Personal information

G-Quadruplex, Metal Complexes, BioInorganic Chemistry, DNA
Italy

Biography

Alessio Terenzi was born in Palermo (1981), Italy. He obtained his master’s degree in chemistry at the University of Palermo (2007), where he also completed his Ph.D (2011), under the supervision of Prof. G. Barone. During his PhD, he worked in Prof. J. M. Quintela’s group at the University of La Coruña, Spain (2009), and as a Marie Curie Early Stage Researcher in Prof. M. J. Hannon’s group at the University of Birmingham, UK (2010). After completing his first postdoc at the University of Palermo (2014), he moved to the University of Vienna, Austria, with a Marie Curie Cofund Fellowship (INDICAR). In Vienna, he developed his project on the in-cell interaction of metal complexes with G-quadruplex DNA motifs, between the Institute of Inorganic Chemistry (Prof. B. Keppler) and the Research Platform of Translational Cancer Therapy Research (Prof. W. Berger). In 2018, thanks to a Marie Skłodowska-Curie Individual Postdoctoral Fellowship, he moved to San Sebastian, Spain, in the group of Prof. L. Salassa, where he worked on the development of photoactivatable anticancer prodrugs, which simultaneously incorporate nuclear imaging capability. In 2020, he obtained a position as Associate Professor of Inorganic Chemistry at the University of Palermo (Italy).

Activities

Employment (6)

Università degli Studi di Palermo: Palermo, Sicilia, IT

2020-01-01 to present | Associate Professor of Inorganic Chemistry (Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF))
Employment
Source: Self-asserted source
Alessio Terenzi

Donostia International Physics Center: San Sebastian, País Vasco, ES

2018-03-01 to 2019-12-31 | Marie Curie postdoc
Employment
Source: Self-asserted source
Alessio Terenzi

University of Vienna: Vienna, AT

2014 to 2018 | Marie Curie COFUND postdoc (Inorganic Chemistry)
Employment
Source: Self-asserted source
Alessio Terenzi

Università degli Studi di Palermo: Palermo, Sicilia, IT

2011 to 2014 | Post Doc (Dip. Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF))
Employment
Source: Self-asserted source
Alessio Terenzi

University of Birmingham: Birmingham, Birmingham, GB

2009 to 2010 | Marie Curie Early Stage Researcher (School of Chemistry)
Employment
Source: Self-asserted source
Alessio Terenzi

Universidade da Coruna: A Coruña, Galicia, ES

2009 to 2009 | Ph.D. visiting student (Chemistry Department)
Employment
Source: Self-asserted source
Alessio Terenzi

Education and qualifications (2)

Università degli Studi di Palermo: Palermo, Sicilia, IT

Master Chemistry (Chemistry)
Education
Source: Self-asserted source
Alessio Terenzi

University of Palermo: Palermo, IT

2008 to 2011-03-15 | Ph.D. in Chemistry (Chemistry)
Qualification
Source: Self-asserted source
Alessio Terenzi

Works (50 of 94)

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Page 1 of 2

A new fluorescent oxaliplatin(iv) complex with EGFR-inhibiting properties for the treatment of drug-resistant cancer cells

Inorganic Chemistry Frontiers
2025 | Journal article
Contributors: Monika Caban; Philipp Fronik; Alessio Terenzi; Anja Federa; Julia H. Bormio Nunes; Rastislav Pitek; Dominik Kirchhofer; Hemma H. Schueffl; Walter Berger; Bernhard K. Keppler et al.
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Crossref

DNA Binding Activity of Functionalized Schiff Base Metal Complexes

European Journal of Inorganic Chemistry
2025-02-21 | Journal article
Contributors: Luisa D'Anna; Laura Marretta; Aurane Froux; Simona Rubino; Valeria Butera; Angelo Spinello; Riccardo Bonsignore; Alessio Terenzi; Giampaolo Barone
Source: check_circle
Crossref

Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes

Journal of Xenobiotics
2025-02-01 | Journal article
Contributors: Roberto Chiarelli; Chiara Martino; Rosaria Scudiero; Alessio Terenzi; Fabiana Geraci
Source: check_circle
Crossref
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Metal centers and aromatic moieties in Schiff base complexes: impact on G-quadruplex stabilization and oncogene downregulation

