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Employment (4)

University of Pittsburgh: Pittsburgh, PA, US

2020-09-01 to present | Assistant Professor (Aging Institute)
Employment
Source: Self-asserted source
Andrey Parkhitko

Harvard Medical School: Boston, MA, US

2013-03-01 to 2020-08-31 | Postdoctoral Fellow (Department of Genetics)
Employment
Source: Self-asserted source
Andrey Parkhitko

Brigham and Women's Hospital: Boston, MA, US

2008-10-01 to 2013-03-01 | Research Associate / Ph.D. student
Employment
Source: Self-asserted source
Andrey Parkhitko

Fox Chase Cancer Center: Philadelphia, PA, US

2006-02 to 2008-09 | M.S. student
Employment
Source: Self-asserted source
Andrey Parkhitko

Education and qualifications (2)

Russian State Medical University: Moscow, RU

2008 to 2013 | Ph.D.
Education
Source: Self-asserted source
Andrey Parkhitko

Russian State Medical University: Moscow, RU

2000-09-01 to 2007-07-01 | M.S.
Education
Source: Self-asserted source
Andrey Parkhitko

Works (28)

Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner

Science Advances
2025-04-16 | Journal article | Author
DOI: 10.1126/sciadv.ads1532
Contributors: Yuji Ikeno; Ora Anna Weisz; Roderick Tan; Jolene Diedrich; Alessandra Sacco; Ian J Sipula; Gene P. Ables; Antonio Pinto; Michael J Jurczak; Robert Brooke et al.
Source: check_circle
AAAS - Science

Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases

Science Advances
2025-03-28 | Journal article | Author
DOI: 10.1126/sciadv.adu1710
Contributors: Valentin Cracan; Andrey Parkhitko
Source: check_circle
AAAS - Science
grade
Preferred source (of 2)‎

Mutation of an insulin-sensitiveDrosophilainsulin-like receptor mutant requires methionine metabolism reprogramming to extend lifespan

2025-03-04 | Preprint
DOI: 10.1101/2025.02.28.640731
Contributors: Marc Tatar; Wenjing Zheng; Shweta Yadav; Rochele Yamamoto; Noelle Curtis-Joseph; Shengxi Li; Lin Wang; Andrey A Parkhitko
Source: check_circle
Crossref

Unique tau‐ and synuclein‐dependent metabolic reprogramming in neurons distinct from normal aging

Aging Cell
2024-11 | Journal article
DOI: 10.1111/acel.14277
Contributors: Shweta Yadav; Aidan Graham; Farazdaq Al Hammood; Chris Garbark; Deepika Vasudevan; Udai Pandey; John M. Asara; Dhivyaa Rajasundaram; Andrey A. Parkhitko
Source: check_circle
Crossref

Combinatorial interventions in aging

Nature Aging
2023-10-02 | Journal article
DOI: 10.1038/s43587-023-00489-9
Contributors: Andrey A. Parkhitko; Elizabeth Filine; Marc Tatar
Source: check_circle
Crossref

Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting

Science
2022-02-18 | Journal article
DOI: 10.1126/science.abc4203
Contributors: Patrick Jouandin; Zvonimir Marelja; Yung-Hsin Shih; Andrey A. Parkhitko; Miriam Dambowsky; John M. Asara; Ivan Nemazanyy; Christian C. Dibble; Matias Simons; Norbert Perrimon
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Crossref

A genetic model of methionine restriction extends Drosophila health- and lifespan

Proceedings of the National Academy of Sciences
2021-10-05 | Journal article
DOI: 10.1073/pnas.2110387118
Contributors: Andrey A. Parkhitko; Lin Wang; Elizabeth Filine; Patrick Jouandin; Dmitry Leshchiner; Richard Binari; John M. Asara; Joshua D. Rabinowitz; Norbert Perrimon
Source: check_circle
Crossref

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

PLOS Genetics
2021-02-16 | Journal article
DOI: 10.1371/journal.pgen.1009354
Contributors: Andrey A. Parkhitko; Maxim V. Frolov; Arashdeep Singh; Sharon Hsieh; Yanhui Hu; Richard Binari; Christopher J. Lord; Sridhar Hannenhalli; Colm J. Ryan; Norbert Perrimon
Source: check_circle
Crossref

