Personal information

Molecular biology, Pathology, Thymic Epithelial tumors pathology, Haematopathology, Immunohistochemistry, Genetics, Mediastinum
Italy

Biography

After training in cell biology/myogenesis in culture during the Medical School, she achieved the Degree in Medicine at "La Sapienza" University in Rome. Then she achieved the specialization in Pathology at the Catholic University of Rome. In 1983, as fellow of the Deutsches Akademisches Austauschdienst (DAAD), she was involved in a research program leaded by Prof. HK Müller-Hermelink on Thymic Epithelial Tumors (TET) at the Pathologisches Institut of the Kiel University, Fed Rep Germany. She has been performing general surgical pathology as staff pathologist first at the Hospital S. Giacomo, Rome (1981-2001), and later (2001- ) at the Regina Elena National Cancer Institute, In 2009, after the retirement of the previous Director, she was Acting Director of the Dept. of Pathology (from September 2009 to april 2010). In that period she attended the Management course at the Luiss University of Rome. At the Pathology Department she is Quality Responsible and, since March 2014, Quality responsible for the Tissue Biobank. She is involved in diagnostic surgical pathology of every organs and systems; moreover, her specialized diagnostic fields are hematopathology and Thymic Epithelial Tumors diagnostics In the years 1990-1993 she was temporary Professor on contract in Embryology at the Institute of Histology and Embryology for Medicine, "La Sapienza" University of Rome. She was co-author of the European histogenetic Thymoma Classification (1985), contributed to the 2004 WHO TET classification and now to the new 2015 WHO TET classification recently published (IARC press).
She is author or co-author of several papers/reviews in international journals, most of them in thymic tumors. She participates to the International Thymic Malignancy Interest Group ( ITMIG) activities and is member of the Staging and Prognostic Factors Committee of the International Association Study Lung Cancer (IASLC), Thymic Domain (SPFC-TD) (2011- 2016 and 2017- ) and IASLC member. Moreover, she is contributing to several groups/ Committees in ITMIG: the Steering Committee, the Biology/Tumor board Group, the Research and the Education Committee. Moreover she contributes to the European Society of Pathology (ESP) (Thymus and Mediastinal Working Group) and is member of the Italian Society for Pathological Anatomy (SIAPEC).She is participating to the Hematopathology working group (GIE) of SIAPEC. She promotes collaborative studies on Thymic Epithelial Tumors and provided molecular genetic data to an italian "Phase II monitored clinical trial for evaluation of treatment of patients with Thymic Epithelial Tumours (TET) or Histiocytosis X (LCH) with Imatinib Mesylate "(FARM6HJ7CA) (AIFA 2007 for rare diseases and orphan drugs). She was granted by the Italian Ministry of Health in the framework of Italy-US program for Rare Disease for research in TET. She is member of the Editorial Board of Case Reports in Pathology ( Hindawi Publishing Corporation) and of the Journal "Mediastinum", launched in 2017 by AME publishing group. Actually, in the ITMIG /IASCL SPFC-TD she is contributing to the Staging project of TET for the next (9th edition) TNM staging manual of the UICC. She promoted and partecipates to multicenter/multidisciplinary collaborative research projects on TET on a national basis based on immunohistochemistry, molecular genetic, molecular biology and collaborates with international networks/biobanks active in TET study. She participated to the Tumor Cancer Genome Atlas (TCGA) on Thymic epithelial tumors (TCGA-THYM), promoted by the NCI-US. Moreover she is contributing to the prospective ITMIG/IASLC worldwide database and to the Virtual Thymic Bank. For the Italian Association Rare Tumors (IART) she is referral pathologist for Thymic Epithelial Tumors. She participated to the project of the International Collaboration on Cancer Reporting (ICCR), promoted by the Canadian Partnership Against Cancer (CPAC) and the US College of American Pathologists (CAP), the UK (RCPath) and Australian (RCPA) Colleges of Pathology; recently the European Society of Pathology (ESP), joined the other societies in the ICCR project. The purpose of ICCR is to uniform the pathological reports of TET according to a shared relevant “dataset” . M. Marino was recently (2015-2016 and 2017) enlisted in the Expert and Collaborator's Register mantained by the Italian National Agency of Health Services (Agenas) in the "research and international relations" area. She recently joined the Biobanking and BioMolecular resources Research Infrastructure of Italy (BBMRI-IT) network and proposed a research project entitled "Global biobanking and networking in an Oncological Institute: infrastructures and shared data collection and organization for clinical, research and Tumor Registry purposes" which was granted by the Current research grants 2015 of the Ministry of Health to the Regina Elena National Cancer Institute.