Inorganic Chemistry Frontiers
2024 | Journal article
Contributors: Aurane Froux; Luisa D'Anna; Aurianne Rainot; Camille Neybecker; Angelo Spinello; Riccardo Bonsignore; Raphaël Rouget; Guillaume Harlé; Alessio Terenzi; Antonio Monari et al.
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Crossref

Novel half Salphen cobalt(iii) complexes: synthesis, DNA binding and anticancer studies

Dalton Transactions
2024 | Journal article
Contributors: Riccardo Bonsignore; Elisa Trippodo; Roberto Di Gesù; Anna Paola Carreca; Simona Rubino; Angelo Spinello; Alessio Terenzi; Giampaolo Barone
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Resolving the Structure of a Guanine Quadruplex in TMPRSS2 Messenger RNA by Circular Dichroism and Molecular Modeling

Chemistry – A European Journal
2024-12-18 | Journal article
Contributors: Luisa D'Anna; Aurane Froux; Aurianne Rainot; Angelo Spinello; Ugo Perricone; Florent Barbault; Stéphanie Grandemange; Giampaolo Barone; Alessio Terenzi; Antonio Monari
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Crossref

In Silico Design of a Solution-Gated Graphene Transistor Sensor for the Efficient Detection of Guanine Quadruplexes

The Journal of Physical Chemistry Letters
2024-10-31 | Journal article
Contributors: Aurianne Rainot; Luisa D’Anna; Alessio Terenzi; Raphael Rouget; Stéphanie Grandemange; Benoit Piro; Giampaolo Barone; Florent Barbault; Antonio Monari
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Crossref

Synergistic Anticancer Effects by Enhancing the G-Quadruplex Binding of Nickel(II) Salphen Complexes through Coupling with S-Doped Carbon Nanodots

ACS Applied Materials & Interfaces
2024-10-23 | Journal article
Contributors: Cinzia Scialabba; Laura Marretta; Luisa D’Anna; Giampaolo Barone; Gennara Cavallaro; Alessio Terenzi; Nicolò Mauro
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Crossref

Alloxazine-Based Ligands and Their Ruthenium Complexes as NADH Oxidation Catalysts and G4 Binders

Inorganic Chemistry
2024-09-02 | Journal article
Contributors: Maria Jesus Móran Plata; Laura Marretta; Lander Gaztelumendi; German E. Pieslinger; Romina R. Carballo; Elixabete Rezabal; Giampaolo Barone; Virginia Martínez-Martínez; Alessio Terenzi; Luca Salassa
Source: check_circle
Crossref

Resolving the Structure of a Guanine Quadruplex in TMPRSS2 Messenger RNA by Circular Dichroism and Molecular Modeling

2024-07-30 | Preprint
Contributors: Luisa D’Anna; Aurane Froux; Aurianne Rainot; Angelo Spinello; Ugo Perricone; Florent Barbault; Stéphanie Grandemange; Giampaolo Barone; Alessio Terenzi; Antonio Monari
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Crossref

Resolving a guanine-quadruplex structure in the SARS-CoV-2 genome through circular dichroism and multiscale molecular modeling

Chemical Science
2023 | Journal article
Contributors: Luisa D'Anna; Tom Miclot; Emmanuelle Bignon; Ugo Perricone; Giampaolo Barone; Antonio Monari; Alessio Terenzi
Source: check_circle
Crossref

Salphen metal complexes as potential anticancer agents: interaction profile and selectivity studies toward the three G-quadruplex units in the KIT promoter

Dalton Transactions
2023 | Journal article
Contributors: Luisa D'Anna; Simona Rubino; Candida Pipitone; Graziella Serio; Carla Gentile; Antonio Palumbo Piccionello; Francesco Giannici; Giampaolo Barone; Alessio Terenzi
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Crossref

How the Metal Ion Affects the 1H NMR Chemical Shift Values of Schiff Base Metal Complexes: Rationalization by DFT Calculations

The Journal of Physical Chemistry A
2023-11-09 | Journal article
Contributors: Valeria Butera; Luisa D’Anna; Simona Rubino; Riccardo Bonsignore; Angelo Spinello; Alessio Terenzi; Giampaolo Barone
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Mechanism of the Covalent Inhibition of Human Transmembrane Protease Serine 2 as an Original Antiviral Strategy

The Journal of Physical Chemistry B
2023-07-20 | Journal article
Contributors: Angelo Spinello; Luisa D’Anna; Emmanuelle Bignon; Tom Miclot; Stéphanie Grandemange; Alessio Terenzi; Giampaolo Barone; Florent Barbault; Antonio Monari
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Synthesis and Characterization of a Luminescent Cyclic Poly(ethylene oxide)–Polypyridyl Ruthenium Complex

