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Employment (1)

Eli Lilly and Company: Indianapolis, IN, US

1998 to present | Senior Research Advisor
Employment
Source: Self-asserted source
Yan Q Chen

Works (21)

The Regulation of Triacylglycerol Metabolism and Lipoprotein Lipase Activity.

Advanced biology
2022-06-08 | Journal article
DOI: 10.1002/adbi.202200093
PMID: 35676229
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif.

Journal of lipid research
2022-03-17 | Journal article
DOI: 10.1016/j.jlr.2022.100198
PMID: 35307397
PMC: PMC9036128
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Angiopoietin-like proteins and postprandial partitioning of fatty acids.

Current opinion in lipidology
2022-02-01 | Journal article
DOI: 10.1097/mol.0000000000000798
PMID: 34789669
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity.

Heliyon
2021-08-30 | Journal article
DOI: 10.1016/j.heliyon.2021.e07898
PMID: 34504977
PMC: PMC8417300
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition.

Journal of lipid research
2021-03-21 | Journal article
DOI: 10.1016/j.jlr.2021.100068
PMID: 33762177
PMC: PMC8079461
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Angiopoietin-like protein 4(E40K) and ANGPTL4/8 complex have reduced, temperature-dependent LPL-inhibitory activity compared to ANGPTL4.

Biochemical and biophysical research communications
2020-11-22 | Journal article
DOI: 10.1016/j.bbrc.2020.11.053
PMID: 33239171
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids.

Journal of lipid research
2020-06-02 | Journal article
DOI: 10.1194/jlr.ra120000781
PMID: 32487544
PMC: PMC7397750
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Affinity capture elution bridging assay: A novel immunoassay format for detection of anti-therapeutic protein antibodies.

Journal of immunological methods
2016-02-10 | Journal article
DOI: 10.1016/j.jim.2016.02.008
PMID: 26874304
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

PCSK9 is present in human cerebrospinal fluid and is maintained at remarkably constant concentrations throughout the course of the day.

Lipids
2014-05-01 | Journal article
DOI: 10.1007/s11745-014-3895-6
PMID: 24659111
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry

Analytical Biochemistry
2013-07 | Journal article
DOI: 10.1016/j.ab.2013.03.016
Part of ISSN: 0003-2697
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation

Biochemical and Biophysical Research Communications
2011-11 | Journal article
DOI: 10.1016/j.bbrc.2011.10.110
Part of ISSN: 0006-291X
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.

Journal of lipid research
2011-09-25 | Journal article
DOI: 10.1194/jlr.m018069
PMID: 21957197
PMC: PMC3220285
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

The Acyl CoenzymeA:Monoacylglycerol Acyltransferase 3 (MGAT3) Gene is a Pseudogene in Mice but Encodes a Functional Enzyme in Rats

Lipids
2011-06 | Journal article
DOI: 10.1007/s11745-011-3537-1
Part of ISSN: 0024-4201
Part of ISSN: 1558-9307
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.

Journal of lipid research
2008-12-15 | Journal article
DOI: 10.1194/jlr.m800567-jlr200
PMID: 19075029
PMC: PMC2666181
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Peroxisome proliferator-activated receptor alpha agonists regulate cholesterol ester transfer protein.

Lipids
2008-05-15 | Journal article
DOI: 10.1007/s11745-008-3187-0
PMID: 18481130
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.

The Journal of biological chemistry
2008-01-31 | Journal article
DOI: 10.1074/jbc.m708151200
PMID: 18238778
PMC: PMC2442282
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Identification and characterization of a major liver lysophosphatidylcholine acyltransferase.

The Journal of biological chemistry
2008-01-14 | Journal article
DOI: 10.1074/jbc.m710422200
PMID: 18195019
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

High-Resolution Quantitative Computed Tomography Demonstrating Selective Enhancement of Medium-Size Collaterals by Placental Growth Factor-1 in the Mouse Ischemic Hindlimb

Circulation
2006-05-23 | Journal article
DOI: 10.1161/circulationaha.105.586818
Part of ISSN: 0009-7322
Part of ISSN: 1524-4539
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Synergistic Effect of Adrenal Steroids and Angiotensin II on Plasminogen Activator Inhibitor-1 Production1

The Journal of Clinical Endocrinology & Metabolism
2000-01-01 | Journal article
DOI: 10.1210/jcem.85.1.6305
Part of ISSN: 0021-972X
Part of ISSN: 1945-7197
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Sp1 Sites Mediate Activation of the Plasminogen Activator Inhibitor-1 Promoter by Glucose in Vascular Smooth Muscle Cells

Journal of Biological Chemistry
1998-04 | Journal article
DOI: 10.1074/jbc.273.14.8225
Part of ISSN: 0021-9258
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen

Multiple enhancer elements mediate induction of c-fos in vascular smooth muscle cells.

Hypertension (Dallas, Tex. : 1979)
1996-06-01 | Journal article
DOI: 10.1161/01.hyp.27.6.1224
PMID: 8641728
Contributors: Yan Q Chen
Source: Self-asserted source
Yan Q Chen
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