Activities

Employment (3)

Regina Elena National Cancer Institute: Roma, Lazio, IT

2001-08 to present | Senior staff pathologist (Pathology)
Employment
Source: Self-asserted source
Mirella Marino

Hospital S Giacomo: Rome, IT

1981-10 to 2001-08 | Staff Pathologist/ Senior staff Pathologist (Pathology)
Employment
Source: Self-asserted source
Mirella Marino

Hospital S. Matteo degli Infermi: Spoleto, IT

1980-10 to 1981-10 | Staff Pathologist (Pathology)
Employment
Source: Self-asserted source
Mirella Marino

Education and qualifications (3)

Catholic University: Rome, IT

1986 to 1989 | Specialization in Haematology (MRCP equivalent) (Haematology)
Education
Source: Self-asserted source
Mirella Marino

Catholic University: Rome, IT

1978 to 1981 | (Specialization in Pathology) (MRCPath equivalent) (Pathology)
Education
Source: Self-asserted source
Mirella Marino

University La Sapienza: Rome, IT

1972-11-01 to 1978-07-24 | Medical Doctor
Education
Source: Self-asserted source
Mirella Marino

Funding (5)

Global biobanking and networking in an Oncological Institute: infrastructures and shared data collection and organization for clinical, research and Tumor Registry purposes

2015-06 to 2016-03 | Grant
Ministry of Health (Rome, IT)
GRANT_NUMBER: -
Source: Self-asserted source
Mirella Marino

A multidisciplinary approach to EGFR activity regulatory mechanisms in Thymic Epithelial Tumors (TET)

2011 to 2012 | Grant
Ministero della Salute (Rome, National, IT)
Source: Self-asserted source
Mirella Marino

“Malignant Thymoma: a rare disease representing a clinically unresolved problem. A phenotypical and proteomic analysis with clinical implications

2007 to 2011 | Grant
Ministero della Salute (Rome, National, IT)
Source: Self-asserted source
Mirella Marino

Multidimensional classification of lymphohematopoietic malignancies

2007 to 2009 | Grant
Ministero della Salute (Rome, National, IT)
Source: Self-asserted source
Mirella Marino

Neuroendocrine growth control and immune modulation in Thymic Epithelial Tumors

2003 to 2005 | Grant
Ministero della Salute (Rome, National, IT)
Source: Self-asserted source
Mirella Marino

Works (50 of 140)

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Structural and Functional Thymic Biomarkers Are Involved in the Pathogenesis of Thymic Epithelial Tumors: An Overview

Immuno
2022-05 | Journal article | Author
Contributors: Enzo Gallo; Maria Teresa Ramieri; Mirella Marino
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Association between CMV and invasive fungal infections after autologous stem cell transplant in lymphoproliferative malignancies: Opportunistic partnership or cause-effect relationship?

International Journal of Molecular Sciences
2019 | Journal article
EID:

2-s2.0-85063607028

Contributors: Marchesi, F.; Pimpinelli, F.; Di Domenico, E.G.; Renzi, D.; Gallo, M.T.; Regazzo, G.; Rizzo, M.G.; Gumenyuk, S.; Toma, L.; Marino, M. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Molecular Classification of Neuroendocrine Tumors of the Thymus

Journal of Thoracic Oncology
2019 | Journal article
EID:

2-s2.0-85067045104

Contributors: Dinter, H.; Bohnenberger, H.; Beck, J.; Bornemann-Kolatzki, K.; Schütz, E.; Küffer, S.; Klein, L.; Franks, T.J.; Roden, A.; Emmert, A. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

The biological resources and molecule archives organization: Turn a need into an opportunity for the Smart Specialization Strategy of the Lazio region,Organizzare risorse biologiche e archivi di molecole: trasformare una necessità in opportunità per la Smart Specialisation Strategy della Regione Lazio

Recenti Progressi in Medicina
2019 | Journal article
EID:

2-s2.0-85062631350

Contributors: Bravo, E.; Franchin, T.; Santoro, F.; Conti, L.; Carrara, S.; Marino, M.; Di Caro, A.; Cigliana, G.; Mandoj, C.; Baselice, S. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

Cancer Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

Cell Systems
2018 | Journal article
EID:

2-s2.0-85055618721

Contributors: Korkut, A.; Zaidi, S.; Kanchi, R.S.; Rao, S.; Gough, N.R.; Schultz, A.; Li, X.; Lorenzi, P.L.; Berger, A.C.; Robertson, G. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Best practices for the management of thymic epithelial tumors: A position paper by the Italian collaborative group for ThYmic MalignanciEs (TYME)

Cancer Treatment Reviews
2018 | Journal article
EID:

2-s2.0-85055280292

Contributors: Imbimbo, M.; Ottaviano, M.; Vitali, M.; Fabbri, A.; Leuzzi, G.; Fiore, M.; Franceschini, D.; Pasello, G.; Perrino, M.; Schiavon, M. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

Cancer Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

Cancer Cell
2018 | Journal article
EID:

2-s2.0-85051096107

Contributors: Kahles, A.; Lehmann, K.-V.; Toussaint, N.C.; Hüser, M.; Stark, S.G.; Sachsenberg, T.; Stegle, O.; Kohlbacher, O.; Sander, C.; Caesar-Johnson, S.J. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Comprehensive Characterization of Cancer Driver Genes and Mutations

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Cell Reports
2018 | Journal article
EID:

2-s2.0-85055628471

Contributors: Wang, Y.; Xu, X.; Maglic, D.; Dill, M.T.; Mojumdar, K.; Ng, P.K.-S.; Jeong, K.J.; Tsang, Y.H.; Moreno, D.; Bhavana, V.H. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

Eighth Edition Staging of Thoracic Malignancies: Implications for the Reporting Pathologist.

Archives of pathology & laboratory medicine
2018 | Journal article
WOSUID:

MEDLINE:29480761

Contributors: Nicholson, Andrew G; Tsao, Ming S; Travis, William D; Patil, Deepa T; Galateau-Salle, Francoise; Marino, Mirella; Dacic, Sanja; Beasley, Mary Beth; Butnor, Kelly J; Yatabe, Yasushi et al.
Source: Self-asserted source
Mirella Marino via ResearcherID
grade
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Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))

Cell
2018 | Journal article
EID:

2-s2.0-85050668698

Contributors: Bailey, M.H.; Tokheim, C.; Porta-Pardo, E.; Sengupta, S.; Bertrand, D.; Weerasinghe, A.; Colaprico, A.; Wendl, M.C.; Kim, J.; Reardon, B. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Erratum: The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))

Cell Reports
2018 | Journal article
EID:

2-s2.0-85048586592

Contributors: Ricketts, C.J.; De Cubas, A.A.; Fan, H.; Smith, C.C.; Lang, M.; Reznik, E.; Bowlby, R.; Gibb, E.A.; Akbani, R.; Beroukhim, R. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Cancer Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

Cancer Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Oncogenic Signaling Pathways in The Cancer Genome Atlas

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Cell Systems
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Pathogenic Germline Variants in 10,389 Adult Cancers

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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PD-L1 Testing in Lung Cancer: An International Pathologist's Initiative in an Unknown “Middle Earth”

Journal of Thoracic Oncology
2018 | Journal article
EID:

2-s2.0-85052301214

Contributors: Marino, M.; Visca, P.; Ottaviano, M.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

Cell
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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RELEVENT Trial: Phase II Trial of Ramucirumab, Carboplatin, and Paclitaxel in Previously Untreated Thymic Carcinoma/B3 Thymoma With Area of Carcinoma

Clinical Lung Cancer
2018 | Journal article
EID:

2-s2.0-85050141353

Contributors: Imbimbo, M.; Vitali, M.; Fabbri, A.; Ottaviano, M.; Pasello, G.; Petrini, I.; Palmieri, G.; Berardi, R.; Zucali, P.; Ganzinelli, M. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

Cell Systems
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Serum miR-22 as potential non-invasive predictor of poor clinical outcome in newly diagnosed, uniformly treated patients with diffuse large B-cell lymphoma: An explorative pilot study

Journal of Experimental and Clinical Cancer Research
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
Preferred source (of 2)‎

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Cell Reports
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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The IASLC Lung Cancer Staging Project: A Renewed Call to Participation

Journal of Thoracic Oncology
2018 | Journal article
EID:

2-s2.0-85045422975

Contributors: Giroux, D.J.; Van Schil, P.; Asamura, H.; Rami-Porta, R.; Chansky, K.; Crowley, J.J.; Rusch, V.W.; Kernstine, K.; Asamura, H.; Rusch, V. et al.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

