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New Zealand

Biography

I'm Associate Professor (lecturer and researcher) in the School of Food Technology and Natural Sciences, Massey University, Manawatū, New Zealand. I teach into undergraduate programs in Molecular Cell Biology, Veterinary Science and Animal Science. A central theme of my research program is understanding the relationship between protein structure and function in various important biological contexts. I have research interests in methanogen enzyme structural biology, biochemistry and evolution; a relatively unexplored research area but with very important implications for several big issues in biology, namely climate change, the origins of life and evolution of the first cells, and the evolutionary divergence of archaea and bacteria. I also have research interests in protein structure and function within a biomedical context investigating the molecular mechanisms behind genetic diseases including developmental neurological and skeletal disorders. Structural biology and biochemistry are particular research specialities of my lab.

Activities

Employment (3)

Massey University: Palmerston North, NZ

Employment
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Massey University

Massey University College of Sciences: Palmerston North, Manawatū, NZ

2003-01-01 to present | Associate Professor (School of Food Technology and Natural Sciences)
Employment
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Andrew J. Sutherland-Smith

Medical Research Council: Cambridge, Cambridgeshire, GB

1998-10 to 2002-12 | Postdoctoral Fellow (Laboratory of Molecular Biology, Structural Studies)
Employment
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Andrew J. Sutherland-Smith

Professional activities (4)

Palmerston North Medical Research Foundation: Palmerston North, Manawatū, NZ

2017-09-27 to present | Board member & Technical Committee
Service
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Andrew J. Sutherland-Smith

New Zealand Society for Biochemistry and Molecular Biology: Wellington, NZ

2003 to present
Membership
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Andrew J. Sutherland-Smith

New Zealand Institute of Chemistry: Christchurch, NZ

1994 to present
Membership
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Andrew J. Sutherland-Smith

Marsden Fund: Wellington, NZ

2017-01 to 2018-12 | Panellist (Physics, Chemistry and Biochemistry Panel)
Service
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Royal Society Te Apārangi

Funding (3)

A sticky question: Does intranuclear aggregation of HDAC4 promote neuronal dysfunction?

2022 to 2025 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-21-MAU-077

GRANT_NUMBER:

MFP-MAU2101

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Royal Society Te Apārangi

The writing is on the wall: elucidating the deep evolutionary links between cell wall synthesis in bacteria and methanogenic archaea

2014 to 2017 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-13-AGR-011

GRANT_NUMBER:

MFP-AGR1301

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Royal Society Te Apārangi

Stretching protein springs: How do cells respond to force?

2011 to 2014 | Contract
Marsden Fund (Wellington, NZ)
PROPOSAL_ID:

MFP-10-MAU-116

GRANT_NUMBER:

MFP-MAU1001

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Royal Society Te Apārangi

Works (50 of 66)

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The crystal structure of methanogen McrD, a methyl-coenzyme M reductase-associated protein

FEBS Open Bio
2024 | Journal article
Contributors: Sutherland-Smith, Andrew J.; Carbone, Vincenzo; Schofield, Linley R.; Cronin, Bryan; Duin, Evert C.; Ronimus, Ron S.
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Structural characterisation of methanogen pseudomurein cell wall peptide ligases homologous to bacterial MurE/F murein peptide ligases

Microbiology
2022-09-30 | Journal article
Contributors: Bishwa P. Subedi; Linley R. Schofield; Vincenzo Carbone; Maximilian Wolf; William F. Martin; Ron S. Ronimus; Andrew J. Sutherland-Smith
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Crossref
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Novel Assessment of Collagen and Its Crosslink Content in the Humerus from Primiparous Dairy Cows with Spontaneous Humeral Fractures Due to Osteoporosis from New Zealand

Biology
2022-09-23 | Journal article
Contributors: Alvaro Wehrle-Martinez; Rafea Naffa; Penny Back; Chris W. Rogers; Kevin Lawrence; Trevor Loo; Andrew Sutherland-Smith; Keren Dittmer
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Crossref
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Archaeal pseudomurein and bacterial murein cell wall biosynthesis share a common evolutionary ancestry

