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National Institutes of Health: Bethesda, Maryland, US

1996-06-01 to present (Laboratory of Chemical Physics)
Employment
Source: Self-asserted source
John M Louis

Works (50 of 182)

Items per page:
Page 1 of 4

Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors

Journal of Medicinal Chemistry
2024-10-24 | Journal article
Contributors: Andrey Kovalevsky; Annie Aniana; Rodolfo Ghirlando; Leighton Coates; Victoria N. Drago; Lauren Wear; Oksana Gerlits; Nashaat T. Nashed; John M. Louis
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Crossref

Characterization of alternate encounter assemblies of SARS-CoV-2 main protease

Journal of Biological Chemistry
2024-09 | Journal article
Contributors: Annie Aniana; Nashaat T. Nashed; Rodolfo Ghirlando; Victoria N. Drago; Andrey Kovalevsky; John M. Louis
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Crossref

Visualizing the Active Site Oxyanion Loop Transition Upon Ensitrelvir Binding and Transient Dimerization of SARS-CoV-2 Main Protease

Journal of Molecular Biology
2024-07 | Journal article
Contributors: Andrey Kovalevsky; Annie Aniana; Leighton Coates; Rodolfo Ghirlando; Nashaat T. Nashed; John M. Louis
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Crossref

Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors

Communications Biology
2023-11-13 | Journal article
Contributors: Annie Aniana; Nashaat T. Nashed; Rodolfo Ghirlando; Leighton Coates; Daniel W. Kneller; Andrey Kovalevsky; John M. Louis
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Crossref

Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors

Journal of Biological Chemistry
2023-07 | Journal article
Contributors: Andrey Kovalevsky; Annie Aniana; Leighton Coates; Peter V. Bonnesen; Nashaat T. Nashed; John M. Louis
Source: check_circle
Crossref

Structures of brain-derived 42-residue amyloid-β fibril polymorphs with unusual molecular conformations and intermolecular interactions

Proceedings of the National Academy of Sciences
2023-03-14 | Journal article
Contributors: Myungwoon Lee; Wai-Ming Yau; John M. Louis; Robert Tycko
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Crossref

Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor

Journal of Molecular Biology
2022-12 | Journal article
Part of ISSN: 0022-2836
Contributors: Andrey Kovalevsky; Leighton Coates; Daniel W. Kneller; Rodolfo Ghirlando; Annie Aniana; Nashaat T. Nashed; John M. Louis
Source: Self-asserted source
John M Louis

Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain

Communications Biology
2022-09-16 | Journal article
Contributors: Nashaat T. Nashed; Daniel W. Kneller; Leighton Coates; Rodolfo Ghirlando; Annie Aniana; Andrey Kovalevsky; John M. Louis
Source: check_circle
Crossref

Global Dynamics of a Protein on the Surface of Anisotropic Lipid Nanoparticles Derived from Relaxation-Based NMR Spectroscopy

The Journal of Physical Chemistry B
2022-08-04 | Journal article
Contributors: Alberto Ceccon; Nina Kubatova; John M. Louis; G. Marius Clore; Vitali Tugarinov
Source: check_circle
Crossref

Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor

Communications Biology
2022-03-01 | Journal article
Contributors: Nashaat T. Nashed; Annie Aniana; Rodolfo Ghirlando; Sai Chaitanya Chiliveri; John M. Louis
Source: check_circle
Crossref

A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins

EMBO Journal
2021 | Journal article
EID:

2-s2.0-85101839981

Part of ISSN: 14602075 02614189
Contributors: Reid Alderson, T.; Adriaenssens, E.; Asselbergh, B.; Pritišanac, I.; Van Lent, J.; Gastall, H.Y.; Wälti, M.A.; Louis, J.M.; Timmerman, V.; Baldwin, A.J. et al.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Concentration-Dependent Structural Transition of the HIV-1 gp41 MPER Peptide into α-Helical Trimers

Angewandte Chemie - International Edition
2021 | Journal article
EID:

2-s2.0-85094215931

Part of ISSN: 15213773 14337851
Contributors: Chiliveri, S.C.; Louis, J.M.; Bax, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Constraints on the Structure of Fibrils Formed by a Racemic Mixture of Amyloid-β Peptides from Solid-State NMR, Electron Microscopy, and Theory

