | Faculty Member
Invited position
Source: check_circle
Faculty Opinions

Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists: Hamilton Central, QLD, AU

2007-05-10 to present
Membership
Source: Self-asserted source
Sebastian George Barton Furness

Australian Society for Biochemistry and Molecular Biology: SA, SA, AU

1999-02-11 to present
Membership
Source: Self-asserted source
Sebastian George Barton Furness

Funding (3)

The molecular basis for efficacy at G protein coupled receptors

2018-01-01 to 2021-12-31 | Grant
Australian Research Council (Canberra, AU)
GRANT_NUMBER: FT180100543
Source: Self-asserted source
Sebastian George Barton Furness via DimensionsWizard

A structural understanding of class B G protein-coupled receptor function

2017-01-01 to 2021-12-31 | Grant
National Health and Medical Research Council (Canberra, AU)
GRANT_NUMBER: 1120919
Source: Self-asserted source
Sebastian George Barton Furness via DimensionsWizard

Understanding the structural basis for Family B G protein-coupled receptor function

2014-01 to 2016-12 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

1059015

Source: Self-asserted source
Sebastian George Barton Furness

Works (50 of 74)

Items per page:
Page 1 of 2

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake

Pharmacology Research & Perspectives
2024-02 | Journal article
Contributors: Seungmin Ham; Saori Mukaida; Masaaki Sato; Peter Keov; Tore Bengtsson; Sebastian Furness; Nicholas D. Holliday; Bronwyn A. Evans; Roger J. Summers; Dana S. Hutchinson
Source: check_circle
Crossref

Cardiac human bitter taste receptors contain naturally occurring variants that alter function

Biochemical Pharmacology
2024-01 | Journal article
Part of ISSN: 0006-2952
Contributors: Conor J. Bloxham; Katina D. Hulme; Fabrizio Fierro; Christian Fercher; Cassandra L. Pegg; Shannon L. O'Brien; Simon R. Foster; Kirsty R. Short; Sebastian G.B. Furness; Melissa E. Reichelt et al.
Source: Self-asserted source
Sebastian George Barton Furness

Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre

The Journal of Physiology
2023-12 | Journal article
Contributors: Mitchell T. Ringuet; Ada Koo; Sebastian G. B. Furness; Stuart J. McDougall; John B. Furness
Source: check_circle
Crossref

Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior

BioRxiv
2023-12-18 | Preprint | Author
Contributors: Farhad Dehkhoda; Mitchell Ringuet; Emily Whitfield; Keith Mutunduwe; Cameron Nowell; Desye Misganaw; Zheng Xu; Mohammed Hossain; Linda Fothergill; Stuart McDougall et al.
Source: Self-asserted source
Sebastian George Barton Furness

G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a

Journal of Neuroendocrinology
2022-09 | Journal article
Contributors: Mitchell Ty Ringuet; John Barton Furness; Sebastian George Barton Furness
Source: check_circle
Crossref

Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors

Biochemical Pharmacology
2022-08 | Journal article
Part of ISSN: 0006-2952
Contributors: Noah B.C. Piper; Emily A. Whitfield; Gregory D. Stewart; Xiaomeng Xu; Sebastian G.B. Furness
Source: Self-asserted source
Sebastian George Barton Furness

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Frontiers in Endocrinology
2021-12-07 | Journal article
Part of ISSN: 1664-2392
Contributors: Kaleeckal G. Harikumar; Thomas Coudrat; Aditya J. Desai; Maoqing Dong; Daniela G. Dengler; Sebastian G. B. Furness; Arthur Christopoulos; Denise Wootten; Eduard A. Sergienko; Patrick M. Sexton et al.
Source: Self-asserted source
Sebastian George Barton Furness

AM833 Is a Novel Agonist of Calcitonin Family G Protein–Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists

Journal of Pharmacology and Experimental Therapeutics
2021-06 | Journal article | Author
Part of ISSN: 0022-3565
Part of ISSN: 1521-0103
Contributors: Madeleine M. Fletcher; Peter Keov; Tin T. Truong; Grace Mennen; Caroline A. Hick; Peishen Zhao; Sebastian George Barton Furness; Thomas Kruse; Trine R. Clausen; Denise Wootten et al.
Source: Self-asserted source
Sebastian George Barton Furness
grade
Preferred source (of 2)‎

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

PLOS Biology
2021-06-04 | Journal article
Contributors: Jesse I. Mobbs; Kylie J. Walters; Matthew J. Belousoff; Kaleeckal G. Harikumar; Sarah J. Piper; Xiaomeng Xu; Sebastian G. B. Furness; Hari Venugopal; Arthur Christopoulos; Radostin Danev et al.
Source: check_circle
Crossref

Dopamine and ghrelin receptor co‐expression and interaction in the spinal defecation centers

Neurogastroenterology & Motility
2021-05 | Journal article
Part of ISSN: 1350-1925
Part of ISSN: 1365-2982
Contributors: JB Furness; Ruslan V. Pustovit; Andrew J. Syder; Mitchell T. Ringuet; Eun Ji Yoo; Andrea Fanjul; Jill Wykosky; Linda J. Fothergill; Emily A. Whitfield; Sebastian G. B. Furness
Source: Self-asserted source
Sebastian George Barton Furness

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Biochemical and Biophysical Research Communications
2020-12 | Journal article
Contributors: Mengjie Liu; Emily A. Whitfield; Linda J. Fothergill; John B. Furness; John D. Wade; Sebastian G.B. Furness; Mohammed Akhter Hossain
Source: check_circle
Crossref

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

Molecular Cell
2020-11 | Journal article
Part of ISSN: 1097-2765
Contributors: Xin Zhang; Matthew J. Belousoff; Peishen Zhao; Albert J. Kooistra; Tin T. Truong; Sheng Yu Ang; Christina Rye Underwood; Thomas Egebjerg; Petr Šenel; Gregory D. Stewart et al.
Source: Self-asserted source
Sebastian George Barton Furness

Structure and dynamics of the active Gs-coupled human secretin receptor

Nature Communications
2020-08-18 | Journal article
Contributors: Maoqing Dong; Giuseppe Deganutti; Sarah J. Piper; Yi-Lynn Liang; Maryam Khoshouei; Matthew J. Belousoff; Kaleeckal G. Harikumar; Christopher A. Reynolds; Alisa Glukhova; Sebastian G. B. Furness et al.
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Crossref

Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

ACS Pharmacology & Translational Science
2020-04-10 | Journal article
Contributors: Yi-Lynn Liang; Matthew J. Belousoff; Madeleine M. Fletcher; Xin Zhang; Maryam Khoshouei; Giuseppe Deganutti; Cassandra Koole; Sebastian G. B. Furness; Laurence J. Miller; Debbie L. Hay et al.
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Crossref

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

Therapeutic Advances in Medical Oncology
2020-01 | Journal article
Part of ISSN: 1758-8359
Part of ISSN: 1758-8359
Contributors: Pragya Gupta; Sebastian G. B. Furness; Lucas Bittencourt; David L. Hare; Peter J. Wookey
Source: Self-asserted source
Sebastian George Barton Furness

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

BMC Cancer
2019-12 | Journal article
Contributors: Anna Ostrovskaya; Caroline Hick; Dana S. Hutchinson; Brett W. Stringer; Peter J. Wookey; Denise Wootten; Patrick M. Sexton; Sebastian G. B. Furness
Source: check_circle
Crossref

The nature of efficacy at G protein-coupled receptors

Biochemical Pharmacology
2019-12 | Journal article
Contributors: Peishen Zhao; Sebastian G.B. Furness
Source: check_circle
Crossref

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

Frontiers in Molecular Neuroscience
2019-08-27 | Journal article
Part of ISSN: 1662-5099
Source: Self-asserted source
Sebastian George Barton Furness

Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

ACS Pharmacology & Translational Science
2019-08-09 | Journal article
Contributors: Christopher Draper-Joyce; Sebastian George Barton Furness
Source: check_circle
Crossref

Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

ACS Pharmacology & Translational Science
2019-06-14 | Journal article
Part of ISSN: 2575-9108
Part of ISSN: 2575-9108
Source: Self-asserted source
Sebastian George Barton Furness

The Molecular Control of Calcitonin Receptor Signaling

ACS Pharmacology & Translational Science
2019-02-08 | Journal article
Part of ISSN: 2575-9108
Part of ISSN: 2575-9108
Source: Self-asserted source
Sebastian George Barton Furness

Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

Biochemical Pharmacology
2018-10 | Journal article
Part of ISSN: 0006-2952
Source: Self-asserted source
Sebastian George Barton Furness

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination

ACS Pharmacology & Translational Science
2018-09-14 | Journal article
Part of ISSN: 2575-9108
Part of ISSN: 2575-9108
Source: Self-asserted source
Sebastian George Barton Furness

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Nature
2018-06 | Journal article
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Sebastian George Barton Furness

Faculty of 1000 evaluation for Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.

F1000 - Post-publication peer review of the biomedical literature
2018-06-06 | Dataset
Contributors: Patrick Sexton; Sebastian Furness
Source: Self-asserted source
Sebastian George Barton Furness via Crossref Metadata Search

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Biochemical Pharmacology
2018-04 | Journal article
Part of ISSN: 0006-2952
Source: Self-asserted source
Sebastian George Barton Furness

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Biochemical Pharmacology
2018-02 | Journal article
Part of ISSN: 0006-2952
Contributors: Emma Dal Maso; Rasmus Just; Caroline Hick; Arthur Christopoulos; Patrick M. Sexton; Denise Wootten; Sebastian G.B. Furness
Source: Self-asserted source
Sebastian George Barton Furness via Crossref Metadata Search

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Nature
2018-02 | Journal article
Part of ISSN: 0028-0836
Contributors: Yi-Lynn Liang; Maryam Khoshouei; Alisa Glukhova; Sebastian G. B. Furness; Peishen Zhao; Lachlan Clydesdale; Cassandra Koole; Tin T. Truong; David M. Thal; Saifei Lei et al.
Source: Self-asserted source
Sebastian George Barton Furness via Crossref Metadata Search

Calcitonin ☆

Reference Module in Neuroscience and Biobehavioral Psychology
2017 | Book chapter
Part of ISBN: 9780128093245
Source: Self-asserted source
Sebastian George Barton Furness

Coding GPCR-G protein specificity.

Cell research
2017-10 | Journal article
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Nature
2017-06 | Journal article
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.

Cancer immunology, immunotherapy : CII
2017-05 | Journal article
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

Faculty of 1000 evaluation for Universal allosteric mechanism for Gα activation by GPCRs.

F1000 - Post-publication peer review of the biomedical literature
2017-04 | Dataset
Contributors: Patrick Sexton; Sebastian Furness; Denise Wootten
Source: Self-asserted source
Sebastian George Barton Furness via Crossref Metadata Search

What determines the magnitude of cellular response for activation of G protein-coupled receptors?

2017-01 | Journal article
Contributors: Furness SG; Wootten D; Sexton PM
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death.

2016 | Journal article
Contributors: Furness S; Hare DL; Kourakis A; Turnley AM; Wookey PJ
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor.

2016-10 | Journal article
Contributors: Wootten D; Reynolds CA; Smith KJ; Mobarec JC; Furness SG; Miller LJ; Christopoulos A; Sexton PM
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

2016-10 | Journal article
Contributors: Furness SG; Liang YL; Nowell CJ; Halls ML; Wookey PJ; Dal Maso E; Inoue A; Christopoulos A; Wootten D; Sexton PM
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.

