Personal information

Websites & social links

Lu's website

Other IDs

ResearcherID: G-4521-2014

Keywords

pre-mRNA splicing, RNA biology, Gene Editing, Gene Therapy

Countries

United States

Activities

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Employment (5)

PerkinElmer Inc: Waltham, MA, US

2021-03-21 to present | Principal Scientist (Molecular Diagnostics)
Employment
Source: Self-asserted source
Zhixiang Lu

Harvard Medical School: Boston, MA, US

2018-06-01 to 2021-03-19 | Staff Scientist (systems biology)
Employment
Source: Self-asserted source
Zhixiang Lu

UCLA Life Sciences: Los Angeles, CA, US

2015-08-01 to 2016-10-30 | Project Scientist (MIMG)
Employment
Source: Self-asserted source
Zhixiang Lu

University of California Los Angeles: Los Angeles, CA, US

2013-01-01 to 2015-07-31 | PostDoc (MIMG)
Employment
Source: Self-asserted source
Zhixiang Lu

University of Iowa Healthcare: Iowa City, IA, US

2009-08-01 to 2012-12-31 | PostDoc Researcher (Internal Medicine)
Employment
Source: Self-asserted source
Zhixiang Lu

Education and qualifications (2)

Kunming Institute of Zoology Chinese Academy of Sciences: Kunming, Yunnan, CN

2004-09-01 to 2009-07-01 | Ph.D. (Molecular genetics and Evolution)
Education
Source: Self-asserted source
Zhixiang Lu

Wuhan University: Wuhan, Hubei, CN

2000-09-01 to 2004-07-01 | B.S. (College of Life Sciences)
Education
Source: Self-asserted source
Zhixiang Lu

Works (29)

Analytical Methods to Evaluate RNA Circularization Efficiency

ELECTROPHORESIS
2024-11 | Journal article
DOI: 10.1002/elps.202400067
Contributors: Yali Sun; Anis H. Khimani; Yanhong Tong; Zhi‐xiang Lu
Source: check_circle
Crossref

Importance of a reference ladder in analytical testing of CRISPR HDR donor ssDNA templates

BioTechniques
2024-10-28 | Journal article
DOI: 10.1080/07366205.2024.2429308
Contributors: Zhi-xiang Lu; Anis H. Khimani; Yanhong Tong
Source: check_circle
Crossref

A novel dual probe-based method for mutation detection using isothermal amplification

PLOS ONE
2024-10-22 | Journal article
DOI: 10.1371/journal.pone.0309541
Contributors: Nidhi Nandu; Padmapriya P. Banada; Michael Miller; Yanhong Tong; Zhi-xiang Lu
Source: check_circle
Crossref

A dual‐reference study design for understanding and improving AAV genome size analysis

ELECTROPHORESIS
2024-09 | Journal article
DOI: 10.1002/elps.202400011
Contributors: Yali Sun; Zhi‐xiang Lu; Michael Miller; Ying Valcour; Anis H Khimani; Jana Bauer; Michael Salomon; Yanhong Tong
Source: check_circle
Crossref

A Novel Dual Probe-based Method for Mutation Detection using Isothermal Amplification

2024-03-27 | Preprint
DOI: 10.1101/2024.03.27.586979
Contributors: Nidhi Nandu; Michael Miller; Yanhong Tong; Zhi-xiang Lu
Source: check_circle
Crossref

Analytical Methods and Platforms for circRNA Vector Engineering to Improve Circularization Efficiency

2024-03-27 | Preprint
DOI: 10.1101/2024.03.25.586602
Contributors: Yali Sun; Anis H. Khimani; Yanhong Tong; Zhi-xiang Lu
Source: check_circle
Crossref

Application of microfluidic chip electrophoresis for high-throughput nucleic acid fluorescence fragment analysis assays

NAR Genomics and Bioinformatics
2023-01-10 | Journal article
DOI: 10.1093/nargab/lqad011
Contributors: Yali Sun; Zhi-xiang Lu; Michael Miller; Thomas Perroud; Yanhong Tong
Source: check_circle
Crossref

