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Employment (4)

University of Maryland School of Medicine: Baltimore, MD, US

2020-10-01 to present | Assistant Professor (Microbiology and Immunology/CVD)
Employment
Source: Self-asserted source
Lynda Coughlan

The Mount Sinai Hospital: New York, NY, US

2017-02-06 to 2020-09-30 | PI/Assistant Professor (Dept of Microbiology, Icahn School of Medicine)
Employment
Source: Self-asserted source
Lynda Coughlan

University of Oxford: Oxford, Oxfordshire, GB

2012-08-01 to 2016-12-31 | Post-doctoral fellow (Jenner Institute)
Employment
Source: Self-asserted source
Lynda Coughlan

University of Glasgow: Glasgow, Glasgow, GB

2009-08-01 to 2012-07-25 | Post-doctoral research associate (Glasgow Cardiovascular Research Centre)
Employment
Source: Self-asserted source
Lynda Coughlan

Education and qualifications (4)

Barts Cancer Institute: London, London, GB

2005-09-01 to 2009-07-25 | PhD (Tumour Biology and Molecular Oncology)
Education
Source: Self-asserted source
Lynda Coughlan

Institut Català d' Oncologia: L'Hospitalet de Llobregat, Catalunya, ES

2008-03-01 to 2008-09-30 (Oncolytic Viral Therapy)
Education
Source: Self-asserted source
Lynda Coughlan

London School of Hygiene and Tropical Medicine: London, London, GB

2004-09-01 to 2005-08-30 | MSc Virology
Education
Source: Self-asserted source
Lynda Coughlan

University College Cork: Cork, IE

1998-09-01 to 2003-06-01 | BSc Microbiology (Microbiology)
Education
Source: Self-asserted source
Lynda Coughlan

Professional activities (7)

International Society for Extracellular Vesicles: New Jersey, New Jersey, US

Membership
Source: Self-asserted source
Lynda Coughlan

American Society of Gene Therapy and Cell Therapy: Milwaukee, Wisconsin, US

Membership
Source: Self-asserted source
Lynda Coughlan

American Society for Microbiology: Washington D.C., District of Columbia, US

Membership
Source: Self-asserted source
Lynda Coughlan

Pediatric Infectious Diseases Society: Arlington, Virginia, US

2017 to present
Membership
Source: Self-asserted source
Lynda Coughlan

British Society for Immunology: London, GB

2016 to present
Membership
Source: Self-asserted source
Lynda Coughlan

International Society for Influenza and other Respiratory Virus Diseases: Atlanta, Georgia, US

2015 to present
Membership
Source: Self-asserted source
Lynda Coughlan

Microbiology Society: London, London, GB

2005 to present | Member
Membership
Source: Self-asserted source
Lynda Coughlan

Funding (10)

Combining innovative molecular adjuvanting approaches with novel adenoviral vector delivery to generate a universal influenza vaccine

2022-07-01 to 2026-06-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI148369
Source: Self-asserted source
Lynda Coughlan via DimensionsWizard

Exosome-display as a strategy to enhance the immunogenicity of SARS-CoV-2 vaccines based on adenoviral vectors.

2020-07 to 2022-07 | Grant
National Institute of Allergy and Infectious Diseases (Md., Md., US)
GRANT_NUMBER:

R21AI157606

Source: Self-asserted source
Lynda Coughlan

Generation of a polycistronic universal influenza virus vaccine based on rare species adenoviral vectors

2019-08-06 to 2021-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI146529
Source: Self-asserted source
Lynda Coughlan via DimensionsWizard

Investigation and exploitation of exosome-display technology to generate a novel pediatric vaccine for Respiratory Syncytial Virus

2018-11 to 2021-10 | Grant
Pediatric Infectious Diseases Society (VA, VA, US)
GRANT_NUMBER:

Pichichero Family Foundation Vaccines for Children Initiative Research Award

Source: Self-asserted source
Lynda Coughlan

Toward a Universal Influenza Virus Vaccine

2018-08 to 2023-08 | Grant
National Institutes of Health (MD, MD, US)
GRANT_NUMBER:

AI097092-06 (Palese)

Source: Self-asserted source
Lynda Coughlan

Development of exosome-display technology to generate novel universal adenoviral vectored influenza vaccines with improved immunogenicity.

