Personal information

cardiomyocytes, drug discovery, disease modeling, toxicology, chelation therapy, heavy metal poisoning, pluripotent stem cells

Activities

Employment (6)

Garvan Institute of Medical Research: Darlinghurst, New South Wales, AU

2024 to present | Stem Cell Scientist
Employment
Source: Self-asserted source
Dr Ashish Mehta

University of Sydney: Sydney, NSW, AU

2022-08 to 2023 (Charles Perkin Centre)
Employment
Source: Self-asserted source
Dr Ashish Mehta

University of Tasmania Menzies Institute for Medical Research: Hobart, TAS, AU

2020-08 to 2022-07
Employment
Source: Self-asserted source
Dr Ashish Mehta

Victor Chang Cardiac Research Institute: Darlinghurst, NSW, AU

2017-08-15 to 2020-02 | Head (iPSC and Phenotyping Research Lab)
Employment
Source: Self-asserted source
Dr Ashish Mehta

National Heart Centre Singapore: Singapore, SG

2010-02-08 to 2017-08-13 | Senior Research Scientist (Research Wing)
Employment
Source: Self-asserted source
Dr Ashish Mehta

Reliance Life Sciences Pvt Ltd: Rabale, Maharashtra, IN

2006-02-08 to 2010-01-30 | Senior Research Scientist (Regenerative Medicine Group)
Employment
Source: Self-asserted source
Dr Ashish Mehta

Education and qualifications (1)

Defence Research and Development Organisation: Gwalior, MP, IN

1996 to 2002 | PhD (Department of Pharmacology and Toxicology)
Education
Source: Self-asserted source
Dr Ashish Mehta

Funding (10)

Elucidating the genetics and biology of spontaneous coronary artery dissection (SCAD): a life-threatening heart disease of women

2018 to present | Grant
NHMRC (Canberra, AU)
Part of GRANT_NUMBER:

APP1161200

Source: Self-asserted source
Dr Ashish Mehta

Mitofusins as novel therapeutic.....cardiac arrhythmias

2017 to 2019 | Grant
NMRC (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

Homing and engraftment of mature ……..mouse model

2015 to 2017 | Grant
SingHealth (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

A cellular model….. dysregulation in cardiac arrhythmia

2014 to 2016 | Grant
SingHealth (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

A cellular model….. dysregulation in cardiac arrhythmia

2014 to 2016 | Grant
SingHealth (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

Autologous stem cell ……. for cardiac repair

2013 to 2015 | Grant
NMRC (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

Contractile cardiac microtissue….drug response

2013 to 2015 | Grant
Ministry of Education SG (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

Pathway of cardiomyogenic……..stem cells

2013 to 2015 | Grant
GOH Foundation SG (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

Relationship of ……. pluripotent stem cells

2012 to 2017 | Grant
BMRC-TCRP (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

Brugada Syndrome: An ….. iPSC approach

2012 to 2014 | Grant
NMRC (Singapore, SG)
Source: Self-asserted source
Dr Ashish Mehta

Works (50 of 53)

Items per page:
Page 1 of 2

A Systematic Review and Meta-Analysis of the Impact of Tumour Mutation Burden on Survival Outcomes in Solid Tumours

2025-02-05 | Preprint
Contributors: Aijia Meng; Alexander Yuile; Hao-Wen Sim; Subotheni Thavaneswaran; Humaira Noor; Jacky Yeung; Ashish Mehta; Joseph Powell; Ashraf Zaman
Source: check_circle
Crossref

Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation

Biomaterials Science
2023 | Journal article
Contributors: Johnny Kuan Un Wong; Ashish Mehta; Thu Thủy Vũ; Giselle C. Yeo
Source: check_circle
Crossref

Arsenic and Cardiovascular Diseases Including the Role of Stem Cells

Handbook of Arsenic Toxicology
2023-02-21 | Book chapter
Contributors: Dr Ashish Mehta
Source: Self-asserted source
Dr Ashish Mehta

Generation and characterisation of four multiple sclerosis iPSC lines from a single family.

Stem cell research
2022-06-05 | Journal article
Contributors: Fortune AJ; Taylor BV; Charlesworth JC; Kathryn Burdon; Blackburn NB; Fletcher JL; Mehta A; Kaylene Young
Source: Self-asserted source
Dr Ashish Mehta

Generation of MNZTASi001-A, a human pluripotent stem cell line from a person with primary progressive multiple sclerosis.

Stem cell research
2021-10-12 | Journal article
Contributors: Mehta A; Lu P; Taylor BV; Charlesworth J; Cook AL; Kathryn Burdon; Hewitt AW; Kaylene Young
Source: Self-asserted source
Dr Ashish Mehta

Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection.

