Personal information

Other IDs

Scopus Author ID: 56459257900

Keywords

HPV, Virus related cancer, genomics, Genome engineering, Biotechnology

Countries

China

Activities

Collapse all

Employment (1)

Wuhan University: Wuhan, CN

2023-01-01 to present | Professor (Department of OB&G)
Employment
Source: Self-asserted source
Zheng Hu

Education and qualifications (2)

Huazhong University of Science and Technology: Wuhan, Hubei, CN

2006-09-01 to 2012-07-01 | M.D. (OB&G)
Education
Source: Self-asserted source
Zheng Hu

Huazhong University of Science and Technology: Wuhan, Hubei, CN

2006-09-01 to 2009-07-01 | Master's degree (Department of urology)
Education
Source: Self-asserted source
Zheng Hu

Professional activities (2)

Department of Education: GuangZhou, CN

National Ten Thousands Plan for Young Top Talents (Department of Education)
Distinction
Source: Self-asserted source
Zheng Hu

Department of Education: GuangZhou, GuangDong, CN

Young Pearl River Scholar (Department of Education)
Distinction
Source: Self-asserted source
Zheng Hu

Funding (4)

dentification of Key genetic/epigenetic Marker(s) in cervical carcinogenesis and development of corresponding Molecular Therapeutics for precision medicine of cervical cancer

Grant
National Natural Science Foundation of China (GuangZhou, CN)
GRANT_NUMBER:

81761148025
Source: Self-asserted source
Zheng Hu

Identification of HPV16 integration into 3p14 and its pathogenesis during cervical carcinoqenesis.

Grant
National Natural Science Foundation of China (Wuhan, CN)
GRANT_NUMBER:

81402158
Source: Self-asserted source
Zheng Hu

National Science and Technology Major Project of the Ministry of science and technology of China

Grant
Ministry of science and technology (GuangZhou, CN)
GRANT_NUMBER:

grant no. 2018ZX10301-402
Source: Self-asserted source
Zheng Hu

The National Ten Thousands Plan for Young Top Talents

Award
Ministry of Education and Science (GuangZhou, CN)
Source: Self-asserted source
Zheng Hu

Works (45)

Systematic high-throughput evaluation reveals FrCas9’s superior specificity and efficiency for therapeutic genome editing

Science Advances
2025-03-28 | Journal article
DOI: 10.1126/sciadv.adu7334
Contributors: Rui Tian; Xun Tian; Meiying Yang; Yuping Song; Tingting Zhao; Chaoyue Zhong; Wei Zhu; Ping Zhou; Zhiqiang Han; Zheng Hu
Source: check_circle
Crossref

SunTag-PE: a modular prime editing system enables versatile and efficient genome editing

Communications Biology
2025-03-18 | Journal article
DOI: 10.1038/s42003-025-07893-4
Contributors: Jiashuo Liu; Jingjing Zhang; Tingting Zhao; Mengya Zhao; Min Su; Ye Chen; Zheying Huang; Yuyan Wang; Chaoyue Zhong; Zheng Hu et al.
Source: check_circle
Crossref

High-Level Arterial Occlusion with Bulldog Clamps for Laparoscopic Myomectomy

Journal of Minimally Invasive Gynecology
2025-02 | Journal article
DOI: 10.1016/j.jmig.2025.02.012
Contributors: Jingjing Zhang; Zhen Li; Zheng Hu
Source: check_circle
Crossref

Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1

iScience
2023-07 | Journal article
DOI: 10.1016/j.isci.2023.107315
Contributors: Xiangyu Tan; Xueqian Wang; Xueyao Liao; Xin Wang; Zhichao Jiang; Wenjia Liang; Chen Cao; Danni Gong; Zheng Hu; Xun Tian
Source: check_circle
Crossref

A Cas12a ortholog with distinct TTNA PAM enables sensitive detection of HPV16/18

Cell Reports Methods
2023-04 | Journal article
DOI: 10.1016/j.crmeth.2023.100444
Contributors: Ye Chen; Lirong Meng; Bin Lang; Lifang Li; Jiashuo Liu; Yuyan Wang; Zheying Huang; Xun Tian; Rui Tian; Zheng Hu
Source: check_circle
Crossref

HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription.

