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ResearcherID: T-1394-2018
Scopus Author ID: 7004586810
SciProfiles: 1893277

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Employment (2)

Institute of Evolutionary Physiology and Biochemistry: Saint Petersburg, RU

2014-10 to present (Molecular Endocrinology and Neurochemistry)
Employment
Source: Self-asserted source
Irina Zakharova

Institute of Evolutionary Physiology and Biochemistry: Saint Petersburg, RU

1996-11-01 to 2014-10 (Comparative Neurochemistry)
Employment
Source: Self-asserted source
Irina Zakharova

Education and qualifications (2)

Institute of Evolutionary Physiology and Biochemistry: Saint Petersburg, RU

1992-11-01 to 1996-11-01 | PhD (Comparative Neurochemistry)
Education
Source: Self-asserted source
Irina Zakharova

Saint Petersburg State University: Saint-Petersburg, RU

1987-09-01 to 1992-06-25 | MS (Chemical Department)
Education
Source: Self-asserted source
Irina Zakharova

Funding (2)

Механизмы возникновения нервно-психических, метаболических и гормональных дисфункций при нервных и эндокринных заболеваниях и пути их коррекции

2017-01 to present | Contract
Russian Academy of Sciences (Moscow, RU)
GRANT_NUMBER:

The state assignment of FASO of Russia No. AAAA-A18-1180112290427-7.
Source: Self-asserted source
Irina Zakharova

Изучение эффективности и молекулярных механизмов нейропротекторного действия инсулина, альфа-токоферола и ганглиозидов при их совместном использовании для предотвращения нейропатий при экспериментальной ишемии мозга и диабете.

2016-01 to present | Grant
Russian Foundation for Basic Research (Moscow, RU)
GRANT_NUMBER:

16-04-00408
Source: Self-asserted source
Irina Zakharova

Works (40)

Low-molecular-weight Ligand of the Thyroid-stimulating Hormone Receptor with the Activity of a Partial Agonist and a Negative Allosteric Modulator

Doklady Biochemistry and Biophysics
2025-01-22 | Journal article
DOI: 10.1134/S1607672924600799
Contributors: K. V. Derkach; E. A. Didenko; V. N. Sorokoumov; I. O. Zakharova; A. O. Shpakov
Source: check_circle
Crossref

The Autophagic and Apoptotic Death of Forebrain Neurons of Rats with Global Brain Ischemia Is Diminished by the Intranasal Administration of Insulin: Possible Mechanism of Its Action

Current Issues in Molecular Biology
2024-06-27 | Journal article
DOI: 10.3390/cimb46070392
Contributors: Irina O. Zakharova; Liubov V. Bayunova; Daria K. Avrova; Alina D. Tretyakova; Alexander O. Shpakov; Natalia F. Avrova
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(1H)-Ones

International Journal of Molecular Sciences
2023-02-24 | Journal article
DOI: 10.3390/ijms24054498
Contributors: Kira V. Derkach; Maxim A. Gureev; Anastasia A. Babushkina; Vladimir N. Mikhaylov; Irina O. Zakharova; Andrey A. Bakhtyukov; Viktor N. Sorokoumov; Alexander S. Novikov; Mikhail Krasavin; Alexander O. Shpakov et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Insulin and α-Tocopherol Enhance the Protective Effect of Each Other on Brain Cortical Neurons under Oxidative Stress Conditions and in Rat Two-Vessel Forebrain Ischemia/Reperfusion Injury

International Journal of Molecular Sciences
2021-10-29 | Journal article
DOI: 10.3390/ijms222111768
Part of ISSN: 1422-0067
Source: Self-asserted source
Irina Zakharova

The Effect of Alpha-Tocopherol on Viability of PC12 Cells during Oxidative Stress and Expression of Genes Encoding Pro- and Anti-Apoptotic Mitochondrial Proteins, SOD2 and Transcription Factors NRF-1, NRF-2 and TFAM

Journal of Evolutionary Biochemistry and Physiology
2020-05 | Journal article
DOI: 10.1134/s0022093020030084
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

The Influence of Intranasally Administered Insulin and C-peptide on AMP-Activated Protein Kinase Activity, Mitochondrial Dynamics and Apoptosis Markers in the Hypothalamus of Rats with Streptozotocin-Induced Diabetes

Journal of Evolutionary Biochemistry and Physiology
2020-05 | Journal article
DOI: 10.1134/s0022093020030035
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus

Bulletin of Experimental Biology and Medicine
2020-01 | Journal article
DOI: 10.1007/s10517-020-04699-8
Part of ISSN: 0007-4888
Part of ISSN: 1573-8221
Source: Self-asserted source
Irina Zakharova

Effect of Insulin on Lipid Peroxidation and Glutathione Levels in a Two-Vessel Occlusion Model of Rat Forebrain Ischemia Followed by Reperfusion

Journal of Evolutionary Biochemistry and Physiology
2019-07 | Journal article
DOI: 10.1134/s0022093019040094
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities

International Journal of Molecular Sciences
2019-07-29 | Journal article
DOI: 10.3390/ijms20153702
Part of ISSN: 1422-0067
Source: Self-asserted source
Irina Zakharova