Stem cell research
2019-10-08 | Journal article
Contributors: Ketan Mishra; Junday K; Claire Wong; Chan AY; Hesselson S; Muller DW; Siiri Iismaa; Mehta A; Graham RM
Source: Self-asserted source
Dr Ashish Mehta

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes.

International journal of cardiology
2018-08-24 | Journal article
Contributors: Chrishan J. Ramachandra; Mehta A; Wong P; Ja KPMM; Regina Fritsche Danielson; Bhat RV; Derek Hausenloy; Kovalik JP; Shim W
Source: Self-asserted source
Dr Ashish Mehta

Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3Δ25bpIntronic Deletion in South Asian Descendants.

JAMA cardiology
2018-06-01 | Journal article
Contributors: Shiv Kumar Viswanathan; Puckelwartz MJ; Mehta A; Chrishan J. Ramachandra; Jagadeesan A; Fritsche-Danielson R; Bhat RV; Wong P; Kandoi S; Jennifer Schwanekamp et al.
Source: Self-asserted source
Dr Ashish Mehta

CYP2J2 inhibition: the arcane mechanism of dronedarone‐induced proarrhythmia

The FASEB Journal
2018-04 | Journal article
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Contributors: Eric Chun Yong Yong Chan; Aneesh Karkhanis; Ashish Mehta; Winston Shim
Source: Self-asserted source
Dr Ashish Mehta

Construction of a vascularized hydrogel for cardiac tissue formation in a porcine model

Journal of Tissue Engineering and Regenerative Medicine
2018-04-10 | Journal article
Contributors: K.P. Myu Mai Ja; Kee Pah Lim; Allen Chen; Sherwin Ting; Shi Qi Li; Nicole Tee; Chrishan Ramachandra; Ashish Mehta; Philip Wong; Steve Oh et al.
Source: check_circle
Crossref

Identification of a targeted and testable antiarrhythmic therapy for long-QT syndrome type 2 using a patient-specific cellular model.

European heart journal
2018-04-01 | Journal article
Contributors: Mehta A; Chrishan J. Ramachandra; Singh P; Chitre A; Lua CH; Mura M; lia crotti; Wong P; Schwartz PJ; Massimiliano Gnecchi et al.
Source: Self-asserted source
Dr Ashish Mehta

Acetylated Signal Transducer and Activator of Transcription 3 Functions as Molecular Adaptor Independent of Transcriptional Activity During Human Cardiogenesis

Stem Cells
2017-10-01 | Journal article
Contributors: Ashish Mehta; Chrishan J. A. Ramachandra; Anuja Chitre; Pritpal Singh; Chong Hui Lua; Winston Shim
Source: check_circle
Crossref

The KCNH2-IVS9-28A/G mutation causes aberrant isoform expression and hERG trafficking defect in cardiomyocytes derived from patients affected by Long QT Syndrome type 2.

International journal of cardiology
2017-04-12 | Journal article
Contributors: Mura M; Mehta A; Chrishan J. Ramachandra; rita zappatore; Federica Pisano; Maria Chiara Ciuffreda; Barbaccia V; lia crotti; Schwartz PJ; Shim W et al.
Source: Self-asserted source
Dr Ashish Mehta

ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells.

Stem cells (Dayton, Ohio)
2016-06-27 | Journal article
Contributors: Chrishan J. Ramachandra; Mehta A; Lua CH; Chitre A; Ja KP; Shim W
Source: Self-asserted source
Dr Ashish Mehta

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes.

Scientific reports
2016-05-04 | Journal article
Contributors: Maillet A; Tan K; Chai X; Sadananda SN; Mehta A; Ooi J; Michael R. Hayden; Mahmoud Pouladi; SUJOY GHOSH; Shim W et al.
Source: Self-asserted source
Dr Ashish Mehta

Arsenic and the Cardiovascular System

Hand Book of Arsenic Toxicology
2015 | Book chapter
Contributors: Dr Ashish Mehta
Source: Self-asserted source
Dr Ashish Mehta

iPSC-derived human cardiac progenitor cells improve ventricular remodelling via angiogenesis and interstitial networking of infarcted myocardium.

Journal of cellular and molecular medicine
2015-11-27 | Journal article
Contributors: Ja KP; Miao Q; Zhen Tee NG; Lim SY; Nandihalli M; Chrishan J. Ramachandra; Mehta A; Shim W
Source: Self-asserted source
Dr Ashish Mehta

ErbB4 Activated p38γ MAPK Isoform Mediates Early Cardiogenesis Through NKx2.5 in Human Pluripotent Stem Cells.

Stem cells (Dayton, Ohio)
2015-10-15 | Journal article
Contributors: Chrishan J. Ramachandra; Mehta A; Wong P; Shim W
Source: Self-asserted source
Dr Ashish Mehta

Molecular pathogenesis of Marfan syndrome.

