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Scopus Author ID: 57208600514

Keywords

Virology, Autophagy, TRIM

Countries

Germany

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Employment (1)

Universitätsklinikum Ulm: Ulm, Baden-Württemberg, DE

2018-07-16 to present | PhD Student (Institute of Molecular Virology)
Employment
Source: Self-asserted source
Lennart Koepke

Education and qualifications (2)

Universität Ulm: Ulm, Baden-Württemberg, DE

2016-10-17 to 2018-07-21 | Master of Science (M.Sc.) (Department of Biology - Biochemistry)
Education
Source: Self-asserted source
Lennart Koepke

Universität Ulm: Ulm, Baden-Württemberg, DE

2012-10-15 to 2016-07-16 | Bachelor of Science (B.Sc.) (Department of Biology - Biochemistry)
Education
Source: Self-asserted source
Lennart Koepke

Works (24)

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

Nature Communications
2023-11-01 | Journal article
DOI: 10.1038/s41467-023-42150-4
Contributors: Maximilian Hirschenberger; Alice Lepelley; Ulrich Rupp; Susanne Klute; Victoria Hunszinger; Lennart Koepke; Veronika Merold; Blaise Didry-Barca; Fanny Wondany; Tim Bergner et al.
Source: check_circle
Crossref

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

Life Science Alliance
2023-06 | Journal article
DOI: 10.26508/lsa.202201745
Contributors: Rayhane Nchioua; Annika Schundner; Susanne Klute; Lennart Koepke; Maximilian Hirschenberger; Sabrina Noettger; Giorgio Fois; Fabian Zech; Alexander Graf; Stefan Krebs et al.
Source: check_circle
Crossref

ARF1 prevents aberrant type I IFN induction by regulating STING activation and recycling

2023-05-01 | Preprint
DOI: 10.1101/2023.04.28.23289152
Contributors: Maximilian Hirschenberger; Alice Lepelley; Ulrich Rupp; Susanne Klute; Victoria Hunszinger; Lennart Koepke; Veronika Merold; Blaise Didry-Barca; Fanny Wondany; Tim Bergner et al.
Source: check_circle
Crossref

Interferon antagonists encoded by SARS-CoV-2 at a glance

Medical Microbiology and Immunology
2023-04 | Journal article
DOI: 10.1007/s00430-022-00734-9
Contributors: Jung-Hyun Lee; Lennart Koepke; Frank Kirchhoff; Konstantin M. J. Sparrer
Source: check_circle
Crossref

Luciferase reporter assays to monitor interferon signaling modulation by SARS-CoV-2 proteins

STAR Protocols
2021-12 | Journal article
DOI: 10.1016/j.xpro.2021.100781
Contributors: Maximilian Hirschenberger; Manuel Hayn; Alexandre Laliberté; Lennart Koepke; Frank Kirchhoff; Konstantin Maria Johannes Sparrer
Source: check_circle
Crossref

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

2021-12-09 | Preprint
DOI: 10.1101/2021.12.06.471527
Contributors: Rayhane Nchioua; Annika Schundner; Dorota Kmiec; Caterina Prelli Bozzo; Fabian Zech; Lennart Koepke; Alexander Graf; Stefan Krebs; Helmut Blum; Manfred Frick et al.
Source: check_circle
Crossref

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Nature Communications
2021-11-25 | Journal article
DOI: 10.1038/s41467-021-27180-0
Contributors: Fabian Zech; Daniel Schniertshauer; Christoph Jung; Alexandra Herrmann; Arne Cordsmeier; Qinya Xie; Rayhane Nchioua; Caterina Prelli Bozzo; Meta Volcic; Lennart Koepke et al.
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Crossref

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

2021-11-17 | Preprint
DOI: 10.1101/2021.11.17.468942
Contributors: Rayhane Nchioua; Annika Schundner; Dorota Kmiec; Caterina Prelli-Bozzo; Fabian Zech; Lennart Koepke; Alexander Graf; Stefan Krebs; Helmut Blum; Manfred Frick et al.
Source: check_circle
Crossref

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

2021-11-17 | Other
DOI: 10.1101/2021.11.16.468777
Contributors: Rayhane Nchioua; Annika Schundner; Susanne Klute; Sabrina Noettger; Fabian Zech; Lennart Koepke; Alexander Graf; Stefan Krebs; Helmut Blum; Dorota Kmiec et al.
Source: check_circle
Crossref

Manipulation of autophagy by SARS-CoV-2 proteins

Autophagy
2021-09-02 | Journal article
DOI: 10.1080/15548627.2021.1953847
Contributors: Lennart Koepke; Maximilian Hirschenberger; Manuel Hayn; Frank Kirchhoff; Konstantin MJ Sparrer
Source: check_circle
Crossref

