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Scopus Author ID: 37034235700

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Employment (7)

Centre of Medicines Discovery: Oxford, Oxfordshire, GB

2022-04-01 to present | Team leader: enzyme crystallography (Nuffield Department of Medicine)
Employment
Source: Self-asserted source
Lizbe Koekemoer

Centre of Medicines Discovery: Oxford OX3 (Oxfordshire), Oxfordshire, GB

2021-01-01 to 2022-03-31 | Postdoctoral Researcher (Nuffield Department of Medicine)
Employment
Source: Self-asserted source
Lizbe Koekemoer

Structural Genomics Consortium: Oxford OX3 (Oxfordshire), Oxfordshire, GB

2019-02-05 to 2020-12-31 | Postdoctoral Researcher (Nuffield Department of Medicine)
Employment
Source: Self-asserted source
Lizbe Koekemoer

H3D, University of Cape Town: Rondebosch, Western Cape, ZA

2016-09-05 to 2019-01-31 | Postdoctoral fellow (H3D)
Employment
Source: Self-asserted source
Lizbe Koekemoer

Stellenbosch University: Matieland, Western Cape, ZA

2012-03-01 to 2016-08-31 | Postdoctoral fellow (Biochemistry)
Employment
Source: Self-asserted source
Lizbe Koekemoer

Unilever SA pty Ltd: Durban, Kwazulu Natal, ZA

2008-05-01 to 2008-05-31 | Evaluation and Claims Assistant manager (Home and Personal Care)
Employment
Source: Self-asserted source
Lizbe Koekemoer

Unilever SA pty Ltd: Durban, Kwazulu-Natal, ZA

2006-04-01 to 2008-04-30 | Evaluation and Claims Technologist (Home and Personal Care)
Employment
Source: Self-asserted source
Lizbe Koekemoer

Education and qualifications (4)

Stellenbosch University Faculty of Science: Matieland, ZA

2008-06-01 to 2011-12-01 | PhD (Biochemistry)
Education
Source: Self-asserted source
Lizbe Koekemoer

Stellenbosch University Faculty of Science: Matieland, ZA

2004-01-01 to 2006-03-30 | M.Sc (Chemistry)
Education
Source: Self-asserted source
Lizbe Koekemoer

Stellenbosch University Faculty of Science: Matieland, ZA

2003-01-01 to 2003-12-01 | Hons B.Sc (Chemistry) cum laude (Chemistry)
Education
Source: Self-asserted source
Lizbe Koekemoer

Stellenbosch University: Matieland, Western Cape, ZA

2000-01-01 to 2002-12-01 | B.Sc (Bio-organic chemistry)
Education
Source: Self-asserted source
Lizbe Koekemoer

Funding (5)

Developing the Next Generation of β-lactamase Inhibitors and Monobactam Antibiotics

2017-03 to 2019-02 | Grant
Newton Fund/SA MRC (Cape town, GB)
Part of GRANT_NUMBER:

26630
Source: Self-asserted source
Lizbe Koekemoer

Elucidating the Structural basis and Biochemical Mechanism of Allosteric Regulation in Cofactor Biosynthetic Enzyme

2014-06 to 2017-05 | Grant
Department of Science and Technology, Ministry of Science and Technology (Cape town, IN)
Part of GRANT_NUMBER:

DST/INT/SOUTH AFRICA/P-04/2014
Source: Self-asserted source
Lizbe Koekemoer

Characterization and inhibition of PanK enzymes

2013-03 to 2016-02 | Award
National Research Foundation (Pretoria, ZA)
GRANT_NUMBER:

85259
Source: Self-asserted source
Lizbe Koekemoer

Characterization of the type III pantothenate kinase encoded by the coaX gene of Mycobacteria tuberculosis, and development of inhibitors directed at this activity.