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

Ageing Research Reviews
2020-12 | Journal article
DOI: 10.1016/j.arr.2020.101188
Contributors: Andrey A. Parkhitko; Elizabeth Filine; Stephanie E. Mohr; Alexey Moskalev; Norbert Perrimon
Source: check_circle
Crossref

Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

eLife
2020-12-15 | Journal article
DOI: 10.7554/eLife.58053
Contributors: Andrey A Parkhitko; Divya Ramesh; Lin Wang; Dmitry Leshchiner; Elizabeth Filine; Richard Binari; Abby L Olsen; John M Asara; Valentin Cracan; Joshua D Rabinowitz et al.
Source: check_circle
Crossref

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

Aging Cell
2019-12 | Journal article
DOI: 10.1111/acel.13034
Contributors: Andrey A. Parkhitko; Patrick Jouandin; Stephanie E. Mohr; Norbert Perrimon
Source: check_circle
Crossref

Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes

Journal of Clinical Investigation
2018-06-11 | Journal article
DOI: 10.1172/jci95231
Part of ISSN: 0021-9738
Contributors: Natalia Rodriguez-Muela; Andrey Parkhitko; Tobias Grass; Rebecca M. Gibbs; Erika M. Norabuena; Norbert Perrimon; Rajat Singh; Lee L. Rubin
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Cancer Research
2017-05 | Journal article
DOI: 10.1158/0008-5472.can-16-2458
Part of ISSN: 0008-5472
Contributors: Hilaire C. Lam; Christian V. Baglini; Alicia Llorente Lope; Andrey A. Parkhitko; Heng-Jia Liu; Nicola Alesi; Izabela A. Malinowska; Darius Ebrahimi-Fakhari; Afshin Saffari; Jane J. Yu et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span inDrosophila

Genes & Development
2016-06 | Journal article
DOI: 10.1101/gad.282277.116
Part of ISSN: 0890-9369
Contributors: Andrey A. Parkhitko; Richard Binari; Nannan Zhang; John M. Asara; Fabio Demontis; Norbert Perrimon
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload

Cardiovascular Pathology
2015-03 | Journal article
DOI: 10.1016/j.carpath.2014.10.005
Part of ISSN: 1054-8807
Contributors: Usamah S. Kayyali; Christopher G. Larsen; Sarah Bashiruddin; Sara L. Lewandowski; Chinmay M. Trivedi; Rod R. Warburton; Andrey A. Parkhitko; Tasha A. Morrison; Elizabeth P. Henske; Yvonne Chekaluk et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

Proceedings of the National Academy of Sciences
2015-01 | Journal article
DOI: 10.1073/pnas.1413185112
Part of ISSN: 0027-8424
Contributors: Elizaveta S. Leshchiner; Andrey Parkhitko; Gregory H. Bird; James Luccarelli; Joseph A. Bellairs; Silvia Escudero; Kwadwo Opoku-Nsiah; Marina Godes; Norbert Perrimon; Loren D. Walensky
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

High-Throughput Drug Screen Identifies Chelerythrine as a Selective Inducer of Death in a TSC2-null Setting

Molecular Cancer Research
2014-09-03 | Journal article
DOI: 10.1158/1541-7786.mcr-14-0440
Part of ISSN: 1541-7786
Contributors: Doug Medvetz; Yang Sun; Chenggang Li; Damir Khabibullin; Murugabaskar Balan; Andrey Parkhitko; Carmen Priolo; John M. Asara; Soumitro Pal; Jane Yu et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells

Physiological Reports
2014-08 | Journal article
DOI: 10.14814/phy2.12107
Part of ISSN: 2051-817X
Contributors: Damir Khabibullin; Douglas A. Medvetz; Miguel Pinilla; Venkatesh Hariharan; Chenggang Li; Anja Hergrueter; Maria Laucho Contreras; Erik Zhang; Andrey Parkhitko; Jane J. Yu et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Kinase mTOR: Regulation and role in maintenance of cellular homeostasis, tumor development, and aging

