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Works (37)

The Structural Biology of T‐Cell Antigen Detection at Close Contacts

Immunological Reviews
2025-05 | Journal article
DOI: 10.1111/imr.70014
Contributors: Yuan Lui; João Ferreira Fernandes; Mai T. Vuong; Sumana Sharma; Ana Mafalda Santos; Simon J. Davis
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A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells

Life Science Alliance
2024-03 | Journal article
DOI: 10.26508/lsa.202302359
Contributors: Sumana Sharma; Toby Whitehead; Mateusz Kotowski; Emily Zhi Qing Ng; Joseph Clarke; Judith Leitner; Yi-Ling Chen; Ana Mafalda Santos; Peter Steinberger; Simon J Davis
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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases

Immunity
2024-02 | Journal article
DOI: 10.1016/j.immuni.2024.01.007
Part of ISSN: 1074-7613
Contributors: Anna H. Lippert; Christopher Paluch; Meike Gaglioni; Mai T. Vuong; James McColl; Edward Jenkins; Martin Fellermeyer; Joseph Clarke; Sumana Sharma; Sara Moreira da Silva et al.
Source: Self-asserted source
Ana Mafalda Santos

Antigen discrimination by T cells relies on size-constrained microvillar contact

Nature Communications
2023-03-23 | Journal article
DOI: 10.1038/s41467-023-36855-9
Part of ISSN: 2041-1723
Contributors: Edward Jenkins; Markus Körbel; Caitlin O'Brien-Ball; James McColl; Kevin Y. Chen; Mateusz Kotowski; Jane Humphrey; Anna H. Lippert; Heather Brouwer; Ana Mafalda Santos et al.
Source: Self-asserted source
Ana Mafalda Santos

The kinase occupancy of T cell coreceptors reconsidered

Proceedings of the National Academy of Sciences
2022-12-06 | Journal article
DOI: 10.1073/pnas.2213538119
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Alexander M. Mørch; Falk Schneider; Edward Jenkins; Ana Mafalda Santos; Scott E. Fraser; Simon Davis; Michael L. Dustin
Source: Self-asserted source
Ana Mafalda Santos

resPAINT: Accelerating Volumetric Super‐Resolution Localisation Microscopy by Active Control of Probe Emission**

Angewandte Chemie International Edition
2022-10-17 | Journal article
DOI: 10.1002/anie.202206919
Part of ISSN: 1433-7851
Part of ISSN: 1521-3773
Contributors: Edward William Sanders; Alexander R. Carr; Ezra Bruggeman; Markus Körbel; Sarah I. Benaissa; Robert F. Donat; Ana M. Santos; James McColl; Kevin O'Holleran; David Klenerman et al.
Source: Self-asserted source
Ana Mafalda Santos

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

Cell
2022-08 | Journal article
DOI: 10.1016/j.cell.2022.07.010
Part of ISSN: 0092-8674
Contributors: Lukas Sušac; Mai T. Vuong; Christoph Thomas; Sören von Bülow; Caitlin O’Brien-Ball; Ana Mafalda Santos; Ricardo A. Fernandes; Gerhard Hummer; Robert Tampé; Simon Davis
Source: Self-asserted source
Ana Mafalda Santos

Single-cell measurements of two-dimensional binding affinity across cell contacts

Biophysical Journal
2021-11 | Journal article
DOI: 10.1016/j.bpj.2021.10.010
Part of ISSN: 0006-3495
Contributors: Manto Chouliara; Victoria Junghans; Tommy Dam; Ana Mafalda Santos; Simon J. Davis; Peter Jönsson
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling

Proceedings of the National Academy of Sciences
2021-09 | Journal article
DOI: 10.1073/pnas.2024250118
Part of ISSN: 0027-8424
Contributors: Kevin Y. Chen; Edward Jenkins; Markus Körbel; Aleks Ponjavic; Anna H. Lippert; Ana Mafalda Santos; Nicole Ashman; Caitlin O'Brien-Ball; Jemma McBride; David Klenerman et al.
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells

FEBS Letters
2021-08 | Journal article
DOI: 10.1002/1873-3468.14153
Contributors: Iztok Urbančič; Lisa Schiffelers; Edward Jenkins; Weijian Gong; Ana Mafalda Santos; Falk Schneider; Caitlin O’Brien‐Ball; Mai Tuyet Vuong; Nicole Ashman; Erdinc Sezgin et al.
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Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions

Biophysical Journal
2021-01 | Journal article
DOI: 10.1016/j.bpj.2020.11.021
Part of ISSN: 0006-3495
Contributors: Anna H. Lippert; Ivan B. Dimov; Alexander K. Winkel; Jane Humphrey; James McColl; Kevin Y. Chen; Ana M. Santos; Edward Jenkins; Kristian Franze; Simon J. Davis et al.
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Aggregation and immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells

2020-12-22 | Preprint
DOI: 10.1101/2020.12.22.422352
Contributors: Iztok Urbančič; Lisa Schiffelers; Edward Jenkins; Weijian Gong; Ana Mafalda Santos; Falk Schneider; Caitlin O’Brien-Ball; Mai Tuyet Vuong; Nicole Ashman; Erdinc Sezgin et al.
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Coreceptors and TCR Signaling – the Strong and the Weak of It

Frontiers in Cell and Developmental Biology
2020-10 | Journal article
DOI: 10.3389/fcell.2020.597627
Part of ISSN: 2296-634X
Contributors: Alexander M. Mørch; Štefan Bálint; Ana Mafalda Santos; Simon J. Davis; Michael L. Dustin
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

vLUME: 3D virtual reality for single-molecule localization microscopy

Nature Methods
2020-10 | Journal article
DOI: 10.1038/s41592-020-0962-1
Part of ISSN: 1548-7091
Contributors: Alexander Spark; Alexandre Kitching; Daniel Esteban-Ferrer; Anoushka Handa; Alexander R. Carr; Lisa-Maria Needham; Aleks Ponjavic; Ana Mafalda Santos; James McColl; Christophe Leterrier et al.
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Effects of a local auxiliary protein on the two-dimensional affinity of a TCR–peptide MHC interaction

Journal of Cell Science
2020-08-01 | Journal article
DOI: 10.1242/jcs.245985
Contributors: Victoria Junghans; Manto Chouliara; Ana Mafalda Santos; Deborah Hatherley; Jan Petersen; Tommy Dam; Lena M. Svensson; Jamie Rossjohn; Simon J. Davis; Peter Jönsson
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The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale

Biophysical Journal
2020-03 | Journal article
DOI: 10.1016/j.bpj.2020.01.019
Part of ISSN: 0006-3495
Contributors: Klara Kulenkampff; Anna H. Lippert; James McColl; Ana Mafalda Santos; Aleks Ponjavic; Edward Jenkins; Jane Humphrey; Alexander Winkel; Kristian Franze; Steven F. Lee et al.
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Detection of Cell Surface Ligands for Human Synovial γδ T Cells

The Journal of Immunology
2019-09 | Journal article
DOI: 10.4049/jimmunol.1900451
Part of ISSN: 0022-1767
Contributors: Cheryl Collins; Yuan Lui; Ana Mafalda Santos; Bryan A. Ballif; Anisha Mahalya Gogerly-Moragoda; Heather Brouwer; Robin Ross; Kuberan Balagurunathan; Sumana Sharma; Gavin J. Wright et al.
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

A cell topography-based mechanism for ligand discrimination by the T cell receptor

Proceedings of the National Academy of Sciences
2019-06 | Journal article
DOI: 10.1073/pnas.1817255116
Part of ISSN: 0027-8424
Contributors: Ricardo A. Fernandes; Kristina A. Ganzinger; Justin C. Tzou; Peter Jönsson; Steven F. Lee; Matthieu Palayret; Ana Mafalda Santos; Alexander R. Carr; Aleks Ponjavic; Veronica T. Chang et al.
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Immune Checkpoints as Therapeutic Targets in Autoimmunity

Frontiers in Immunology
2018-10-08 | Journal article
DOI: 10.3389/fimmu.2018.02306
Part of ISSN: 1664-3224
Contributors: Christopher Paluch; Ana Mafalda Santos; Consuelo Anzilotti; Richard J. Cornall; Simon J. Davis
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Dimensions and Interactions of Large T-Cell Surface Proteins

Frontiers in Immunology
2018-09 | Journal article
DOI: 10.3389/fimmu.2018.02215
Part of ISSN: 1664-3224
Contributors: Victoria Junghans; Ana Mafalda Santos; Yuan Lui; Simon J. Davis; Peter Jönsson
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Membrane Ultrastructure and T Cell Activation

Frontiers in Immunology
2018-09 | Journal article
DOI: 10.3389/fimmu.2018.02152
Part of ISSN: 1664-3224
Contributors: Johannes Pettmann; Ana Mafalda Santos; Omer Dushek; Simon J. Davis
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Hydrodynamic trapping measures the interaction between membrane-associated molecules

Scientific Reports
2018-08 | Journal article
DOI: 10.1038/s41598-018-30285-0
Part of ISSN: 2045-2322
Contributors: Victoria Junghans; Jana Hladilkova; Ana Mafalda Santos; Mikael Lund; Simon J. Davis; Peter Jönsson
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Single-Molecule Light-Sheet Imaging of Suspended T Cells

Biophysical Journal
2018-05 | Journal article
DOI: 10.1016/j.bpj.2018.02.044
Part of ISSN: 0006-3495
Contributors: Aleks Ponjavic; James McColl; Alexander R. Carr; Ana Mafalda Santos; Klara Kulenkampff; Anna Lippert; Simon J. Davis; David Klenerman; Steven F. Lee
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

Capturing resting T cells: the perils of PLL.