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Nature Communications
2021-07-28 | Journal article
DOI: 10.1038/s41467-021-24817-y
Contributors: Caterina Prelli Bozzo; Rayhane Nchioua; Meta Volcic; Lennart Koepke; Jana Krüger; Desiree Schütz; Sandra Heller; Christina M. Stürzel; Dorota Kmiec; Carina Conzelmann et al.
Source: check_circle
Crossref

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Cell Reports
2021-05 | Journal article
DOI: 10.1016/j.celrep.2021.109126
Contributors: Manuel Hayn; Maximilian Hirschenberger; Lennart Koepke; Rayhane Nchioua; Jan Hendrik Straub; Susanne Klute; Victoria Hunszinger; Fabian Zech; Caterina Prelli Bozzo; Wasim Aftab et al.
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Crossref

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

2021-05-31 | Other
DOI: 10.1101/2021.05.31.446386
Contributors: Fabian Zech; Daniel Schniertshauer; Christoph Jung; Alexandra Herrmann; Qinya Xie; Rayhane Nchioua; Caterina Prelli Bozzo; Meta Volcic; Lennart Koepke; Jana Krüger et al.
Source: check_circle
Crossref

The antiviral activities of TRIM proteins

Current Opinion in Microbiology
2021-02 | Journal article
DOI: 10.1016/j.mib.2020.07.005
Contributors: Lennart Koepke; Michaela U Gack; Konstantin MJ Sparrer
Source: check_circle
Crossref

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

Nature Metabolism
2021-02-03 | Journal article
DOI: 10.1038/s42255-021-00347-1
Contributors: Janis A. Müller; Rüdiger Groß; Carina Conzelmann; Jana Krüger; Uta Merle; Johannes Steinhart; Tatjana Weil; Lennart Koepke; Caterina Prelli Bozzo; Clarissa Read et al.
Source: check_circle
Crossref

An improved method for high-throughput quantification of autophagy in mammalian cells

Scientific Reports
2020 | Journal article
DOI: 10.1038/s41598-020-68607-w
EID:

2-s2.0-85088379711

Part of ISBN:

20452322
Contributors: Koepke, L.; Winter, B.; Grenzner, A.; Regensburger, K.; Engelhart, S.; van der Merwe, J.A.; Krebs, S.; Blum, H.; Kirchhoff, F.; Sparrer, K.M.J.
Source: Self-asserted source
Lennart Koepke via Scopus - Elsevier

Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids

Cellular and Molecular Gastroenterology and Hepatology
2020-11-10 | Journal article
DOI: 10.1016/j.jcmgh.2020.11.003
DOI: 10.1101/2020.06.10.144816
Source: Self-asserted source
Lennart Koepke
grade
Preferred source (of 2)‎

HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression

Nucleic Acids Research
2020-11-04 | Journal article
DOI: 10.1093/nar/gkaa832
Source: Self-asserted source
Lennart Koepke

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -λ

2020-10-15 | Preprint
DOI: 10.1101/2020.10.15.340612
Contributors: Manuel Hayn; Maximilian Hirschenberger; Lennart Koepke; Jan H Straub; Rayhane Nchioua; Maria H Christensen; Susanne Klute; Caterina Prelli Bozzo; Wasim Aftab; Fabian Zech et al.
Source: check_circle
Crossref

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

Science
2020-09-04 | Journal article
DOI: 10.1126/science.abc8665
Contributors: Matthias Thoms; Robert Buschauer; Michael Ameismeier; Lennart Koepke; Timo Denk; Maximilian Hirschenberger; Hanna Kratzat; Manuel Hayn; Timur Mackens-Kiani; Jingdong Cheng et al.
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1

Nature Microbiology
2020-07-20 | Journal article
DOI: 10.1038/s41564-020-0753-6
Contributors: Meta Volcic; Konstantin M. J. Sparrer; Lennart Koepke; Dominik Hotter; Daniel Sauter; Christina M. Stürzel; Myriam Scherer; Thomas Stamminger; Thomas G. Hofmann; Nathalie J. Arhel et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

Nature Microbiology
2019-09 | Journal article
DOI: 10.1038/s41564-019-0460-3
Part of ISSN: 2058-5276
Source: Self-asserted source
Lennart Koepke
grade
Preferred source (of 2)‎

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Cell Reports
2019-05 | Journal article
DOI: 10.1016/j.celrep.2019.04.063
Part of ISSN: 2211-1247
Source: Self-asserted source
Lennart Koepke
grade
Preferred source (of 2)‎

IFITM proteins promote SARS-CoV-2 infection of human lung cells

Other
DOI: 10.1101/2020.08.18.255935
Contributors: Caterina Prelli Bozzo; Rayhane Nchioua; Meta Volcic; Lukas Wettstein; Tatjana Weil; Jana Krüger; Sandra Heller; Carina Conzelmann; Janis Müller; Rüdiger Gross et al.
Source: Self-asserted source
Lennart Koepke via Crossref Metadata Search
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