Nucleic acids research
2023-03-02 | Journal article | Author
DOI: 10.1093/nar/gkad105
PMID: 36864748
Contributors: Tian R; Huang Z; Li L; Yuan J; Zhang Q; Meng L; Lang B; Hong Y; Zhong C; Tian X et al.
Source: Self-asserted source
Zheng Hu

VIS Atlas: A Database of Virus Integration Sites in Human Genome from NGS Data to Explore Integration Patterns

Genomics, Proteomics & Bioinformatics
2023-02 | Journal article
DOI: 10.1016/j.gpb.2023.02.005
Part of ISSN: 1672-0229
Contributors: Ye Chen; Yuyan Wang; Ping Zhou; Hao Huang; Rui Li; Zhen Zeng; Zifeng Cui; Rui Tian; Zhuang Jin; Jiashuo Liu et al.
Source: Self-asserted source
Zheng Hu

FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity

Nature Communications
2022-12 | Journal article
DOI: 10.1038/s41467-022-29089-8
Part of ISSN: 2041-1723
Source: Self-asserted source
Zheng Hu

Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway.

Current cancer drug targets
2022-08-22 | Journal article
DOI: 10.2174/1568009622666220822191039
PMID: 36017858
Contributors: Zheng Hu
Source: Self-asserted source
Zheng Hu

Genome-wide virus-integration analysis reveals a common insertional mechanism of HPV, HBV and EBV.

Clinical and translational medicine
2022-08-01 | Journal article
DOI: 10.1002/ctm2.971
PMID: 35968887
PMC: PMC9376973
Contributors: Zheng Hu
Source: Self-asserted source
Zheng Hu

Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells

Molecular Therapy - Oncolytics
2022-03 | Journal article
DOI: 10.1016/j.omto.2021.12.011
Part of ISSN: 2372-7705
Source: Self-asserted source
Zheng Hu

A Fifteen-Gene Classifier to Predict Neoadjuvant Chemotherapy Responses in Patients with Stage IB to IIB Squamous Cervical Cancer

Advanced Science
2021 | Journal article
DOI: 10.1002/advs.202001978
EID:

2-s2.0-85102642402

Part of ISSN: 21983844
Contributors: Tian, X.; Wang, X.; Cui, Z.; Liu, J.; Huang, X.; Shi, C.; Zhang, M.; Liu, T.; Du, X.; Li, R. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Periostin<sup>+</sup>cancer-associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma

Molecular Oncology
2021 | Journal article
DOI: 10.1002/1878-0261.12837
EID:

2-s2.0-85096801953

Part of ISSN: 18780261 15747891
Contributors: Wei, W.-F.; Chen, X.-J.; Liang, L.-J.; Yu, L.; Wu, X.-G.; Zhou, C.-F.; Wang, Z.-C.; Fan, L.-S.; Hu, Z.; Liang, L. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

DeepHBV: a deep learning model to predict hepatitis B virus (HBV) integration sites

BMC Ecology and Evolution
2021-12 | Journal article
DOI: 10.1186/s12862-021-01869-8
Part of ISSN: 2730-7182
Source: Self-asserted source
Zheng Hu

Somatic mutations and CRISPR/Cas9 library screening integrated analysis identifies cervical cancer drug‐resistant pathways

Clinical and Translational Medicine
2021-12 | Journal article
DOI: 10.1002/ctm2.632
Contributors: Chen Cao; Ting Liu; Qinghua Zhang; Rui Li; Zhen Zeng; Zifeng Cui; Xin Wang; Danni Gong; Xun Tian; Zheng Hu
Source: check_circle
Crossref

Feasibility and Accuracy of Menstrual Blood Testing for High-risk Human Papillomavirus Detection With Capture Sequencing

