Personal information

Websites & social links

http://www.strukturbiochemie.uni-koeln.de/

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Scopus Author ID: 6603740234

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Germany

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Employment (1)

Universität zu Köln: Cologne, DE

Employment
Source: Self-asserted source
Karsten Niefind

Funding (6)

Exploration and Exploitation of Secondary Sites of Protein Kinase CK2

2022-01-01 to present | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.13045801
GRANT_NUMBER: 505676396
Source: Self-asserted source
Karsten Niefind via DimensionsWizard

Nuclear Activities of DNA-Associated Immune Receptors

2015-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4841854
GRANT_NUMBER: 283906930
Source: Self-asserted source
Karsten Niefind via DimensionsWizard

Structure-function analysis of Arabidopsis EDS1 immune signalling complexes (B07)

2011-01-01 to 2015-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4827970
GRANT_NUMBER: 207296643
Source: Self-asserted source
Karsten Niefind via DimensionsWizard

Structure-function relationships of protein kinase CK2

2010-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4819291
GRANT_NUMBER: 173792144
Source: Self-asserted source
Karsten Niefind via DimensionsWizard

Structural and biochemical characterisation of plant EDS1 disease resistance regulatory complexes

2007-01-01 to 2011-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4794158
GRANT_NUMBER: 39953024
Source: Self-asserted source
Karsten Niefind via DimensionsWizard

Structure-function-correlations of protein kinase CK2

2001-01-01 to 2010-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4763901
GRANT_NUMBER: 5335544
Source: Self-asserted source
Karsten Niefind via DimensionsWizard

Works (50 of 102)

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Page 1 of 3

Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthesis, Biological Evaluation, and Structural Studies on E-/Z-Isomers

ACS Pharmacology & Translational Science
2024-12-13 | Journal article
DOI: 10.1021/acsptsci.4c00426
Contributors: Hendrik Rumler; Claudia Schmithals; Christian Werner; Andre Bollacke; Dagmar Aichele; Claudia Götz; Karsten Niefind; Bernhard Wünsch; Joachim Jose
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Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2α′Cys336Ser as an Exquisite Crystallographic Tool

Kinases and Phosphatases
2023-11-25 | Journal article
DOI: 10.3390/kinasesphosphatases1040018
Contributors: Christian Werner; Dirk Lindenblatt; Kaido Viht; Asko Uri; Karsten Niefind
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A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4

Protein Science
2023-04 | Journal article
DOI: 10.1002/pro.4624
Contributors: Martin Voss; Leland J. Cseke; Walter Gassmann; Karsten Niefind
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Crossref

Analyzing the interactome of human CK2β in prostate carcinoma cells reveals HSP70 ‐1 and Rho guanin nucleotide exchange factor 12 as novel interaction partners

FASEB BioAdvances
2023-03 | Journal article
DOI: 10.1096/fba.2022-00098
Contributors: Anna Nickelsen; Claudia Götz; Florian Lenz; Karsten Niefind; Simone König; Joachim Jose
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Crossref

De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway

Human Genetics and Genomics Advances
2022-07 | Journal article
DOI: 10.1016/j.xhgg.2022.100111
Part of ISSN: 2666-2477
Contributors: Maria Asif; Emrah Kaygusuz; Marwan Shinawi; Anna Nickelsen; Tzung-Chien Hsieh; Prerana Wagle; Birgit S. Budde; Jennifer Hochscherf; Uzma Abdullah; Stefan Höning et al.
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Karsten Niefind via Crossref Metadata Search

Structural and Enzymological Evidence for an Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2αLys198Arg

Frontiers in Molecular Biosciences
2022-04-04 | Journal article
DOI: 10.3389/fmolb.2022.831693
Part of ISSN: 2296-889X
Contributors: Christian Werner; Alexander Gast; Dirk Lindenblatt; Anna Nickelsen; Karsten Niefind; Joachim Jose; Jennifer Hochscherf
Source: Self-asserted source
Karsten Niefind via Crossref Metadata Search

Molecular Plasticity of Crystalline CK2α′ Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity

Journal of Medicinal Chemistry
2022-01-27 | Journal article
DOI: 10.1021/acs.jmedchem.1c00063
Contributors: Dirk Lindenblatt; Violetta Applegate; Anna Nickelsen; Merlin Klußmann; Ines Neundorf; Claudia Götz; Joachim Jose; Karsten Niefind
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Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin

European Journal of Medicinal Chemistry
2021-03 | Journal article
DOI: 10.1016/j.ejmech.2021.113223
Contributors: Alexander Schnitzler; Karsten Niefind
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Crossref

Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase

Bioorganic Chemistry
2021-01 | Journal article
DOI: 10.1016/j.bioorg.2020.104502
Part of ISSN: 0045-2068
Contributors: K. Chojnacki; D. Lindenblatt; P. Wińska; M. Wielechowska; C. Toelzer; K. Niefind; M. Bretner
Source: Self-asserted source
Karsten Niefind via Crossref Metadata Search

Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile

Catalysts
2020-11-04 | Journal article
DOI: 10.3390/catal10111281
Contributors: Daniel Bakonyi; Christine Toelzer; Michael Stricker; Werner Hummel; Karsten Niefind; Harald Gröger
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Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2

Journal of Medicinal Chemistry
2020-07-23 | Journal article
DOI: 10.1021/acs.jmedchem.0c00587
Contributors: Dirk Lindenblatt; Anna Nickelsen; Violetta M. Applegate; Joachim Jose; Karsten Niefind
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Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2

Bioorganic Chemistry
2020-03 | Journal article
DOI: 10.1016/j.bioorg.2020.103608
Part of ISSN: 0045-2068
Source: Self-asserted source
Karsten Niefind

Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation

Journal of Structural Biology
2019 | Journal article
DOI: 10.1016/j.jsb.2019.09.007
Part of ISSN: 1047-8477
Contributors: Martin Voss; Christine Toelzer; Deepak D. Bhandari; Jane E. Parker; Karsten Niefind
Source: Self-asserted source
Karsten Niefind via Crossref Metadata Search

Design of CK2β‐Mimicking Peptides as Tools To Study the CK2α/CK2β Interaction in Cancer Cells

ChemMedChem
2019-04-17 | Journal article
DOI: 10.1002/cmdc.201800786
Contributors: Dirk Lindenblatt; Mareike Horn; Claudia Götz; Karsten Niefind; Ines Neundorf; Markus Pietsch
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Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures

ACS Omega
2019-03-31 | Journal article
DOI: 10.1021/acsomega.8b03415
Part of ISSN: 2470-1343
Part of ISSN: 2470-1343
Source: Self-asserted source
Karsten Niefind
grade
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An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis.

Nature communications
2019-02 | Journal article
DOI: 10.1038/s41467-019-08783-0
PMID: 30770836
PMC: PMC6377607
Contributors: Bhandari DD; Lapin D; Kracher B; von Born P; Bautor J; Niefind K; Parker JE
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2′ site binding inhibitor

Acta Crystallographica Section F Structural Biology Communications
2018-08-01 | Journal article
DOI: 10.1107/S2053230X1800537X
Contributors: Jennifer Hochscherf; Markus Pietsch; William Tieu; Kevin Kuan; Andrew D. Abell; Michael Gütschow; Karsten Niefind
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Biological properties and structural study of new aminoalkyl derivatives of benzimidazole and benzotriazole, dual inhibitors of CK2 and PIM1 kinases.

Bioorganic chemistry
2018-06 | Journal article
DOI: 10.1016/j.bioorg.2018.06.022
PMID: 29966873
Contributors: Chojnacki K; Wińska P; Wielechowska M; Łukowska-Chojnacka E; Tölzer C; Niefind K; Bretner M
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.

Acta crystallographica. Section F, Structural biology communications
2018-04 | Journal article
DOI: 10.1107/s2053230x18005253
PMID: 29717999
Contributors: Pichlo C; Toelzer C; Chojnacki K; Öcal S; Uthoff M; Ruegenberg S; Hermanns T; Schacherl M; Denzel MS; Hofmann K et al.
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors

Pharmaceuticals
2018-02 | Journal article
DOI: 10.3390/ph11010023
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
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Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′

Pharmaceuticals
2017-12-13 | Journal article
DOI: 10.3390/ph10040098
Contributors: Jennifer Hochscherf; Dirk Lindenblatt; Benedict Witulski; Robin Birus; Dagmar Aichele; Christelle Marminon; Zouhair Bouaziz; Marc Le Borgne; Joachim Jose; Karsten Niefind
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Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor

Pharmaceuticals
2017-01 | Journal article
DOI: 10.3390/ph10010009
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Multidisciplinary Digital Publishing Institute
grade
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Impressions from the conformational and configurational space captured by protein kinase CK2

Protein Kinase CK2 Cellular Function in Normal and Disease States
2015 | Book chapter
Part of DOI: 10.1007/978-3-319-14544-0_2
EID:

