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Activities

Employment (2)

Boston College: Chestnut Hill, MA, US

1990-09-01 to present | Professor (Biology)
Employment
Source: Self-asserted source
Charles Hoffman

Harvard Medical School: Boston, MA, US

1986-09-01 to 1990-08-15 | Postdoctoral Fellow (Genetics)
Employment
Source: Self-asserted source
Charles Hoffman

Education and qualifications (2)

Tufts University - Boston Campus: Boston, MA, US

1980-09-01 to 1986-07-01 | PhD (Molecular Biology and Microbiology)
Education
Source: Self-asserted source
Charles Hoffman

Massachusetts Institute of Technology: Cambridge, MA, US

1976-09-01 to 1980-06-01 | SB (Biology)
Education
Source: Self-asserted source
Charles Hoffman

Professional activities (6)

Scotch Malt Whisky Society of America: New York City, NY, US

Member Ambassador for Boston
Membership
Source: Self-asserted source
Charles Hoffman

Luxuriant Flowing Hair Club for Scientists: Cambridge, MA, US

Membership
Source: Self-asserted source
Charles Hoffman

Genetics Society of America: Bethesda, MD, US

Membership
Source: Self-asserted source
Charles Hoffman

American Society for Microbiology: Washington, DC, US

Membership
Source: Self-asserted source
Charles Hoffman

American Association for the Advancement of Science: DC, DC, US

Membership
Source: Self-asserted source
Charles Hoffman

NCATS/NIH: Rockville, MD, US

2017-11-01 to 2025-04-30 | Visiting Scientist (Assay Development and Screening Technology)
Invited position
Source: Self-asserted source
Charles Hoffman

Funding (8)

Testing the specificity and efficacy of compounds that inhibit cAMP signaling, for the development of potential therapeutics for FD/MAS

2024-02 to 2025-02 | Grant
Orphan Disease Foundation (Philadelphia, PA, US)
Source: Self-asserted source
Charles Hoffman

Pharmacologic Inhibition of PDE11A for Age-Related Memory Disorders

2020-09-15 to 2025-04-30 | Grant
National Institute on Aging (Baltimore, US)
GRANT_NUMBER: R01AG067836
Source: Self-asserted source
Charles Hoffman via DimensionsWizard

Identification and characterization of novel cell-permeable, small molecule adenylyl cyclase inhibitors for future development as drugs to treat FD/MAS

2019-02 to 2020-01 | Grant
Orphan Disease Foundation (Philadelphia PA, US)
GRANT_NUMBER:

MDBR-19-112-FD/MAS

Source: Self-asserted source
Charles Hoffman

Small molecule HTSs for AC and GNAS inhibitors

2018-09 to 2019-09 | Contract
National Institutes of Health (Md., Md., US)
GRANT_NUMBER:

H5106841

Source: Self-asserted source
Charles Hoffman

EAGER: Selective Biodamage with Shaped THz Light Fields

2018-01 to 2019-07 | Grant
National Science Foundation (VA, VA, US)
Part of GRANT_NUMBER:

1748906

Source: Self-asserted source
Charles Hoffman

An in vivo screen for biological and chemical regulators of mammalial PDEs

2007-01-01 to 2009-06-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: R21GM079662
Source: Self-asserted source
Charles Hoffman via DimensionsWizard

Characterization of the S. Pombe cAMP Pathway

1991-07-01 to 2007-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: R01GM046226
Source: Self-asserted source
Charles Hoffman via DimensionsWizard

S POMBE CAMP SIGNAL PATHWAY

1991-07-01 to 1996-06-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: R29GM046226
Source: Self-asserted source
Charles Hoffman via DimensionsWizard

Works (50 of 76)

Items per page:
Page 1 of 2

First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders

Journal of Medicinal Chemistry
2024-10-10 | Journal article
Contributors: Shams ul Mahmood; Jeremy Eberhard; Charles S. Hoffman; Dennis Colussi; John Gordon; Wayne Childers; Elvis Amurrio; Janvi Patel; Michy P. Kelly; David P. Rotella
Source: check_circle
Crossref

Revised fission yeast gene and allele nomenclature guidelines for machine readability

GENETICS
2023-11-01 | Journal article
Contributors: Manuel Lera-Ramírez; Jürg Bähler; Juan Mata; Kim Rutherford; Charles S Hoffman; Sarah Lambert; Snezhana Oliferenko; Sophie G Martin; Kathleen L Gould; Li-Lin Du et al.
Source: check_circle
Crossref

First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline

Journal of Medicinal Chemistry
2023-10-20 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Shams ul Mahmood; Mariana Lozano Gonzalez; Sreedhar Tummalapalli; Jeremy Eberhard; Judy Ly; Charles S. Hoffman; Michy P. Kelly; John Gordon; Dennis Colussi; Wayne Childers et al.
Source: Self-asserted source
Charles Hoffman

Evaluation of Known Human PDE Inhibitors Against Nematode PDE4s

2023-02-24 | Preprint
Contributors: Clianta S Anindya; Charles S Hoffman
Source: check_circle
Crossref

cAMP export by the fission yeast Schizosaccharomyces pombe.

