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Activities

Employment (6)

University of Gothenburg: Gothenburg, SE

2014-04 to present | Professor (Molecular and Clinical Medicine)
Employment
Source: Self-asserted source
Giovanni Solinas

University of Fribourg: Fribourg, CH

2007-07 to 2014-04 | Assistant Professor (Medicine, Physiology)
Employment
Source: Self-asserted source
Giovanni Solinas

University of California San Diego: La Jolla, CA, US

2003-01-01 to 2007-06 | Post-Doctoral Research Fellow (Pharmacology)
Employment
Source: Self-asserted source
Giovanni Solinas

University of Fribourg: Fribourg, CH

2002 to 2003 | Post-Doctoral Scientist (Medicine, Physiology)
Employment
Source: Self-asserted source
Giovanni Solinas

University of Fribourg: Fribourg, CH

1998 to 2002-07-18 | Ph.D. student (Biochemistry)
Employment
Source: Self-asserted source
Giovanni Solinas

Istituto Sperimentale per la Cerealicoltura: Bergamo, IT

1996 to 1998 | Civil service/ junior researcher
Employment
Source: Self-asserted source
Giovanni Solinas

Education and qualifications (2)

University of Fribourg: Fribourg, Fribourg, CH

2002-07-18 | Ph.D. Natural Sciences (Biochemistry)
Education
Source: Self-asserted source
Giovanni Solinas

Universita Statale di Milano: Milan, IT

1996-11-20 | M.Sc. Food Science and Technology
Education
Source: Self-asserted source
Giovanni Solinas

Funding (27)

Developing Optimal PI3K-targeted Cancer Therapies from a Better Understanding of the Insulin System

2024-01 to 2026-12 | Grant
Swedish Cancer Society (Stockholm, SE)
GRANT_NUMBER:

23 2829 Pj

Source: Self-asserted source
Giovanni Solinas

Defining Feedback Loops Between Phosphoinositide 3-kinases (PI3Ks) Isoforms and Insulin to Harness the Full Potential of PI3K-Targeted Therapies

2023-01 to 2026-12 | Grant
Swedish Research Council (Stockholm, SE)
GRANT_NUMBER:

2022-01033

Source: Self-asserted source
Giovanni Solinas

Mechanistic characterization of the adiposecretin effect: a novel paradigm for the insulin system to treat obesity-driven diabetes

2023-01 to 2025-12 | Grant
Diabetesfonden (Sundbyberg, SE)
GRANT_NUMBER:

DIA2022-753

Source: Self-asserted source
Giovanni Solinas

Defining the Role of PI3K Isoforms in Adipose Tissue Lipolysis and Thermogenesis to Treat Obesity with Isoform-Selective PI3K Inhibitors

2022 to 2024 | Salary award
Sahlgrenska Akademin (Gothenburg, SE)
GRANT_NUMBER:

Dnr.GU 2020/2590

Source: Self-asserted source
Giovanni Solinas

Resolving the Role of Specific Phosphoinositide 3-kinases (PI3Ks) Isoforms in Metabolism-Insulin Loops Driving Tumor-Promotion

2021-01 to 2023-12 | Grant
Cancerfonden (Stockholm, SE)
GRANT_NUMBER:

20 0840 PjF

Source: Self-asserted source
Giovanni Solinas

Identifying the specific class-1 PI3Ks and their mechanisms of action mediating the suppression of adipose tissue lipolysis and thermogenesis to treat obesity-driven diabetes

2021-01 to 2021-12 | Grant
Diabetesfonden (JOHANNESHOV, SE)
GRANT_NUMBER:

DIA2020-564

Source: Self-asserted source
Giovanni Solinas

Defining the role of specific class-1 PI3Ks in adipose tissue lipolysis and browning to treat obesity-driven diabetes

2019-11 to 2022-10 | Grant
Novo Nordisk Fonden (Hellerup, DK)
GRANT_NUMBER:

NNF19OC0057174

Source: Self-asserted source
Giovanni Solinas

Defining the role of specific Class-1 PI3Ks in glucose homeostasis and adiposity to treat obesity-driven diabetes

2019-01 to 2019-12 | Grant
Diabetesfonden (JOHANNESHOV, SE)
GRANT_NUMBER:

DIA 2018-384

Source: Self-asserted source
Giovanni Solinas

Defining the role of PI3Kγ in adipose tissue lipolysis and browning to treat type-2 diabetes

2018-10 to 2019-09 | Grant
Novo Nordisk Fonden (Hellerup, DK)
GRANT_NUMBER:

NNF 34410

Source: Self-asserted source
Giovanni Solinas

Defining the role of the metabolic effects of PI3K and PI3K inactivation in tumor promotion-progression in lean and obese individuals

2018-01 to 2020-12 | Grant
Cancerfonden (Stockholm, SE)
GRANT_NUMBER:

