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Microbiology, antibiotic resistance, enzymology, pharmacology, cell signaling

Biography

2017-present Assistant Professor, Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, USA, with Dr. Timothy Palzkill

2015-2017 Instructor, Department of Pharmacology, Baylor College of Medicine, Houston, USA, Dr. Timothy Palzkill

2013-2015 Postdoctoral Fellow, Department of Pharmacology, Baylor College of Medicine, Houston, USA, Dr. Timothy Palzkill

2009-2013 Postdoctoral Fellow, Department of Pharmacology, University of Iowa, Iowa City, USA, Dr. Songhai Chen

2004-2009 Predoctoral Researcher, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Drs. Liandong Huan and Jin Zhong

2001-2004 Master Student, Beijing Institute of Radiation Medicine, Beijing, China, Dr. Pingkun Zhou

Activities

Education and qualifications (3)

Institute of Microbiology ,Chinese Academy of Sciences: Beijing, Beijing, CN

2004-09-01 to 2009-07-01 | Ph. D.
Education
Source: Self-asserted source
Zhizeng Sun

Beijing Institute of Radiation Medicine: Beijing, Beijing, CN

2001-09-01 to 2004-07-01 | MS
Education
Source: Self-asserted source
Zhizeng Sun

Henan University: Kaifeng, Henan, CN

1996-09-01 to 2000-07-01 | BS (Biology)
Education
Source: Self-asserted source
Zhizeng Sun

Works (16)

Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops

Journal of Biological Chemistry
2024-01 | Journal article
Contributors: Zhizeng Sun; Hanfeng Lin; Liya Hu; Neetu Neetu; Banumathi Sankaran; Jin Wang; B.V. Venkataram Prasad; Timothy Palzkill
Source: check_circle
Crossref

Streptococcus pyogenes genes that promote pharyngitis in primates

JCI Insight
2020-06-04 | Journal article
Contributors: Luchang Zhu; Randall J. Olsen; Stephen B. Beres; Matthew Ojeda Saavedra; Samantha L. Kubiak; Concepcion C. Cantu; Leslie Jenkins; Andrew S. Waller; Zhizeng Sun; Timothy Palzkill et al.
Source: check_circle
Crossref

Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

Nature Communications
2018-10-30 | Journal article
Contributors: Zhizeng Sun; Liya Hu; Banumathi Sankaran; B. V. Venkataram Prasad; Timothy Palzkill
Source: check_circle
Crossref

Co-occurrence of NDM-5, OXA-181, and CMY-2 in a Clinical E. coli Isolate From a Patient in the United States.

Open forum infectious diseases
2017-10 | Journal article
Contributors: Miller W; Rios R; Diaz L; Panesso D; Chang M; Sun Z; Palzkill T; Arias C
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations.

Scientific reports
2016-09 | Journal article
Contributors: Sun Z; Mehta SC; Adamski CJ; Gibbs RA; Palzkill T
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion.

Oncotarget
2016-04 | Journal article
Contributors: Ye Y; Tang X; Sun Z; Chen S
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.

Cellular signalling
2014-08 | Journal article
Contributors: Ye Y; Sun Z; Guo A; Song LS; Grobe JL; Chen S
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

Bovicin HJ50-like lantibiotics, a novel subgroup of lantibiotics featured by an indispensable disulfide bridge.

PloS one
2014-05 | Journal article
Contributors: Wang J; Ma H; Ge X; Zhang J; Teng K; Sun Z; Zhong J
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

Cerecidins, novel lantibiotics from Bacillus cereus with potent antimicrobial activity.

Applied and environmental microbiology
2014-02 | Journal article
Contributors: Wang J; Zhang L; Teng K; Sun S; Sun Z; Zhong J
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.

The Journal of biological chemistry
2013-04 | Journal article
Contributors: Sun Z; Smrcka AV; Chen S
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein.

Cellular signalling
2012-08 | Journal article
Contributors: Sun Z; Runne C; Tang X; Lin F; Chen S
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.

The Journal of biological chemistry
2011-11 | Journal article
Contributors: Sun Z; Tang X; Lin F; Chen S
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer.

The Journal of biological chemistry
2011-02 | Journal article
Contributors: Tang X; Sun Z; Runne C; Madsen J; Domann F; Henry M; Lin F; Chen S
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

[Advances in the study of nisin resistance--a review].

Wei sheng wu xue bao = Acta microbiologica Sinica
2010-09 | Journal article
Contributors: Chu X; Lin Y; Sun Z; Huan L; Zhong J
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

Adverse effect of nisin resistance protein on nisin-induced expression system in Lactococcus lactis.

Microbiological research
2009-10 | Journal article
Contributors: Liang X; Sun Z; Zhong J; Zhang Q; Huan L
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central

Novel mechanism for nisin resistance via proteolytic degradation of nisin by the nisin resistance protein NSR.

Antimicrobial agents and chemotherapy
2009-03 | Journal article
Contributors: Sun Z; Zhong J; Liang X; Liu J; Chen X; Huan L
Source: Self-asserted source
Zhizeng Sun via Europe PubMed Central