2012-03 to 2013-02 | Award
Universiteit Stellenbosch (Stellenbosch, ZA)
Source: Self-asserted source
Lizbe Koekemoer

Pantothenate kinase: Characterization of a fourth type of the enzyme and identification of type-specific PanK inhibitors

2008-03 to 2011-12 | Award
National Research Foundation (Pretoria, ZA)
Source: Self-asserted source
Lizbe Koekemoer

Works (37)

Heterologous production, purification and crystallization of 24C-sterol methyltransferase fromCandida albicans

2025-02-05 | Preprint
DOI: 10.1101/2025.02.05.636639
Contributors: Nokwanda S. Mpontshane; Michael Fairhead; Diederik J. Opperman; Rodney Hart; Valmary van Breda; Frank von Delft; Lizbé Koekemoer; Carmien Tolmie
Source: check_circle
Crossref

Crystal structure of Fatty Acid Thioesterase A bound by 129 fragments provides diverse development opportunities

2024-12-25 | Preprint
DOI: 10.1101/2024.12.23.629660
Contributors: Ekaterina Kot; Matteo P. Ferla; Patricia H. Hollinshead; Charlie W.E. Tomlinson; Daren Fearon; Jasmin C. Aschenbrenner; Lizbé Koekemoer; Max Winokan; Michael Fairhead; Xiaomin Ni et al.
Source: check_circle
Crossref

Crystallisation of West Nile virus NS2B-NS3 protease in P64 (PDB ID:8CO8) v1

2024-10-18 | Preprint
DOI: 10.17504/protocols.io.x54v9293zl3e/v1
Contributors: blake.h.balcomb not provided; Peter Marples; Lizbé Koekemoer; Daren Fearon; michael fairhead
Source: check_circle
Crossref

Zika virus NS2B-NS3 protease binding assay for compound screen using grating-coupled interferometry v1

2024-10-18 | Preprint
DOI: 10.17504/protocols.io.n92ld8o79v5b/v1
Contributors: Eda Capkin; Korvus Wang; Xiaomin Ni; Lizbé Koekemoer; warren.thompson not provided; Frank von Delft; Mary-Ann Xavier
Source: check_circle
Crossref

Crystallisation of Enterovirus D68 3C protease v1

2024-10-02 | Preprint
DOI: 10.17504/protocols.io.rm7vzjp45lx1/v1
Contributors: ryan Lithgo; Peter Marples; Lizbé Koekemoer; Daren Fearon
Source: check_circle
Crossref

Crystallisation of SARS-CoV-2 N Protein v1

2024-10-02 | Preprint
DOI: 10.17504/protocols.io.8epv5r8ydg1b/v1
Contributors: Peter Marples; Lizbé Koekemoer; Daren Fearon
Source: check_circle
Crossref

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening

2024-08-23 | Preprint
DOI: 10.1101/2024.08.23.609196
Contributors: Jasmin C. Aschenbrenner; Andre Schutzer de Godoy; Michael Fairhead; Charles W.E. Tomlinson; Max Winokan; Blake H. Balcomb; Eda Capkin; Anu V. Chandran; Mathew Golding; Lizbe Koekemoer et al.
Source: check_circle
Crossref

Crystallisation protocol for SARS-CoV-2 nsp3 macrodomain in P43 v1

2024-08-15 | Preprint
DOI: 10.17504/protocols.io.e6nvw1qb2lmk/v1
Contributors: Jasmin Aschenbrenner; Peter Marples; Charlie Tomlinson; Lizbé Koekemoer; Daren Fearon
Source: check_circle
Crossref

Crystallisation of Enterovirus coxsackievirus A16 2A protease v1

2024-06-26 | Preprint
DOI: 10.17504/protocols.io.q26g715eqgwz/v1
Contributors: ryan Lithgo; Peter Marples; Lizbé Koekemoer; Daren Fearon
Source: check_circle
Crossref

Crystallisation of MERS-CoV Mpro v1

2024-06-26 | Preprint
DOI: 10.17504/protocols.io.8epv5rn84g1b/v1
Contributors: blake.h.balcomb not provided; Peter Marples; Lizbé Koekemoer; Daren Fearon; Charlie Tomlinson
Source: check_circle
Crossref

Crystallisation of SARS-CoV-2 Mpro v1

2024-06-26 | Preprint
DOI: 10.17504/protocols.io.261ge5emyg47/v1
Contributors: blake.h.balcomb not provided; Peter Marples; Lizbé Koekemoer; Daren Fearon; Charlie Tomlinson
Source: check_circle
Crossref

Crystallisation protocol for SARS-CoV-2 nsp3 macrodomain in P1 21 1 v1

2024-06-24 | Preprint
DOI: 10.17504/protocols.io.261ge5ej7g47/v1
Contributors: Jasmin Aschenbrenner; Peter Marples; Lizbé Koekemoer; Charlie Tomlinson; Daren Fearon
Source: check_circle
Crossref

