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Employment (1)

Eli Lilly and Company: Indianapolis, IN, US

2004-08 to present | Director-Research & Development (LEM)
Employment
Source: Self-asserted source
Eugene Y. Zhen

Works (31)

Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality

Circulation
2025-01-21 | Journal article
DOI: 10.1161/CIRCULATIONAHA.124.069272
Contributors: Günther Silbernagel; Yan Q. Chen; Hongxia Li; Deven Lemen; Yi Wen; Eugene Y. Zhen; Martin Rief; Marcus E. Kleber; Graciela E. Delgado; Mark A. Sarzynski et al.
Source: check_circle
Crossref

Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity

Proceedings of the National Academy of Sciences
2024-04-23 | Journal article
DOI: 10.1073/pnas.2322332121
Contributors: Yan Q. Chen; Ye Yang; Eugene Y. Zhen; Thomas P. Beyer; Hongxia Li; Yi Wen; Mariam Ehsani; Nicholas Jackson; Katherine Xie; Hyesoo Jung et al.
Source: check_circle
Crossref

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Journal of Lipid Research
2022-05 | Journal article
DOI: 10.1016/j.jlr.2022.100198
Part of ISSN: 0022-2275
Source: Self-asserted source
Eugene Y. Zhen

ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition

Journal of Lipid Research
2021 | Journal article
DOI: 10.1016/j.jlr.2021.100068
Part of ISSN: 0022-2275
Source: Self-asserted source
Eugene Y. Zhen

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids

Journal of Lipid Research
2020-08 | Journal article
DOI: 10.1194/jlr.ra120000781
Part of ISSN: 0022-2275
Source: Self-asserted source
Eugene Y. Zhen

Distinct hemodynamic responses to (pyr)apelin-13 in large animal models

American Journal of Physiology-Heart and Circulatory Physiology
2020-04-01 | Journal article
DOI: 10.1152/ajpheart.00365.2019
Part of ISSN: 0363-6135
Part of ISSN: 1522-1539
Contributors: Eugene Y. Zhen
Source: Self-asserted source
Eugene Y. Zhen

Definition of the Interaction Domain and Electron Transfer Route between Cytochrome c and Cytochrome Oxidase

Biochemistry
2019-10-08 | Journal article
DOI: 10.1021/acs.biochem.9b00646
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Eugene Y. Zhen

Pharmacokinetics and Pharmacodynamics of LY2599666, a PEG-Linked Antigen Binding Fragment that Targets Soluble Monomer Amyloid-β

Journal of Alzheimer's Disease
2019-03-12 | Journal article
DOI: 10.3233/jad-180925
Part of ISSN: 1387-2877
Part of ISSN: 1875-8908
Contributors: Eugene Y. Zhen
Source: Self-asserted source
Eugene Y. Zhen

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein

Biochemical Journal
2016-03-01 | Journal article
DOI: 10.1042/bj20151085
Part of ISSN: 0264-6021
Part of ISSN: 1470-8728
Source: Self-asserted source
Eugene Y. Zhen

Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma

Analytical Biochemistry
2013-11 | Journal article
DOI: 10.1016/j.ab.2013.07.006
Part of ISSN: 0003-2697
Source: Self-asserted source
Eugene Y. Zhen

Proteomic Analysis of Demyelinated and Remyelinating Brain Tissue following Dietary Cuprizone Administration

Journal of Molecular Neuroscience
2010-10 | Journal article
DOI: 10.1007/s12031-010-9354-9
Part of ISSN: 0895-8696
Part of ISSN: 1559-1166
Source: Self-asserted source
Eugene Y. Zhen

The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

Biochemical and Biophysical Research Communications
2009-11 | Journal article
DOI: 10.1016/j.bbrc.2009.08.163
Part of ISSN: 0006-291X
Source: Self-asserted source
Eugene Y. Zhen

Small-molecule affinity chromatography coupled mass spectrometry for drug target deconvolution

Expert Opinion on Drug Discovery
2009-07 | Journal article
DOI: 10.1517/17460440903005565
Part of ISSN: 1746-0441
Part of ISSN: 1746-045X
Source: Self-asserted source
Eugene Y. Zhen

Characterization of metalloprotease cleavage products of human articular cartilage

Arthritis & Rheumatism
2008-08 | Journal article
DOI: 10.1002/art.23654
Part of ISSN: 0004-3591
Part of ISSN: 1529-0131
Source: Self-asserted source
Eugene Y. Zhen