International journal of cardiology
2015-03-31 | Journal article
Contributors: Chrishan J. Ramachandra; Mehta A; Guo KW; Wong P; Tan JL; Shim W
Source: Self-asserted source
Dr Ashish Mehta

A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells.

PloS one
2014-07-28 | Journal article
Contributors: Mehta A; Verma V; Nandihalli M; Chrishan J. Ramachandra; Sequiera GL; Sudibyo Y; Chung Y; William Sun; Shim W
Source: Self-asserted source
Dr Ashish Mehta

Phasic modulation of Wnt signaling enhances cardiac differentiation in human pluripotent stem cells by recapitulating developmental ontogeny.

Biochimica et biophysica acta
2014-06-28 | Journal article
Contributors: Mehta A; Chrishan J. Ramachandra; Sequiera GL; Sudibyo Y; Nandihalli M; Yong PJ; Koh CH; Shim W
Source: Self-asserted source
Dr Ashish Mehta

Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes.

Cardiovascular research
2014-03-12 | Journal article | Author
Contributors: Dr Ashish Mehta; Sequiera GL; Chrishan J. Ramachandra; Sudibyo Y; Chung Y; Sheng J; Wong KY; Tan TH; Wong P; Liew R et al.
Source: Self-asserted source
Dr Ashish Mehta
grade
Preferred source (of 2)‎

A Simple Protocol for the Generation of Cardiomyocytes from Human Pluripotent Stem Cells

Methods Mol Biol
2013 | Journal article
DOI:

10.1007/7651_2013_54

Contributors: Sequiera, G. L.; Mehta, A.; Shim, W.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Arsenic induced neuronal apoptosis in guinea pigs is Ca2+ dependent and abrogated by chelation therapy: role of voltage gated calcium channels

Neurotoxicology
2013 | Journal article
DOI:

10.1016/j.neuro.2013.01.006 10.1016/j.neuro.2013.01.006. Epub 2013 Jan 29.

Contributors: Pachauri, V.; Mehta, A.; Mishra, D.; Flora, S. J.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Cardiac stem cell therapy: stemness or commitment?

Cell Transplant
2013 | Journal article
DOI:

10.3727/096368912X653282 10.3727/096368912X653282. Epub 2012 Aug 27.

Contributors: Mehta, A.; Shim, W.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Critical path in cardiac stem cell therapy: an update on cell delivery

Cytotherapy
2013 | Journal article
DOI:

10.1016/j.jcyt.2012.11.003 10.1016/j.jcyt.2012.11.003. Epub 2013 Jan 5.

Contributors: Shim, W.; Mehta, A.; Wong, P.; Chua, T.; Koh, T. H.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Ontogenic development of cardiomyocytes derived from transgene-free human induced pluripotent stem cells and its homology with human heart

Life Sci
2013 | Journal article
DOI:

10.1016/j.lfs.2012.10.020 10.1016/j.lfs.2012.10.020. Epub 2012 Nov 7.

Contributors: Sequiera, G. L.; Mehta, A.; Ooi, T. H.; Shim, W.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Pharmacoelectrophysiology of viral-free induced pluripotent stem cell-derived human cardiomyocytes

Toxicol Sci
2013 | Journal article
DOI:

10.1093/toxsci/kfs309 10.1093/toxsci/kfs309. Epub 2012 Oct 22.

Contributors: Mehta, A.; Chung, Y.; Sequiera, G. L.; Wong, P.; Liew, R.; Shim, W.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani

PLoS One
2011 | Journal article
DOI:

10.1371/journal.pone.0025273 10.1371/journal.pone.0025273. Epub 2011 Sep 23.

Contributors: Verma, S.; Mehta, A.; Shaha, C.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

G-CSF for stem cell therapy in acute myocardial infarction: friend or foe?

Cardiovasc Res
2011 | Journal article
DOI:

10.1093/cvr/cvq301

Contributors: Shim, W.; Mehta, A.; Lim, S. Y.; Zhang, G.; Lim, C. H.; Chua, T.; Wong, P.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells

Cardiovasc Res
2011 | Journal article
DOI:

10.1093/cvr/cvr132

Contributors: Mehta, A.; Chung, Y. Y.; Ng, A.; Iskandar, F.; Atan, S.; Wei, H.; Dusting, G.; Sun, W.; Wong, P.; Shim, W.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Intrinsic properties and external factors determine the differentiation bias of human embryonic stem cell lines

Cell Biol Int
2010 | Journal article
DOI:

10.1042/CBI20100283

Contributors: Mehta, A.; Mathew, S.; Viswanathan, C.; Sen Majumdar, A.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Molecular and cellular characterization of expanded and cryopreserved human limbal epithelial stem cells reveal unique immunological properties.