2017-08 to 2018-08 | Contract
National Institute of Allergy and Infectious Diseases (MD, MD, US)
Source: Self-asserted source
Lynda Coughlan

Investigation and exploitation of exosomes in the development of novel influenza vaccines with improved immunogenicity

2017-07 to 2018-07 | Grant
Sigma Delta Epsilon-Graduate Women in Science (MN, MN, US)
Source: Self-asserted source
Lynda Coughlan

Investigation and exploitation of exosomes in the development of novel influenza vaccines with improved immunogenicity

2016-09 to 2019-08 | Grant
British Medical Association (London, GB)
Source: Self-asserted source
Lynda Coughlan

Investigation and exploitation of exosomes to improve vaccines for emerging viral infections

2016-08 to 2017-08 | Grant
Royal Society of Tropical Medicine and Hygiene (London, GB)
GRANT_NUMBER: GR000550
Source: Self-asserted source
Lynda Coughlan

Improving the immunogenicity of antigens expressed by viral vectored vaccines for infectious disease by use of exosome-display technology

2015-06 to 2016-12 | Grant
University of Oxford (Oxford, GB)
GRANT_NUMBER: MRF/TT2015/2150
Source: Self-asserted source
Lynda Coughlan

Works (50 of 56)

Items per page:
Page 1 of 2

An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases

mBio
2025-02-05 | Journal article
Contributors: Kari Ann Shirey; John Joseph; Lynda Coughlan; Haye Nijhuis; Alan W. Varley; Jorge C. G. Blanco; Stefanie N. Vogel; Sara Cherry
Source: check_circle
Crossref

Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination drives Th2-skewed response and is reduced with age

2025-01-28 | Preprint
Contributors: Moataz Noureddine; Lauren Chang; Farah El-Ayache; Gabriel Laghlali; Eleanor Burgess; Leonie Grueneberg; Prajakta Warang; Kaijun Jiang; Haye Nijhuis; Lynda Coughlan et al.
Source: check_circle
Crossref

Anti-neuraminidase and anti-hemagglutinin stalk responses to different influenza a(H7N9) vaccine regimens.

Vaccine
2025-01-04 | Journal article
Contributors: El Sahly HM; Anderson EJ; Jackson LA; Neuzil KM; Atmar RL; Bernstein DI; Chen WH; Creech CB; Frey SE; Goepfert P et al.
Source: Self-asserted source
Lynda Coughlan

A chimeric haemagglutinin-based universal influenza virus vaccine boosts human cellular immune responses directed towards the conserved haemagglutinin stalk domain and the viral nucleoprotein.

EBioMedicine
2024-05-27 | Journal article
Contributors: Bliss CM; Nachbagauer R; Mariottini C; Cuevas F; Feser J; Naficy A; Bernstein DI; Guptill J; Walter EB; Berlanda-Scorza F et al.
Source: Self-asserted source
Lynda Coughlan

Outpacing antiviral resistance: new treatments for influenza virus infection.

The Lancet. Infectious diseases
2024-02-05 | Journal article
Contributors: Coughlan L; Neuzil KM
Source: Self-asserted source
Lynda Coughlan

Viral platform engineering for targeted gene delivery to human hematopoietic stem cells

Molecular Therapy
2024-01 | Journal article
Contributors: Samanta Del Veliz; Lynda Coughlan
Source: check_circle
Crossref

Chimeric hemagglutinin split vaccines elicit broadly cross-reactive antibodies and protection against group 2 influenza viruses in mice.

Science advances
2023-09-13 | Journal article | Author
Contributors: Eduard Puente-Massaguer; Kirill Vasilev; Annika; Madhumathi Loganathan; Benjamin Francis; Michael Scherm; Guha Asthagiri Arunkumar; Irene González-Domínguez; Xueyong Zhu; Ian Wilson et al.
Source: Self-asserted source
Lynda Coughlan

Always a bridesmaid, never a bride: Committing to flu neuraminidase as a vaccine target

Molecular Therapy
2023-07 | Journal article
Contributors: Cosette Schneider; Lynda Coughlan
Source: check_circle
Crossref

Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination

Journal of Virology
2023-03-30 | Journal article
Contributors: Fatima Amanat; Jordan Clark; Juan Manuel Carreño; Shirin Strohmeier; Temima Yellin; Philip S. Meade; Disha Bhavsar; Hiromi Muramatsu; Weina Sun; Lynda Coughlan et al.
Source: check_circle
Crossref

Enhancing the protection of influenza virus vaccines with BECC TLR4 adjuvant in aged mice.

Scientific reports
2023-01-13 | Journal article
Contributors: Haupt R; Baracco L; Harberts EM; Loganathan M; Kerstetter LJ; Krammer F; Coughlan L; Ernst RK; Frieman MB
Source: Self-asserted source
Lynda Coughlan

RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine.