ACS Macro Letters
2023-07-18 | Journal article
Contributors: M. Ali Aboudzadeh; Vanessa Rodríguez-Fanjul; Alessio Terenzi; Estibaliz Gónzalez de San Román; José I. Miranda; Ana M. Pizarro; Luca Salassa; Fabienne Barroso-Bujans
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Crossref

Predicting the Three-Dimensional Structure of the c-KIT Proto-Oncogene Promoter and the Dynamics of Its Strongly Coupled Guanine Quadruplexes

The Journal of Physical Chemistry Letters
2023-05-25 | Journal article
Contributors: Emmanuelle Bignon; Angelo Spinello; Tom Miclot; Luisa D’Anna; Cosimo Ducani; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari; Alessio Terenzi
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Mechanism of the Covalent Inhibition of Human Transmembrane Protease Serine 2 as an Original Antiviral Strategy

2023-04-24 | Preprint
Contributors: Angelo Spinello; Luisa D’Anna; Emmanuelle Bignon; Tom Miclot; Stéphanie Grandemange; Alessio Terenzi; Giampaolo Barone; Florent Barbault; Antonio Monari
Source: check_circle
Crossref

Resolving a Guanine-Quadruplex Structure in the SARS-CoV-2 Genome through Circular Dichroism and Multiscale Molecular Modeling

2023-04-13 | Preprint
Contributors: Luisa D’Anna; Tom Miclot; Emmanuelle Bignon; Ugo Perricone; Giampaolo Barone; Antonio Monari; Alessio Terenzi
Source: check_circle
Crossref

Understanding the Interactions of Guanine Quadruplexes with Peptides as Novel Strategies for Diagnosis or Tuning Biological Functions

ChemBioChem
2023-03-14 | Journal article
Contributors: Tom Miclot; Aurane Froux; Luisa D'Anna; Emmanuelle Bignon; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari; Alessio Terenzi
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Crossref

Predicting the Three-dimensional Structure of the c-KITOncogene Promoter and the Dynamics of Strongly Coupled Guanine-Quadruplexes

2023-02-23 | Preprint
Contributors: Emmanuelle Bignon; Angelo Spinello; Tom Miclot; Luisa D’ Anna; Cosimo Ducani; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari; Alessio Terenzi
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Crossref

Structure of the 5′ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1

Chemical Communications
2022 | Journal article
Contributors: Emmanuelle Bignon; Tom Miclot; Alessio Terenzi; Giampaolo Barone; Antonio Monari
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Crossref

G-quadruplex recognition by DARPIns through epitope/paratope analogy

2022-06-16 | Preprint
Contributors: Tom Miclot; Emmanuelle Bignon; Alessio Terenzi; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari
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Crossref

Never Cared for What They Do: High Structural Stability of Guanine-Quadruplexes in the Presence of Strand-Break Damage

Molecules
2022-05-19 | Journal article
Contributors: Tom Miclot; Cécilia Hognon; Emmanuelle Bignon; Alessio Terenzi; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari
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Crossref
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Structure of the 5’ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1†

2021-12-13 | Preprint
Contributors: Emmanuelle Bignon; Tom Miclot; Alessio Terenzi; Giampaolo Barone; Antonio Monari
Source: check_circle
Crossref

Never cared for what they do. High structural stability of Guanine-quadruplexes in presence of strand-break damages

2021-12-01 | Other
Contributors: Tom Miclot; Cécilia Hognon; Emmanuelle Bignon; Alessio Terenzi; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari
Source: check_circle
Crossref

Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism

Communications Chemistry
2021-11-25 | Journal article
Contributors: Alessio Terenzi; Mery La Franca; Sushilla van Schoonhoven; Rostyslav Panchuk; Álvaro Martínez; Petra Heffeter; Redding Gober; Christine Pirker; Petra Vician; Christian R. Kowol et al.
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Structure and Dynamics of RNA Guanine Quadruplexes in SARS-CoV-2 Genome. Original Strategies against Emerging Viruses