An Immuno-Chemo-Proteomics Method for Drug Target Deconvolution

Journal of Proteome Research
2008-08-01 | Journal article
DOI: 10.1021/pr800222q
Part of ISSN: 1535-3893
Part of ISSN: 1535-3907
Source: Self-asserted source
Eugene Y. Zhen

Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice

Biomarker Insights
2008-01 | Journal article
DOI: 10.4137/bmi.s632
Part of ISSN: 1177-2719
Part of ISSN: 1177-2719
Source: Self-asserted source
Eugene Y. Zhen

Quantification of heart fatty acid binding protein as a biomarker for drug-induced cardiac and musculoskeletal necroses

PROTEOMICS – Clinical Applications
2007-07 | Journal article
DOI: 10.1002/prca.200700006
Part of ISSN: 1862-8346
Part of ISSN: 1862-8354
Source: Self-asserted source
Eugene Y. Zhen

Strategic Use of Immunoprecipitation and LC/MS/MS for Trace-Level Protein Quantification:  Myosin Light Chain 1, a Biomarker of Cardiac Necrosis

Analytical Chemistry
2007-06-01 | Journal article
DOI: 10.1021/ac070051f
Part of ISSN: 0003-2700
Part of ISSN: 1520-6882
Source: Self-asserted source
Eugene Y. Zhen

Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration

PLoS Genetics
2007-05-11 | Journal article
DOI: 10.1371/journal.pgen.0030082
Part of ISSN: 1553-7404
Source: Self-asserted source
Eugene Y. Zhen

Ampicillin/penicillin-binding protein interactions as a model drug-target system to optimize affinity pull-down and mass spectrometric strategies for target and pathway identification

PROTEOMICS
2005-05 | Journal article
DOI: 10.1002/pmic.200301088
Part of ISSN: 1615-9853
Part of ISSN: 1615-9861
Source: Self-asserted source
Eugene Y. Zhen

Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics

The FASEB Journal
2005-02 | Journal article
DOI: 10.1096/fj.04-2911fje
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Eugene Y. Zhen

An integrated strategy for the discovery of drug targets by the analysis of protein–protein interactions

International Journal of Mass Spectrometry
2004-11 | Journal article
DOI: 10.1016/j.ijms.2003.12.039
Part of ISSN: 1387-3806
Source: Self-asserted source
Eugene Y. Zhen

Development of an LC-MALDI method for the analysis of protein complexes

Journal of the American Society for Mass Spectrometry
2004-06-01 | Journal article
DOI: 10.1016/j.jasms.2004.02.004
Part of ISSN: 1044-0305
Source: Self-asserted source
Eugene Y. Zhen

Characterization of Glycosylation Sites of the Epidermal Growth Factor Receptor

Biochemistry
2003-05-01 | Journal article
DOI: 10.1021/bi027101p
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Eugene Y. Zhen

Mutants of the CuA Site in Cytochrome c Oxidase of Rhodobacter sphaeroides: I. Spectral and Functional Properties

Biochemistry
2002-02-01 | Journal article
DOI: 10.1021/bi0114628
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Eugene Y. Zhen

Formation of the “Peroxy” Intermediate in Cytochrome <i>c</i> Oxidase Is Associated with Internal Proton/Hydrogen Transfer

Biochemistry
2000-11-01 | Journal article
DOI: 10.1021/bi0013748
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Eugene Y. Zhen

Definition of the Interaction Domain for Cytochrome con Cytochrome c Oxidase

Journal of Biological Chemistry
1999-12 | Journal article
DOI: 10.1074/jbc.274.53.38032
Part of ISSN: 0021-9258
Source: Self-asserted source
Eugene Y. Zhen

Definition of the Interaction Domain for Cytochrome con Cytochrome c Oxidase

Journal of Biological Chemistry
1999-12 | Journal article
DOI: 10.1074/jbc.274.53.38042
Part of ISSN: 0021-9258
Source: Self-asserted source
Eugene Y. Zhen

Proton uptake controls electron transfer in cytochrome <i>c</i> oxidase

Proceedings of the National Academy of Sciences
1998-11-10 | Journal article
DOI: 10.1073/pnas.95.23.13606
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Eugene Y. Zhen

Overexpression and Purification of CytochromecOxidase fromRhodobacter sphaeroides

Protein Expression and Purification
1998-08 | Journal article
DOI: 10.1006/prep.1998.0903
Part of ISSN: 1046-5928
Source: Self-asserted source
Eugene Y. Zhen

Analysis of site-directed mutants locates a non-redox-active metal near the active site of cytochrome c oxidase of Rhodobacter sphaeroides

Biochemistry
1995-06-13 | Journal article
DOI: 10.1021/bi00023a004
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Eugene Y. Zhen
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