A Semi-Quantitative Isothermal Diagnostic Assay Utilizing Competitive Amplification

Analytical Chemistry
2021-07-13 | Journal article
DOI: 10.1021/acs.analchem.1c01576
Part of ISSN: 0003-2700
Part of ISSN: 1520-6882
Contributors: Zhixiang Lu; Christopher Mancuso; Zhi-Xiang Lu; Jason Qian; Sarah Boswell; Michael Springer
Source: Self-asserted source
Zhixiang Lu

An enhanced isothermal amplification assay for viral detection

Nature Communications
2020-11-20 | Journal article
DOI: 10.1038/s41467-020-19258-y
Contributors: Jason Qian; Sarah A. Boswell; Christopher Chidley; Zhi-xiang Lu; Mary E. Pettit; Benjamin L. Gaudio; Jesse M. Fajnzylber; Ryan T. Ingram; Rebecca H. Ward; Jonathan Z. Li et al.
Source: check_circle
Crossref

Barcoded microbial system for high-resolution object provenance

Science
2020-06-05 | Journal article
DOI: 10.1126/science.aba5584
Contributors: Jason Qian; Zhi-xiang Lu; Christopher P. Mancuso; Han-Ying Jhuang; Rocío del Carmen Barajas-Ornelas; Sarah A. Boswell; Fernando H. Ramírez-Guadiana; Victoria Jones; Akhila Sonti; Kole Sedlack et al.
Source: check_circle
Crossref

An enhanced isothermal amplification assay for viral detection

2020-05-29 | Preprint
DOI: 10.1101/2020.05.28.118059
Contributors: Jason Qian; Sarah A. Boswell; Christopher Chidley; Zhi-xiang Lu; Mary E. Pettit; Benjamin L. Gaudio; Jesse M. Fajnzylber; Ryan T. Ingram; Rebecca H. Ward; Jonathan Z. Li et al.
Source: check_circle
Crossref

Forensic microbial system for high-resolution object provenance

2020-03-16 | Preprint
DOI: 10.1101/2020.03.14.990804
Contributors: Jason Qian; Zhi-xiang Lu; Christopher P. Mancuso; Han-Ying Jhuang; Rocío del Carmen Barajas-Ornelas; Sarah Boswell; Fernando H. Ramírez-Guadiana; Victoria Jones; Akhila Sonti; Kole Sedlack et al.
Source: check_circle
Crossref

Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells.

Nucleic acids research
2016-09-26 | Journal article
DOI: 10.1093/nar/gkw851
PMID: 27672039
PMC: PMC5314791
Source: Self-asserted source
Zhixiang Lu

m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome

Nature Methods
2016-08-04 | Journal article
DOI: 10.1038/nmeth.3898
Contributors: Benoit Molinie; Jinkai Wang; Kok Seong Lim; Roman Hillebrand; Zhi-xiang Lu; Nicholas Van Wittenberghe; Benjamin D Howard; Kaveh Daneshvar; Alan C Mullen; Peter Dedon et al.
Source: check_circle
Crossref

The contribution of Alu exons to the human proteome.

Genome biology
2016-01-28 | Journal article
DOI: 10.1186/s13059-016-0876-5
PMID: 26821878
PMC: PMC4731929
Source: Self-asserted source
Zhixiang Lu

Advances in Computational Genomics

BioMed Research International
2015 | Journal article
DOI: 10.1155/2015/187803
Contributors: Leng Han; Yan Guo; Zhixi Su; Siyuan Zheng; Zhixiang Lu
Source: check_circle
Crossref

Discover hidden splicing variations by mapping personal transcriptomes to personal genomes.