microPublication biology
2021-04-02 | Journal article
Source: Self-asserted source
Charles Hoffman

lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast

Communications Biology
2021-03-05 | Journal article
Contributors: Satoshi Senmatsu; Ryuta Asada; Arisa Oda; Charles S. Hoffman; Kunihiro Ohta; Kouji Hirota
Source: check_circle
Crossref

Towards spectrally selective catastrophic response

Physical Review E
2020-06-18 | Journal article
Contributors: V. R. Gabriele; A. Shvonski; C. S. Hoffman; M. Giersig; A. Herczynski; M. J. Naughton; K. Kempa
Source: check_circle
Crossref

lncRNA transcriptional initiation induces chromatin remodeling within a limited range in the fission yeast fbp1 promoter

2019-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Charles Hoffman

A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening

2019-08 | Journal article
Part of ISSN: 0898-6568
Source: Self-asserted source
Charles Hoffman

Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression.

Molecular and cellular biology
2018-08 | Journal article
Contributors: Umeda M; Tsunekawa C; Senmatsu S; Asada R; Abe T; Ohta K; Hoffman CS; Hirota K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays

Cellular Signalling
2017-12 | Journal article
Contributors: Ana Santos de Medeiros; Arlene R. Wyman; Manal A. Alaamery; Christina Allain; F. Douglas Ivey; Lili Wang; Hai Le; James P. Morken; Alawi Habara; Cuong Le et al.
Source: check_circle
Crossref

Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

Nucleic acids research
2017-09 | Journal article
Contributors: Asada R; Umeda M; Adachi A; Senmatsu S; Abe T; Iwasaki H; Ohta K; Hoffman CS; Hirota K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1.

Genes & genetic systems
2017-06 | Journal article
Contributors: Adachi A; Senmatsu S; Asada R; Abe T; Hoffman CS; Ohta K; Hirota K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes.

2016-09 | Journal article
Contributors: Xu C; Wyman AR; Alaamery MA; Argueta SA; Ivey FD; Meyers JA; Lerner A; Burdo TH; Connolly T; Hoffman CS et al.
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

A Brief History of Schizosaccharomyces pombe Research: A Perspective Over the Past 70 Years.

2016-06 | Journal article
Contributors: Fantes PA; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Local potentiation of stress-responsive genes by upstream noncoding transcription.

2016-06 | Journal article
Contributors: Takemata N; Oda A; Yamada T; Galipon J; Miyoshi T; Suzuki Y; Sugano S; Hoffman CS; Hirota K; Ohta K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Corrigendum. An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.

2016-03 | Journal article
Contributors: Hoffman CS; Wood V; Fantes PA
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

A yeast-based high-throughput screen for modulators of phosphodiesterase activity.

2015 | Journal article
Contributors: de Medeiros AS; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Fission yeast-based high-throughput screens for PKA pathway inhibitors and activators.

2015 | Journal article
Contributors: de Medeiros AS; Kwak G; Vanderhooft J; Rivera S; Gottlieb R; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.

2015-10 | Journal article
Contributors: Hoffman CS; Wood V; Fantes PA
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central
grade
Preferred source (of 2)‎

Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor.

2015-03 | Journal article
Contributors: Asada R; Takemata N; Hoffman CS; Ohta K; Hirota K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.

2014-02 | Journal article
DOI:

10.1128/EC.00277-13

PMID:

24297439

PMC:

PMC3910974

Contributors: Mudge DK; Yang F; Currie BM; Kim JM; Yeda K; Bashyakarla VK; Ivey FD; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition.

2013 | Journal article
DOI:

10.1371/journal.pone.0071279

PMID:

23967182

PMC:

PMC3743849

Contributors: Demirbas D; Wyman AR; Shimizu-Albergine M; Cakici O; Beavo JA; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Use of PKA-mediated phenotypes for genetic and small-molecule screens in Schizosaccharomyces pombe.

2013-12 | Journal article
DOI:

10.1042/BST20130159

PMID:

24256276

Contributors: de Medeiros AS; Magee A; Nelson K; Friedberg L; Trocka K; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

2012-09 | Journal article
DOI:

10.1128/EC.00123-12

PMID:

22771823

PMC:

PMC3445983

Contributors: Tong K; Keller T; Hoffman CS; Annunziato AT
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Use of a ura5+-lys7+ cassette to construct unmarked gene knock-ins in Schizosaccharomyces pombe.

2012-02 | Journal article
DOI:

10.1007/s00294-011-0360-4

PMID:

22198627

Contributors: Mudge DK; Hoffman CA; Lubinski TJ; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.

2012-01 | Journal article
DOI:

10.1016/j.chembiol.2011.12.010

PMID:

22284362

Contributors: Ceyhan O; Birsoy K; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

A fission yeast-based platform for phosphodiesterase inhibitor HTSs and analyses of phosphodiesterase activity.

2011 | Journal article
DOI:

10.1007/978-3-642-17969-3_5

PMID:

21695638

Contributors: Demirbas D; Ceyhan O; Wyman AR; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases.