JAMA Network Open
2021-12-23 | Journal article
DOI: 10.1001/jamanetworkopen.2021.40644
Part of ISSN: 2574-3805
Source: Self-asserted source
Zheng Hu

The comparison of ZFNs, TALENs, and SpCas9 by GUIDE-seq in HPV-targeted gene therapy

Molecular Therapy - Nucleic Acids
2021-08 | Journal article
DOI: 10.1016/j.omtn.2021.08.008
Part of ISSN: 2162-2531
Source: Self-asserted source
Zheng Hu

Non-homologous dsODN increases the mutagenic effects of CRISPR-Cas9 to disrupt oncogene E7 in HPV positive cells

Cancer Gene Therapy
2021-06-10 | Journal article
DOI: 10.1038/s41417-021-00355-z
Part of ISSN: 0929-1903
Part of ISSN: 1476-5500
Source: Self-asserted source
Zheng Hu

DeepEBV: A deep learning model to predict Epstein-Barr virus (EBV) integration sites

Bioinformatics
2021-05-19 | Journal article
DOI: 10.1093/bioinformatics/btab388
Part of ISSN: 1367-4803
Part of ISSN: 1460-2059
Source: Self-asserted source
Zheng Hu

Transcriptome Analysis in Yeast Reveals the Externality of Position Effects.

Molecular biology and evolution
2021-04-19 | Journal article
DOI: 10.1093/molbev/msab104
PMID: 33871622
Source: Self-asserted source
Zheng Hu
grade
Preferred source (of 2)‎

An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy

EBioMedicine
2020 | Journal article
DOI: 10.1016/j.ebiom.2020.102897
EID:

2-s2.0-85088216318

Part of ISSN: 23523964
Contributors: Niu, G.; Jin, Z.; Zhang, C.; He, D.; Gao, X.; Zou, C.; Zhang, W.; Ding, J.; Das, B.C.; Severinov, K. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Dissimilation of synonymous codon usage bias in virus–host coevolution due to translational selection

Nature Ecology and Evolution
2020 | Journal article
DOI: 10.1038/s41559-020-1124-7
EID:

2-s2.0-85081564252

Part of ISSN: 2397334X
Contributors: Chen, F.; Wu, P.; Deng, S.; Zhang, H.; Hou, Y.; Hu, Z.; Zhang, J.; Chen, X.; Yang, J.-R.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

FHIT and C-MYC expression in cervical histology and cytology as biomarkers for detecting high-grade intraepithelial neoplasia in human papillomavirus-positive women

Cancer Biomarkers
2020 | Journal article
DOI: 10.3233/CBM-182232
EID:

2-s2.0-85081587238

Part of ISSN: 18758592 15740153
Contributors: Yang, F.; Cui, Z.; Liao, Y.; Tian, R.; Fan, W.; Jin, Z.; Hu, Z.; Yao, S.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer

Journal of Genetics and Genomics
2020 | Journal article
DOI: 10.1016/j.jgg.2020.05.006
EID:

2-s2.0-85092198912

Part of ISSN: 18735533 16738527
Contributors: Cao, C.; Hong, P.; Huang, X.; Lin, D.; Cao, G.; Wang, L.; Feng, B.; Wu, P.; Shen, H.; Xu, Q. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Hyperbranched poly(β-amino ester) based polyplex nanopaticles for delivery of CRISPR/Cas9 system and treatment of HPV infection associated cervical cancer

Journal of Controlled Release
2020 | Journal article
DOI: 10.1016/j.jconrel.2020.02.045
EID:

2-s2.0-85080978984

Part of ISSN: 18734995 01683659
Contributors: Gao, X.; Jin, Z.; Tan, X.; Zhang, C.; Zou, C.; Zhang, W.; Ding, J.; Das, B.C.; Severinov, K.; Hitzeroth, I.I. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs’ cleavage by CRISPR/Cas13a system

Antiviral Research
2020 | Journal article
DOI: 10.1016/j.antiviral.2020.104794
EID:

2-s2.0-85083590689

Part of ISSN: 18729096 01663542
Contributors: Chen, Y.; Jiang, H.; Wang, T.; He, D.; Tian, R.; Cui, Z.; Tian, X.; Gao, Q.; Ma, X.; Yang, J. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

DeepHPV: a deep learning model to predict human papillomavirus integration sites.