The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect

PLOS ONE
2019-03-14 | Journal article
DOI: 10.1371/journal.pone.0213779
Contributors: Kira Derkach; Guillermo López Lluch; Irina Zakharova; Inna Zorina; Andrey Bakhtyukov; Irina Romanova; Liubov Bayunova; Alexander Shpakov
Source: check_circle
Crossref

4-oxo-1,4-dihydrocinnoline Derivative with Phosphatase 1B Inhibitor Activity Enhances Leptin Signal Transduction in Hypothalamic Neurons

Journal of Evolutionary Biochemistry and Physiology
2018-07 | Journal article
DOI: 10.1134/s0022093018040038
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

Insulin Administration Prevents Accumulation of Conjugated Dienes and Trienes and Inactivation of Na+, K+-ATPase in the Rat Cerebral Cortex during Two-Vessel Forebrain Ischemia and Reperfusion

Journal of Evolutionary Biochemistry and Physiology
2018-05 | Journal article
DOI: 10.1134/s0022093018030109
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on Modulation of Protein Kinase B (Akt) Activity

Journal of Evolutionary Biochemistry and Physiology
2018-05 | Journal article
DOI: 10.1134/s0022093018030043
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

The Dependence of the Protective Effect of Insulin on Its Concentration and Modulation of ERK1/2 Activity under the Conditions of Oxidative Stress in Cortical Neurons

Neurochemical Journal
2018-01 | Journal article
DOI: 10.1134/s1819712417040110
Part of ISSN: 1819-7124
Part of ISSN: 1819-7132
Source: Self-asserted source
Irina Zakharova

Metabolic parameters and functional state of hypothalamic signaling systems in AY/a mice with genetic predisposition to obesity and the effect of metformin

Doklady Biochemistry and Biophysics
2017-11 | Journal article
DOI: 10.1134/s1607672917060096
Part of ISSN: 1607-6729
Part of ISSN: 1608-3091
Source: Self-asserted source
Irina Zakharova

α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress.

International Journal of Molecular Sciences
2017-01-21 | Journal article
Part of DOI: 10.3390/ijms18010216
Source: Self-asserted source
Irina Zakharova

The effects of alpha-tocoferol and H2O2 on the mitochondrial membrane potential and Bax/Bcl-xL ratio in PC12 cells

Neurochemical Journal
2016-10 | Journal article
DOI: 10.1134/s1819712416040152
Part of ISSN: 1819-7124
Part of ISSN: 1819-7132
Source: Self-asserted source
Irina Zakharova

Alpha-tocopherol prevents a dramatic oxidative stress-induced decline of the Bcl-2 concentration in cortical neurons

Neurochemical Journal
2016-07 | Journal article
DOI: 10.1134/s1819712416030144
Part of ISSN: 1819-7124
Part of ISSN: 1819-7132
Source: Self-asserted source
Irina Zakharova

Alpha-tocopherol prevents long-term activation of ERK1/2 in neurons of the brain cortex under conditions of oxidative stress

Neurochemical Journal
2015-10 | Journal article
DOI: 10.1134/s1819712415040170
Part of ISSN: 1819-7124
Part of ISSN: 1819-7132
Source: Self-asserted source
Irina Zakharova

Role of Protein Kinase Akt Activation in Protective Effect of Ganglioside GM1 on PC12 Cells Exposed to H2O2.

Bull Exp Biol Med.
2015-09 | Journal article
DOI: 10.1007/s10517-015-3026-2.
Source: Self-asserted source
Irina Zakharova

GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity.

Neurochemical Research
2014-11 | Journal article
Part of DOI: 10.1007/s11064-014-1428-6
Source: Self-asserted source
Irina Zakharova

Metabolic effects of ganglioside GM1 on PC12 cells in oxidative stress depend on modulation of activity of tyrosine kinase Trk of receptors

Journal of Evolutionary Biochemistry and Physiology
2013-01 | Journal article
DOI: 10.1134/s0022093013010039
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity: Effects of Cadmium, Mercury, and Copper

The Scientific World Journal
2012 | Journal article
DOI: 10.1100/2012/136063
Part of ISSN: 1537-744X
Source: Self-asserted source
Irina Zakharova

Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump

Journal of Hypertension
2012-09 | Journal article
DOI: 10.1097/hjh.0b013e328356399b
Part of ISSN: 0263-6352
Source: Self-asserted source
Irina Zakharova

α-Tocopherol at Nanomolar Concentration Protects PC12 Cells from Hydrogen Peroxide-Induced Death and Modulates Protein Kinase Activities

International Journal of Molecular Sciences
2012-09-14 | Journal article
DOI: 10.3390/ijms130911543
Part of ISSN: 1422-0067
Source: Self-asserted source
Irina Zakharova

Alpha-tocopherol at nanomolar concentrations increases the viability of PC12 cells under oxidative stress conditions. The effects of modulation of signaling systems

Neurochemical Journal
2011-09 | Journal article
DOI: 10.1134/s181971241103007x
Part of ISSN: 1819-7124
Part of ISSN: 1819-7132
Source: Self-asserted source
Irina Zakharova