Nature immunology
2018-03 | Journal article
DOI: 10.1038/s41590-018-0048-8
PMID: 29476188
Contributors: Santos AM; Ponjavic A; Fritzsche M; Fernandes RA; de la Serna JB; Wilcock MJ; Schneider F; Urbančič I; McColl J; Anzilotti C et al.
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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Reconstitution of immune cell interactions in free-standing membranes

Journal of Cell Science
2018-01-01 | Journal article
DOI: 10.1242/jcs.219709
Part of ISSN: 1477-9137
Contributors: Edward Jenkins; Ana Mafalda Santos; Caitlin O'Brien-Ball; James H. Felce; Martin J. Wilcock; Deborah Hatherley; Michael L. Dustin; Simon J. Davis; Christian Eggeling; Erdinc Sezgin
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

A Protein Expression Toolkit for Studying Signaling in T Cells

The Immune Synapse
2017 | Other
DOI: 10.1007/978-1-4939-6881-7_28
Contributors: Ana Mafalda Santos; Jiandong Huo; Deborah Hatherley; Mami Chirifu; Simon J. Davis
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search
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Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation

Science Advances
2017-06-02 | Journal article
DOI: 10.1126/sciadv.1603032
Contributors: Marco Fritzsche; Ricardo A. Fernandes; Veronica T. Chang; Huw Colin-York; Mathias P. Clausen; James H. Felce; Silvia Galiani; Christoph Erlenkämper; Ana M. Santos; John M. Heddleston et al.
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Three-Dimensional Super-Resolution in Eukaryotic Cells Using the Double-Helix Point Spread Function.

Biophysical journal
2017-04 | Journal article
DOI: 10.1016/j.bpj.2017.02.023
PMID: 28402886
Contributors: Carr AR; Ponjavic A; Basu S; McColl J; Santos AM; Davis S; Laue ED; Klenerman D; Lee SF
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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Rituximab capping triggers intracellular reorganization of B cells

Matters
2017-01 | Journal article
DOI: 10.19185/matters.201612000001
Contributors: Thomas Koller; Siebe Blok; Ana Mafalda Santos; Anna Oszmiana; Daniel Davis; Erdinc Sezgin; Christian Eggeling
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain.

Frontiers in Immunology
2016 | Journal article
DOI: 10.3389/fimmu.2016.00416
PMID: 27790215
PMC: PMC5061727
Contributors: Bessa Pereira C; Bocková M; Santos RF; Santos AM; Martins de Araújo M; Oliveira L; Homola J; Carmo AM
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

Proceedings of the National Academy of Sciences of the United States of America
2016-05 | Journal article
DOI: 10.1073/pnas.1513918113
PMID: 27114505
PMC: PMC4878507
Contributors: Jönsson P; Southcombe JH; Santos AM; Huo J; Fernandes RA; McColl J; Lever M; Evans EJ; Hudson A; Chang VT et al.
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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CalQuo: automated, simultaneous single-cell and population-level quantification of global intracellular Ca2+ responses.

Scientific reports
2015-11 | Journal article
DOI: 10.1038/srep16487
PMID: 26563585
PMC: PMC4643230
Contributors: Fritzsche M; Fernandes RA; Colin-York H; Santos AM; Lee SF; Lagerholm BC; Davis SJ; Eggeling C
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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T cell activation regulates CD6 alternative splicing by transcription dynamics and SRSF1.

Journal of immunology (Baltimore, Md. : 1950)
2014-07 | Journal article
DOI: 10.4049/jimmunol.1400038
PMID: 24890719
Contributors: da Glória VG; Martins de Araújo M; Mafalda Santos A; Leal R; de Almeida SF; Carmo AM; Moreira A
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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A streamlined implementation of the glutamine synthetase-based protein expression system.

BMC biotechnology
2013-09 | Journal article
DOI: 10.1186/1472-6750-13-74
PMID: 24063773
PMC: PMC3850363
Contributors: Knox R; Nettleship JE; Chang VT; Hui ZK; Santos AM; Rahman N; Ho LP; Owens RJ; Davis SJ
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

European Journal of Immunology
2011-11 | Journal article
DOI: 10.1002/eji.201040528
Contributors: Marta I. Oliveira; Carine M. Gonçalves; Mafalda Pinto; Stéphanie Fabre; Ana Mafalda Santos; Simon F. Lee; Mónica A. A. Castro; Raquel J. Nunes; Rita R. Barbosa; Jane R. Parnes et al.
Source: Self-asserted source
Ana Mafalda Santos via Crossref Metadata Search

A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.

The Journal of biological chemistry
2011-09 | Journal article
DOI: 10.1074/jbc.m111.230102
PMID: 21757751
PMC: PMC3162391
Contributors: Bamberger M; Santos AM; Gonçalves CM; Oliveira MI; James JR; Moreira A; Lozano F; Davis SJ; Carmo AM
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry.

Journal of the American Chemical Society
2006-12 | Journal article
DOI: 10.1021/ja0661919
PMID: 17165715
Contributors: Moorhouse AD; Santos AM; Gunaratnam M; Moore M; Neidle S; Moses JE
Source: Self-asserted source
Ana Mafalda Santos via Europe PubMed Central
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Peer review (1 review for 1 publication/grant)

Review activity for Communications biology. (1)
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