2011-03 | Journal article
DOI:

10.1016/j.cellsig.2010.11.013

PMID:

21118717

PMC:

PMC3012454

Contributors: Demirbas D; Ceyhan O; Wyman AR; Ivey FD; Allain C; Wang L; Sharuk MN; Francis SH; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

2010-04 | Journal article
DOI:

10.1128/EC.00010-10

PMID:

20139237

PMC:

PMC2863420

Contributors: Ivey FD; Taglia FX; Yang F; Lander MM; Kelly DA; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

New classes of PDE7 inhibitors identified by a fission yeast-based HTS.

2010-04 | Journal article
DOI:

10.1177/1087057110362100

PMID:

20228279

PMC:

PMC2854023

Contributors: Alaamery MA; Wyman AR; Ivey FD; Allain C; Demirbas D; Wang L; Ceyhan O; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

2009-03 | Journal article
DOI:

10.1371/journal.pgen.1000408

PMID:

19266076

PMC:

PMC2646135

Contributors: Roux AE; Leroux A; Alaamery MA; Hoffman CS; Chartrand P; Ferbeyre G; Rokeach LA
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.

2008-11 | Journal article
DOI:

10.1038/nature07348

PMID:

18820678

Contributors: Hirota K; Miyoshi T; Kugou K; Hoffman CS; Shibata T; Ohta K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators.

2008-04 | Journal article
DOI:

10.1016/j.molcel.2008.02.016

PMID:

18406330

PMC:

PMC2423209

Contributors: Leem YE; Ripmaster TL; Kelly FD; Ebina H; Heincelman ME; Zhang K; Grewal SI; Hoffman CS; Levin HL
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

2008-04 | Journal article
DOI:

10.1534/genetics.107.086165

PMID:

18430926

PMC:

PMC2323787

Contributors: Alaamery MA; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases.

2008-01 | Journal article
DOI:

10.1177/1087057107312127

PMID:

18227226

PMC:

PMC2851203

Contributors: Ivey FD; Wang L; Demirbas D; Allain C; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

2007-01 | Journal article
DOI:

10.1074/jbc.M607464200

PMID:

17052979

Contributors: Benson LJ; Phillips JA; Gu Y; Parthun MR; Hoffman CS; Annunziato AT
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Propping up our knowledge of G protein signaling pathways: diverse functions of putative noncanonical Gbeta subunits in fungi.

2007-01 | Journal article
DOI:

10.1126/stke.3702007pe3

PMID:

17244888

Contributors: Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling.

2006-12 | Journal article
DOI:

10.1128/EC.00272-06

PMID:

17028240

PMC:

PMC1694817

Contributors: Hirota K; Hoffman CS; Ohta K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Cloning the Schizosaccharomyces pombe lys2+ gene and construction of new molecular genetic tools.

2006-06 | Journal article
DOI:

10.1007/s00294-006-0065-2

PMID:

16491385

Contributors: Hoffman RL; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.

2006-05 | Journal article
DOI:

10.1534/genetics.106.055699

PMID:

16489217

PMC:

PMC1461440

Contributors: Kao RS; Morreale E; Wang L; Ivey FD; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.

2005-12 | Journal article
DOI:

10.1534/genetics.105.047233

PMID:

16143612

PMC:

PMC1456081

Contributors: Wang L; Griffiths K Jr; Zhang YH; Ivey FD; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.

2005-04 | Journal article
DOI:

10.1073/pnas.0502270102

PMID:

15831585

PMC:

PMC1087962

Contributors: Ivey FD; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Except in every detail: comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

2005-03 | Journal article
DOI:

10.1128/EC.4.3.495-503.2005

PMID:

15755912

PMC:

PMC1087802

Contributors: Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe.

2005-02 | Journal article
DOI:

10.1042/BST0330257

PMID:

15667320

Contributors: Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses.

2004 | Journal article
DOI:

10.1093/nar/gkh251

PMID:

14762213

PMC:

PMC373364

Contributors: Hirota K; Hasemi T; Yamada T; Mizuno KI; Hoffman CS; Shibata T; Ohta K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Strategies for gene disruptions and plasmid constructions in fission yeast.

2004-07 | Journal article
DOI:

10.1016/j.ymeth.2003.11.014

PMID:

15157886

Contributors: Wang L; Kao R; Ivey FD; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

2004-06 | Journal article
DOI:

10.1128/EC.3.3.610-619.2004

PMID:

15189983

PMC:

PMC420129

Contributors: Stiefel J; Wang L; Kelly DA; Janoo RT; Seitz J; Whitehall SK; Hoffman CS
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

Fission yeast Tup1-like repressors repress chromatin remodeling at the fbp1+ promoter and the ade6-M26 recombination hotspot.

2003-10 | Journal article
PMID:

14573465

PMC:

PMC1462784

Contributors: Hirota K; Hoffman CS; Shibata T; Ohta K
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central

The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

2003-04 | Journal article
PMID:

12715160

Contributors: Yang P; Du H; Hoffman CS; Marcus S
Source: Self-asserted source
Charles Hoffman via Europe PubMed Central
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