The Immune Landscape of Cancer

Immunity
2018 | Journal article
Source: Self-asserted source
Mirella Marino
grade
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The Integrated Genomic Landscape of Thymic Epithelial Tumors

Cancer Cell
2018 | Journal article
WOSUID:

WOS:000424864000012

Contributors: Radovich, Milan; Pickering, Curtis R.; Felau, Ina; Ha, Gavin; Zhang, Hailei; Jo, Heejoon; Hoadley, Katherine A.; Anur, Pavana; Zhang, Jiexin; McLellan, Mike et al.
Source: Self-asserted source
Mirella Marino via ResearcherID
grade
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Unique case of atypical type A thymoma with vertebral metastasis and high 18-fluorodeoxyglucose avidity

ANZ Journal of Surgery
2018 | Journal article
EID:

2-s2.0-85053264364

Contributors: Chiappetta, M.; Marino, M.; Facciolo, F.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Histopathology
2017 | Journal article
WOSUID:

WOS:000394988100002

Contributors: Nicholson, Andrew G.; Detterbeck, Frank; Marx, Alexander; Roden, Anja C.; Marchevsky, Alberto M.; Mukai, Kiyoshi; Chen, Gang; Marino, Mirella; den Bakker, Michael A.; Yang, Woo-Ick et al.
Source: Self-asserted source
Mirella Marino via ResearcherID
grade
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Induction Therapy versus Initial Surgery in Advanced Thymic Tumors: Perioperative and Oncological Outcome

Thoracic and Cardiovascular Surgeon
2017 | Journal article
WOSUID:

WOS:000398820400013

Contributors: Leuzzi, Giovanni; Alessandrini, Gabriele; Sperduti, Isabella; Forcella, Daniele; Marino, Mirella; Ceribelli, Anna; Facciolo, Francesco
Source: Self-asserted source
Mirella Marino via ResearcherID
grade
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The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer

Journal of Thoracic Oncology
2017 | Journal article
WOSUID:

WOS:000405256300008

Contributors: Chansky, Kari; Detterbeck, Frank C.; Nicholson, Andrew G.; Rusch, Valerie W.; Vallieres, Eric; Groome, Patti; Kennedy, Catherine; Krasnik, Mark; Peake, Michael; Shemanski, Lynn et al.
Source: Self-asserted source
Mirella Marino via ResearcherID
grade
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Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation

Molecular Cancer
2017 | Journal article
WOSUID:

WOS:000401185200001

Contributors: Bellissimo, Teresa; Ganci, Federica; Gallo, Enzo; Sacconi, Andrea; Tito, Claudia; De Angelis, Luciana; Pulito, Claudio; Masciarelli, Silvia; Diso, Daniele; Anile, Marco et al.
Source: Self-asserted source
Mirella Marino via ResearcherID
grade
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Thymoma and thymic carcinoma

Tumors and Cancers: Endocrine Glands - Blood - Marrow - Lymph
2017 | Book
EID:

2-s2.0-85054231782

Contributors: Facciolo, F.; Marino, M.; Ramieri, M.T.
Source: Self-asserted source
Mirella Marino via Scopus - Elsevier

Brain stereotactic biopsy flow cytometry for central nervous system lymphoma characterization: advantages and pitfalls

Journal of Experimental & Clinical Cancer Research
2016 | Journal article
WOSUID:

WOS:000385273300002

Contributors: Cordone, Iole; Masi, Serena; Carosi, Mariantonia; Vidiri, Antonello; Marchesi, Francesco; Marino, Mirella; Telera, Stefano; Pasquale, Alessia; Mengarelli, Andrea; Conti, Laura et al.
Source: Self-asserted source
Mirella Marino via ResearcherID
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Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors

Cancer Biology & Therapy
2016 | Journal article
WOSUID:

WOS:000370615000009

Contributors: Bellissimo, Teresa; Russo, Emanuele; Ganci, Federica; Vico, Carmen; Sacconi, Andrea; Longo, Flavia; Vitolo, Domenico; Anile, Marco; Disio, Daniele; Marino, Mirella et al.
Source: Self-asserted source
Mirella Marino via ResearcherID
grade
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Peer review (4 reviews for 4 publications/grants)

Review activity for BMC cancer (1)
Review activity for JTO clinical and research reports. (1)
Review activity for Lung cancer. (1)
Review activity for Medical oncology. (1)