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Mitochondrial Biogenesis, OXPHOS system

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Universidad de Zaragoza: Zaragoza, Aragón, ES

Researcher (Academic) (Bioquímica y Biología Molecular y Celular)
Employment
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Universidad de Zaragoza

Education and qualifications (1)

Universidad de Zaragoza: Zaragoza, Aragón, ES

1991-06 to present | Doctor en Veterinaria (Bioquímica y Biología Molceular y Celular)
Education
Source: Self-asserted source
Patricio Fernández-Silva

Works (50 of 77)

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How hot can mitochondria be? Incubation at temperatures above 43 °C induces the degradation of respiratory complexes and supercomplexes in intact cells and isolated mitochondria

Mitochondrion
2023-03 | Journal article
Contributors: Raquel Moreno-Loshuertos; Joaquín Marco-Brualla; Patricia Meade; Ruth Soler-Agesta; José A. Enriquez; Patricio Fernández-Silva
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Crossref

A Mutation in Mouse MT-ATP6 Gene Induces Respiration Defects and Opposed Effects on the Cell Tumorigenic Phenotype

International Journal of Molecular Sciences
2023-01-09 | Journal article
Contributors: Raquel Moreno-Loshuertos; Nieves Movilla; Joaquín Marco-Brualla; Ruth Soler-Agesta; Patricia Ferreira; José Antonio Enríquez; Patricio Fernández-Silva
Source: check_circle
Crossref

Corrigendum: Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

Nature
2017 | Journal article
WOSUID:

MEDLINE:27926738

Contributors: Latorre-Pellicer, Ana; Moreno-Loshuertos, Raquel; Lechuga-Vieco, Ana Victoria; Sanchez-Cabo, Fatima; Torroja, Carlos; Acin-Perez, Rebeca; Calvo, Enrique; Aix, Esther; Gonzalez-Guerra, Andres; Logan, Angela et al.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Adjusting MtDNA Quantification in Whole Blood for Peripheral Blood Platelet and Leukocyte Counts

Plos One
2016 | Journal article
WOSUID:

WOS:000385505800023

Contributors: Hurtado-Roca, Yamilee; Ledesma, Marta; Gonzalez-Lazaro, Monica; Moreno-Loshuertos, Raquel; Fernandez-Silva, Patricio; Antonio Enriquez, Jose; Laclaustra, Martin
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

Nature
2016 | Journal article
WOSUID:

WOS:000380856600031

Contributors: Latorre-Pellicer, Ana; Moreno-Loshuertos, Raquel; Victoria Lechuga-Vieco, Ana; Sanchez-Cabo, Fatima; Torroja, Carlos; Acin-Perez, Rebeca; Calvo, Enrique; Aix, Esther; Gonzalez-Guerra, Andres; Logan, Angela et al.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency

Cell Reports
2016 | Journal article
WOSUID:

WOS:000374236700019

Contributors: Guaras, Adela; Perales-Clemente, Ester; Calvo, Enrique; Acin-Perez, Rebeca; Loureiro-Lopez, Marta; Pujol, Claire; Martinez-Carrascoso, Isabel; Nunez, Estefania; Garcia-Marques, Fernando; Angeles Rodriguez-Hernandez, Maria et al.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Role of Delta(1)-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi

Journal of Biological Chemistry
2015 | Journal article
WOSUID:

WOS:000351613600037

Contributors: Mantilla, Brian S.; Paes, Lisvane S.; Pral, Elizabeth M. F.; Martil, Daiana E.; Thiemann, Otavio H.; Fernandez-Silva, Patricio; Bastos, Erick L.; Silber, Ariel M.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

Cell Metabolism
2014 | Journal article
WOSUID:

WOS:000341396300015

Contributors: Acin-Perez, Rebeca; Carrascoso, Isabel; Baixauli, Francesc; Roche-Molina, Marta; Latorre-Pellicer, Ana; Fernandez-Silva, Patricio; Mittelbrunn, Maria; Sanchez-Madrid, Francisco; Perez-Martos, Acisclo; Lowell, Clifford A. et al.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Structural Insights into the Coenzyme Mediated Monomer-Dimer Transition of the Pro-Apoptotic Apoptosis Inducing Factor

