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Works (4)

Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation

Journal of Medicinal Chemistry
2024-05-23 | Journal article
DOI: 10.1021/acs.jmedchem.4c00560
Contributors: Magnus Pfaffenbach; Philippe N. Bolduc; Zhili Xin; Fang Gao; Ryan Evans; Terry Fang; Jayanth V. Chodaparambil; Kate L. Henry; Pei Li; Steven Mathieu et al.
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A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors

ACS Medicinal Chemistry Letters
2024-05-09 | Journal article
DOI: 10.1021/acsmedchemlett.4c00102
Contributors: Philippe N. Bolduc; Magnus Pfaffenbach; Ryan Evans; Zhili Xin; Kate L. Henry; Fang Gao; Terry Fang; John Silbereis; Jorge Vera Rebollar; Pei Li et al.
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The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke

Journal of Medicinal Chemistry
2024-03-28 | Journal article
DOI: 10.1021/acs.jmedchem.3c02226
Contributors: Ryan Evans; Philippe N. Bolduc; Magnus Pfaffenbach; Fang Gao; Tricia May-Dracka; Terry Fang; Brian T. Hopkins; Jayanth V Chodaparambil; Kate L. Henry; Pei Li et al.
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Synthesis of N-Substituted 3-Amino-2-pyridones

Organic Letters
2022-08-26 | Journal article
DOI: 10.1021/acs.orglett.2c02189
Contributors: Philippe N. Bolduc; Magnus Pfaffenbach; Vanna D. Blasczak; Steven R. Mathieu; Emily A. Peterson
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Peer review (2 reviews for 2 publications/grants)

Review activity for Journal of medicinal chemistry. (1)
Review activity for Organic letters. (1)
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