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sex hormone, oestrogen receptor, androgen receptor, endometrium, endometrial adenocarcinoma, endometriosis, pericyte, scarless healing
United Kingdom

Biography

Elected Fellow Society of Biology (FSB) 2011
Elected Fellow Academy of Medical Sciences (FMedSCi) 2012
Fellow ad eundem, Royal College of Obstetricians and Gynaecologists (FRCOG) 2015
Elected Fellow Royal Society of Edinburgh (FRSE) 2019
Elected Member of the Academy of Europe (Academia Europaea) 2022
Academy of Medical Sciences.
Nominations Committee 2023-
Registrar, 2016-2021
Academic Careers Committee 2012-2016
Section 5 Fellows appointment committee 2014-2016
Task group ‘Impact of Team Science on Career Progression’ 2014-2016: co-chair 2 year followup workshop 2018.
Clinical Fellows Interview Panel 2014
Medical Research Council
Population and Systems Medicine Board (PSMB) 2012-2016
Non-Clinical Training and Career Development Panel 2020-2024
Medals Award Committee 2020-
Society for Endocrinology
Science Committee. 2012-2016
Finance Committee 2014-2018

Activities

Employment (10)

University of Edinburgh: Edinburgh, Edinburgh, GB

2015-01-01 to present | Professor, Principal Investigator (MRC Centre for Inflammation Research)
Employment
Source: Self-asserted source
Philippa Saunders

University of Edinburgh: Edinburgh, Edinburgh, GB

2012-08-01 to 2018-12-31 | Director of Postgraduate Research (College of Medicine and Veterinary Medicine)
Employment
Source: Self-asserted source
Philippa Saunders

University of Edinburgh: Edinburgh, Edinburgh, GB

2011 to 2012 | Director, MRC Centre for Reproductive Health (MRC Centre for Reproductive Health)
Employment
Source: Self-asserted source
Philippa Saunders

University of Edinburgh: Edinburgh, Edinburgh, GB

2007 to 2011 | Head, The University of Edinburgh Centre for Reproductive Biology (University of Edinburgh Centre for Reproductive Biology)
Employment
Source: Self-asserted source
Philippa Saunders

University of Edinburgh: Edinburgh, Edinburgh, GB

2005 to 2011 | Honorary Professor (University of Edinburgh)
Employment
Source: Self-asserted source
Philippa Saunders

Medical Research Council: London, London, GB

1989 to 2011 | Programme Leader, MRC Human Reproductive Sciences Unit (MRC Human Reproductive Sciences Unit)
Employment
Source: Self-asserted source
Philippa Saunders

University of Edinburgh: Edinburgh, Edinburgh, GB

1998 to 2005 | Honorary Research Fellow (University of Edinburgh)
Employment
Source: Self-asserted source
Philippa Saunders

University of Edinburgh: Edinburgh, Edinburgh, GB

1987 to 1989 | Research Fellow (Department of Obstetrics and Gynaecology)
Employment
Source: Self-asserted source
Philippa Saunders

Zoological Society of London Institute of Zoology: London, London, GB

1984 to 1987 | Research Associate
Employment
Source: Self-asserted source
Philippa Saunders

University of Florida: Gainesville, FL, US

1981 to 1984 | Postdoctoral Associate (Department of Biochemistry)
Employment
Source: Self-asserted source
Philippa Saunders

Education and qualifications (1)

University of Cambridge: Cambridge, Cambridgeshire, GB

1981 | PhD Physiology
Education
Source: Self-asserted source
Philippa Saunders

Professional activities (5)

Faculty Opinions: London, GB

2016-02-05 to present | Faculty Member
Invited position
Source: check_circle
Faculty Opinions

Society for Endocrinology: London, GB

1987-01-01 to present | Ordinary
Membership
Source: Self-asserted source
Philippa Saunders

University of Edinburgh: Edinburgh, Scotland, GB

2022-02-15 | Tam Dalyell Prize For Public Engagement
Distinction
Source: Self-asserted source
Philippa Saunders

Academy of Medical Sciences: London, England, GB

2016-06-01 to 2021-06-30 | Registrar
Invited position
Source: Self-asserted source
Philippa Saunders

Society for Endocrinology: Bristol, GB

2019-11-13 | Society Medal
Distinction
Source: Self-asserted source
Philippa Saunders

Funding (15)