Biochemistry
2014 | Journal article
WOSUID:

WOS:000338089700014

Contributors: Ferreira, Patricia; Villanueva, Raquel; Martinez-Julvez, Marta; Herguedas, Beatriz; Marcuello, Carlos; Fernandez-Silva, Patricio; Cabon, Lauriane; Hermoso, Juan A.; Lostao, Anabel; Susin, Santos A. et al.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Length variation in the mouse mitochondrial tRNAArg DHU loop size promotes oxidative phosphorylation functional differences

2013 | Journal article
DOI:

10.1111/febs.12466

Part of ISSN:

1742464X 17424658

EID:

2-s2.0-84885295391

Contributors: Moreno-Loshuertos, R.; Pérez-Martos, A.; Fernández-Silva, P.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency

2013 | Journal article
DOI:

10.1016/j.cell.2013.08.032

Part of ISSN:

00928674 10974172

EID:

2-s2.0-84884909413

Contributors: Cogliati, S.; Frezza, C.; Soriano, M.E.; Varanita, T.; Quintana-Cabrera, R.; Corrado, M.; Cipolat, S.; Costa, V.; Casarin, A.; Gomes, L.C. et al.
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Patricio Fernández-Silva via Scopus - Elsevier
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Supercomplex assembly determines electron flux in the mitochondrial electron transport chain

2013 | Journal article
DOI:

10.1126/science.1230381

Part of ISSN:

00368075 10959203

EID:

2-s2.0-84879617853

Contributors: Lapuente-Brun, E.; Moreno-Loshuertos, R.; Aciń-Pérez, R.; Latorre-Pellicer, A.; Colaś, C.; Balsa, E.; Perales-Clemente, E.; Quirós, P.M.; Calvo, E.; Rodríguez-Hernández, M.A. et al.
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Patricio Fernández-Silva via Scopus - Elsevier
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TcP5CDH modulates mitochondrial respiratory chain in the protozoan specie Trypanosoma cruzi

Febs Journal
2012 | Journal article
WOSUID:

WOS:000308128601247

Contributors: Mantilla, B. S.; Paes, L. S.; Cosentino-Gomes, D.; Martil, D. E.; Thiemann, O. H.; Bastos, E. L.; Fernandez-Silva, P.; Meyer-Fernandes, J. R.; Silber, A. M.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

A genome-wide shRNA screen for new OxPhos related genes

2011 | Journal article
DOI:

10.1016/j.mito.2011.01.007

Part of ISSN:

15677249

EID:

2-s2.0-79953730751

Contributors: Bayona-Bafaluy, M.P.; Sánchez-Cabo, F.; Fernández-Silva, P.; Pérez-Martos, A.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Allotopic expression of mitochondrial-encoded genes in mammals: Achieved goal, undemonstrated mechanism or impossible task?

2011 | Journal article
DOI:

10.1093/nar/gkq769

Part of ISSN:

03051048 13624962

EID:

2-s2.0-78651344935

Contributors: Perales-Clemente, E.; Fernández-Silva, P.; Acín-Pérez, R.; Pérez-Martos, A.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Evolution meets disease: Penetrance and functional epistasis of mitochondrial tRNA mutations

2011 | Journal article
DOI:

10.1371/journal.pgen.1001379

Part of ISSN:

15537390 15537404

EID:

2-s2.0-79955592354

Contributors: Moreno-Loshuertos, R.; Ferrín, G.; Acín-Pérez, R.; Gallardo, M.E.; Viscomi, C.; Pérez-Martos, A.; Zeviani, M.; Fernández-Silva, P.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Tissue-specific differences in mitochondrial activity and biogenesis

2011 | Journal article
DOI:

10.1016/j.mito.2010.09.011

Part of ISSN:

15677249

EID:

2-s2.0-78650032424

Contributors: Fernández-Vizarra, E.; Enríquez, J.A.; Pérez-Martos, A.; Montoya, J.; Fernández-Silva, P.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Five entry points of the mitochondrially encoded subunits in mammalian complex I assembly

