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Assay development, HTS

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United States

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Employment (1)

St. Jude Children’s Research Hospital: Memphis, TN, US

2006-11 to present | Principal HTS Scientist (Chemical Biology and Therapeutics)
Employment
Source: Self-asserted source
Wenwei Lin

Works (50 of 66)

Items per page:
Page 1 of 2

Addition/Correction to “First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy”

Journal of Medicinal Chemistry
2024-12-12 | Journal article
DOI: 10.1021/acs.jmedchem.4c02834
Contributors: Andrew D. Huber; Young-Hwan Jung; Yongtao Li; Wenwei Lin; Jing Wu; Shyaron Poudel; Annalise G. Carrigan; Ashutosh Mishra; Anthony A. High; Taosheng Chen
Source: check_circle
Crossref

Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases

ACS Medicinal Chemistry Letters
2024-11-14 | Journal article
DOI: 10.1021/acsmedchemlett.4c00416
Contributors: Wenwei Lin; Taosheng Chen
Source: check_circle
Crossref

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy

Journal of Medicinal Chemistry
2024-10-24 | Journal article
DOI: 10.1021/acs.jmedchem.4c01926
Contributors: Andrew D. Huber; Young-Hwan Jung; Yongtao Li; Wenwei Lin; Jing Wu; Shyaron Poudel; Annalise G. Carrigan; Ashutosh Mishra; Anthony A. High; Taosheng Chen
Source: check_circle
Crossref

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic Acids Research
2024-02-28 | Journal article
DOI: 10.1093/nar/gkad1175
Contributors: Andrew D Huber; Shyaron Poudel; Jing Wu; Darcie J Miller; Wenwei Lin; Lei Yang; Monicah N Bwayi; Mary Ashley Rimmer; Rebecca R Florke Gee; Jayaraman Seetharaman et al.
Source: check_circle
Crossref

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure
2023-09 | Journal article
DOI: 10.1016/j.str.2023.08.020
Part of ISSN: 0969-2126
Contributors: Andrew D. Huber; Shyaron Poudel; Yongtao Li; Wenwei Lin; Jing Wu; Darcie J. Miller; Taosheng Chen
Source: Self-asserted source
Wenwei Lin

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Proceedings of the National Academy of Sciences
2023-03-07 | Journal article
DOI: 10.1073/pnas.2217804120
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Wenwei Lin; Andrew Huber; Shyaron Poudel; Yongtao Li; Jayaraman Seetharaman; Darcie J. Miller; Taosheng Chen
Source: Self-asserted source
Wenwei Lin

Design and Optimization of 1<i>H</i>-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR

Journal of Medicinal Chemistry
2022-12-22 | Journal article
DOI: 10.1021/acs.jmedchem.2c01640
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Yongtao Li; Wenwei Lin; Sergio C Chai; Jing Wu; Kavya Annu; Taosheng Chen
Source: Self-asserted source
Wenwei Lin

Small molecule SJ572946 activates BAK to initiate apoptosis

iScience
2022-10 | Journal article
DOI: 10.1016/j.isci.2022.105064
Part of ISSN: 2589-0042
Contributors: Wenwei Lin
Source: Self-asserted source
Wenwei Lin

Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader

ACS Medicinal Chemistry Letters
2022-10-13 | Journal article
DOI: 10.1021/acsmedchemlett.2c00300
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Contributors: Anand Divakaran; Cole R. Scholtz; Huda Zahid; Wenwei Lin; Elizabeth C. Griffith; Richard E. Lee; Taosheng Chen; Daniel A Harki; william pomerantz
Source: Self-asserted source
Wenwei Lin

SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1

ACS Medicinal Chemistry Letters
2022-08-11 | Journal article
DOI: 10.1021/acsmedchemlett.2c00223
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Contributors: Andrew D. Huber; Yongtao Li; Wenwei Lin; Annalise N. Galbraith; Ashutosh Mishra; Shaina N. Porter; Jing Wu; Rebecca R. Florke Gee; Wei Zhuang; Shondra M. Pruett-Miller et al.
Source: Self-asserted source
Wenwei Lin

Biological evaluation and synthesis of calcitroic acid

Bioorganic Chemistry
2021-11 | Journal article
DOI: 10.1016/j.bioorg.2021.105310
Part of ISSN: 0045-2068
Source: Self-asserted source
Wenwei Lin

A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay

STAR Protocols
2021-09 | Journal article
DOI: 10.1016/j.xpro.2021.100702
Contributors: Qiong Wu; Wenwei Lin; Zhen-Mei Li; Zoran Rankovic; Stephen W. White; Taosheng Chen; Jun Yang
Source: check_circle
Crossref

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.