Advanced Pain Discovery Platform (APDP) ADVANTAGE

2022-06 to 2026-05 | Grant
UK Research and Innovation (London, GB)
GRANT_NUMBER:

MR/W002426/1

Source: Self-asserted source
Philippa Saunders

Identifying disease promoting macrophages and tissue-identity in endometriosis

2019-09 to 2022-08 | Grant
Medical Research Council (London, GB)
GRANT_NUMBER:

MR/S002456/1

Source: Self-asserted source
Philippa Saunders

Delivering Translational Opportunities From Edinburgh (DTOFE)

2018-03-01 to 2020-02-28 | Grant
Medical Research Council (London, GB)
GRANT_NUMBER: MC_PC_17159
Source: Self-asserted source
Philippa Saunders via DimensionsWizard

Mass Spectrometry imaging in translational endocrine research

2017-07-01 to 2023-01-01 | Grant
Wellcome Trust (London, GB)
GRANT_NUMBER:

grant.202794/Z/16/Z

Source: Self-asserted source
Philippa Saunders via DimensionsWizard

CB2 agonists as a novel treatment for women with endometriosis-associated pain

2017-01 to 2018-12 | Grant
Medical Research Council (LONDON, GB)
GRANT_NUMBER:

MR/P00265X/1

Source: Self-asserted source
Philippa Saunders

Androgens and women’s health: developing new therapies for endometriosis.

2016-10 to 2021-02 | Grant
Medical Research Council (London, GB)
Source: Self-asserted source
Philippa Saunders

iNKT cells as drivers for preterm labour

Source: Self-asserted source
Philippa Saunders via DimensionsWizard
grade
Preferred source (of 2)‎

Integrated multi-dimensional molecular organ imaging

Source: Self-asserted source
Philippa Saunders via DimensionsWizard

Developmental Clinical Studies - Reversing endometrial glucocorticoid deficiency in heavy menstrual bleeding

Source: Self-asserted source
Philippa Saunders via DimensionsWizard
grade
Preferred source (of 2)‎

Impact of sex steroids on immune and vascular cell function in the reproductive system

Source: Self-asserted source
Philippa Saunders via DimensionsWizard

MRC Centre for Reproductive Health

Source: Self-asserted source
Philippa Saunders via DimensionsWizard
grade
Preferred source (of 2)‎

Impact of oestrogens and androgens on immune cells, the vasculature and reproductive stroma

2011-04 to 2017-03 | Grant
Medical Research Council (Swindon, GB)
GRANT_NUMBER:

G1100356/1

Source: Self-asserted source
Philippa Saunders

The role of androgens in endometrial proliferation and differentiation.

Source: Self-asserted source
Philippa Saunders via DimensionsWizard

Androgens and male fertility

Source: Self-asserted source
Philippa Saunders via DimensionsWizard

Oestrogen receptors and reproductive competence

Source: Self-asserted source
Philippa Saunders via DimensionsWizard
grade
Preferred source (of 2)‎

Works (50 of 348)

Items per page:
Page 1 of 7

Exploring pre-diagnosis hospital contacts in women with endometriosis using ICD-10: a Danish case–control study

Human Reproduction
2025-02-01 | Journal article
Contributors: Anna Melgaard; Claus Høstrup Vestergaard; Ulrik Schiøler Kesmodel; Bettina Wulff Risør; Axel Forman; Krina T Zondervan; Mintu Nath; Dolapo Ayansina; Philippa T K Saunders; Andrew W Horne et al.
Source: check_circle
Crossref

Endometriosis: cannabidiol therapy for symptom relief

Trends in Pharmacological Sciences
2024-12 | Journal article
Contributors: Lucy H.R. Whitaker; Clive Page; Charles Morgan; Andrew W. Horne; Philippa T.K. Saunders
Source: check_circle
Crossref

Endometriosis: recent advances that could accelerate diagnosis and improve care

Trends in Molecular Medicine
2024-09 | Journal article
Contributors: Meaghan J. Griffiths; Andrew W. Horne; Douglas A. Gibson; Neil Roberts; Philippa T.K. Saunders
Source: check_circle
Crossref

Dynamic roles of ILC3 in endometrial repair and regeneration

2024-08-10 | Preprint
Contributors: Antonia O. Cuff; Ee Von Woon; Thomas Bainton; Brendan Browne; Phoebe M. Kirkwood; Frances Collins; Douglas A. Gibson; Philippa T.K. Saunders; Andrew W. Horne; Mark R. Johnson et al.
Source: check_circle
Crossref