2010 | Journal article
DOI:

10.1128/MCB.00025-10

Part of ISSN:

02707306

EID:

2-s2.0-77953432125

Contributors: Perales-Clemente, E.; Fernández-Vizarra, E.; Acín-Pérez, R.; Movilla, N.; Bayona-Bafaluy, M.P.; Moreno-Loshuertos, R.; Pérez-Martos, A.; Fernández-Silva, P.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Isolation of mitochondria for biogenetical studies: An update

2010 | Journal article
DOI:

10.1016/j.mito.2009.12.148

Part of ISSN:

15677249

EID:

2-s2.0-77949916467

Contributors: Fernández-Vizarra, E.; Ferrín, G.; Pérez-Martos, A.; Fernández-Silva, P.; Zeviani, M.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Cisplatin-mediated impairment of mitochondrial DNA metabolism inversely correlates with glutathione levels

2008 | Journal article
DOI:

10.1042/BJ20071615

Part of ISSN:

02646021

EID:

2-s2.0-49649102090

Contributors: Garrido, N.; Pérez-Martos, A.; Faro, M.; Lou-Bonafonte, J.M.; Fernández-Silva, P.; López-Pérez, M.J.; Montoya, J.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Functional genetic analysis of the mammalian mitochondrial DNA encoded peptides: A mutagenesis approach

2008 | Book
DOI:

10.1007/978-1-59745-261-8-28

Part of ISSN:

10643745

EID:

2-s2.0-58149340811

Contributors: Bayona-Bafaluy, M.P.; Movilla, N.; Pérez-Martos, A.; Fernández-Silva, P.; Enriquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier

Functional genetic analysis of the mammalian mitochondrial DNA encoded peptides: a mutagenesis approach.

2008 | Journal article
DOI:

10.1007/978-1-59745-261-8_28

PMID:

19066042

Contributors: Bayona-Bafaluy MP; Movilla N; Pérez-Martos A; Fernández-Silva P; Enriquez JA
Source: Self-asserted source
Patricio Fernández-Silva via Europe PubMed Central

Functional genetic analysis of the mammalian mitochondrial DNA encoded peptides: a mutagenesis approach.

Methods in molecular biology (Clifton, N.J.)
2008 | Journal article
WOSUID:

MEDLINE:19066042

Contributors: Bayona-Bafaluy, Maria Pilar; Movilla, Nieves; Perez-Martos, Acisclo; Fernandez-Silva, Patricio; Enriquez, Jose Antonio
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Mitochondrial gene expression is regulated at multiple levels and differentially in the heart and liver by thyroid hormones

2008 | Journal article
DOI:

10.1007/s00294-008-0194-x

Part of ISSN:

01728083

EID:

2-s2.0-47249148789

Contributors: Fernández-Vizarra, E.; Enriquez, J.A.; Pérez-Martos, A.; Montoya, J.; Fernández-Silva, P.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Respiratory Active Mitochondrial Supercomplexes

2008 | Journal article
DOI:

10.1016/j.molcel.2008.10.021

Part of ISSN:

10972765

EID:

2-s2.0-55949098781

Contributors: Acín-Pérez, R.; Fernández-Silva, P.; Peleato, M.L.; Pérez-Martos, A.; Enriquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Restoration of electron transport without proton pumping in mammalian mitochondria

2008 | Journal article
DOI:

10.1073/pnas.0810518105

Part of ISSN:

00278424 10916490

EID:

2-s2.0-57749093494

Contributors: Perales-Clemente, E.; Bayona-Bafaluy, M.P.; Pérez-Martos, A.; Barrientos, A.; Fernández-Silva, P.; Enriquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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In Vivo and In Organello Analyses of Mitochondrial Translation

2007 | Book
DOI:

10.1016/S0091-679X(06)80028-2

Part of ISSN:

0091679X

EID:

2-s2.0-34147119553

Contributors: Fernández-Silva, P.; Acín-Pérez, R.; Fernández-Vizarra, E.; Pérez-Martos, A.; Enriquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Reply to "Reactive oxygen species and the segregation of mtDNA sequence variants" [2]

