Personal information

lung disease, tissue regeneration, Wnt signaling, epithelial cell biology, COPD, IPF
United States

Activities

Works (24)

Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD

JCI Insight
2024-11-08 | Journal article
Contributors: Justin Sui; Hanxi Xiao; Ugonna Mbaekwe; Nai-Chun Ting; Kaley Murday; Qianjiang Hu; Alyssa D. Gregory; Theodore S. Kapellos; Ali Öender Yildirim; Melanie Königshoff et al.
Source: check_circle
Crossref

Teatime: epigallocatechin gallate targets fibroblast–epithelial cell crosstalk to combat lung fibrosis

Journal of Clinical Investigation
2024-09-17 | Journal article
Contributors: Olivier Burgy; Melanie Königshoff
Source: check_circle
Crossref

The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes

European Respiratory Journal
2024-06 | Journal article
Contributors: Kassandra Allbright; John Villandre; Laura E. Crotty Alexander; Michael Zhang; Kambez H. Benam; John Evankovich; Melanie Königshoff; Divay Chandra
Source: check_circle
Crossref

Human-Derived Precision-Cut Lung Slices (hPCLS): Agarose Filling, Coring and Slicing Protocol v1

2024-02-22 | Preprint
Contributors: Ricardo Pineda; John Sembrat; Carter Kessler; Nayra Cardenes; Melanie Königshoff
Source: check_circle
Crossref

Senescence induction by DNA-damage in PCLS v1

2024-02-22 | Preprint
Contributors: Delphine Beaulieu; Nayra Cardenes; Melanie Königshoff
Source: check_circle
Crossref

Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology
2023-11 | Journal article
Contributors: Justin Sui; Jennifer C. Boatz; Jian Shi; Qianjiang Hu; Xiaoyun Li; Yingze Zhang; Melanie Königshoff; Corrine R. Kliment
Source: check_circle
Crossref

Deep-Masker: A Deep Learning–based Tool to Assess Chord Length from Murine Lung Images

American Journal of Respiratory Cell and Molecular Biology
2023-08 | Journal article
Contributors: Jiantao Pu; Adriana S. Leme; Camilla de Lima e Silva; Cameron Beeche; Toru Nyunoya; Melanie Königshoff; Divay Chandra
Source: check_circle
Crossref

IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors’ Function

American Journal of Respiratory Cell and Molecular Biology
2023-04 | Journal article
Contributors: Chiara Ciminieri; Manon E. Woest; Niki L. Reynaert; Irene H. Heijink; René Wardenaar; Diana C. J. Spierings; Corry-Anke Brandsma; Melanie Königshoff; Reinoud Gosens
Source: check_circle
Crossref

Listen to the WNT; It Talks: WNT7A Drives Epithelial–Mesenchymal Cross-Talk within the Fibrotic Niche in Idiopathic Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology
2023-03 | Journal article
Contributors: Melanie Königshoff; Oliver Eickelberg
Source: check_circle
Crossref

Powering the formation of alveoli

eLife
2022-06-09 | Journal article
Contributors: Qianjiang Hu; Melanie Königshoff
Source: check_circle
Crossref

National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration

American Journal of Respiratory Cell and Molecular Biology
2021-07 | Journal article
Contributors: Robert E. Hynds; William J. Zacharias; Marko Z. Nikolić; Melanie Königshoff; Oliver Eickelberg; Reinoud Gosens; Paolo de Coppi; Sam M. Janes; Edward Morrisey; Hans Clevers et al.
Source: check_circle
Crossref

Simultaneous Pharmacologic Inhibition of Yes‐Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic‐co‐Glycolic) Acid–Encapsulated Microparticles Improves Pulmonary Hypertension

Journal of the American Heart Association
2021-06-15 | Journal article
Contributors: Abhinav P. Acharya; Ying Tang; Thomas Bertero; Yi‐Yin Tai; Lloyd D. Harvey; Chen‐Shan C. Woodcock; Wei Sun; Ricardo Pineda; Nilay Mitash; Melanie Königshoff et al.
Source: check_circle
Crossref

Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema

Stem Cells
2020-11-01 | Journal article
Contributors: Yan Hu; John-Poul Ng-Blichfeldt; Chiharu Ota; Chiara Ciminieri; Wenhua Ren; Pieter S. Hiemstra; Jan Stolk; Reinoud Gosens; Melanie Königshoff
Source: check_circle
Crossref

Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery

American Journal of Respiratory Cell and Molecular Biology
2020-06 | Journal article
Contributors: Hani N. Alsafadi; Franziska E. Uhl; Ricardo H. Pineda; Kolene E. Bailey; Mauricio Rojas; Darcy E. Wagner; Melanie Königshoff
Source: check_circle
Crossref

Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended ex vivo Culture

American Journal of Respiratory Cell and Molecular Biology
2019-09-12 | Journal article
Contributors: Kolene E. Bailey; Christopher Pino; Mallory L Lennon; Anne Lyons; Jeffrey G Jacot; Steven R Lammers; Melanie Königshoff; Chelsea M Magin
Source: check_circle
Crossref

The oncogene ECT2 contributes to a hyperplastic, proliferative lung epithelial cell phenotype in IPF

American Journal of Respiratory Cell and Molecular Biology
2019-05-30 | Journal article
Contributors: Henrik M Ulke; Kathrin Mutze; Mareike Lehmann; Darcy E Wagner; Katharina Heinzelmann; Andreas Günther; Oliver Eickelberg; Melanie Königshoff
Source: check_circle
Crossref

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis

American Journal of Physiology-Lung Cellular and Molecular Physiology
2018-11-01 | Journal article
Contributors: Katharina Heinzelmann; Mareike Lehmann; Michael Gerckens; Nina Noskovičová; Marion Frankenberger; Michael Lindner; Rudolf Hatz; Jürgen Behr; Anne Hilgendorff; Melanie Königshoff et al.
Source: check_circle
Crossref

Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures

American Journal of Physiology-Lung Cellular and Molecular Physiology
2018-05-01 | Journal article
Contributors: Gerald Burgstaller; Arunima Sengupta; Sarah Vierkotten; Gerhard Preissler; Michael Lindner; Jürgen Behr; Melanie Königshoff; Oliver Eickelberg
Source: check_circle
Crossref

Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond

American Journal of Respiratory and Critical Care Medicine
2018-04-01 | Journal article
Contributors: Kambez H. Benam; Melanie Königshoff; Oliver Eickelberg
Source: check_circle
Crossref

Towards a global initiative for fibrosis treatment (GIFT)

ERJ Open Research
2017-10 | Journal article
Contributors: Maria Molina-Molina; Alvar Agusti; Bruno Crestani; David A. Schwartz; Melanie Königshoff; Rachel C. Chambers; Toby M. Maher; Rosa Faner; Ana Lucia Mora; Mauricio Rojas et al.
Source: check_circle
Crossref

‘WNT-er is coming’ : WNT signalling in chronic lung diseases

Thorax
2017-08-17 | Journal article
Contributors: H A Baarsma; M Königshoff
Source: check_circle
Crossref

An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices

American Journal of Physiology-Lung Cellular and Molecular Physiology
2017-06-01 | Journal article
Contributors: Hani N. Alsafadi; Claudia A. Staab-Weijnitz; Mareike Lehmann; Michael Lindner; Britta Peschel; Melanie Königshoff; Darcy E. Wagner
Source: check_circle
Crossref

Lung volumes predict survival in patients with chronic lung allograft dysfunction

European Respiratory Journal
2017-04 | Journal article
Contributors: Nikolaus Kneidinger; Katrin Milger; Silke Janitza; Felix Ceelen; Gabriela Leuschner; Julien Dinkel; Melanie Königshoff; Thomas Weig; René Schramm; Hauke Winter et al.
Source: check_circle
Crossref

WNT Signaling in Lung Aging and Disease

Annals of the American Thoracic Society
2016-12 | Journal article
Contributors: Mareike Lehmann; Hoeke A. Baarsma; Melanie Königshoff
Source: check_circle
Crossref

Peer review (1 review for 1 publication/grant)

Review activity for Genome medicine. (1)