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Employment (2)

University of Colorado Boulder: Boulder, CO, US

2008-10-01 to present | Faculty (Developmental, Cell, and Developmental Biology)
Employment
Source: Self-asserted source
JINGSHI SHEN

Columbia University Medical Center: New York, NY, US

2004-10-01 to 2008-10-01 | Postdoctoral Fellow (Physiology and Cellular Biophysics)
Employment
Source: Self-asserted source
JINGSHI SHEN

Education and qualifications (2)

Columbia University: New York, NY, US

2004-10-01 | Ph.D. (Biological Sciences)
Education
Source: Self-asserted source
JINGSHI SHEN

Tsinghua University: Beijing, Beijing, CN

1998 | B.S. (Biological Sciences and Biotechnology)
Education
Source: Self-asserted source
JINGSHI SHEN

Works (35)

A Commander-independent function of COMMD3 in endosomal trafficking

2025-02-17 | Preprint
DOI: 10.7554/eLife.105264.1
Contributors: Galen T Squiers; Chun Wan; James Gorder; Harrison Puscher; Jingshi Shen
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Crossref

A Commander-independent function of COMMD3 in endosomal trafficking

2025-02-17 | Preprint
DOI: 10.7554/eLife.105264
Contributors: Galen T Squiers; Chun Wan; James Gorder; Harrison Puscher; Jingshi Shen
Source: check_circle
Crossref

A Commander-independent function of COMMD3 in endosomal trafficking

2024-12-17 | Preprint
DOI: 10.1101/2024.12.12.628173
Contributors: Galen T. Squiers; Chun Wan; James Gorder; Harrison Puscher; Jingshi Shen
Source: check_circle
Crossref

Structural basis of pseudoGTPase-mediated protein-protein interactions

2024-11-01 | Preprint
DOI: 10.1101/2024.10.30.620932
Contributors: Bing Wang; Rui Yang; Chun Wan; Yuan Tian; Jingyi Wu; Sayantan Roy; Suzhao Li; Jingshi Shen; Qian Yin
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Crossref

An AAGAB-to-CCDC32 handover mechanism controls the assembly of the AP2 adaptor complex

Proceedings of the National Academy of Sciences
2024-08-20 | Journal article
DOI: 10.1073/pnas.2409341121
Contributors: Chun Wan; Harrison Puscher; Yan Ouyang; Jingyi Wu; Yuan Tian; Suzhao Li; Qian Yin; Jingshi Shen
Source: check_circle
Crossref

Cyanine lipids promote the shedding of extracellular vesicles from cell membranes

Precision Nanomedicine
2023-09-15 | Journal article
DOI: 10.33218/001c.88009
Contributors: Dmitri Simberg; Hanmant Gaikwad; David Siegel; Ashlynn Barnes; Masamitsu Kanada; Chun Wan; Jingshi Shen; Irina Balyasnikova
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Crossref

Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module

Science Advances
2023-02-24 | Journal article
DOI: 10.1126/sciadv.ade2540
Contributors: Shifeng Wang; Xu Chen; Lauren Crisman; Ximing Dou; Christina S. Winborn; Chun Wan; Harrison Puscher; Qian Yin; Matthew J. Kennedy; Jingshi Shen
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Crossref

Faithful SM proteins chaperone SNAREs on path to successful assembly

Proceedings of the National Academy of Sciences
2023-01-17 | Journal article
DOI: 10.1073/pnas.2219769120
Contributors: Haijia Yu; Jingshi Shen
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Crossref

Oligomer-to-monomer transition underlies the chaperone function of AAGAB in AP1/AP2 assembly

Proceedings of the National Academy of Sciences
2023-01-10 | Journal article
DOI: 10.1073/pnas.2205199120
Contributors: Yuan Tian; Ishara Datta; Rui Yang; Chun Wan; Bing Wang; Lauren Crisman; Huan He; Chad A. Brautigam; Suzhao Li; Jingshi Shen et al.
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Crossref

Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system

Communications Biology
2022-11-11 | Journal article
DOI: 10.1038/s42003-022-04050-z
Contributors: Chun Wan; Michael H. B. Stowell; Jingshi Shen
Source: check_circle
Crossref

Oligomer-to-Monomer Transition Underlies the Chaperone Function of AAGAB in AP1/AP2 Assembly

2022-03-12 | Preprint
DOI: 10.1101/2022.03.11.483825
Contributors: Yuan Tian; Ishara Datta; Rui Yang; Chun Wan; Bing Wang; Huan He; Suzhao Li; Jingshi Shen; Qian Yin
Source: check_circle
Crossref

PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes

Science Advances
2020-11-27 | Journal article
DOI: 10.1126/sciadv.abc3243
Contributors: Bridget L. Menasche; Eric M. Davis; Shifeng Wang; Yan Ouyang; Suzhao Li; Haijia Yu; Jingshi Shen
Source: check_circle
Crossref

Genetic evidence for an inhibitory role of tomosyn in insulin‐stimulated GLUT4 exocytosis