2007 | Journal article
DOI:

10.1038/ng0507-572

Part of ISSN:

10614036 15461718

EID:

2-s2.0-34247590988

Contributors: Enriquez, J.A.; Moreno-Loshuertos, R.; Acín-Pérez, R.; Movilla, N.; Gallardo, M.E.; De Córdoba, S.R.; Pérez-Martos, A.; Fernández-Silva, P.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants

2006 | Journal article
DOI:

10.1038/ng1897

Part of ISSN:

10614036 15461718

EID:

2-s2.0-33750428601

Contributors: Moreno-Loshuertos, R.; Acín-Pérez, R.; Fernández-Silva, P.; Movilla, N.; Pérez-Martos, A.; De Cordoba, S.R.; Gallardo, M.E.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Isolation of mitochondria from mammalian tissues and cultured cells

2006 | Book
DOI:

10.1016/B978-012164730-8/50082-4

EID:

2-s2.0-84884858773

Contributors: Fernández-Vizarra, E.; Fernández-Silva, P.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier

Advances in mammalian mitochondrial DNA transcription

New Frontiers in Mitochondrial Biogenesis and Disease 2005
2005 | Journal article
WOSUID:

CCC:000233078600001

Contributors: Fernandez-Vizarra, E; Fernandez-Silva, P; Lopez-Perez, MJ; Montoya, J
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

In vitro transcription termination activity of the Drosophila mitochondrial DNA-binding protein DmTTF

2005 | Journal article
DOI:

10.1016/j.bbrc.2005.03.173

Part of ISSN:

0006291X

EID:

2-s2.0-17444402819

Contributors: Roberti, M.; Fernandez-Silva, P.; Polosa, P.L.; Fernandez-Vizarra, E.; Bruni, F.; Deceglie, S.; Montoya, J.; Gadaleta, M.N.; Cantatore, P.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Respiratory complex III is required to maintain complex I in mammalian mitochondria

2004 | Journal article
DOI:

10.1016/S1097-2765(04)00124-8

Part of ISSN:

10972765

EID:

2-s2.0-12144291508

Contributors: Acín-Pérez, R.; Bayona-Bafaluy, M.P.; Fernández-Silva, P.; Moreno-Loshuertos, R.; Pérez-Martos, A.; Bruno, C.; Moraes, C.T.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA

2003 | Journal article
DOI:

10.1093/hmg/ddg021

Part of ISSN:

09646906

EID:

2-s2.0-0037321294

Contributors: Acín-Pérez, R.; Bayona-Bafaluy, M.P.; Bueno, M.; Machicado, C.; Fernández-Silva, P.; Pérez-Martos, A.; Montoya, J.; López-Pérez, M.J.; Sancho, J.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier

An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA

Human Molecular Genetics
2003 | Journal article
WOSUID:

WOS:000180913800012

Contributors: Acin-Perez, R; Bayona-Bafaluy, MP; Bueno, M; Machicado, C; Fernandez-Silva, P; Perez-Martos, A; Montoya, J; Lopez-Perez, MJ; Sancho, J; Enriquez, JA
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Replication and transcription of mammalian mitochondrial DNA

2003 | Journal article
DOI:

10.1113/eph8802514

Part of ISSN:

09580670

EID:

2-s2.0-0037252462

Contributors: Fernández-Silva, P.; Enriquez, J.A.; Montoya, J.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Revisiting the mouse mitochondrial DNA sequence

2003 | Journal article
DOI:

10.1093/nar/gkg739

Part of ISSN:

03051048

EID:

2-s2.0-10744232965

Contributors: Bayona-Bafaluy, M.P.; Acín-Pérez, R.; Mullikin, J.C.; Park, J.S.; Moreno-Loshuertos, R.; Hu, P.; Perez-Martos, A.; Fernández-Silva, P.; Bai, Y.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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The thankless task of playing genetics with mammalian mitochondrial DNA: A 30-year review

2002 | Journal article
DOI:

10.1016/S1567-7249(02)00044-2

Part of ISSN:

15677249

EID:

2-s2.0-0036838354

Contributors: Bayona-Bafaluy, M.P.; Fernández-Silva, P.; Enríquez, J.A.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Sea urchin mtDBP is a two-faced transcription termination factor with a biased polarity depending on the RNA polymerase

2001 | Journal article
Part of ISSN:

03051048

EID:

2-s2.0-0035890656

Contributors: Fernandez-Silva, P.; Polosa, P.L.; Roberti, M.; Di Ponzio, B.; Gadaleta, M.N.; Montoya, J.; Cantatore, P.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier

Sea urchin mtDBP is a two-faced transcription termination factor with a biased polarity depending on the RNA polymerase

Nucleic Acids Research
2001 | Journal article
WOSUID:

WOS:000172378000025

Contributors: Fernandez-Silva, P; Polosa, PL; Roberti, M; Di Ponzio, B; Gadaleta, MN; Montoya, J; Cantatore, P
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Iron(II) induces changes in the conformation of mammalian mitochondrial DNA resulting in a reduction of its transcriptional rate

2000 | Journal article
DOI:

10.1016/S0014-5793(00)01768-3

Part of ISSN:

00145793

EID:

2-s2.0-0342954789

Contributors: Asín, J.; Pérez-Martos, A.; Fernández-Silva, P.; Montoya, J.; Andreu, A.L.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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The genetics of mitochondrial epilepsy

Revista De Neurologia
2000 | Journal article
WOSUID:

WOS:000086157000009

Contributors: Montoya, J; Playan, A; Alcaine, MJ; Solano, A; Fernandez-Silva, P; Enriquez, JA
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

The mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke- like episode syndrome-associated human mitochondrial tRNA(Leu(UUR)) mutation causes aminoacylation deficiency and concomitant reduced association of mRNA with ribosomes

2000 | Journal article
DOI:

10.1074/jbc.M908734199

Part of ISSN:

00219258

EID:

2-s2.0-0034705419

Contributors: Chomyn, A.; Enriquez, J.A.; Micol, V.; Fernandez-Silva, P.; Attardi, G.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Autonomous regulation in mammalian mitochondrial DNA transcription

1999 | Journal article
DOI:

10.1515/BC.1999.094

Part of ISSN:

14316730

EID:

2-s2.0-0345493790

Contributors: Enríquez, J.A.; Fernández-Sílva, P.; Montoya, J.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier
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Direct regulation of mitochondrial RNA synthesis by thyroid hormone

1999 | Journal article
Part of ISSN:

02707306

EID:

2-s2.0-0344097294

Contributors: Enríquez, J.A.; Fernández-Silva, P.; Garrido-Pérez, N.; López-Pérez, M.J.; Pérez-Martos, A.; Montoya, J.
Source: Self-asserted source
Patricio Fernández-Silva via Scopus - Elsevier

Direct regulation of mitochondrial RNA synthesis by thyroid hormone

Molecular and Cellular Biology
1999 | Journal article
WOSUID:

WOS:000077647100064

Contributors: Enriquez, JA; Fernandez-Silva, P; Garrido-Perez, N; Montoya, J
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain

Genomics
1998 | Magazine article
PMID:

9878253

Source: Self-asserted source
Patricio Fernández-Silva

Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain

Genomics
1998 | Journal article
WOSUID:

WOS:000077932000015

Contributors: Petruzzella, V; Tiranti, V; Fernandez, P; Ianna, P; Carrozzo, R; Zeviani, M
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease

Cell
1998 | Journal article
WOSUID:

WOS:000074205700009

Contributors: Casari, G; De Fusco, M; Ciarmatori, S; Zeviani, M; Mora, M; Fernandez, P; De Michele, G; Filla, A; Cocozza, S; Marconi, R et al.
Source: Self-asserted source
Patricio Fernández-Silva via ResearcherID

Spastic Paraplegia and OXPHOS Impairment Caused by Mutations in Paraplegin, a Nuclear-Encoded Mitochondrial Metalloprotease

Cell
1998 | Magazine article
PMID:

9635427

Source: Self-asserted source
Patricio Fernández-Silva
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Review activity for Redox biology. (1)