FEMS Microbes
2021 | Journal article
Contributors: Bishwa P Subedi; William F Martin; Vincenzo Carbone; Eduardus C Duin; Bryan Cronin; Julia Sauter; Linley R Schofield; Andrew J Sutherland-Smith; Ron S Ronimus
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Strigolactones regulate sepal senescence in Arabidopsis

Journal of Experimental Botany
2021 | Journal article
Contributors: Xu, Xi; Jibran, Rubina; Wang, Yanting; Dong, Lemeng; Flokova, Kristyna; Esfandiari, Azadeh; McLachlan, Andrew R. G.; Heiser, Axel; Sutherland-Smith, Andrew J.; Brummell, David A. et al.
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Covalent Functionalization of Bioengineered Polyhydroxyalkanoate Spheres Directed by Specific Protein-Protein Interactions

Frontiers in Bioengineering and Biotechnology
2020 | Journal article
Contributors: Wong, Jin Xiang; Gonzalez-Miro, Majela; Sutherland-Smith, Andrew J.; Rehm, Bernd H. A.
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Investigation of Cell Envelope-Associated Proteins in Rumen Methanogens as Targets for Understanding Host-Microbe Interactions

The FASEB Journal
2020 | Journal article
Contributors: Yeung, Juliana; Shu, Dairu; Ferguson, Timothy; Altermann, Eric; Khanum, Sofia; Gupta, Sandeep; Loo, Trevor; Sutherland-Smith, Andrew; Heiser, Axel; Janssen, Peter et al.
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A nucleotidyl transferase from Methanothermobacter thermautotroptrophicus (Mth528)

2020-07-08 | Other
Contributors: V. Carbone; L. Schofield; A. Sutherland-Smith; R. Ronimus
Source: Self-asserted source
Andrew J. Sutherland-Smith via Crossref Metadata Search

Strigolactone defective mutants ofArabidopsisexhibit delayed sepal senescence

2020-01-08 | Preprint
Contributors: Xi Xu; Rubina Jibran; Yanting Wang; Lemeng Dong; Kristyna Flokova; Azadeh Esfandiari; Andrew McLachlan; Axel Heiser; Andrew Sutherland-Smith; Harro Bouwmeester et al.
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Crossref

Discovering Inhibitors of Rumen Methanogens Using High-Throughput X-ray Crystallography and Enzyme Screening Techniques

Acta Crystallographica Section A: Foundations and Advances
2018 | Journal article
Contributors: Carbone, Vincenzo; Schofield, Linley R.; Sutherland-Smith, Andrew J.; Ronimus, Ron S.
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Structural determination of archaeal UDP-N-acetylglucosamine 4-epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP-N-acetylmuramic acid

Proteins: Structure, Function, and Bioinformatics
2018 | Journal article
Contributors: Carbone, Vincenzo; Schofield, Linley R.; Sang, Carrie; Sutherland-Smith, Andrew J.; Ronimus, Ron S.
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Biallelic mutations in <i>CYP26B1</i> : A differential diagnosis for Pfeiffer and Antley-Bixler syndromes

American Journal of Medical Genetics Part A
2016 | Journal article
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The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase

Journal of Biological Chemistry
2016 | Journal article
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Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.

American journal of human genetics
2016-07 | Journal article
Contributors: Wade EM; Daniel PB; Jenkins ZA; McInerney-Leo A; Leo P; Morgan T; Addor MC; Adès LC; Bertola D; Bohring A et al.
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Andrew J. Sutherland-Smith via Europe PubMed Central
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Developing a video tracking method to study interactions between close pairs of optically trapped particles in three dimensions

Applied Optics
2015 | Journal article
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Diverse phenotypic consequences of mutations affecting the C-terminus of FLNA

Journal of Molecular Medicine
2015 | Journal article
Contributors: van Kogelenberg, Margriet; Clark, Alice R.; Jenkins, Zandra; Morgan, Tim; Anandan, Ananda; Sawyer, Gregory M.; Edwards, Matthew; Dudding, Tracy; Homfray, Tessa; Castle, Bruce et al.
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Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase

Journal of Biological Chemistry
2015 | Journal article
Contributors: Carbone, Vincenzo; Schofield, Linley R.; Zhang, Yanli; Sang, Carrie; Dey, Debjit; Hannus, Ingegerd M.; Martin, William F.; Sutherland-Smith, Andrew J.; Ronimus, Ron S.
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Mouse ADP-dependent Glucokinase; AMP bound

2015-11 | Other
Contributors: J.P. Richter; R.S. Ronimus; A.J. Sutherland-Smith
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Andrew J. Sutherland-Smith via Crossref Metadata Search
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Crystal structure of G1PDH with NADPH from Methanocaldococcus jannaschii

2015-07 | Other
Contributors: V. Carbone; R.S. Ronimus; L.R. Schofield; A.J. Sutherland-Smith
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Andrew J. Sutherland-Smith via Crossref Metadata Search
grade
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Crystal structure of the Methanocaldococcus jannaschii G1PDH

2015-07 | Other
Contributors: V. Carbone; R.S. Ronimus; L.R. Schofield; A.J. Sutherland-Smith
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Andrew J. Sutherland-Smith via Crossref Metadata Search
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Crystal structure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP

2015-07 | Other
Contributors: V. Carbone; R.S. Ronimus; L.R. Schofield; A.J. Sutherland-Smith
Source: Self-asserted source
Andrew J. Sutherland-Smith via Crossref Metadata Search

Rotating angled plate diffusing wave spectroscopy

International Journal of Nanotechnology
2014 | Journal article
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Beyond BLASTing: Tertiary and Quaternary Structure Analysis Helps Identify Major Vault Proteins

Genome Biology and Evolution
2013 | Journal article
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In Silico Resurrection of the Major Vault Protein Suggests It Is Ancestral in Modern Eukaryotes

Genome Biology and Evolution
2013 | Journal article
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Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

Nature Genetics
2013 | Journal article
Contributors: Cappello, Silvia; Gray, Mary J.; Badouel, Caroline; Lange, Simona; Einsiedler, Melanie; Srour, Myriam; Chitayat, David; Hamdan, Fadi F.; Jenkins, Zandra A.; Morgan, Tim et al.
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The crystal structure of methenyltetrahydromethanopterin cyclohydrolase from Methanobrevibacter ruminantium

Proteins: Structure, Function, and Bioinformatics
2013 | Journal article
Contributors: Carbone, Vincenzo; Schofield, Linley R.; Beattie, Amy K.; Sutherland-Smith, Andrew J.; Ronimus, Ron S.
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Crystal Structure of Methenyltetrahydromethanopterin Cyclohydrolase from Methanobrevibacter ruminantium

2013-07 | Other
Contributors: V. Carbone; L.R. Schofield; A.K. Beattie; A.J. Sutherland-Smith; R.S. Ronimus
Source: Self-asserted source
Andrew J. Sutherland-Smith via Crossref Metadata Search
grade
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Crystal Structure of the Filamin N-Terminal Region Reveals a Hinge between the Actin Binding and First Repeat Domains

Journal of Molecular Biology
2012 | Journal article
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Expression and role in glycolysis of human ADP-dependent glucokinase

Molecular and Cellular Biochemistry
2012 | Journal article
Contributors: Richter, Susan; Richter, Jan P.; Mehta, Sunali Y.; Gribble, Amanda M.; Sutherland-Smith, Andrew J.; Stowell, Kathryn M.; Print, Cristin G.; Ronimus, Ron S.; Wilson, William R.
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Crystal Structure of Human Filamin B Actin Binding Domain with 1st Filamin Repeat

2012-10-10 | Other
Contributors: G.M. Sawyer; A.J. Sutherland-Smith
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Andrew J. Sutherland-Smith via Crossref Metadata Search
grade
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The crystal structures of dystrophin and utrophin spectrin repeats: implications for domain boundaries.