Traffic
2020-10 | Journal article
DOI: 10.1111/tra.12760
Contributors: Shifeng Wang; Yinghui Liu; Lauren Crisman; Chun Wan; Jessica Miller; Haijia Yu; Jingshi Shen
Source: check_circle
Crossref

A myosin-7B–dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos

Proceedings of the National Academy of Sciences
2020-05-19 | Journal article
DOI: 10.1073/pnas.1918617117
Contributors: Qi Zhang; Yue Xu; Juhyung Lee; Michal Jarnik; Xufeng Wu; Juan S. Bonifacino; Jingshi Shen; Yihong Ye
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Crossref

Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis

Journal of Biological Chemistry
2019-12 | Journal article
DOI: 10.1074/jbc.RA119.010821
Contributors: Shifeng Wang; Lauren Crisman; Jessica Miller; Ishara Datta; Daniel R. Gulbranson; Yuan Tian; Qian Yin; Haijia Yu; Jingshi Shen
Source: check_circle
Crossref

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis

Nature Communications
2015 | Journal article
DOI: 10.1038/ncomms9852
PMID: 26572858
Source: Self-asserted source
JINGSHI SHEN

Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding

Journal of the American Chemical Society
2015-10 | Journal article
DOI: 10.1021/jacs.5b08306
PMID: 26431309
Source: Self-asserted source
JINGSHI SHEN

Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins

Cell Reports
2015-06 | Journal article
DOI: 10.1016/j.celrep.2015.05.026
PMID: 26074080
Source: Self-asserted source
JINGSHI SHEN

A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics

Cell Research
2014-12 | Journal article
DOI: 10.1038/cr.2014.159
PMID: 25475060
Source: Self-asserted source
JINGSHI SHEN

The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulation

The Journal of Biological Chemistry
2014-09 | Journal article
DOI: 10.1074/jbc.M114.591487
PMID: 25063806
Source: Self-asserted source
JINGSHI SHEN

Directing traffic into the future

Developmental Cell
2013-12 | Journal article
PMID: 24482802
Source: Self-asserted source
JINGSHI SHEN

Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins

Proceedings of the National Academy of Sciences of the United States of America
2013-08 | Journal article
DOI: 10.1073/pnas.1311232110
PMID: 23918365
Source: Self-asserted source
JINGSHI SHEN

Synip arrests soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent membrane fusion as a selective target membrane SNARE-binding inhibitor

The Journal of Biological Chemistry
2013-06 | Journal article
DOI: 10.1074/jbc.M113.465450
PMID: 23665562
Source: Self-asserted source
JINGSHI SHEN

Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner

Molecular Biology of the Cell
2013-04 | Journal article
DOI: 10.1091/mbc.E12-11-0810
PMID: 23427263
Source: Self-asserted source
JINGSHI SHEN

Topological arrangement of the intracellular membrane fusion machinery

Molecular Biology of the Cell
2011-07 | Journal article
DOI: 10.1091/mbc.E11-03-0190
PMID: 21633111
Source: Self-asserted source
JINGSHI SHEN

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex

Proceedings of the National Academy of Sciences of the United States of America
2010-12 | Journal article
DOI: 10.1073/pnas.1012997108
PMID: 21139055
Source: Self-asserted source
JINGSHI SHEN

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion

The Journal of Cell Biology
2010-07 | Journal article
DOI: 10.1083/jcb.201003148
PMID: 20603329
Source: Self-asserted source
JINGSHI SHEN

SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes

Proceedings of the National Academy of Sciences of the United States of America
2008-02 | Journal article
DOI: 10.1073/pnas.0712125105
PMID: 18268324
Source: Self-asserted source
JINGSHI SHEN

Selective activation of cognate SNAREpins by Sec1/Munc18 proteins

Cell
2007-01 | Journal article
DOI: 10.1016/j.cell.2006.12.016
PMID: 17218264
Source: Self-asserted source
JINGSHI SHEN

ER stress signaling by regulated proteolysis of ATF6

Methods (San Diego, Calif.)
2005-04 | Journal article
DOI: 10.1016/j.ymeth.2004.10.011
PMID: 15804611
Source: Self-asserted source
JINGSHI SHEN

Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

Molecular and Cellular Biology
2005-02 | Journal article
DOI: 10.1128/MCB.25.3.921-932.2005
PMID: 15657421
Source: Self-asserted source
JINGSHI SHEN

Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6

The Journal of Biological Chemistry
2004-10 | Journal article
DOI: 10.1074/jbc.M408466200
PMID: 15299016
Source: Self-asserted source
JINGSHI SHEN

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

Developmental Cell
2002-07 | Journal article
PMID: 12110171
Source: Self-asserted source
JINGSHI SHEN

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

The Journal of Biological Chemistry
2002-04 | Journal article
DOI: 10.1074/jbc.M110636200
PMID: 11821395
Source: Self-asserted source
JINGSHI SHEN

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response

The Journal of Biological Chemistry
2000-09 | Journal article
DOI: 10.1074/jbc.M003322200
PMID: 10856300
Source: Self-asserted source
JINGSHI SHEN
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