Biochemistry (Moscow)
2014-02 | Journal article
DOI: 10.1134/s0006297914020023
Part of ISSN: 0006-2979
Contributors: A. A. Parkhitko; O. O. Favorova; D. I. Khabibullin; V. N. Anisimov; E. P. Henske
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

The Journal of Experimental Medicine
2014-01-06 | Journal article
DOI: 10.1084/jem.20131080
Part of ISSN: 0022-1007
Contributors: Chenggang Li; Po-Shun Lee; Yang Sun; Xiaoxiao Gu; Erik Zhang; Yanan Guo; Chin-Lee Wu; Neil Auricchio; Carmen Priolo; Jing Li et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide

Molecular Cancer Research
2013 | Journal article
DOI: 10.1158/1541-7786.mcr-13-0258-t
Part of ISSN: 1541-7786
Contributors: Andrey A. Parkhitko; Carmen Priolo; Jonathan L. Coloff; Jihye Yun; Julia J. Wu; Kenji Mizumura; Wenping Xu; Izabela A. Malinowska; Jane Yu; David J. Kwiatkowski et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Faslodex Inhibits Estradiol-Induced Extracellular Matrix Dynamics and Lung Metastasis in a Model of Lymphangioleiomyomatosis

American Journal of Respiratory Cell and Molecular Biology
2013-07 | Journal article
DOI: 10.1165/rcmb.2012-0476oc
Part of ISSN: 1044-1549
Contributors: Chenggang Li; Xiaobo Zhou; Yang Sun; Erik Zhang; John D. Mancini; Andrey Parkhitko; Tasha A. Morrison; Edwin K. Silverman; Elizabeth P. Henske; Jane J. Yu
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Cell
2013-05 | Journal article
DOI: 10.1016/j.cell.2013.04.023
Part of ISSN: 0092-8674
Contributors: Alfred Csibi; Sarah-Maria Fendt; Chenggang Li; George Poulogiannis; Andrew Y. Choo; Douglas J. Chapski; Seung Min Jeong; Jamie M. Dempsey; Andrey Parkhitko; Tasha Morrison et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Autophagy: Mechanisms, regulation, and its role in tumorigenesis

Biochemistry (Moscow)
2013-04 | Journal article
DOI: 10.1134/s0006297913040044
Part of ISSN: 0006-2979
Contributors: A. A. Parkhitko; O. O. Favorova; E. P. Henske
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Autophagy

Autophagy
2011-11 | Journal article
DOI: 10.4161/auto.7.11.17652
Part of ISSN: 1554-8627
Contributors: Jane Yu; Andrey Parkhitko; Elizabeth Petri Henske
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

Proceedings of the National Academy of Sciences
2011-07-11 | Journal article
DOI: 10.1073/pnas.1104361108
Part of ISSN: 0027-8424
Contributors: A. Parkhitko; F. Myachina; T. A. Morrison; K. M. Hindi; N. Auricchio; M. Karbowniczek; J. J. Wu; T. Finkel; D. J. Kwiatkowski; J. J. Yu et al.
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Mammalian Target of Rapamycin Signaling and Autophagy: Roles in Lymphangioleiomyomatosis Therapy

Proceedings of the American Thoracic Society
2010-02 | Journal article
DOI: 10.1513/pats.200909-104js
Part of ISSN: 1546-3222
Contributors: J. Yu; A. A. Parkhitko; E. P. Henske
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Interaction of Epstein-Barr Virus Latent Membrane Protein 1 with SCFHOS/β-TrCPE3 Ubiquitin Ligase Regulates Extent of NF-κB Activation

Journal of Biological Chemistry
2003-09 | Journal article
DOI: 10.1074/jbc.m307962200
Part of ISSN: 0021-9258
Contributors: Weigang Tang; Oleg A. Pavlish; Vladimir S. Spiegelman; Andrey A. Parkhitko; Serge Y. Fuchs
Source: Self-asserted source
Andrey Parkhitko via Crossref Metadata Search

Peer review (1 review for 1 publication/grant)

Review activity for Nature aging. (1)
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