PloS one
2012-07 | Journal article
Contributors: Muthu M; Richardson KA; Sutherland-Smith AJ
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Andrew J. Sutherland-Smith via Europe PubMed Central
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Characterization of a Dual-Function Domain That Mediates Membrane Insertion and Excision of Ff Filamentous Bacteriophage

Journal of Molecular Biology
2011 | Journal article
Contributors: Bennett, Nicholas J.; Gagic, Dragana; Sutherland-Smith, Andrew J.; Rakonjac, Jasna
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Craniosynostosis and Multiple Skeletal Anomalies in Humans and Zebrafish Result from a Defect in the Localized Degradation of Retinoic Acid

The American Journal of Human Genetics
2011 | Journal article
Contributors: Laue, Kathrin; Pogoda, Hans-Martin; Daniel, Philip B.; van Haeringen, Arie; Alanay, Yasemin; von Ameln, Simon; Rachwalski, Martin; Morgan, Tim; Gray, Mary J.; Breuning, Martijn H. et al.
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Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?

Biophysical Reviews
2011 | Journal article
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Structure and functional characterisation of utrophin and dystrophin N-terminal first spectrin repeats

Acta Crystallographica Section A: Foundations and Advances
2011 | Journal article
Contributors: Muthu, Muralidharan; Sutherland-Smith, Andrew J.
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The C313Y Piedmontese mutation decreases myostatin covalent dimerisation and stability

BMC Research Notes
2011 | Journal article
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Cytotoxic Aggregation and Amyloid Formation by the Myostatin Precursor Protein

Plos One
2010 | Journal article
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Disease-associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains

Journal of Molecular Biology
2009 | Journal article
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Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders†

Human Molecular Genetics
2009 | Journal article
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Structure of the actin-binding domain of human filamin A (reduced)

2009-10 | Other
Contributors: A.R. Clark; G.M. Sawyer; S.P. Robertson; A.J. Sutherland-Smith
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Andrew J. Sutherland-Smith via Crossref Metadata Search

Proceedings of the 188th Scientific Meeting of the Otago Medical School Research Society, Thursday 5 July 2007

New Zealand Medical Journal
2007 | Journal article
Contributors: Bicknell, L.; Sutherland-Smith, A.; Pitt, J.; Maw, M.; Ramadas, R.; Aftimos, S.; Robertson, S.
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The Emery-Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A

The FEBS Journal
2006 | Journal article
Contributors: Roberts, Rhys C.; Sutherland-Smith, Andrew J.; Wheeler, Matthew A.; Jensen, Ole Norregaard; Emerson, Lindsay J.; Spiliotis, Ioannis I.; Tate, Christopher G.; Kendrick-Jones, John; Ellis, Juliet A.
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DNA sequence analysis for structure/function and mutation studies in Becker muscular dystrophy

Clinical Genetics
2005 | Journal article
Contributors: Hamed, SA; Sutherland-Smith, AJ; Gorospe, JRM; Kendrick-Jones, J; Hoffman, EP
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Nuclear envelope proteins involved in muscular dystrophies

The FEBS Journal
2005 | Journal article
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An open or closed case for the conformation of calponin homology domains on F-actin?

Journal of Muscle Research and Cell Motility
2004 | Journal article
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Missense mutations in the actin binding domain (ABD) of dystrophin cause muscular dystrophy by disrupting protein stability

Neurology
2004 | Journal article
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An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin

Journal of Molecular Biology
2003 | Journal article
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Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans

Nature Genetics
2003 | Journal article
Contributors: Robertson, SP; Twigg, SRF; Sutherland-Smith, AJ; Biancalana, V; Gorlin, RJ; Horn, D; Kenwrick, SJ; Kim, CA; Morava, E; Newbury-Ecob, R et al.
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The location and structure of utrophin on F-Actin.

Biophysical Journal
2003 | Journal article
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3-D imaging of dystrophin and utrophin on F-actin

Biophysical Journal
2002 | Journal article
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Peer review (20 reviews for 12 publications/grants)

Review activity for Biochemistry. (3)
Review activity for BMC genetics. (1)
Review activity for FEBS letters. (2)
Review activity for Human molecular genetics. (3)
Review activity for Journal of Molecular Biology. (1)
Review activity for Journal of molecular biology. (2)
Review activity for Journal of structural biology. (2)
Review activity for Molecular biology and evolution. (1)
Review activity for Nature structural & molecular biology. (1)
Review activity for PeerJ. (1)
Review activity for PloS one. (2)
Review activity for Protein science. (1)