CAN2017/472

Source: Self-asserted source
Giovanni Solinas

Defining the role and molecular mechanisms of PI3Kalpha and PI3Kgamma in the control of adiposity, glucose homeostasis, and insulin signaling

2018-01 to 2018-12 | Grant
Diabetesfonden (JOHANNESHOV, SE)
GRANT_NUMBER:

DIA2017-232

Source: Self-asserted source
Giovanni Solinas

Defining the role of microvascular insulin resistance - Implications for novel prevention and treatment strategies for type 2 diabetes

2017-01-01 to 2020-12-31 | Grant
Swedish Research Council (Stockholm, SE)
GRANT_NUMBER: 2016-02660_VR
Source: Self-asserted source
Giovanni Solinas via DimensionsWizard

Investigating the Role of Class-1 PI3K signaling in Obesity-Mediated Tumor Promotion: the interplay between fat metabolism, inflammatory cells and angiogenesis

2015-06-01 to 2018-06-30 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 154499
Source: Self-asserted source
Giovanni Solinas via DimensionsWizard

Investigating the role of PI3Kgamma in the Immunometabolism of Obesity and Insulin Resistance

2015-01-01 to 2017-12-31 | Grant
Swedish Research Council (Stockholm, SE)
GRANT_NUMBER: 2014-03019_VR
Source: Self-asserted source
Giovanni Solinas via DimensionsWizard

Investigating the Role of the Pro-Inflammatory Kinases JNK1 and PI3Kγ in the Beta-Cell Failure Occurring During Type-2 Diabetes.

2015-01 to 2015-12 | Grant
Novo Nordisk Fonden (Hellerup, DK)
GRANT_NUMBER:

10919

Source: Self-asserted source
Giovanni Solinas

Personal startup package

2014-08 to present | Grant
University of Gothenburg (Gothenburg, SE)
Source: Self-asserted source
Giovanni Solinas

Investigating the Role of PI3Kgamma in Obesity and Insulin Resistance

2014-05 to 2016-04 | Grant
Swiss National Science Foundation (SNSF) (Berne, CH)
GRANT_NUMBER:

152998

Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

Identifying the molecular mechanisms of PI3Ky in obesity-mediated tumor promotion

2013 to present | Grant
European Foundation for the Study of Diabetes (Düsseldorf, DE)
Source: Self-asserted source
Giovanni Solinas

PI3Kgamma signalling in obesity

2012 to present | Award
Fondation Endocrinologie Geneve (Geneva, CH)
Source: Self-asserted source
Giovanni Solinas

Investigating the role of PI3Kgamma in obesity-related diseases

2011-05-01 to 2014-04-30 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER: 135684
Source: Self-asserted source
Giovanni Solinas via DimensionsWizard

Investigating the role of P13Kץ in obesity-mediated hepatocellular carcinoma promotion

2010 to present | Grant
European Foundation for the Study of Diabetes (Düsseldorf, DE)
Source: Self-asserted source
Giovanni Solinas

Investigating the role of phosphoinositide-3 kinase γ in diet-induced obesity and insulin resistance

2009 to present | Salary award
European Foundation for the Study of Diabetes (Düsseldorf, DE)
Source: Self-asserted source
Giovanni Solinas

Investigating the Role of the Inflammatory Kinase JNK1 in Chronic High-Fat Feeding Toxicity

2008-05 to 2009-04 | Grant
Roche Reseach Foundation (Basel, CH)
Source: Self-asserted source
Giovanni Solinas

Functional study of the role of JNK in obesity and insulin resistance

2008-02 to 2011-01 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER:

118172

Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

Dissecting the action of the kinase JNK1 in obesity

2008-01 to 2008-12 | Grant
Novartis Foundation, formerly Ciba-Geigy- Jubilee-Foundation (Basel, CH)
Source: Self-asserted source
Giovanni Solinas

Investigating the molecular Mechanisms of JNK1 in Type-2 Diabetes

2004-11 to 2007-06 | Salary award
American Diabetes Association (VA, VA, US)
Source: Self-asserted source
Giovanni Solinas

Dissecting the role of the stress activated protein kinase JNK1 in the pathophysiology of obesity and type-2 diabetes

2003-02 to 2004-01 | Salary award
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER:

100983

Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

Works (50 of 66)

Items per page:
Page 1 of 2

Ablation of PI3Kγ in neurons protects mice from diet-induced obesity MASLD and insulin resistance

iScience
2025-01 | Journal article
Contributors: Angela Molinaro; Arianna Mazzoli; Andrea Usseglio Gaudi; Amit Chand Gupta; Vagner Ramon Rodrigues Silva; Damien Ramel; Muriel Laffargue; Johan Ruud; Barbara Becattini; Giovanni Solinas
Source: check_circle
Crossref

Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect

Cell Reports
2024 | Journal article
Contributors: Becattini, Barbara; Molinaro, Angela; Henricsson, Marcus; Boren, Jan; Solinas, Giovanni
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

An adipoincretin effect links adipostasis with insulin secretion

Trends in Endocrinology & Metabolism
2024-06 | Journal article
Contributors: Giovanni Solinas; Barbara Becattini
Source: check_circle
Crossref

Insulin Hypersecretion as Promoter of Body Fat Gain and Hyperglycemia.