Frontiers in immunology
2022-11-08 | Journal article
Contributors: Jangra S; Laghlali G; Choi A; Rathnasinghe R; Chen Y; Yildiz S; Coughlan L; García-Sastre A; De Geest BG; Schotsaert M
Source: Self-asserted source
Lynda Coughlan

The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination

npj Vaccines
2022-08-30 | Journal article
Contributors: Johannes B. Goll; Aarti Jain; Travis L. Jensen; Rafael Assis; Rie Nakajima; Algis Jasinskas; Lynda Coughlan; Sami R. Cherikh; Casey E. Gelber; S. Khan et al.
Source: check_circle
Crossref

Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice.

Microbiology spectrum
2022-06 | Journal article
Contributors: González-Domínguez I; Martínez JL; Slamanig S; Lemus N; Liu Y; Lai TY; Carreño JM; Singh G; Singh G; Schotsaert M et al.
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice.

Molecular therapy : the journal of the American Society of Gene Therapy
2022-01 | Journal article
Contributors: Bliss CM; Freyn AW; Caniels TG; Leyva-Grado VH; Nachbagauer R; Sun W; Tan GS; Gillespie VL; McMahon M; Krammer F et al.
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Adenovirus-based vaccines-a platform for pandemic preparedness against emerging viral pathogens.

Molecular therapy : the journal of the American Society of Gene Therapy
2022-01 | Journal article
Contributors: Coughlan L; Kremer EJ; Shayakhmetov DM
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Caught in a trap: How pre-clinical studies in laboratory mice exaggerate vaccine responses.

Cell reports. Medicine
2021-12 | Journal article
Contributors: Coughlan L
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Broadly neutralizing antibodies target a hemagglutinin anchor epitope.

Nature
2021-12-23 | Journal article
Source: Self-asserted source
Lynda Coughlan
grade
Preferred source (of 2)‎

Vaccination with SARS-CoV-2 variants of concern protects mice from challenge with wild-type virus

PLOS Biology
2021-12-16 | Journal article
Contributors: Fatima Amanat; Sarah L. Rowland-Jones; Shirin Strohmeier; Philip S. Meade; Nicholas Dambrauskas; Barbara Mühlemann; Derek J. Smith; Vladimir Vigdorovich; D. Noah Sather; Lynda Coughlan et al.
Source: check_circle
Crossref

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.

Science advances
2021-12-01 | Journal article
Source: Self-asserted source
Lynda Coughlan

A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses

Nature Communications
2021-10-27 | Journal article
Contributors: Weina Sun; Yonghong Liu; Fatima Amanat; Irene González-Domínguez; Stephen McCroskery; Stefan Slamanig; Lynda Coughlan; Victoria Rosado; Nicholas Lemus; Sonia Jangra et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models.

Nature communications
2021-10-20 | Journal article
Source: Self-asserted source
Lynda Coughlan

Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner.

mBio
2021-07-27 | Journal article
Source: Self-asserted source
Lynda Coughlan

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

mBio
2021-04-27 | Journal article
Contributors: Fatima Amanat; Shirin Strohmeier; Raveen Rathnasinghe; Michael Schotsaert; Lynda Coughlan; Adolfo García-Sastre; Florian Krammer; Vincent R. Racaniello
Source: check_circle
Crossref

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.

Science (New York, N.Y.)
2021-01 | Journal article
Contributors: White KM; Rosales R; Yildiz S; Kehrer T; Miorin L; Moreno E; Jangra S; Uccellini MB; Rathnasinghe R; Coughlan L et al.
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central
grade
Preferred source (of 2)‎

Adenoviral Vectors as Vaccines for Emerging Avian Influenza Viruses.

Frontiers in immunology
2021-01-29 | Journal article
Source: Self-asserted source
Lynda Coughlan

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.

Angewandte Chemie (International ed. in English)
2021-01-19 | Journal article
Source: Self-asserted source
Lynda Coughlan

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial.

Nature medicine
2020-12-07 | Journal article
Source: Self-asserted source
Lynda Coughlan

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans.

Science translational medicine
2020-12-01 | Journal article
Source: Self-asserted source
Lynda Coughlan

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

Vaccines
2020-11-09 | Journal article
Contributors: Juan Manuel Carreño; Jacqueline U. McDonald; Tara Hurst; Peter Rigsby; Eleanor Atkinson; Lethia Charles; Raffael Nachbagauer; Mohammad Amin Behzadi; Shirin Strohmeier; Lynda Coughlan et al.
Source: check_circle
Crossref

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.

