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Employment (1)

Leidos Biomedical Research, Inc. : Frederick, MD, US

2002-09 to present | Research Associate III (Basic Science Program, Molecular Targets Program)
Employment
Source: Self-asserted source
Lauren R. H. Krumpe

Education and qualifications (2)

Hood College: Frederick , MD, US

Master of Science (Biomedical Science)
Education
Source: Self-asserted source
Lauren R. H. Krumpe

University of Maryland: College Park, Md., US

2001 | Bachelor of Science (Neurobiology and Physiology)
Education
Source: Self-asserted source
Lauren R. H. Krumpe

Works (20)

Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues

Chemical Science
2024 | Journal article
DOI: 10.1039/D4SC01976H
Contributors: Taylor B. Smallwood; Lauren R. H. Krumpe; Colton D. Payne; Victoria G. Klein; Barry R. O'Keefe; Richard J. Clark; Christina I. Schroeder; K. Johan Rosengren
Source: check_circle
Crossref

Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2.

Proceedings of the National Academy of Sciences of the United States of America
2023-02-28 | Journal article | Author
DOI: 10.1073/pnas.2214561120
PMID: 36853940
PMC: PMC10013841
Contributors: Jordana Muñoz Basagoiti; Fábio Luís Lima Monteiro; Lauren R. H. Krumpe; Victoria Armario-Najera; Shenoy SR; Perez-Zsolt D; Westgarth HJ; Gemma Villorbina Noguera; Bomfim LM; Raïch-Regué D et al.
Source: Self-asserted source
Lauren R. H. Krumpe
grade
Preferred source (of 2)‎

An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics

2022-12-20 | Preprint
DOI: 10.1101/2022.12.19.521044
Contributors: Shayan G. Borhani; Max Z. Levine; Lauren H. Krumpe; Jennifer Wilson; Curtis J. Henrich; Barry R. O’Keefe; Donald Lo; G. Sitta Sittampalam; Alexander G. Godfrey; R. Dwayne Lunsford et al.
Source: check_circle
Crossref

Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea.

Molecules (Basel, Switzerland)
2021-06-11 | Journal article
DOI: 10.3390/molecules26123594
PMID: 34208349
PMC: PMC8231123
Contributors: Chang-Kwon Kim; Krumpe LRH; Emily Smith; Henrich CJ; Isaac Brownell; Wendt KL; Robert H. Cichewicz; Barry O'Keefe; Kirk Gustafson
Source: Self-asserted source
Lauren R. H. Krumpe

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I.

Journal of the American Chemical Society
2020-12-02 | Journal article
DOI: 10.1021/jacs.0c10418
PMID: 33263997
Source: Self-asserted source
Lauren R. H. Krumpe

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge.

The Journal of infectious diseases
2020-05-01 | Journal article
DOI: 10.1093/infdis/jiz630
PMID: 32037447
PMC: PMC7199786
Source: Self-asserted source
Lauren R. H. Krumpe

The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation.

Cell chemical biology
2019-05-30 | Journal article
DOI: 10.1016/j.chembiol.2019.04.011
PMID: 31155509
PMC: PMC6697619
Source: Self-asserted source
Lauren R. H. Krumpe

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

Journal of natural products
2019-01-02 | Journal article
DOI: 10.1021/acs.jnatprod.8b00871
PMID: 30600998
PMC: PMC7462088
Source: Self-asserted source
Lauren R. H. Krumpe

Gene-silencing suppressors for high-level production of the HIV-1 entry inhibitor griffithsin in Nicotiana benthamiana.

Process biochemistry (Barking, London, England)
2018-04-10 | Journal article
DOI: 10.1016/j.procbio.2018.04.006
PMID: 32288594
PMC: PMC7108441
Source: Self-asserted source
Lauren R. H. Krumpe

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1).

SLAS discovery : advancing life sciences R & D
2017-07-01 | Journal article
DOI: 10.1177/2472555217717200
PMID: 28697309
Source: Self-asserted source
Lauren R. H. Krumpe

A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.

Viruses
2016-06-06 | Journal article
DOI: 10.3390/v8060158
PMID: 27275831
PMC: PMC4926178
Source: Self-asserted source
Lauren R. H. Krumpe

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus.

Retrovirology
2015-01-23 | Journal article
DOI: 10.1186/s12977-014-0127-3
PMID: 25613831
PMC: PMC4419512
Source: Self-asserted source
Lauren R. H. Krumpe

The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus.

Antiviral research
2014-10-05 | Journal article
DOI: 10.1016/j.antiviral.2014.09.012
PMID: 25265598
PMC: PMC4258435
Source: Self-asserted source
Lauren R. H. Krumpe

Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.

Journal of the American Chemical Society
2014-05-28 | Journal article
DOI: 10.1021/ja502754f
PMID: 24820959
PMC: PMC4227816
Source: Self-asserted source
Lauren R. H. Krumpe

T7 lytic phage-displayed peptide libraries: construction and diversity characterization.

Methods in molecular biology (Clifton, N.J.)
2014-01-01 | Journal article
DOI: 10.1007/978-1-62703-673-3_4
PMID: 24146396
Source: Self-asserted source
Lauren R. H. Krumpe

Atomic-resolution crystal structure of the antiviral lectin scytovirin.

Protein science : a publication of the Protein Society
2007-10-26 | Journal article
DOI: 10.1110/ps.073157507
PMID: 17965185
PMC: PMC2222830
Source: Self-asserted source
Lauren R. H. Krumpe

Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library.

BMC biotechnology
2007-10-05 | Journal article
DOI: 10.1186/1472-6750-7-65
PMID: 17919322
PMC: PMC2174457
Source: Self-asserted source
Lauren R. H. Krumpe

Potential of phage-displayed peptide library technology to identify functional targeting peptides.

Expert opinion on drug discovery
2007-04-01 | Journal article
DOI: 10.1517/17460441.2.4.525
PMID: 20150977
PMC: PMC2818987
Source: Self-asserted source
Lauren R. H. Krumpe

T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries.

Proteomics
2006-08-01 | Journal article
DOI: 10.1002/pmic.200500606
PMID: 16819727
Source: Self-asserted source
Lauren R. H. Krumpe

The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs.

International journal of peptide research and therapeutics
2006-03-03 | Journal article
DOI: 10.1007/s10989-005-9002-3
PMID: 19444323
PMC: PMC2678933
Source: Self-asserted source
Lauren R. H. Krumpe
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