Crystallization of Enterovirus coxsackievirus A16 2A protease v1

2024-04-26 | Preprint
DOI: 10.17504/protocols.io.3byl49kdzgo5/v1
Contributors: ryan Lithgo; Peter Marples; Lizbé Koekemoer; Daren Fearon
Source: check_circle
Crossref

Crystallization of Enterovirus D68 3C protease v1

2024-04-26 | Preprint
DOI: 10.17504/protocols.io.5qpvoky29l4o/v1
Contributors: ryan Lithgo; Peter Marples; Lizbé Koekemoer; Daren Fearon
Source: check_circle
Crossref

Crystallization of MERS-CoV Mpro v1

2024-04-26 | Preprint
DOI: 10.17504/protocols.io.ewov194x7lr2/v1
Contributors: blake.h.balcomb not provided; Peter Marples; Lizbé Koekemoer; Daren Fearon; Charlie Tomlinson
Source: check_circle
Crossref

Crystallization of SARS-CoV-2 Mpro v1

2024-04-26 | Preprint
DOI: 10.17504/protocols.io.kqdg326y7v25/v1
Contributors: blake.h.balcomb not provided; Peter Marples; Lizbé Koekemoer; Daren Fearon; Charlie Tomlinson
Source: check_circle
Crossref

Crystallization of SARS-CoV-2 N Protein v1

2024-04-26 | Preprint
DOI: 10.17504/protocols.io.4r3l2q4b3l1y/v1
Contributors: Peter Marples; Lizbé Koekemoer; Daren Fearon
Source: check_circle
Crossref

Crystallization of SARS-CoV-2 nsp15 NendoU v1

2024-04-26 | Preprint
DOI: 10.17504/protocols.io.36wgqn4yogk5/v1
Contributors: Peter Marples; Daren Fearon; Lizbé Koekemoer; Andre Schutzer de Godoy
Source: check_circle
Crossref

Crystallization of Zika virus NS3 helicase v1

2024-04-26 | Preprint
DOI: 10.17504/protocols.io.e6nvw152dlmk/v1
Contributors: Andre Schutzer de Godoy; Peter Marples; Lizbé Koekemoer
Source: check_circle
Crossref

A selection of Golden Gate vectors to simplify recombinant protein production inEscherichia coli

2024-02-13 | Preprint
DOI: 10.1101/2024.02.13.579886
Contributors: Michael Fairhead; Lizbe Koekemoer; Eleanor Williams; Frank von Delft
Source: check_circle
Crossref

Efficient large-scale exploration of fragment hit progression by exploiting binding-site purification of actives (B-SPA) through combining multi-step array synthesis and HT crystallography.

2024-02-09 | Preprint
DOI: 10.26434/chemrxiv-2023-6m2s0-v2
Contributors: Harold Grosjean; Anthony Aimon; Storm Hassell-Hart; Warren Thompson; Lizbé Koekemoer; James Bennett; Cameron Anderson; Conor Wild; William Bradshaw; Edward A FitzGerald et al.
Source: check_circle
Crossref

Crystallization of Zika virus NS2B-NS3 protease v1

2024-01-08 | Preprint
DOI: 10.17504/protocols.io.eq2lyj51mlx9/v1
Contributors: xiaomin.ni not provided; Peter Marples; Daren Fearon; Lizbé Koekemoer
Source: check_circle
Crossref

ASAP protocol: Crystallization of Enterovirus D68 3C protease (PDB code 8CNX) v1

2023-12-19 | Preprint
DOI: 10.17504/protocols.io.n92ldm6jnl5b/v1
Contributors: ryan.lithgo not provided; Peter Marples; daren.fearon not provided; Lizbé Koekemoer
Source: check_circle
Crossref

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

Science
2023-11-10 | Journal article
DOI: 10.1126/science.abo7201
Contributors: Melissa L. Boby; Daren Fearon; Matteo Ferla; Mihajlo Filep; Lizbé Koekemoer; Matthew C. Robinson; John D. Chodera; Alpha A. Lee; Nir London; Annette von Delft et al.
Source: check_circle
Crossref