Microbiome: The impact of the microbiota–gut–brain axis on endometriosis-associated symptoms: mechanisms and opportunities for personalised management strategies

Reproduction and Fertility
2024-05-13 | Journal article
Contributors: Francesca Hearn-Yeates; Andrew W Horne; Siobhain M O’Mahony; Philippa T K Saunders
Source: check_circle
Crossref

Investigating endometriosis development and endometriosis-related pain over time and in relation to estrogen in a laparoscopic mouse model

2024-03-30 | Preprint
Contributors: Daniëlle Peterse; Alejandra Verhassel; Amelie Fassbender; F. O Dorien; Arne Vanhie; Anne-Sophie Van Rompuy; Philippa Saunders; Joris Vriens; Thomas M. D’Hooghe
Source: check_circle
Crossref

Symptom tracking in endometriosis using digital technologies: Knowns, unknowns, and future prospects.

Cell reports. Medicine
2023-09-01 | Journal article
Contributors: Edgley K; Horne AW; Saunders PTK; Tsanas A
Source: Self-asserted source
Philippa Saunders

Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function.

Communications biology
2023-08-16 | Journal article | Author
Contributors: Sally-Anne Mortlock; Sahar Houshdaran; Kosti I; NILUFER RAHMIOGLU; Nezhat C; Allison Vitonis; Andrews SV; Grosjean P; Paranjpe M; Andrew Horne et al.
Source: Self-asserted source
Philippa Saunders

The Influence of Sex Hormones in Liver Function and Disease

Cells
2023-06-11 | Journal article
Contributors: Alvile Kasarinaite; Matthew Sinton; Philippa T. K. Saunders; David C. Hay
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Editorial: Menstruation: Myths, mechanisms, models and malfunctions

Frontiers in Reproductive Health
2023-04-03 | Journal article
Part of ISSN: 2673-3153
Contributors: Fiona L. Cousins; Philippa T. K. Saunders
Source: Self-asserted source
Philippa Saunders

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Nature genetics
2023-03-13 | Journal article
Contributors: NILUFER RAHMIOGLU; Mortlock S; Ghiasi M; Peter Loof Møller; Stefansdottir L; Galarneau G; Turman C; Danning R; Matthew H. Law; Yadav Sapkota et al.
Source: Self-asserted source
Philippa Saunders

Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis

International Journal of Molecular Sciences
2023-01-26 | Journal article
Contributors: Miguel A. Tejada; Carles Antunez; Paulina Nunez-Badinez; Bianca De Leo; Philippa T. Saunders; Katy Vincent; Antonio Cano; Jens Nagel; Raul Gomez
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

eLife
2022-12-16 | Journal article
Contributors: Phoebe M Kirkwood; Douglas A Gibson; Isaac Shaw; Ross Dobie; Olympia Kelepouri; Neil C Henderson; Philippa TK Saunders
Source: check_circle
Crossref

A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization.

Frontiers in endocrinology
2022-11-16 | Journal article
Contributors: Shaw IW; Kirkwood PM; Rebourcet D; Cousins FL; Ainslie RJ; Livingstone DEW; Smith LB; Saunders PTK; Gibson DA
Source: Self-asserted source
Philippa Saunders

Endometriosis among African women

Reproduction and Fertility
2022-07-01 | Journal article
Contributors: Ezekiel O Mecha; Joseph N Njagi; Roselydiah N Makunja; Charles O A Omwandho; Philippa T K Saunders; Andrew W Horne
Source: check_circle
Crossref

A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation

2022-05-30 | Preprint
Contributors: I.W. Shaw; P.M. Kirkwood; D. Rebourcet; F.L. Cousins; R.J. Ainslie; D.E.W. Livingstone; L.B. Smith; P.T.K. Saunders; D.A. Gibson
Source: check_circle
Crossref

Insights from genomic studies on the role of sex steroids in the aetiology of endometriosis

Reproduction and Fertility
2022-04-01 | Journal article
Contributors: Philippa T K Saunders
Source: check_circle
Crossref

Improving the diagnosis of endometrial hyperplasia using computerized analysis and immunohistochemical biomarkers

2022-03-08 | Preprint
Contributors: Peter A Sanderson; Arantza Esnal-Zufiaurre; Mark J Arends; C Simon Herrington; Frances Collins; Alistair RW Williams; Philippa TK Saunders
Source: check_circle
Crossref

Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain

Biomedicines
2022-02-21 | Journal article
Contributors: Miguel A. Tejada; Ana I. Santos-Llamas; Lesley Escriva; Juan J. Tarin; Antonio Cano; Maria J. Fernández-Ramírez; Paulina Nunez-Badinez; Bianca De Leo; Philippa T. K. Saunders; Victor Vidal et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Female Reproductive Systems: Hormone Dependence and Receptor Expression.