2016-06 | Journal article
Contributors: Wootten D; Reynolds CA; Smith KJ; Mobarec JC; Koole C; Savage EE; Pabreja K; Simms J; Sridhar R; Furness SG et al.
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

2016-03 | Journal article
Contributors: Wootten D; Reynolds CA; Koole C; Smith KJ; Mobarec JC; Simms J; Quon T; Coudrat T; Furness SG; Miller LJ et al.
Source: Self-asserted source
Sebastian George Barton Furness via Europe PubMed Central

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

British Journal of Pharmacology
2015 | Journal article | Author
SOURCE-WORK-ID:

94a3c9a9-53c7-4406-b870-865cc04980e0

EID:

2-s2.0-84919629630

Contributors: Anna Evelyn Cook; Shailesh Natvarbhai Mistry; Karen Joan Gregory; Sebastian George Barton Furness; Patrick Sexton; Peter John Scammells; Arthur Conigrave; Arthur Christopoulos; Katherine Leach
Source: check_circle
Monash University

F1000Prime Recommendation

2015-07-08 | Other | Author
Contributors: Patrick Sexton; Sebastian George Barton Furness
Source: check_circle
F1000

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation

British Journal of Pharmacology
2014 | Journal article | Author
SOURCE-WORK-ID:

d21a14f4-b461-468a-86b9-6bd13f1e70a6

EID:

2-s2.0-84895164679

Contributors: Kavita Pabreja; Muzaida Mohd; Cassandra Renee Koole; Denise Laura Wootten; Sebastian George Barton Furness
Source: check_circle
Monash University

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

PLoS ONE
2014 | Journal article | Author
SOURCE-WORK-ID:

a9f2b943-95b6-4392-b5e1-b07df5358a43

EID:

2-s2.0-84898623294

Contributors: Kim Vietz Andreassen; Sara Toftegaard Hjuler; Sebastian George Barton Furness; Patrick Sexton; Arthur Christopoulos; Olivier Nosjean; Morten Asser Karsdal; Kim Henriksen
Source: check_circle
Monash University

F1000Prime Recommendation

2014-09-03 | Other | Author
Contributors: Patrick Sexton; Denise Wootten; Sebastian George Barton Furness
Source: check_circle
F1000

F1000Prime Recommendation

2014-02-17 | Other | Author
Contributors: Patrick Sexton; Sebastian George Barton Furness
Source: check_circle
F1000

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

BioTechniques
2013 | Journal article | Author
SOURCE-WORK-ID:

5ceca0d4-de0c-4c9d-a9ab-621e7df49540

EID:

2-s2.0-84876494666

Contributors: Emilia Elizabeth Savage; Denise Laura Wootten; Arthur Christopoulos; Patrick Sexton; Sebastian George Barton Furness
Source: check_circle
Monash University

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

Biochemical Society Transactions
2013 | Journal article | Author
SOURCE-WORK-ID:

db4a48a6-1e0c-411f-abc7-1afe81d440c6

EID:

2-s2.0-84873193828

Contributors: Cassandra Renee Koole; Kavita Pabreja; Emilia Elizabeth Savage; Denise Laura Wootten; Sebastian George Barton Furness; Laurence J Miller; Arthur Christopoulos; Patrick Sexton
Source: check_circle
Monash University

F1000Prime Recommendation

2013-06-04 | Other | Author
Contributors: Patrick Sexton; Sebastian George Barton Furness
Source: check_circle
F1000

F1000Prime Recommendation

2013-04-02 | Other | Author
Contributors: Patrick Sexton; Sebastian George Barton Furness; Denise Wootten
Source: check_circle
F1000

Consequences of splice variation on secretin family G protein-coupled receptor function

British Journal of Pharmacology
2012 | Journal article | Author
SOURCE-WORK-ID:

78dfe17e-f5c6-4d29-abca-2c9b00ae90a5

EID:

2-s2.0-84859716892

Contributors: Sebastian George Barton Furness; Denise L Wootten; Arthur Christopoulos; Patrick Sexton
Source: check_circle
Monash University
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Peer review (40 reviews for 7 publications/grants)

Review activity for Amino acids. (1)
Review activity for Biochemical pharmacology. (11)
Review activity for Communications biology. (2)
Review activity for eLife (1)
Review activity for Faculty Opinions (23)
Review activity for Nature communications (1)
Review activity for Trends in pharmacological sciences. (1)