Nature communications
2021-07-02 | Journal article
DOI: 10.1038/s41467-021-24168-8
PMID: 34215733
Source: Self-asserted source
Wenwei Lin

Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

Clinical and Translational Science
2021-05-31 | Journal article
DOI: 10.1111/cts.13012
Part of ISSN: 1752-8054
Part of ISSN: 1752-8062
Source: Self-asserted source
Wenwei Lin

General Stepwise Approach to Optimize a TR-FRET Assay for Characterizing the BRD/PROTAC/CRBN Ternary Complex

ACS Pharmacology & Translational Science
2021-04-09 | Journal article
DOI: 10.1021/acsptsci.1c00032
Part of ISSN: 2575-9108
Part of ISSN: 2575-9108
Source: Self-asserted source
Wenwei Lin

Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70

Journal of Medicinal Chemistry
2021-02-11 | Journal article
DOI: 10.1021/acs.jmedchem.0c02201
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Wenwei Lin

17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma

iScience
2021-01 | Journal article
DOI: 10.1016/j.isci.2020.101996
Contributors: Shivendra Singh; Ahmed Abu-Zaid; Wenwei Lin; Jonathan Low; Alireza Abdolvahabi; Hongjian Jin; Qiong Wu; Bailey Cooke; Jie Fang; John Bowling et al.
Source: check_circle
Crossref

Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel–Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay

ACS Omega
2020-12-28 | Journal article
DOI: 10.1021/acsomega.0c05221
Part of ISSN: 2470-1343
Part of ISSN: 2470-1343
Source: Self-asserted source
Wenwei Lin

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response

2020-12-07 | Other
DOI: 10.1101/2020.12.06.407973
Contributors: Chen He; Ke Xu; Xiaoyan Zhu; Paige S. Dunphy; Brian Gudenas; Wenwei Lin; Nathaniel Twarog; Laura D. Hover; Chang-Hyuk Kwon; Lawryn H. Kasper et al.
Source: check_circle
Crossref

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay

Bioconjugate Chemistry
2020-11-18 | Journal article
DOI: 10.1021/acs.bioconjchem.0c00507
Part of ISSN: 1043-1802
Part of ISSN: 1520-4812
Source: Self-asserted source
Wenwei Lin

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.

Nature communications
2020-10-01 | Journal article
DOI: 10.1038/s41467-020-18708-x
PMID: 33004795
PMC: PMC7529893
Source: Self-asserted source
Wenwei Lin

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning.

Cellular and molecular life sciences : CMLS
2020-03-30 | Journal article
DOI: 10.1007/s00018-020-03505-y
PMID: 32232515
Source: Self-asserted source
Wenwei Lin

CITCO Directly Binds to and Activates Human Pregnane X Receptor.

Molecular pharmacology
2019-12-27 | Journal article
DOI: 10.1124/mol.119.118513
PMID: 31882411
PMC: PMC6978709
Source: Self-asserted source
Wenwei Lin

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.

Drug discovery today
2019-02-04 | Journal article
DOI: 10.1016/j.drudis.2019.01.021
PMID: 30731240
PMC: PMC6421094
Source: Self-asserted source
Wenwei Lin

Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4

SLAS Discovery
2018 | Journal article
DOI: 10.1177/2472555217735035
Contributors: Diouf, Barthelemy; Lin, Wenwei; Goktug, Asli; Grace, Christy R. R.; Waddell, Michael Brett; Bao, Ju; Shao, Youming; Heath, Richard J.; Zheng, Jie J.; Shelat, Anang A. et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction

Adv Protein Chem Struct Biol
2018 | Journal article
SOURCE-WORK-ID:

0619181714514-47
Contributors: Lin, Wenwei; Chen, Taosheng
Source: Self-asserted source
Wenwei Lin via ResearcherID

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins

Science Signaling
2018-08-14 | Journal article
DOI: 10.1126/scisignal.aaq1077
Contributors: Sirish K. Ippagunta; Julie A. Pollock; Naina Sharma; Wenwei Lin; Taosheng Chen; Kazuki Tawaratsumida; Anthony A. High; Jaeki Min; Yizhe Chen; R. Kiplin Guy et al.
Source: check_circle
Crossref

