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Employment (2)

Johns Hopkins Medicine: Baltimore, Maryland, US

2022-10 to present | Associate Professor (Oncology)
Employment
Source: Self-asserted source
W. Nathaniel Brennen

Johns Hopkins Medicine: Baltimore, Maryland, US

2014-11 to 2022-09 | Assistant Professor (Oncology)
Employment
Source: Self-asserted source
W. Nathaniel Brennen

Works (36)

AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

Molecular Cancer Therapeutics
2024-10-01 | Journal article
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
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Crossref

Data from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Figure S1 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Figure S2 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
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Crossref

Figure S3 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Figure S4 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Figure S5 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Figure S6 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Figure S7 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Figure S8 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Table S1 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
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Crossref

Table S2 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Table S3 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Table S4 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Table S5 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Table S6 from AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer

2024-10-01 | Preprint
Contributors: Mannan Nouri; Andreas Varkaris; Maya Ridinger; Susan L. Dalrymple; Christopher M. Dennehy; John T. Isaacs; David J. Einstein; W.N. Brennen; Steven P. Balk
Source: check_circle
Crossref

Defining the challenges and opportunities for using patient‐derived models in prostate cancer research

The Prostate
2024-05 | Journal article
Contributors: W. Nathaniel Brennen; Clémentine Le Magnen; Sofia Karkampouna; Nicolas Anselmino; Nathalie Bock; Nicholas Choo; Ashlee K. Clark; Ilsa M. Coleman; Robin Dolgos; Alison M. Ferguson et al.
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Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer

Nature Reviews Urology
2024-05 | Journal article
Contributors: Joakin O. Mori; Isra Elhussin; W. Nathaniel Brennen; Mindy K. Graham; Tamara L. Lotan; Clayton C. Yates; Angelo M. De Marzo; Samuel R. Denmeade; Srinivasan Yegnasubramanian; William G. Nelson et al.
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The Hallmarks of Precancer

Cancer Discovery
2024-04-04 | Journal article
Contributors: Mary M. Stangis; Zhengyi Chen; Jimin Min; Sarah E. Glass; Jordan O. Jackson; Megan D. Radyk; Xen Ping Hoi; W. Nathaniel Brennen; Ming Yu; Huy Q. Dinh et al.
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Targeting the fibroblast growth factor pathway in molecular subtypes of castration‐resistant prostate cancer

The Prostate
2024-01 | Journal article
Contributors: Mark P. Labrecque; Lisha G. Brown; Ilsa M. Coleman; Holly M. Nguyen; Susan Dalrymple; W. Nathaniel Brennen; John T. Isaacs; Dapei Li; Bryce Lakely; Diana C. DeLucia et al.
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Data from Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling

2023-04-03 | Preprint
Contributors: Jin-Yih Low; W. Nathaniel Brennen; Alan K. Meeker; Elina Ikonen; Brian W. Simons; Marikki Laiho
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Crossref

Data from Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling

2023-04-03 | Preprint
Contributors: Jin-Yih Low; W. Nathaniel Brennen; Alan K. Meeker; Elina Ikonen; Brian W. Simons; Marikki Laiho
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Crossref

Supplementary Figures 1-5 from Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling

2023-04-03 | Preprint
Contributors: Jin-Yih Low; W. Nathaniel Brennen; Alan K. Meeker; Elina Ikonen; Brian W. Simons; Marikki Laiho
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Crossref

Supplementary Figures 1-5 from Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling

2023-04-03 | Preprint
Contributors: Jin-Yih Low; W. Nathaniel Brennen; Alan K. Meeker; Elina Ikonen; Brian W. Simons; Marikki Laiho
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Crossref

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

Nature Communications
2023-03-23 | Journal article
Contributors: Peng Lu; Karolyn A. Oetjen; Diane E. Bender; Marianna B. Ruzinova; Daniel A. C. Fisher; Kevin G. Shim; Russell K. Pachynski; W. Nathaniel Brennen; Stephen T. Oh; Daniel C. Link et al.
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Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype

Neoplasia
2022-10 | Journal article
Contributors: Amber E. de Groot; Kayla V. Myers; Timothy E.G. Krueger; W. Nathaniel Brennen; Sarah R. Amend; Kenneth J. Pienta
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Crossref

There are gremlins in prostate cancer

Nature Cancer
2022-05-27 | Journal article
Contributors: Laura A. Sena; W. Nathaniel Brennen; John T. Isaacs
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Characterization of tumor‐associated macrophages in prostate cancer transgenic mouse models

The Prostate
2021-07 | Journal article
Contributors: Amber E. de Groot; Kayla V. Myers; Timothy E. G. Krueger; Ashley L. Kiemen; Natalia H. Nagy; Alexandria Brame; Vicente E. Torres; Zhongyuan Zhang; Levent Trabzonlu; W. Nathaniel Brennen et al.
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Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer

JCI Insight
2021-04-22 | Journal article
Contributors: W. Nathaniel Brennen; Yezi Zhu; Ilsa M. Coleman; Susan L. Dalrymple; Lizamma Antony; Radhika A. Patel; Brian Hanratty; Roshan Chikarmane; Alan K. Meeker; S. Lilly Zheng et al.
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A novel method for detection of exfoliated prostate cancer cells in urine by RNA in situ hybridization

Prostate Cancer and Prostatic Diseases
2021-03-20 | Journal article
Contributors: Jillian N. Eskra; Daniel Rabizadeh; Leslie Mangold; Elizabeth Fabian; W. Nathaniel Brennen; David B. Yeater; Kenneth J. Pienta; Alan W. Partin; William B. Isaacs; Christian P. Pavlovich et al.
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Overcoming Stromal Barriers to Immuno-Oncological Responses via Fibroblast Activation Protein-Targeted Therapy

Immunotherapy
2021-02 | Journal article
Contributors: W Nathaniel Brennen; Daniel L J Thorek; Wen Jiang; Timothy E Krueger; Lizamma Antony; Samuel R Denmeade; John T Isaacs
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A hemi‐spleen injection model of liver metastasis for prostate cancer

The Prostate
2020-10 | Journal article
Contributors: Brian W. Simons; Susan Dalrymple; Marc Rosen; Lei Zheng; W. Nathaniel Brennen
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Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling

Molecular Cancer Research
2020-09-01 | Journal article
Contributors: Jin-Yih Low; W. Nathaniel Brennen; Alan K. Meeker; Elina Ikonen; Brian W. Simons; Marikki Laiho
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In Reply to the Letter to the Editor from Raj et al.: Clinical Evidence Indicates Allogeneic Mesenchymal Stem Cells Do Not Pose a Significant Risk for Cancer Progression in the Context of Cell‐Based Drug Delivery

STEM CELLS Translational Medicine
2019-03-29 | Journal article
Contributors: W. Nathaniel Brennen; Michael T. Schweizer; Hao Wang; Trinity J. Bivalacqua; Alan W. Partin; Su Jin Lim; Carolyn Chapman; Rehab Abdallah; Oren Levy; Neil A. Bhowmick et al.
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Tumor‐infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

The Prostate
2019-02 | Journal article
Contributors: Timothy E. Krueger; Daniel L. J. Thorek; Alan K. Meeker; John T. Isaacs; W. Nathaniel Brennen
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Concise Review: Mesenchymal Stem Cell‐Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise

STEM CELLS Translational Medicine
2018-09-01 | Journal article
Contributors: Timothy E. G. Krueger; Daniel L. J. Thorek; Samuel R. Denmeade; John T. Isaacs; W. Nathaniel Brennen
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Peer review (4 reviews for 2 publications/grants)

Review activity for Histochemistry and cell biology. (1)
Review activity for Journal of experimental & clinical cancer research. (3)