Nucleic acids research
2015-11-17 | Journal article
DOI: 10.1093/nar/gkv1099
PMID: 26578562
PMC: PMC4678817
Source: Self-asserted source
Zhixiang Lu

Gene self-control: when pre-mRNA splicing variants become competingendogenous RNAs

Frontiers in Genetics
2014 | Journal article
DOI:

doi:10.3389/fgene.2014.00405
Contributors: Lu ZX
Source: Self-asserted source
Zhixiang Lu via ResearcherID

Species-specific Exon Loss in Human Transcriptomes

Molecular Biology and Evolution
2014 | Journal article
DOI:

doi: 10.1093/molbev/msu317
Contributors: Wang, J; Lu, ZX; Tokheim, CJ; Miller, SE; Xing, Y
Source: Self-asserted source
Zhixiang Lu via ResearcherID

Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization

Mol Cancer Res
2014 | Journal article
DOI:

10.1158/1541-7786.MCR-14-0366
Contributors: Lu, ZX.; Huang, Q.; Park, J. W.; Shen, S.; Lin, L.; Tokheim, C. J.; Henry, M. D.; Xing, Y.
Source: Self-asserted source
Zhixiang Lu via ResearcherID

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

Proceedings of the National Academy of Sciences
2014-12-23 | Journal article
DOI: 10.1073/pnas.1419161111
Contributors: Shihao Shen; Juw Won Park; Zhi-xiang Lu; Lan Lin; Michael D. Henry; Ying Nian Wu; Qing Zhou; Yi Xing
Source: check_circle
Crossref

Genetic Control of pre-mRNA Splicing and Diseases

Enliven: Journal of Genetics, Molecular and Cellular Biology
2014-05-28 | Journal article
Contributors: Zhixiang Lu
Source: Self-asserted source
Zhixiang Lu

GLiMMPS: Robust statistical model for regulatory variation of alternative splicing using RNA-seq data.

2013-07 | Journal article
DOI:

10.1186/gb-2013-14-7-r74

PMID:

23876401
Contributors: Zhao K; Lu ZX; Park JW; Zhou Q; Xing Y
Source: Self-asserted source
Zhixiang Lu via Europe PubMed Central

MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data.

2012-04 | Journal article
DOI:

10.1093/nar/gkr1291

PMID:

22266656

PMC:

PMC3333886
Contributors: Shen S; Park JW; Huang J; Dittmar KA; Lu ZX; Zhou Q; Carstens RP; Xing Y
Source: Self-asserted source
Zhixiang Lu via Europe PubMed Central

Genetic variation of pre-mRNA alternative splicing in human populations.

2012 | Journal article
DOI:

10.1002/wrna.120

PMID:

22095823

PMC:

PMC3339278
Contributors: Lu ZX; Jiang P; Xing Y
Source: Self-asserted source
Zhixiang Lu via Europe PubMed Central

Transcriptome landscape of the human placenta.

2012 | Journal article
DOI:

10.1186/1471-2164-13-115

PMID:

22448651

PMC:

PMC3368734
Contributors: Kim J; Zhao K; Jiang P; Lu ZX; Wang J; Murray JC; Xing Y
Source: Self-asserted source
Zhixiang Lu via Europe PubMed Central

Context-dependent robustness to 5' splice site polymorphisms in human populations.

2011-03 | Journal article
DOI:

10.1093/hmg/ddq553

PMID:

21224255

PMC:

PMC3043661
Contributors: Lu ZX; Jiang P; Cai JJ; Xing Y
Source: Self-asserted source
Zhixiang Lu via Europe PubMed Central

Functional characterization of the human-specific (type II) form of kallikrein 8, a gene involved in learning and memory.

2009-02 | Journal article
DOI:

10.1038/cr.2009.4

PMID:

19125171
Contributors: Lu ZX; Huang Q; Su B
Source: Self-asserted source
Zhixiang Lu via Europe PubMed Central

A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory.

2007-10 | Journal article
DOI:

10.1002/humu.20547

PMID:

17487847
Contributors: Lu ZX; Peng J; Su B
Source: Self-asserted source
Zhixiang Lu via Europe PubMed Central

Peer review (2 reviews for 2 publications/grants)

Review activity for Chinese medicine. (1)
Review activity for Genes and genomics. (1)
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