An unexpected protein interaction promotes drug resistance in leukemia

Nat Commun
2017 | Journal article
SOURCE-WORK-ID:

0619181714514-51
Contributors: Pitre, Aaron; Wang, Yao; Fukuda, Yu; Schuetz, John D.; Ge, Yubin; Lin, Wenwei; Chen, Taosheng; Temirov, Jamshid; Peters, Jennifer L.; Centonze, Victoria E. et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase

Sci Rep
2017 | Journal article
SOURCE-WORK-ID:

0619181714514-52
Contributors: Oladimeji, Peter O.; Lin, Wenwei; Brewer, C. Trent; Chen, Taosheng
Source: Self-asserted source
Wenwei Lin via ResearcherID

High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor

Assay Drug Dev. Technol.
2017 | Journal article
DOI: 10.1089/adt.2017.809
Contributors: Lin, Wenwei; Goktug, Asli N.; Wu, Jing; Currier, Duane G.; Chen, Taosheng
Source: Self-asserted source
Wenwei Lin via ResearcherID

Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL

Blood Adv
2017 | Journal article
SOURCE-WORK-ID:

0619181714514-50
Contributors: Roberts, Kathryn G.; Yang, Yung-Li; Payne-Turner, Debbie; Files, Jacob K.; Dickerson, Kirsten; Gu, Zhaohui; Janke, Laura J.; Mullighan, Charles G.; Lin, Wenwei; Chen, Taosheng et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID

SPA70 is a potent antagonist of human pregnane X receptor

Nat Commun
2017 | Journal article
SOURCE-WORK-ID:

0619181714514-53
Contributors: Lin, Wenwei; Wang, Yue-Ming; Chai, Sergio C.; Wu, Jing; Chen, Taosheng; Lv, Lili; Zhang, Qijun; Zheng, Jie; Griffin, Patrick R.; Wang, Yong-Dong
Source: Self-asserted source
Wenwei Lin via ResearcherID

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

Cancer Res.
2017 | Journal article
DOI: 10.1158/0008-5472.can-16-0826
Contributors: Yang, Jun; Milasta, Sandra; Hu, Dongli; Al Tahan, Alaa M.; Interiano, Rodrigo B.; Zhou, Junfang; Davidson, Jesse; Low, Jonathan; Lin, Wenwei; Bao, Ju et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

ACS Chem. Biol.
2017 | Journal article
DOI: 10.1021/acschembio.7b00527
Contributors: Genthe, Jamie R.; Min, Jaeki; Farmer, Dana M.; Shelat, Anang A.; Grenet, Jose A.; Lin, Wenwei; Finkelstein, David; Vrijens, Karen; Chen, Taosheng; Guy, R. Kiplin et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID

A phosphotyrosine switch regulates organic cation transporters

Nat. Commun.
2016 | Journal article
DOI: 10.1038/ncomms10880
Contributors: Sprowl, Jason A.; Ong, Su Sien; Gibson, Alice A.; Hu, Shuiying; Du, Guoqing; Lin, Wenwei; Li, Lie; Bharill, Shashank; Ness, Rachel A.; Stecula, Adrian et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

Eur J Med Chem
2016 | Journal article
DOI: 10.1016/j.ejmech.2015.12.018
Contributors: Lin, W.; Yang, L.; Chai, S. C.; Lu, Y.; Chen, T.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor

Drug Metab Dispos
2016 | Journal article
DOI: 10.1124/dmd.116.071993
Contributors: Cherian, M. T.; Yang, L.; Chai, S. C.; Lin, W.; Chen, T.
Source: Self-asserted source
Wenwei Lin via ResearcherID

A directed high-throughput screening approach for the identification of a novel small molecule inhibitor of Constitutive Androstane Receptor (CAR)

2015 | Conference paper
SOURCE-WORK-ID:

0619181714514-66
Contributors: Cherian, Milu T.; Lin, Wenwei; Yang, Lei; Chen, Taosheng
Source: Self-asserted source
Wenwei Lin via ResearcherID