Advances in experimental medicine and biology
2022-01 | Journal article
Contributors: Kuan KKW; Saunders PTK
Source: Self-asserted source
Philippa Saunders via Europe PubMed Central

Mechanisms of Scarless Repair at Time of Menstruation: Insights From Mouse Models

Frontiers in Reproductive Health
2022-01-06 | Journal article
Part of ISSN: 2673-3153
Source: Self-asserted source
Philippa Saunders

Single cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

2021-12-21 | Preprint
Contributors: Phoebe M Kirkwood; Douglas A Gibson; Isaac Shaw; Ross Dobie; Olympia Kelepouri; Neil C Henderson; Philippa TK Saunders
Source: check_circle
Crossref

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

Science Immunology
2021-11-19 | Journal article
Part of ISSN: 2470-9468
Source: Self-asserted source
Philippa Saunders

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

Pain
2021-09 | Journal article
Part of ISSN: 0304-3959
Part of ISSN: 1872-6623
Source: Self-asserted source
Philippa Saunders

Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

EBioMedicine
2021-07 | Journal article
Part of ISSN: 2352-3964
Source: Self-asserted source
Philippa Saunders

Insights Gained from Genomic Studies on the Role of Sex Steroids in the Aetiology of Endometriosis

2021-07-02 | Other
Contributors: Philippa TK Saunders
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Cell
2021-05 | Journal article
Contributors: Philippa T.K. Saunders; Andrew W. Horne
Source: check_circle
Crossref

Single‐cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium

The FASEB Journal
2021-04 | Journal article
Contributors: Phoebe M. Kirkwood; Douglas A. Gibson; James R. Smith; John R. Wilson‐Kanamori; Olympia Kelepouri; Arantza Esnal‐Zufiaurre; Ross Dobie; Neil C. Henderson; Philippa T. K. Saunders
Source: check_circle
Crossref

Pelvic pain correlates with peritoneal macrophage abundance not endometriosis

Reproduction and Fertility
2021-03-23 | Journal article
Part of ISSN: 2633-8386
Source: Self-asserted source
Philippa Saunders

Dichloroacetate as a possible treatment for endometriosis-associated pain: a single-arm open-label exploratory clinical trial (EPiC).

Pilot and feasibility studies
2021-03-12 | Journal article
Source: Self-asserted source
Philippa Saunders
grade
Preferred source (of 2)‎

Targeting colony stimulating factor-1 receptor signalling to treat ectopic pregnancy

Scientific Reports
2020-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Philippa Saunders
grade
Preferred source (of 2)‎

Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet

Molecular and Cellular Endocrinology
2020-08 | Journal article
Part of ISSN: 0303-7207
Source: Self-asserted source
Philippa Saunders

Single cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium

2020-08-20 | Preprint
Contributors: PM Kirkwood; DA Gibson; JR Smith; JR Wilson-Kanamori; O Kelepouri; A Esnal-Zufiaurre; R Dobie; NC Henderson; PTK Saunders
Source: check_circle
Crossref

Peritoneal macrophage phenotype correlates with pain scores in women with suspected endometriosis

2020-08-03 | Preprint
Contributors: Douglas A Gibson; Frances Collins; Bianca De Leo; Andrew W Horne; Philippa TK Saunders
Source: check_circle
Crossref

Research priorities for endometriosis differ among patients, clinicians, and researchers

American Journal of Obstetrics and Gynecology
2020-06 | Journal article
Contributors: Paula C. Brady; Andrew W. Horne; Philippa T.K. Saunders; Ann M. Thomas; Stacey A. Missmer; Leslie V. Farland
Source: check_circle
Crossref

Androgens, oestrogens and endometrium: a fine balance between perfection and pathology.

The Journal of endocrinology
2020-06-01 | Journal article
Source: Self-asserted source
Philippa Saunders

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages.