Experimental eye research
2010-11-18 | Journal article
Contributors: Vasania VS; Prasad P; Gill RK; Mehta A; Viswanathan C; Sarang S; Majumdar AS
Source: Self-asserted source
Dr Ashish Mehta

Combinational chelation therapy abrogates lead-induced neurodegeneration in rats

Toxicol Appl Pharmacol
2009 | Journal article
DOI:

10.1016/j.taap.2009.07.001

Contributors: Pachauri, V.; Saxena, G.; Mehta, A.; Mishra, D.; Flora, S. J.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies

Biochem Pharmacol
2009 | Journal article
DOI:

10.1016/j.bcp.2009.07.003

Contributors: Flora, S. J.; Mehta, A.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Prevention of arsenic-induced hepatic apoptosis by concomitant administration of garlic extracts in mice

Chem Biol Interact
2009 | Journal article
DOI:

10.1016/j.cbi.2008.08.017

Contributors: Flora, S. J.; Mehta, A.; Gupta, R.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Assessment of drug induced developmental toxicity using human embryonic stem cells

Cell Biol Int
2008 | Journal article
DOI:

10.1016/j.cellbi.2008.08.012

Contributors: Mehta, A.; Konala, V. B.; Khanna, A.; Majumdar, A. S.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Heavy metal induced oxidative stress & its possible reversal by chelation therapy

Indian J Med Res
2008 | Journal article
Contributors: Flora, S. J.; Mittal, M.; Mehta, A.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Reversal of arsenic-induced hepatic apoptosis with combined administration of DMSA and its analogues in guinea pigs: role of glutathione and linked enzymes

Chem Res Toxicol
2008 | Journal article
DOI:

10.1021/tx700315a

Contributors: Mishra, D.; Mehta, A.; Flora, S. J.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

8-Methyl-4-(3-diethylaminopropylamino) pyrimido [4',5';4,5] thieno (2,3-b) quinoline (MDPTQ), a quinoline derivate that causes ROS-mediated apoptosis in leukemia cell lines

Toxicol Appl Pharmacol
2007 | Journal article
DOI:

10.1016/j.taap.2007.04.005

Contributors: Shenoy, S.; Vasania, V. S.; Gopal, M.; Mehta, A.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects

Biol Trace Elem Res
2007 | Journal article
DOI:

10.1007/s12011-007-0064-2

Contributors: Flora, S. J.; Mehta, A.; Gautam, P.; Jatav, P. C.; Pathak, U.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca(2+)

J Pharmacol Exp Ther
2007 | Journal article
DOI:

10.1124/jpet.107.121996

Contributors: Flora, S. J.; Saxena, G.; Mehta, A.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Mechanism of metalloid-induced death in Leishmania spp.: role of iron, reactive oxygen species, Ca2+, and glutathione

Free Radic Biol Med
2006 | Journal article
DOI:

10.1016/j.freeradbiomed.2006.01.024

Contributors: Mehta, A.; Shaha, C.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Monoisoamyl dimercaptosuccinic acid induced changes in pregnant female rats during late gestation and lactation

Reprod Toxicol
2006 | Journal article
DOI:

10.1016/j.reprotox.2005.05.008

Contributors: Mehta, A.; Pant, S. C.; Flora, S. J.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity

J Biol Chem
2004 | Journal article
DOI:

10.1074/jbc.M309341200

Contributors: Mehta, A.; Shaha, C.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Comparative hepatic and renal toxicity of cadmium in male and female rats

J Environ Biol
2004 | Journal article
Contributors: Gubrelay, U.; Mehta, A.; Singh, M.; Flora, S. J.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats

Toxicology
2004 | Journal article
DOI:

10.1016/j.tox.2003.09.010

Contributors: Flora, S. J.; Mehta, A.; Rao, P. V.; Kannan, G. M.; Bhaskar, A. S.; Dube, S. N.; Pant, B. P.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA

Comp Biochem Physiol C Toxicol Pharmacol
2003 | Journal article
DOI:

10.1016/S1532-0456(02)00269-7

Contributors: Flora, S. J.; Mehta, A.; Satsangi, K.; Kannan, G. M.; Gupta, M.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication

Chem Biol Interact
2003 | Journal article
DOI:

10.1016/S0009-2797(03)00025-5

Contributors: Flora, S. J.; Pande, M.; Mehta, A.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID

Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats

J Appl Toxicol
2003 | Journal article
DOI:

10.1002/jat.890

Contributors: Flora, S. J.; Mehta, A.
Source: Self-asserted source
Dr Ashish Mehta via ResearcherID
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