A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate Kinases

J. Med. Chem.
2015 | Journal article
DOI: 10.1021/jm501585q
Contributors: Sharma, Lalit Kumar; Leonardi, Roberta; Lin, Wenwei; Boyd, Vincent A.; Goktug, Asli; Shelat, Anang A.; Chen, Taosheng; Jackowski, Suzanne; Rock, Charles O.
Source: Self-asserted source
Wenwei Lin via ResearcherID

CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor

Mol Pharmacol
2015 | Journal article
DOI: 10.1124/mol.115.097782
Contributors: Cherian, M. T.; Lin, W.; Wu, J.; Chen, T.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Development of chemical biology probes of the pro-apoptotic Bcl-2 effector protein BAK

2015 | Conference paper
SOURCE-WORK-ID:

0619181714514-63
Contributors: Singh, Geetika; Guibao, Cristina; Shadrick, William; Lin, Wenwei; Royappa, Grace; Chen, Taosheng; Moldoveanu, Tudor; Lee, Richard E.
Source: Self-asserted source
Wenwei Lin via ResearcherID

PRL-3 Mediates the Protein Maturation of ULBP2 by Regulating the Tyrosine Phosphorylation of HSP60

J. Immunol.
2015 | Journal article
DOI: 10.4049/jimmunol.1400817
Contributors: Leung, Wai-Hang; Vong, Queenie P.; Lin, Wenwei; Bouck, David; Wendt, Susanne; Sullivan, Erin; Li, Ying; Bari, Rafijul; Chen, Taosheng; Leung, Wing
Source: Self-asserted source
Wenwei Lin via ResearcherID

Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo

Biochem. Pharmacol. (Amsterdam, Neth.)
2015 | Journal article
DOI: 10.1016/j.bcp.2015.06.018
Contributors: Wang, Yue-Ming; Chai, Sergio C.; Lin, Wenwei; Chai, Xiaojuan; Elias, Ayesha; Wu, Jing; Ong, Su Sien; Pondugula, Satyanarayana R.; Beard, Jordan A.; Schuetz, Erin G. et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe

Bioconjug Chem
2014 | Journal article
DOI: 10.1021/bc5002856
Contributors: Lin, W.; Liu, J.; Jeffries, C.; Yang, L.; Lu, Y.; Lee, R. E.; Chen, T.
Source: Self-asserted source
Wenwei Lin via ResearcherID

High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor

PLoS One
2014 | Journal article
SOURCE-WORK-ID:

0619181714515-69
Contributors: Walters, Brandon J.; Diao, Shiyong; Iconaru, Luigi I.; Dearman, Jennifer; Zuo, Jian; Lin, Wenwei; Goktug, Asli; Chen, Taosheng; Brimble, Mark
Source: Self-asserted source
Wenwei Lin via ResearcherID

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor

Bioorg Med Chem
2014 | Journal article
DOI: 10.1016/j.bmc.2014.04.014
Contributors: Yu, D. D.; Lin, W.; Forman, B. M.; Chen, T.
Source: Self-asserted source
Wenwei Lin via ResearcherID

A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay

Anal Biochem
2013 | Journal article
DOI: 10.1016/j.ab.2013.09.009
Contributors: Lin, W.; Chen, T.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

Bioorg Med Chem
2013 | Journal article
DOI: 10.1016/j.bmc.2013.04.069
Contributors: Yu, D. D.; Lin, W.; Chen, T.; Forman, B. M.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4)

Biochem. Pharmacol. (Amsterdam, Neth.)
2013 | Journal article
DOI: 10.1016/j.bcp.2013.08.063
Contributors: Wang, Chunmei; Lin, Wenwei; Playa, Hilaire; Sun, Shan; Cameron, Keyuna; Buolamwini, John K.
Source: Self-asserted source
Wenwei Lin via ResearcherID

Identification of small molecule activators of BMP signaling

PLoS One
2013 | Journal article
DOI: 10.1371/journal.pone.0059045
Contributors: Vrijens, Karen; Lin, Wenwei; Cui, Jimmy; Farmer, Dana; Low, Jonathan; Pronier, Elodie; Zeng, Fu-Yue; Shelat, Anang A.; Guy, Kiplin; Taylor, Michael R. et al.
Source: Self-asserted source
Wenwei Lin via ResearcherID
Items per page:
Page 1 of 2

Peer review (8 reviews for 3 publications/grants)

Review activity for Biochemistry and biophysics reports. (1)
Review activity for Bioorganic chemistry. (1)
Review activity for ChemMedChem. (6)
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