2-s2.0-84943743149
Contributors: Hochscherf, J.; Schnitzler, A.; Issinger, O.-G.; Niefind, K.
Source: Self-asserted source
Karsten Niefind via Scopus - Elsevier

Synthesis, biological activity and structural study of new benzotriazole-based protein kinase CK2 inhibitors

RSC Advances
2015 | Journal article
DOI: 10.1039/c5ra12114k
EID:

2-s2.0-84940843047
Contributors: Swider, R.; Masłyk, M.; Zapico, J.M.; Coderch, C.; Panchuk, R.; Skorokhyd, N.; Schnitzler, A.; Niefind, K.; De Pascual-Teresa, B.; Ramos, A.
Source: Self-asserted source
Karsten Niefind via Scopus - Elsevier

A novel esterase subfamily with α/β-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferases.

FEBS letters
2015-12 | Journal article
DOI: 10.1002/1873-3468.12031
PMID: 26787467
Contributors: Tölzer C; Pal S; Watzlawick H; Altenbuchner J; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2α Complex Structures.

ACS chemical biology
2015-05 | Journal article
DOI: 10.1021/acschembio.5b00235
PMID: 25961323
Contributors: Guerra B; Bischoff N; Bdzhola VG; Yarmoluk SM; Issinger OG; Golub AG; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells.

Cancer letters
2014-10 | Journal article
DOI: 10.1016/j.canlet.2014.10.026
PMID: 25449433
Contributors: Guerra B; Rasmussen TD; Schnitzler A; Jensen HH; Boldyreff BS; Miyata Y; Marcussen N; Niefind K; Issinger OG
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2α/CK2β interaction.

Analytical biochemistry
2014-09 | Journal article
DOI: 10.1016/j.ab.2014.09.003
PMID: 25233003
Contributors: Hochscherf J; Lindenblatt D; Steinkrüger M; Yoo E; Ulucan Ö; Herzig S; Issinger OG; Helms V; Götz C; Neundorf I et al.
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Evidence for aggregation of protein kinase CK2 in the cell: a novel strategy for studying CK2 holoenzyme interaction by BRET(2).

Molecular and cellular biochemistry
2014-08 | Journal article
DOI: 10.1007/s11010-014-2196-y
PMID: 25148873
Contributors: Hübner GM; Larsen JN; Guerra B; Niefind K; Vrecl M; Issinger OG
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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The protein kinase CK2(Andante) holoenzyme structure supports proposed models of autoregulation and trans-autophosphorylation.

Journal of molecular biology
2014-03 | Journal article
DOI: 10.1016/j.jmb.2014.02.018
PMID: 24594356
Contributors: Schnitzler A; Olsen BB; Issinger OG; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Chemical calendar: 100 years ago,Chemiekalender: vor 100 Jahren

Nachrichten aus der Chemie
2013 | Journal article
DOI: 10.1515/nachrchem.2013.61.3.370
EID:

2-s2.0-84875694913
Contributors: Niefind, K.
Source: Self-asserted source
Karsten Niefind via Scopus - Elsevier

Structural Bases of Protein Kinase CK2 Function and Inhibition

Protein Kinase CK2
2013 | Book chapter
Part of DOI: 10.1002/9781118482490.ch1
EID:

2-s2.0-84886828965
Contributors: Niefind, K.; Battistutta, R.
Source: Self-asserted source
Karsten Niefind via Scopus - Elsevier

Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity.

Cell host & microbe
2013-12 | Journal article
DOI: 10.1016/j.chom.2013.11.006
PMID: 24331460
Contributors: Wagner S; Stuttmann J; Rietz S; Guerois R; Brunstein E; Bautor J; Niefind K; Parker JE
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Enzyme-substrate complexes of the quinate/shikimate dehydrogenase from Corynebacterium glutamicum enable new insights in substrate and cofactor binding, specificity, and discrimination.

Biological chemistry
2013-11 | Journal article
DOI: 10.1515/hsz-2013-0170
PMID: 23929881
Contributors: Höppner A; Schomburg D; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Patterns of sequence variation in families of homologous proteins

2013-08 | Other
OTHER-ID:

C6948
Contributors: Blundell T; Cooper J; Donnelly D; Driessen H; Edwards Y; Eisenmenger F; Frazao C; Johnson M; Niefind K; Newman M
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central

First structure of protein kinase CK2 catalytic subunit with an effective CK2β-competitive ligand.