Science immunology
2020-06-01 | Journal article
Source: Self-asserted source
Philippa Saunders

Profiling the expression and function of oestrogen receptor isoform ER46 in human endometrial tissues and uterine natural killer cells.

Human reproduction (Oxford, England)
2020-03 | Journal article
Contributors: Gibson DA; Esnal-Zufiaurre A; Bajo-Santos C; Collins F; Critchley HOD; Saunders PTK
Source: Self-asserted source
Philippa Saunders via Europe PubMed Central

A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1)

PLOS ONE
2020-01-17 | Journal article
Part of ISSN: 1932-6203
Source: Self-asserted source
Philippa Saunders

Endometriosis-Associated Pain - Do Preclinical Rodent Models Provide a Good Platform for Translation?

Advances in anatomy, embryology, and cell biology
2020-01-01 | Journal article
Source: Self-asserted source
Philippa Saunders

What Have We Learned from Animal Models of Endometriosis and How Can We Use the Knowledge Gained to Improve Treatment of Patients?

Advances in anatomy, embryology, and cell biology
2020-01-01 | Journal article
Source: Self-asserted source
Philippa Saunders

Repurposing dichloroacetate for the treatment of women with endometriosis

Proceedings of the National Academy of Sciences
2019-12-17 | Journal article
Contributors: Andrew W. Horne; S. Furquan Ahmad; Roderick Carter; Ioannis Simitsidellis; Erin Greaves; Chloe Hogg; Nicholas M. Morton; Philippa T. K. Saunders
Source: check_circle
Crossref

Snapshot: Endometriosis

Cell
2019-12-12 | Journal article
Source: Self-asserted source
Philippa Saunders

The ERβ5 splice variant increases oestrogen responsiveness of ERαpos Ishikawa cells.

Endocrine-related cancer
2019-11-01 | Journal article
Source: Self-asserted source
Philippa Saunders

Profiling the expression and function of ER46 in human endometrial tissues and uterine NK cells

2019-09-23 | Other
Contributors: Douglas A Gibson; Arantza Esnal-Zufiaurre; Cristina Bajo-Santos; Frances Collins; Hilary OD Critchley; Philippa TK Saunders
Source: check_circle
Crossref

Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2019-07 | Journal article
Contributors: Forster R; Sarginson A; Velichkova A; Hogg C; Dorning A; Horne AW; Saunders PTK; Greaves E
Source: Self-asserted source
Philippa Saunders via Europe PubMed Central

Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus.

The Journal of endocrinology
2019-07 | Journal article
Contributors: Simitsidellis I; Esnal Zufiaurre A; Kelepouri O; O'Flaherty E; Gibson DA; Saunders PT
Source: Self-asserted source
Philippa Saunders via Europe PubMed Central

Androgens and androgen receptor: Above and beyond

Molecular and Cellular Endocrinology
2018 | Journal article
EID:

2-s2.0-85042620743

Contributors: Gibson, D.A.; Saunders, P.T.K.; McEwan, I.J.
Source: Self-asserted source
Philippa Saunders via Scopus - Elsevier

Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age

Fertility and Sterility
2018 | Journal article
EID:

2-s2.0-85041622371

Contributors: Gibson, D.A.; Simitsidellis, I.; Kelepouri, O.; Critchley, H.O.D.; Saunders, P.T.K.
Source: Self-asserted source
Philippa Saunders via Scopus - Elsevier

Endometrial intracrinology: Oestrogens, androgens and endometrial disorders

International Journal of Molecular Sciences
2018 | Journal article
EID:

2-s2.0-85055581994

Contributors: Gibson, D.A.; Simitsidellis, I.; Collins, F.; Saunders, P.T.K.
Source: Self-asserted source
Philippa Saunders via Scopus - Elsevier
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Items per page:
Page 1 of 7

Peer review (55 reviews for 14 publications/grants)

Review activity for Cell and tissue research. (2)
Review activity for Communications biology. (2)
Review activity for Endocrine reviews. (2)
Review activity for F1000Research. (2)
Review activity for Faculty Opinions (33)
Review activity for iScience. (1)
Review activity for Journal of inflammation. (1)
Review activity for Journal of translational medicine. (1)
Review activity for Nature communications (1)
Review activity for Nature genetics. (1)
Review activity for Science translational medicine. (1)
Review activity for Scientific data. (1)
Review activity for The journal of clinical endocrinology and metabolism. (5)
Review activity for UK Research and Innovation (2)