ASAP protocol: Crystallization of Enterovirus A71 3C protease (PDB code 8CNY) v1

2023-09-07 | Preprint
DOI: 10.17504/protocols.io.yxmvm3e89l3p/v1
Contributors: ryan.lithgo not provided; Peter Marples; daren.fearon not provided; Lizbé Koekemoer
Source: check_circle
Crossref

High-throughput crystallography for rapid fragment growth from crude arrays by low-cost robotics

2023-03-28 | Preprint
DOI: 10.26434/chemrxiv-2023-6m2s0
Contributors: Harold Grosjean; Anthony Aimon; Storm Hassell-Hart; Warren Thompson; Lizbé Koekemoer; James Bennett; Cameron Anderson; Edward A FitzGerald; Tobias Krojer; Anthony Bradley et al.
Source: check_circle
Crossref

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

2022-07-26 | Preprint
DOI: 10.1101/2022.07.26.501559
Contributors: Mingda Ye; Mpho Makola; Joseph A. Newman; Michael Fairhead; Elizabeth Maclean; Nathan D. Wright; Lizbé Koekemoer; Andrew Thompson; Gustavo A. Bezerra; Gangshun Yi et al.
Source: check_circle
Crossref

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity

Journal of Medicinal Chemistry
2022-05-02 | Journal article
DOI: 10.1021/acs.jmedchem.2c00266
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Lizbe Koekemoer

Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds

ChemMedChem
2022-04-05 | Journal article
DOI: 10.1002/cmdc.202100641
Part of ISSN: 1860-7179
Part of ISSN: 1860-7187
Source: Self-asserted source
Lizbe Koekemoer

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Cell Stem Cell
2022-02 | Journal article
DOI: 10.1016/j.stem.2021.12.010
Part of ISSN: 1934-5909
Source: Self-asserted source
Lizbe Koekemoer

The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity

ACS Chemical Biology
2021-11-19 | Journal article
DOI: 10.1021/acschembio.1c00535
Part of ISSN: 1554-8929
Part of ISSN: 1554-8937
Source: Self-asserted source
Lizbe Koekemoer

The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting

Acta Crystallographica Section D Structural Biology
2021-01-01 | Journal article
DOI: 10.1107/s2059798320014114
Part of ISSN: 2059-7983
Source: Self-asserted source
Lizbe Koekemoer
grade
Preferred source (of 2)‎

Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics

[]
2020-10-30 | Preprint
DOI: 10.1101/2020.10.29.339317
Source: Self-asserted source
Lizbe Koekemoer
grade
Preferred source (of 2)‎

Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of β-Lactam Target-Mediated Resistance

Journal of Molecular Biology
2019 | Journal article
DOI: 10.1016/j.jmb.2019.07.010
EID:

2-s2.0-85068829612
Contributors: Bellini, D.; Koekemoer, L.; Newman, H.; Dowson, C.G.
Source: Self-asserted source
Lizbe Koekemoer via Scopus - Elsevier

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity.

Antimicrobial agents and chemotherapy
2015 | Journal article
DOI: 10.1128/aac.04970-14
PMID: 25845876
PMC: PMC4432145
Contributors: Macuamule CJ; Tjhin ET; Jana CE; Barnard L; Koekemoer L; de Villiers M; Saliba KJ; Strauss E
Source: Self-asserted source
Lizbe Koekemoer via Europe PubMed Central
grade
Preferred source (of 2)‎

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.

The FEBS journal
2014-10 | Journal article
DOI: 10.1111/febs.13013
PMID: 25156889
Contributors: de Villiers M; Barnard L; Koekemoer L; Snoep JL; Strauss E
Source: Self-asserted source
Lizbe Koekemoer via Europe PubMed Central
grade
Preferred source (of 2)‎

3-Fluoroaspartate and pyruvoyl-dependant aspartate decarboxylase: exploiting the unique characteristics of fluorine to probe reactivity and binding.

Chemistry (Weinheim an Der Bergstrasse, Germany)
2010-09 | Journal article
DOI: 10.1002/chem.201000622
PMID: 20645337
Contributors: de Villiers J; Koekemoer L; Strauss E
Source: Self-asserted source
Lizbe Koekemoer via Europe PubMed Central
grade
Preferred source (of 2)‎
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