Briefings in bioinformatics
2020-10-16 | Journal article
DOI: 10.1093/bib/bbaa242
PMID: 33059369
Source: Self-asserted source
Zheng Hu

Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women

Translational Oncology
2019 | Journal article
DOI: 10.1016/j.tranon.2019.04.012
EID:

2-s2.0-85065609705

Part of ISSN: 19365233
Contributors: Jiang, Y.; Zhu, C.; He, D.; Gao, Q.; Tian, X.; Ma, X.; Wu, J.; Das, B.C.; Severinov, K.; Hitzeroth, I.I. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Risk stratification of cervical lesions using capture sequencing and machine learning method based on HPV and human integrated genomic profiles

Carcinogenesis
2019 | Journal article
DOI: 10.1093/carcin/bgz094
EID:

2-s2.0-85073582629

Part of ISSN: 14602180 01433334
Contributors: Tian, R.; Cui, Z.; He, D.; Tian, X.; Gao, Q.; Ma, X.; Yang, J.-R.; Wu, J.; Das, B.C.; Severinov, K. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

LNMICC promotes nodal metastasis of cervical cancer by reprogramming fatty acid metabolism

Cancer Research
2018 | Journal article
DOI: 10.1158/0008-5472.CAN-17-2356
EID:

2-s2.0-85042189081

Part of ISSN: 15387445 00085472
Contributors: Shang, C.; Wang, W.; Liao, Y.; Chen, Y.; Liu, T.; Du, Q.; Huang, J.; Liang, Y.; Liu, J.; Zhao, Y. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy

Molecular Therapy
2018 | Journal article
DOI: 10.1016/j.ymthe.2018.07.019
EID:

2-s2.0-85053705965

Part of ISSN: 15250024 15250016
Contributors: Zhu, D.; Shen, H.; Tan, S.; Hu, Z.; Wang, L.; Yu, L.; Tian, X.; Ding, W.; Ren, C.; Gao, C. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Precision screening and treatment of human papilloma virus related cervical cancer

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
2018 | Journal article
EID:

2-s2.0-85066439615

Part of ISSN: 10089292
Contributors: Hu, Z.; Ma, D.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

The precision prevention and therapy of HPV-related cervical cancer: new concepts and clinical implications

Cancer Medicine
2018 | Journal article
DOI: 10.1002/cam4.1501
EID:

2-s2.0-85053480024

Part of ISSN: 20457634
Contributors: Hu, Z.; Ma, D.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas.

Frontiers of medicine
2018-04-12 | Journal article
DOI: 10.1007/s11684-017-0572-1
PMID: 29651774
PMC: PMC7088620
Source: Self-asserted source
Zheng Hu
grade
Preferred source (of 2)‎

Decreased expression of ALDH5A1 predicts prognosis in patients with ovarian cancer

Cancer Biology and Therapy
2017 | Journal article
DOI: 10.1080/15384047.2017.1295175
EID:

2-s2.0-85016116926

Part of ISSN: 15558576 15384047
Contributors: Tian, X.; Han, Y.; Yu, L.; Luo, B.; Hu, Z.; Li, X.; Yang, Z.; Wang, X.; Huang, W.; Wang, H. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Deletion of HPV18 E6 and E7 genes using dual sgRNA-directed CRISPR/Cas9 inhibits growth of cervical cancer cells

International Journal of Clinical and Experimental Medicine
2017 | Journal article
EID:

2-s2.0-85021379230

Part of ISSN: 19405901
Contributors: Yu, L.; Hu, Z.; Gao, C.; Feng, B.; Wang, L.; Tian, X.; Ding, W.; Jin, X.; Ma, D.; Wang, H.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer

Journal of Experimental and Clinical Cancer Research
2016 | Journal article
DOI: 10.1186/s13046-016-0445-5
EID:

2-s2.0-84992756758

Part of ISSN: 17569966
Contributors: Liu, T.-Y.; Chen, J.; Shang, C.-L.; Shen, H.-W.; Huang, J.-M.; Liang, Y.-C.; Wang, W.; Zhao, Y.-H.; Liu, D.; Shu, M. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Nature Genetics
2015 | Journal article
DOI: 10.1038/ng.3178
EID:

2-s2.0-84926211535

Part of ISSN: 15461718 10614036
Contributors: Hu, Z.; Zhu, D.; Wang, W.; Li, W.; Jia, W.; Zeng, X.; Ding, W.; Yu, L.; Wang, X.; Wang, L. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy

Journal of Clinical Investigation
2015 | Journal article
DOI: 10.1172/JCI78206
EID:

2-s2.0-84920484581

Part of ISSN: 15588238 00219738
Contributors: Hu, Z.; Ding, W.; Zhu, D.; Yu, L.; Jiang, X.; Wang, X.; Zhang, C.; Wang, L.; Ji, T.; Liu, D. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Amplification and overexpression of TP63 and MYC as biomarkers for transition of cervical intraepithelial neoplasia to cervical cancer

International Journal of Gynecological Cancer
2014 | Journal article
DOI: 10.1097/IGC.0000000000000122
EID:

2-s2.0-84900439255

Part of ISSN: 15251438 1048891X
Contributors: Zhu, D.; Jiang, X.-H.; Jiang, Y.-H.; Ding, W.-C.; Zhang, C.-L.; Shen, H.; Wang, X.-L.; Ma, D.; Hu, Z.; Wang, H.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Disruption of HPV16-E7 by CRISPR/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells

BioMed Research International
2014 | Journal article
DOI: 10.1155/2014/612823
EID:

2-s2.0-84923561654

Part of ISSN: 23146141 23146133
Contributors: Hu, Z.; Yu, L.; Zhu, D.; Ding, W.; Wang, X.; Zhang, C.; Wang, L.; Jiang, X.; Shen, H.; He, D. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

SIX1 promotes tumor lymphangiogenesis by coordinating TGFβ signals that increase expression of VEGF-C

Cancer Research
2014 | Journal article
DOI: 10.1158/0008-5472.CAN-13-3598
EID:

2-s2.0-84907502240

Part of ISSN: 15387445 00085472
Contributors: Liu, D.; Li, L.; Zhang, X.-X.; Wan, D.-Y.; Xi, B.-X.; Hu, Z.; Ding, W.-C.; Zhu, D.; Wang, X.-L.; Wang, W. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Zinc finger nucleases targeting the human papillomavirus E7 oncogene induce E7 disruption and a transformed Phenotype in HPV16/18-positive cervical cancer cells

Clinical Cancer Research
2014 | Journal article
DOI: 10.1158/1078-0432.CCR-14-0250
EID:

2-s2.0-84919764923

Part of ISSN: 15573265 10780432
Contributors: Ding, W.; Zhu, D.; Hu, Z.; Jiang, X.; Yu, L.; Wang, X.; Zhang, C.; Wang, L.; Ji, T.; Li, K. et al.
Source: Self-asserted source
Zheng Hu via Scopus - Elsevier

Fibulin-5 is down-regulated in urothelial carcinoma of bladder and inhibits growth and invasion of human bladder cancer cell line 5637.

Urologic oncology
2009-09-19 | Journal article
DOI: 10.1016/j.urolonc.2009.06.004
PMID: 19767220
Source: Self-asserted source
Zheng Hu

A radially expanding sheath for urethral dilation.

Medical hypotheses
2009-07-08 | Journal article
DOI: 10.1016/j.mehy.2009.04.057
PMID: 19589646
Source: Self-asserted source
Zheng Hu

Peer review (1 review for 1 publication/grant)

Review activity for Cell reports. (1)
How many people are using ORCID?