Immunity
2020-10 | Journal article
Contributors: Guthmiller JJ; Lan LY; Fernández-Quintero ML; Han J; Utset HA; Bitar DJ; Hamel NJ; Stovicek O; Li L; Tepora M et al.
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central
grade
Preferred source (of 2)‎

Snatching the Crown from SARS-CoV-2

Cell Host & Microbe
2020-09 | Journal article
Contributors: Lynda Coughlan
Source: check_circle
Crossref

Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines.

Frontiers in immunology
2020-05-19 | Journal article
Source: Self-asserted source
Lynda Coughlan

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice.

Molecular therapy : the journal of the American Society of Gene Therapy
2020-04-19 | Journal article
Source: Self-asserted source
Lynda Coughlan

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

Emerging Microbes & Infections
2020-01 | Journal article
Contributors: Raveen Rathnasinghe; Shirin Strohmeier; Fatima Amanat; Virginia L. Gillespie; Florian Krammer; Adolfo García-Sastre; Lynda Coughlan; Michael Schotsaert; Melissa B. Uccellini
Source: check_circle
Crossref

Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice.

Molecular therapy. Methods & clinical development
2019-12-24 | Journal article
Source: Self-asserted source
Lynda Coughlan

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

Nature Communications
2019-02-14 | Journal article
Contributors: Alexander T. Baker; Alexander Greenshields-Watson; Lynda Coughlan; James A. Davies; Hanni Uusi-Kerttula; David K. Cole; Pierre J. Rizkallah; Alan L. Parker
Source: check_circle
Crossref

Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine

Cell Host and Microbe
2018 | Journal article
EID:

2-s2.0-85049315230

Contributors: Coughlan, L.; Palese, P.
Source: Self-asserted source
Lynda Coughlan via Scopus - Elsevier

Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults.

EBioMedicine
2018-03 | Journal article
Contributors: Coughlan L; Sridhar S; Payne R; Edmans M; Milicic A; Venkatraman N; Lugonja B; Clifton L; Qi C; Folegatti PM et al.
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.

Molecular cancer therapeutics
2018-02 | Journal article
Contributors: Man YKS; Davies JA; Coughlan L; Pantelidou C; Blázquez-Moreno A; Marshall JF; Parker AL; Halldén G
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central
grade
Preferred source (of 2)‎

Defining a novel role for the coxsackie and adenovirus receptor in human adenovirus serotype 5 transduction in vitro in the presence of mouse serum.

Journal of Virology
2017-04 | Journal article
Source: Self-asserted source
Lynda Coughlan
grade
Preferred source (of 3)‎

Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies.

2016-05 | Journal article
Contributors: Uusi-Kerttula H; Davies J; Coughlan L; Hulin-Curtis S; Jones R; Hanna L; Chester JD; Parker AL
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in mice.

2015 | Journal article
Contributors: Dicks MD; Spencer AJ; Coughlan L; Bauza K; Gilbert SC; Hill AV; Cottingham MG
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges

Vaccines
2015 | Journal article
EID:

2-s2.0-85016872290

Part of ISSN: 2076393X
Source: Self-asserted source
Lynda Coughlan
grade
Preferred source (of 2)‎

Adenoviral vectors as novel vaccines for influenza.

2015-03 | Journal article
Contributors: Coughlan L; Mullarkey C; Gilbert S
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Genetically engineering adenoviral vectors for gene therapy.

2014 | Journal article
Contributors: Coughlan L
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation.

2014-04 | Journal article
Contributors: Coughlan L; Uusi-Kerttula H; Ma J; Degg BP; Parker AL; Baker AH
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens.

2014-03 | Journal article
Contributors: Antrobus RD; Coughlan L; Berthoud TK; Dicks MD; Hill AV; Lambe T; Gilbert SC
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses.

2014-01 | Journal article
Contributors: Antrobus RD; Berthoud TK; Mullarkey CE; Hoschler K; Coughlan L; Zambon M; Hill AV; Gilbert SC
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery.

2012-12 | Journal article
Contributors: Coughlan L; Bradshaw AC; Parker AL; Robinson H; White K; Custers J; Goudsmit J; Van Roijen N; Barouch DH; Nicklin SA et al.
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses.

2012-12 | Journal article
Contributors: Bradshaw AC; Coughlan L; Miller AM; Alba R; van Rooijen N; Nicklin SA; Baker AH
Source: Self-asserted source
Lynda Coughlan via Europe PubMed Central
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Peer review (4 reviews for 3 publications/grants)

Review activity for Nature microbiology. (1)
Review activity for PloS one. (1)
Review activity for PLOS pathogens : (2)