Diabetes
2024-06-01 | Journal article
Contributors: Bettina Mittendorfer; Johnson JD; Solinas G; Jansson PA
Source: Self-asserted source
Giovanni Solinas

Activation of GFRAL<sup>+</sup> neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor.

Cell reports
2024-03-19 | Journal article
Contributors: Engström Ruud L; Font-Gironès F; Zajdel J; Kern L; Teixidor-Deulofeu J; Mannerås-Holm L; Carreras A; Becattini B; Björefeldt A; Hanse E et al.
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

Adipocyte PI3K links adipostasis with basal insulin secretion through an adipoincretin effect

2023-06-08 | Preprint
Contributors: Barbara Becattini; Angela Molinaro; Marcus Henricsson; Jan Boren; Giovanni Solinas
Source: check_circle
Crossref

Adipocyte PI3K Links Adipostasis with Basal Insulin Secretion Through an Adipoincretin Effect

2023-04-26 | Preprint
Contributors: Barbara Becattini; Angela Molinaro; Marcus Henricsson; Jan Borén; Giovanni Solinas
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

PI3K and AKT at the Interface of Signaling and Metabolism

Current Topics in Microbiology and Immunology
2022 | Journal article
Contributors: Solinas, Giovanni; Becattini, Barbara
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 3)‎

Somatic ablation of IKK beta in liver and leukocytes is not tolerated in obese mice but hepatic IKK beta deletion improves fatty liver and insulin sensitivity

The FASEB Journal
2022 | Journal article
Contributors: Silva, Vagner Ramon R.; Molinaro, Angela; Gaudi, Andrea Usseglio; Fryk, Emanuel; Sardi, Claudia; Hammarlund, Maria; Mjornstedt, Filip; Johansson, Maria E.; Becattini, Barbara; Jansson, Per-Anders et al.
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Tubular <i>IKK</i>β Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration

International Journal of Molecular Sciences
2022 | Journal article
Contributors: Dahlke, Eileen; Engmann, Toni; Anan, Yaman; Haesler, Robert; Solinas, Giovanni; Theilig, Franziska
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

PI3K gamma promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation

JHEP Reports
2021 | Journal article
Contributors: Becattini, Barbara; Breasson, Ludovic; Sardi, Claudia; Zani, Fabio; Solinas, Giovanni
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 3)‎

Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study.

EBioMedicine
2021-03-09 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant phenotype

Scientific Reports
2020 | Journal article
Contributors: Molinaro, Angela; Becattini, Barbara; Solinas, Giovanni
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 3)‎

JNK1 ablation improves pancreatic β-cell mass and function in db/db diabetic mice without affecting insulin sensitivity and adipose tissue inflammation.

FASEB bioAdvances
2020-12-30 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS

Cell Metabolism
2019-04 | Journal article
Part of ISSN: 1550-4131
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 3)‎

MBOAT7 is anchored to endomembranes by six transmembrane domains.

Journal of structural biology
2019-04 | Journal article
Contributors: Caddeo A; Jamialahmadi O; Solinas G; Pujia A; Mancina RM; Pingitore P; Romeo S
Source: Self-asserted source
Giovanni Solinas via Europe PubMed Central
grade
Preferred source (of 2)‎

Impaired subcutaneous insulin delivery in type 2 diabetes patients

Diabetologia
2018 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync

Novel genetic features associated with 8p11-p12 amplification in breast carcinoma

Cancer Research
2018 | Journal article
Contributors: Parris, Toshima Z.; Biermann, Jana; Engqvist, Hanna; Ronnerman, Elisabeth Werner; Truve, Katarina; Nemes, Szilard; Forssell-Aronsson, Eva; Solinas, Giovanni; Kovacs, Aniko; Karlsson, Per et al.
Source: check_circle
Web of Science Researcher Profile Sync

Obesity promotes the expansion of metastasis-initiating cells in breast cancer.

Breast cancer research : BCR
2018-09 | Journal article
Contributors: Bousquenaud M; Fico F; Solinas G; Rüegg C; Santamaria-Martínez A
Source: Self-asserted source
Giovanni Solinas via Europe PubMed Central
grade
Preferred source (of 2)‎

Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast carcinoma.