The Journal of Physical Chemistry Letters
2021-10-28 | Journal article
Contributors: Tom Miclot; Cécilia Hognon; Emmanuelle Bignon; Alessio Terenzi; Marco Marazzi; Giampaolo Barone; Antonio Monari
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Antiproliferative Properties and G-Quadruplex-Binding of Symmetrical Naphtho[1,2-b:8,7-b’]dithiophene Derivatives

Molecules
2021-07-16 | Journal article
Contributors: Antonino Lauria; Gabriele La Monica; Alessio Terenzi; Giuseppe Mannino; Riccardo Bonsignore; Alessia Bono; Anna Maria Almerico; Giampaolo Barone; Carla Gentile; Annamaria Martorana
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Forever Young: Structural Stability of Telomeric Guanine Quadruplexes in the Presence of Oxidative DNA Lesions**

Chemistry – A European Journal
2021-06-16 | Journal article
Contributors: Tom Miclot; Camille Corbier; Alessio Terenzi; Cécilia Hognon; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari
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Crossref

Structure and dynamics of RNA guanine quadruplexes in SARS-CoV-2 genome. Original strategies against emerging viruses

2021-05-21 | Other
Contributors: Tom Miclot; Cécilia Hognon; Emmanuelle Bignon; Alessio Terenzi; Marco Marazzi; Giampaolo Barone; Antonio Monari
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Crossref

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib

Bioorganic Chemistry
2020 | Journal article
EID:

2-s2.0-85082482736

Part of ISBN:

10902120 00452068

Contributors: Bielec, B.; Schueffl, H.; Terenzi, A.; Berger, W.; Heffeter, P.; Keppler, B.K.; Kowol, C.R.
Source: Self-asserted source
Alessio Terenzi via Scopus - Elsevier

Influence of thermally induced structural transformations on the magnetic and luminescence properties of tartrate-based chiral lanthanide organic-frameworks

Journal of Materials Chemistry C
2020 | Journal article
Contributors: Uxua Huizi-Rayo; Andoni Zabala-Lekuona; Alessio Terenzi; Carlos M. Cruz; Juan M. Cuerva; Antonio Rodríguez-Diéguez; Jose Angel García; José M. Seco; Eider San Sebastian; Javier Cepeda
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Forever Young: Structural Stability of Telomeric Guanine-Quadruplexes in Presence of Oxidative DNA Lesions

2020-11-26 | Other
Contributors: Tom Miclot; Camille Corbier; Alessio Terenzi; Cécilia Hognon; Stéphanie Grandemange; Giampaolo Barone; Antonio Monari
Source: check_circle
Crossref

Molecular Basis of SARS-CoV-2 Infection and Rational Design of Potential Antiviral Agents: Modeling and Simulation Approaches

Journal of Proteome Research
2020-11-06 | Journal article
Contributors: Antonio Francés-Monerris; Cécilia Hognon; Tom Miclot; Cristina García-Iriepa; Isabel Iriepa; Alessio Terenzi; Stéphanie Grandemange; Giampaolo Barone; Marco Marazzi; Antonio Monari
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Enantiospecific Response in Cross-Polarization Solid-State Nuclear Magnetic Resonance of Optically Active Metal Organic Frameworks

Journal of the American Chemical Society
2020-10-21 | Journal article
Contributors: Eider San Sebastian; Javier Cepeda; Uxua Huizi-Rayo; Alessio Terenzi; Daniel Finkelstein-Shapiro; Daniel Padro; Jose Ignacio Santos; Jon M. Matxain; Jesus M. Ugalde; Vladimiro Mujica
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124I Radiolabeling of a AuIII‐NHC Complex for In Vivo Biodistribution Studies

Angewandte Chemie
2020-09-21 | Journal article
Contributors: Federica Guarra; Alessio Terenzi; Christine Pirker; Rossana Passannante; Dina Baier; Ennio Zangrando; Vanessa Gómez‐Vallejo; Tarita Biver; Chiara Gabbiani; Walter Berger et al.
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124I Radiolabeling of a AuIII‐NHC Complex for In Vivo Biodistribution Studies

Angewandte Chemie International Edition
2020-09-21 | Journal article
Contributors: Federica Guarra; Alessio Terenzi; Christine Pirker; Rossana Passannante; Dina Baier; Ennio Zangrando; Vanessa Gómez‐Vallejo; Tarita Biver; Chiara Gabbiani; Walter Berger et al.
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Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses

The Journal of Physical Chemistry Letters
2020-07-16 | Journal article
Contributors: Cécilia Hognon; Tom Miclot; Cristina Garcı́a-Iriepa; Antonio Francés-Monerris; Stephanie Grandemange; Alessio Terenzi; Marco Marazzi; Giampaolo Barone; Antonio Monari
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Crossref

124I-Radiolabeling of a Au(III)-NHC Complex for in Vivo Biodistribution Studies

2020-06-08 | Other
Contributors: Federica Guarra; Alessio Terenzi; Christine Pirker; Rossana Passannante; Dina Baier; Ennio Zangrando; Vanessa Gómez; Tarita Biver; Chiara Gabbiani; Walter Berger et al.
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Crossref

124I-Radiolabeling of a Au(III)-NHC Complex for in Vivo Biodistribution Studies

2020-06-08 | Other
Contributors: Federica Guarra; Alessio Terenzi; Christine Pirker; Rossana Passannante; Dina Baier; Ennio Zangrando; Vanessa Gómez; Tarita Biver; Chiara Gabbiani; Walter Berger et al.
Source: check_circle
Crossref

Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses

2020-04-10 | Other
Contributors: Cécilia Hognon; Tom Miclot; Cristina Garcia Iriepa; Antonio Francés-Monerris; Stephanie Grandemange; Alessio Terenzi; Marco Marazzi; Giampaolo Barone; Antonio Monari
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Crossref

124I-Radiolabeling of a Au(III)-NHC Complex for in Vivo Biodistribution Studies

2020-03-19 | Other
Contributors: Federica Guarra; Alessio Terenzi; Christine Pirker; Rossana Passannante; Dina Baier; Ennio Zangrando; Vanessa Gómez; Tarita Biver; Chiara Gabbiani; Walter Berger et al.
Source: check_circle
Crossref

Anticancer platinum agents and light

Inorganica Chimica Acta
2019 | Journal article
EID:

2-s2.0-85068534626

Contributors: Gurruchaga-Pereda, J.; Martínez, Á.; Terenzi, A.; Salassa, L.
Source: Self-asserted source
Alessio Terenzi via Scopus - Elsevier

Near-infrared photochemistry assisted by upconverting nanoparticles

Photoactive Inorganic Nanoparticles: Surface Composition and Nanosystem Functionality
2019 | Book chapter
EID:

2-s2.0-85080839623

Contributors: Terenzi, A.; Salassa, L.
Source: Self-asserted source
Alessio Terenzi via Scopus - Elsevier

Ruthenium-arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition

Dalton Transactions
2019 | Journal article
EID:

2-s2.0-85070689706

Contributors: Hager, L.A.; Mokesch, S.; Kieler, C.; Alonso-De Castro, S.; Baier, D.; Roller, A.; Kandioller, W.; Keppler, B.K.; Berger, W.; Salassa, L. et al.
Source: Self-asserted source
Alessio Terenzi via Scopus - Elsevier

Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

Antioxidants
2019-10-10 | Journal article
Contributors: Alessio Terenzi; Hugo Gattuso; Angelo Spinello; Bernhard K. Keppler; Christophe Chipot; François Dehez; Giampaolo Barone; Antonio Monari
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Crossref
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Metal Complexes of Oxadiazole Ligands: An Overview

International Journal of Molecular Sciences
2019-07-16 | Journal article
Contributors: Giovanni Salassa; Alessio Terenzi
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Interplay of Three G-Quadruplex Units in the KIT Promoter

Journal of the American Chemical Society
2019-07-03 | Journal article
Contributors: Cosimo Ducani; Giulio Bernardinelli; Björn Högberg; Bernhard K. Keppler; Alessio Terenzi
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Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

Angewandte Chemie International Edition
2019-06-11 | Journal article
Part of ISSN: 1433-7851
Source: Self-asserted source
Alessio Terenzi
grade
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Catalysis Concepts in Medicinal Inorganic Chemistry

Chemistry – A European Journal
2019-05-10 | Journal article
Contributors: Silvia Alonso‐de Castro; Alessio Terenzi; Juan Gurruchaga‐Pereda; Luca Salassa
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Items per page:
Page 1 of 2

Peer review (10 reviews for 6 publications/grants)

Review activity for ACS medicinal chemistry letters. (1)
Review activity for ACS omega. (2)
Review activity for Angewandte Chemie. (1)
Review activity for Inorganic chemistry. (1)
Review activity for Journal of inorganic biochemistry. (4)
Review activity for Journal of the American Chemical Society. (1)