ACS chemical biology
2013-03 | Journal article
DOI: 10.1021/cb3007133
PMID: 23474121
Contributors: Raaf J; Guerra B; Neundorf I; Bopp B; Issinger OG; Jose J; Pietsch M; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.

Organic & biomolecular chemistry
2012-11 | Journal article
DOI: 10.1039/c2ob26022k
PMID: 23032938
Contributors: Enkvist E; Viht K; Bischoff N; Vahter J; Saaver S; Raidaru G; Issinger OG; Niefind K; Uri A
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.

Acta crystallographica. Section D, Biological crystallography
2012-07 | Journal article
DOI: 10.1107/s0907444912016587
PMID: 22868753
Contributors: Klopffleisch K; Issinger OG; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α'.

Molecular and cellular biochemistry
2011-07 | Journal article
DOI: 10.1007/s11010-011-0948-5
PMID: 21739153
Contributors: Bischoff N; Raaf J; Olsen B; Bretner M; Issinger OG; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Protein kinase CK2: a catalyst for biology, medicine and structural biochemistry.

Molecular and cellular biochemistry
2011-07 | Journal article
DOI: 10.1007/s11010-011-0940-0
PMID: 21761205
Contributors: Ahmed K; Issinger OG; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.

Journal of molecular biology
2011-04 | Journal article
DOI: 10.1016/j.jmb.2011.04.047
PMID: 21549129
Contributors: Hansen G; Gielen-Haertwig H; Reinemer P; Schomburg D; Harrenga A; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity.

The New phytologist
2011-03 | Journal article
DOI: 10.1111/j.1469-8137.2011.03675.x
PMID: 21434927
Contributors: Rietz S; Stamm A; Malonek S; Wagner S; Becker D; Medina-Escobar N; Vlot AC; Feys BJ; Niefind K; Parker JE
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101.

Acta crystallographica. Section F, Structural biology and crystallization communications
2011-01 | Journal article
DOI: 10.1107/S1744309110051249
PMID: 21301097
PMC: PMC3034619
Contributors: Wagner S; Rietz S; Parker JE; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Structure of the human protein kinase CK2 catalytic subunit CK2α' and interaction thermodynamics with the regulatory subunit CK2β.

Journal of molecular biology
2011-01 | Journal article
DOI: 10.1016/j.jmb.2011.01.020
PMID: 21241709
Contributors: Bischoff N; Olsen B; Raaf J; Bretner M; Issinger OG; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface.

Biochemistry
2010-12 | Journal article
DOI: 10.1021/bi1013563
PMID: 21142136
Contributors: Raaf J; Bischoff N; Klopffleisch K; Brunstein E; Olsen BB; Vilk G; Litchfield DW; Issinger OG; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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The three-dimensional structure of AKR11B4, a glycerol dehydrogenase from Gluconobacter oxydans, reveals a tryptophan residue as an accelerator of reaction turnover.

Journal of molecular biology
2010-09 | Journal article
DOI: 10.1016/j.jmb.2010.09.049
PMID: 20887732
Contributors: Richter N; Breicha K; Hummel W; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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Crystallization and preliminary crystallographic analysis of Gre2p, an NADP(+)-dependent alcohol dehydrogenase from Saccharomyces cerevisiae.

Acta crystallographica. Section F, Structural biology and crystallization communications
2010-06 | Journal article
DOI: 10.1107/S1744309110018889
PMID: 20606287
PMC: PMC2898475
Contributors: Breicha K; Müller M; Hummel W; Niefind K
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
grade
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Structural basis of the constitutive activity of protein kinase CK2.

Methods in enzymology
2010-01 | Journal article
DOI: 10.1016/b978-0-12-381298-8.00025-3
PMID: 21036248
Contributors: Olsen BB; Guerra B; Niefind K; Issinger OG
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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Erratum: Protein kinase CK2: From structures to insights (Cellular and Molecular Life Sciences (2009) 66 (1800-1816) DOI: 10.1007/s00018-009-9149-8)

Cellular and Molecular Life Sciences
2009 | Journal article
DOI: 10.1007/s00018-009-0128-x
EID:

2-s2.0-70349866641
Contributors: Niefind, K.; Raaf, J.; Issinger, O.-G.
Source: Self-asserted source
Karsten Niefind via Scopus - Elsevier

Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design.

Biochimica et biophysica acta
2009-09 | Journal article
DOI: 10.1016/j.bbapap.2009.09.022
PMID: 19796713
Contributors: Niefind K; Issinger OG
Source: Self-asserted source
Karsten Niefind via Europe PubMed Central
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