Oncotarget
2018-05 | Journal article
Contributors: Parris TZ; Rönnerman EW; Engqvist H; Biermann J; Truvé K; Nemes S; Forssell-Aronsson E; Solinas G; Kovács A; Karlsson P et al.
Source: Self-asserted source
Giovanni Solinas via Europe PubMed Central
grade
Preferred source (of 2)‎

JNK at the crossroad of obesity, insulin resistance, and cell stress response

Molecular Metabolism
2017 | Journal article
Contributors: Solinas, Giovanni; Becattini, Barbara
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

The role of PI3K gamma signaling within leukocytes in obesity-driven inflammation and insulin resistance

European Journal of Clinical Investigation
2017 | Journal article
Contributors: Solinas, G.; Breasson, L.; Becattini, B.; Sardi, C.; Molinaro, A.; Marone, R.; Botindari, F.; Bousquenaud, M.; Ruegg, C.; Wymann, M.
Source: check_circle
Web of Science Researcher Profile Sync

The role of PI3Kγ in metabolism and macrophage activation.

Oncotarget
2017-10 | Journal article
Contributors: Solinas G; Becattini B
Source: Self-asserted source
Giovanni Solinas via Europe PubMed Central
grade
Preferred source (of 2)‎

PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.

FASEB journal
2017-09 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity.

Science Signaling
2017-07 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

JNK at the crossroad of obesity, insulin resistance, and cell stress response.

Molecular Metabolism
2017-02 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage

The FASEB Journal
2016 | Journal article
Contributors: Becattini, Barbara; Zani, Fabio; Breasson, Ludovic; Sardi, Claudia; D'Agostino, Vito Giuseppe; Choo, Min-Kyung; Provenzani, Alessandro; Park, Jin Mo; Solinas, Giovanni
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.

FASEB journal
2016-05 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 2)‎

De novo lipogenesis in metabolic homeostasis: More friend than foe?

Molecular Metabolism
2015-05 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression.

Molecular Metabolism
2013 | Journal article
WOSUID:

WOS:000209637800019

Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors.

Annals of the New York Academy of Sciences
2013-03 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage.

Diabetes
2013-02 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Molecular pathways linking metabolic inflammation and thermogenesis.

Obesity Reviews
2012-12 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

High identification rates of endogenous neuropeptides from mouse brain.

Journal of Proteome Research
2012-05 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.

PNAS
2011-10 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation.

Cell
2011-09 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Per2 plays a major role in the control of liver glycogen metabolism and fasting glycaemia

Diabetologia
2010 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync

PI3K gamma in non-hematopoietic cells plays a major role in the promotion of obesity, inflammation and glucose intolerance

Diabetologia
2010 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync

Body composition phenotypes in pathways to obesity and the metabolic syndrome.

Int. J. Obes.
2010-12 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Leptin signalling coordinates lipid oxidation with thermogenesis and defence against oxidative stress.

Clin. Exp. Pharmacol.
2010-10 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction.

FASEB Journal
2010-08 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Role of JNK activation in pancreatic beta-cell death by streptozotocin.

Mol. Cell. Endocrinol.
2010-06 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth.

Diabetes
2009-10 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

A central role for PI3K gamma in obesity and insulin resistance

Diabetologia
2008 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync

Enhanced adipose tissue PI3K activity and lipogenic capacity during catch-up growth: Relevance to muscle-adipose glucose redistribution

International Journal of Obesity
2008 | Journal article
Contributors: Summermatter, S.; Arsenijevic, D.; Marcelino, H.; Buchala, A.; Aprikian, O.; Assimacopoulos-Jeannet, F.; Seydoux, J.; Montani, J. P.; Solinas, G.; Dulloo, A. G.
Source: check_circle
Web of Science Researcher Profile Sync

JNK in hematopoietic-derived cells plays a key role in the development of obesity-induced inflammation and insulin resistance

International Journal of Obesity
2008 | Journal article
Contributors: Solinas, G.; Vilcu, C.; Luo, J-L; Naugler, W.; Grivennikov, S.; Neels, J. G.; Bandyopadhyay, G. K.; Olefsky, J. M.; Karin, M.
Source: check_circle
Web of Science Researcher Profile Sync

JNK1 in hematopoietic cells contributes to high-fat-diet-induced inflammation and insulin resistance

European Journal of Clinical Investigation
2008 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.

PNAS
2008-10 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase.

FASEB Journal
2008-03 | Journal article
Source: Self-asserted source
Giovanni Solinas
grade
Preferred source (of 4)‎

JNK in macrophages plays a key role in the development of obesity-induced insulin resistance

Diabetologia
2007 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync
Items per page:
Page 1 of 2

Peer review (12 reviews for 4 publications/grants)

Review activity for Biochemical and biophysical research communications. (1)
Review activity for Cell reports. (2)
Review activity for Metabolism, clinical and experimental. (8)
Review activity for PLoS biology. (1)