Journal of the American Chemical Society
2021 | Journal article
EID:

2-s2.0-85114024428

Part of ISSN: 15205126 00027863
Contributors: Raskatov, J.A.; Foley, A.R.; Louis, J.M.; Yau, W.-M.; Tycko, R.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding

Biophysical Journal
2021 | Journal article
EID:

2-s2.0-85106359667

Part of ISSN: 15420086 00063495
Contributors: Henry, E.R.; Harper, J.; Glass, K.E.; Metaferia, B.; Louis, J.M.; Eaton, W.A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography

IUCrJ
2021-11-01 | Journal article
Part of ISSN: 2052-2525
Source: Self-asserted source
John M Louis

Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease

Journal of Medicinal Chemistry
2021-10-27 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
John M Louis

Transient lipid-bound states of spike protein heptad repeats provide insights into SARS-CoV-2 membrane fusion.

Science advances
2021-10-08 | Journal article
Source: Self-asserted source
John M Louis

Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease

Proceedings of the National Academy of Sciences of the United States of America
2020 | Journal article
EID:

2-s2.0-85087465736

Part of ISSN: 10916490 00278424
Contributors: Henry, E.R.; Cellmer, T.; Dunkelberger, E.B.; Metaferia, B.; Hofrichter, J.; Li, Q.; Ostrowski, D.; Ghirlando, R.; Louis, J.M.; Moutereau, S. et al.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles

Proceedings of the National Academy of Sciences of the United States of America
2020 | Journal article
EID:

2-s2.0-85084509874

Part of ISSN: 10916490 00278424
Contributors: Gupta, S.; Louis, J.M.; Tycko, R.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Fast three-color single-molecule FRET using statistical inference

Nature Communications
2020 | Journal article
EID:

2-s2.0-85087387912

Part of ISSN: 20411723
Contributors: Yoo, J.; Kim, J.-Y.; Louis, J.M.; Gopich, I.V.; Chung, H.S.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Inhibition of HIV maturation via selective unfolding and cross-linking of Gag polyprotein by a mercaptobenzamide acetylator

Journal of the American Chemical Society
2020 | Journal article
EID:

2-s2.0-85067635717

Part of ISSN: 15205126 00027863
Contributors: Miller Jenkins, L.M.; Paine, E.L.; Deshmukh, L.; Nikolayevskiy, H.; Lyons, G.C.; Scerba, M.T.; Rosenker, K.G.; Luecke, H.F.; Louis, J.M.; Chertova, E. et al.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Probing the Interaction between HIV-1 Protease and the Homodimeric p66/p66’ Reverse Transcriptase Precursor by Double Electron-Electron Resonance EPR Spectroscopy

ChemBioChem
2020 | Journal article
EID:

2-s2.0-85087860496

Part of ISSN: 14397633 14394227
Contributors: Schmidt, T.; Louis, J.M.; Clore, G.M.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Proton transfer and drug binding details revealed in neutron diffraction studies of wild-type and drug resistant HIV-1 protease

Methods in Enzymology
2020 | Book chapter
EID:

2-s2.0-85077718831

Part of ISSN: 15577988 00766879
Contributors: Kovalevsky, A.; Gerlits, O.; Beltran, K.; Weiss, K.L.; Keen, D.A.; Blakeley, M.P.; Louis, J.M.; Weber, I.T.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design

ACS Omega
2020 | Journal article
EID:

2-s2.0-85085651873

Part of ISSN: 24701343
Contributors: Kumar, M.; Mandal, K.; Blakeley, M.P.; Wymore, T.; Kent, S.B.H.; Louis, J.M.; Das, A.; Kovalevsky, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Diverse Folding Pathways of HIV-1 Protease Monomer on a Rugged Energy Landscape

Biophysical Journal
2019 | Journal article
EID:

2-s2.0-85072780582

Part of ISSN: 15420086 00063495
Contributors: Yoo, J.; Louis, J.M.; Chung, H.S.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Dysregulated interactions triggered by a neuropathy-causing mutation in the IPV motif of HSP27

bioRxiv
2019 | Other
EID:

2-s2.0-85095635985

Part of ISSN: 26928205
Contributors: Reid Alderson, T.; Adriaenssens, E.; Asselbergh, B.; Pritišanac, I.; Gastall, H.Y.; Wälti, M.A.; Louis, J.M.; Timmerman, V.; Baldwin, A.J.; Benesch, J.L.P.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Importance of time-ordered non-uniform sampling of multi-dimensional NMR spectra of Aβ<sup>1–42</sup> peptide under aggregating conditions

Journal of Biomolecular NMR
2019 | Journal article
EID:

2-s2.0-85070924381

Part of ISSN: 15735001 09252738
Contributors: Ying, J.; Barnes, C.A.; Louis, J.M.; Bax, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Observation of β-Amyloid Peptide Oligomerization by Pressure-Jump NMR Spectroscopy

Journal of the American Chemical Society
2019 | Journal article
EID:

2-s2.0-85071788460

Part of ISSN: 15205126 00027863
Contributors: Barnes, C.A.; Robertson, A.J.; Louis, J.M.; Anfinrud, P.; Bax, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Co-Evolutionary Fitness Landscapes for Sequence Design

Angewandte Chemie - International Edition
2018 | Journal article
EID:

2-s2.0-85044229725

Part of ISSN: 15213773 14337851
Contributors: Tian, P.; Louis, J.M.; Baber, J.L.; Aniana, A.; Best, R.B.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Probing the mechanism of inhibition of amyloid-β(1–42)–induced neurotoxicity by the chaperonin GroEL

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
EID:

2-s2.0-85058667428

Part of ISSN: 10916490 00278424
Contributors: Wälti, M.A.; Steiner, J.; Meng, F.; Chung, H.S.; Louis, J.M.; Ghirlando, R.; Tugarinov, V.; Nath, A.; Marius Clore, G.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Three-Color Single-Molecule FRET and Fluorescence Lifetime Analysis of Fast Protein Folding

Journal of Physical Chemistry B
2018 | Journal article
EID:

2-s2.0-85054877177

Part of ISSN: 15205207 15206106
Contributors: Yoo, J.; Louis, J.M.; Gopich, I.V.; Chung, H.S.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Tilted, Uninterrupted, Monomeric HIV-1 gp41 Transmembrane Helix from Residual Dipolar Couplings

Journal of the American Chemical Society
2018 | Journal article
EID:

2-s2.0-85040353084

Part of ISSN: 15205126 00027863
Contributors: Chiliveri, S.C.; Louis, J.M.; Ghirlando, R.; Baber, J.L.; Bax, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Binding kinetics and substrate selectivity in HIV-1 protease−Gag interactions probed at atomic resolution by chemical exchange NMR

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
EID:

2-s2.0-85033701981

Part of ISSN: 10916490 00278424
Contributors: Deshmukh, L.; Tugarinov, V.; Louis, J.M.; Clore, G.M.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Oligomerization of the tetramerization domain of p53 probed by two- and three-color single-molecule FRET

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
EID:

2-s2.0-85027398348

Part of ISSN: 10916490 00278424
Contributors: Chung, H.S.; Meng, F.; Kim, J.-Y.; McHale, K.; Gopich, I.V.; Louis, J.M.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K

Journal of Medicinal Chemistry
2017 | Journal article
EID:

2-s2.0-85015079543

Part of ISSN: 15204804 00222623
Contributors: Gerlits, O.; Keen, D.A.; Blakeley, M.P.; Louis, J.M.; Weber, I.T.; Kovalevsky, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Analysis of Fluorescence Lifetime and Energy Transfer Efficiency in Single-Molecule Photon Trajectories of Fast-Folding Proteins

Journal of Physical Chemistry B
2016 | Journal article
EID:

2-s2.0-84957900175

Part of ISSN: 15205207 15206106
Contributors: Chung, H.S.; Louis, J.M.; Gopich, I.V.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme

Biochemistry
2016 | Journal article
EID:

2-s2.0-84969268618

Part of ISSN: 15204995 00062960
Contributors: Park, J.H.; Sayer, J.M.; Aniana, A.; Yu, X.; Weber, I.T.; Harrison, R.W.; Louis, J.M.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Evolution under Drug Pressure Remodels the Folding Free-Energy Landscape of Mature HIV-1 Protease

Journal of Molecular Biology
2016 | Journal article
EID:

2-s2.0-84969941008

Part of ISSN: 10898638 00222836
Contributors: Louis, J.M.; Roche, J.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Insights into the conformation of the membrane proximal regions critical to the trimerization of the HIV-1 gp41 ectodomain bound to dodecyl phosphocholine micelles

PLoS ONE
2016 | Journal article
EID:

2-s2.0-84983494535

Part of ISSN: 19326203
Contributors: Louis, J.M.; Baber, J.L.; Ghirlando, R.; Aniana, A.; Bax, A.; Roche, J.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site

Angewandte Chemie - International Edition
2016 | Journal article
EID:

2-s2.0-84960153447

Part of ISSN: 15213773 14337851
Contributors: Gerlits, O.; Wymore, T.; Das, A.; Shen, C.-H.; Parks, J.M.; Smith, J.C.; Weiss, K.L.; Keen, D.A.; Blakeley, M.P.; Louis, J.M. et al.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Structural studies of a rationally selected multi-drug resistant HIV-1 protease reveal synergistic effect of distal mutations on flap dynamics

PLoS ONE
2016 | Journal article
EID:

2-s2.0-85006337696

Part of ISSN: 19326203
Contributors: Agniswamy, J.; Louis, J.M.; Roche, J.; Harrison, R.W.; Weber, I.T.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
EID:

2-s2.0-84994571037

Part of ISSN: 10916490 00278424
Contributors: Deshmukh, L.; Louis, J.M.; Ghirlando, R.; Clore, G.M.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding

Journal of Biomolecular NMR
2015 | Journal article
EID:

2-s2.0-84939934293

Part of ISSN: 15735001 09252738
Contributors: Roche, J.; Louis, J.M.; Aniana, A.; Ghirlando, R.; Bax, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Conformation of inhibitor-free HIV-1 protease derived from NMR spectroscopy in a weakly oriented solution

ChemBioChem
2015 | Journal article
EID:

2-s2.0-84920859679

Part of ISSN: 14397633 14394227
Contributors: Roche, J.; Louis, J.M.; Bax, A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Dependence of distance distributions derived from double electron-electron resonance pulsed EPR spectroscopy on pulse-sequence time

Angewandte Chemie - International Edition
2015 | Journal article
EID:

2-s2.0-84924366049

Part of ISSN: 15213773 14337851
Contributors: Baber, J.L.; Louis, J.M.; Clore, G.M.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Evidence of distinct channel conformations and substrate binding affinities for the mitochondrial outer membrane protein translocase pore Tom40

Journal of Biological Chemistry
2015 | Journal article
EID:

2-s2.0-84944910098

Part of ISSN: 1083351X 00219258
Contributors: Kuszak, A.J.; Jacobs, D.; Gurnev, P.A.; Shiota, T.; Louis, J.M.; Lithgow, T.; Bezrukov, S.M.; Rostovtseva, T.K.; Buchanan, S.K.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease

Biochemistry
2015 | Journal article
EID:

2-s2.0-84941119672

Part of ISSN: 15204995 00062960
Contributors: Louis, J.M.; Deshmukh, L.; Sayer, J.M.; Aniana, A.; Clore, G.M.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Pressure-induced structural transition of mature HIV-1 protease from a combined NMR/MD simulation approach

Proteins: Structure, Function and Bioinformatics
2015 | Journal article
EID:

2-s2.0-84954376298

Part of ISSN: 10970134 08873585
Contributors: Roche, J.; Louis, J.M.; Bax, A.; Best, R.B.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20

Journal of Medicinal Chemistry
2015 | Journal article
EID:

2-s2.0-84933060024

Part of ISSN: 15204804 00222623
Contributors: Agniswamy, J.; Louis, J.M.; Shen, C.-H.; Yashchuk, S.; Ghosh, A.K.; Weber, I.T.
Source: Self-asserted source
John M Louis via Scopus - Elsevier

Testing Landscape Theory for Biomolecular Processes with Single Molecule Fluorescence Spectroscopy

Physical Review Letters
2015 | Journal article
EID:

2-s2.0-84937863219

Part of ISSN: 10797114 00319007
Contributors: Truex, K.; Chung, H.S.; Louis, J.M.; Eaton, W.A.
Source: Self-asserted source
John M Louis via Scopus - Elsevier
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