Protective and Antioxidative Effects of GM1 Ganglioside in PC12 Cells Exposed to Hydrogen Peroxide are Mediated by Trk Tyrosine Kinase

Neurochemical Research
2010-01 | Journal article
DOI: 10.1007/s11064-009-0033-6
Part of ISSN: 0364-3190
Part of ISSN: 1573-6903
Source: Self-asserted source
Irina Zakharova

Role of tyrosine kinase of Trk-Receptors in realization of antioxidant effect of ganglioside GM1 in PC12 cells

Journal of Evolutionary Biochemistry and Physiology
2009-10 | Journal article
DOI: 10.1134/s0022093009050028
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

A Decrease of neuroprotective effect of ganglioside GM1 on PC12 cells under conditions of oxidative stress in the presence of inhibitor of tyrosine kinase of Trk-receptors

Journal of Evolutionary Biochemistry and Physiology
2008-08 | Journal article
DOI: 10.1134/s0022093008040042
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

Neuroprotective Effect of Ganglioside GM1 on the Cytotoxic Action of Hydrogen Peroxide and Amyloid β-peptide in PC12 cells

Neurochemical Research
2007-06-22 | Journal article
DOI: 10.1007/s11064-007-9304-2
Part of ISSN: 0364-3190
Part of ISSN: 1573-6903
Source: Self-asserted source
Irina Zakharova

Effects of oxidative stress inhibitors, neurotoxins, and ganglioside GM1 on Na+,K+-ATPase activity in PC12 Cells and brain synaptosomes

Journal of Evolutionary Biochemistry and Physiology
2007-04 | Journal article
DOI: 10.1134/s0022093007020056
Part of ISSN: 0022-0930
Part of ISSN: 1608-3202
Source: Self-asserted source
Irina Zakharova

Cocaine inhibits cromakalim-activated K + currents in follicle-enclosed Xenopus oocytes

Naunyn-Schmiedeberg's Archives of Pharmacology
2004-02-01 | Journal article
DOI: 10.1007/s00210-003-0838-9
Part of ISSN: 0028-1298
Part of ISSN: 1432-1912
Source: Self-asserted source
Irina Zakharova

Effect of Glutamate and Inhibitors of Various Pathways of Free Radical Production on Na+,K+-ATPase Activity and Accumulation of Lipids Peroxidation Products in Rat Brain Cortex Synaptosomes

Journal of Evolutionary Biochemistry and Physiology
2004-01 | Journal article
DOI: 10.1023/b:joey.0000031004.52291.78
Part of ISSN: 0022-0930
Source: Self-asserted source
Irina Zakharova

Mitogen-Activated Protein Kinase Regulates Dopamine Transporter Surface Expression and Dopamine Transport Capacity

The Journal of Neuroscience
2003-09-17 | Journal article
DOI: 10.1523/jneurosci.23-24-08480.2003
Part of ISSN: 0270-6474
Part of ISSN: 1529-2401
Source: Self-asserted source
Irina Zakharova

Enhanced Responsiveness to Novelty and Cocaine Is Associated with Decreased Basal Dopamine Uptake and Release in the Nucleus Accumbens: Quantitative Microdialysis in Rats under Transient Conditions

The Journal of Neuroscience
2003-04-01 | Journal article
DOI: 10.1523/jneurosci.23-07-03076.2003
Part of ISSN: 0270-6474
Part of ISSN: 1529-2401
Source: Self-asserted source
Irina Zakharova

Different metabolic effects of ganglioside GM1 in brain synaptosomes and phagocytic cells.

Neurochemical Research
2002 | Journal article
DOI: 10.1023/a:1020296605444
Part of ISSN: 0364-3190
Source: Self-asserted source
Irina Zakharova
grade
Preferred source (of 2)‎

The effect of cold stress on ganglioside fatty acid composition and ganglioside-bound sialic acid content of rat brain subcellular fractions

Journal of Thermal Biology
2001-06 | Journal article
DOI: 10.1016/s0306-4565(00)00045-0
Part of ISSN: 0306-4565
Source: Self-asserted source
Irina Zakharova

The use of antioxidants to prevent glutamate-induced derangement of calcium ion metabolism in rat cerebral cortex synaptosomes

Neuroscience and Behavioral Physiology
2000-09 | Journal article
DOI: 10.1007/bf02462611
Part of ISSN: 0097-0549
Part of ISSN: 1573-899X
Source: Self-asserted source
Irina Zakharova
grade
Preferred source (of 2)‎

[The antioxidant prevention of disorders in calcium ion metabolism under the action of glutamate on the synaptosomes of the rat cerebral cortex].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
1999-04-01 | Journal article
PMID: 10513381
Source: Self-asserted source
Irina Zakharova

Inhibition of glutamate-induced intensification of free radical reactions by gangliosides: possible role in their protective effect in rat cerebellar granule cells and brain synaptosomes.

Neurochemical Research
1998 | Journal article
DOI: 10.1023/a:1021076220411
Part of ISSN: 0364-3190
Source: Self-asserted source
Irina Zakharova
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