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Other IDs

Scopus Author ID: 7101907113

Keywords

Dab1, Reelin, Stk25, Autism, Neuronal Migration, Alzheimer's

Countries

United States

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Employment (2)

SUNY Upstate Medical University : Syracuse, NY, US

2008 to present | Associate Professor (Neuroscience & Physiology)
Employment
Source: Self-asserted source
Brian Howell

National Institute of Neurological Disorders and Stroke: Bethesda, MD, US

1999 to 2008 | Investigator (Neurogenetics)
Employment
Source: Self-asserted source
Brian Howell

Education and qualifications (3)

Fred Hutchinson Cancer Research Center: Seattle, WA, US

1992 to 1999 | Post-Doc (Basic Science)
Education
Source: Self-asserted source
Brian Howell

McGill University: Montreal, QC, CA

1985 to 1992 | PhD (Biochemistry)
Education
Source: Self-asserted source
Brian Howell

University of Western Ontario : London, ON, CA

1981 to 1985 | BSc (Department of Biochemistry)
Education
Source: Self-asserted source
Brian Howell

Funding (3)

Resolving the genetic interaction between DAB1 and APOE4 in Alzheimer's.

2023-02-15 to 2025-01-31 | Grant
National Institute on Aging (Baltimore, US)
URL: https://app.dimensions.ai/details/grant/grant.13254206
GRANT_NUMBER: R21AG080800
Source: Self-asserted source
Brian Howell via DimensionsWizard

Regulation of Neuronal Lamination and Dendritogenesis by Reelin-Dab1 Signaling

2011-07-01 to 2016-06-30 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
GRANT_NUMBER: 5R01NS073662-04
GRANT_NUMBER: 5R01NS073662-04
Source: Self-asserted source
Brian Howell via DimensionsWizard

Molecular Mechanisms That Control Neuronal Positioning During Development

Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
GRANT_NUMBER: 1Z01NS002987-09
GRANT_NUMBER: 1Z01NS002987-09
Source: Self-asserted source
Brian Howell via DimensionsWizard

Works (50 of 60)

Items per page:
Page 1 of 2

Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.

Neurobiology of aging
2022-07-29 | Journal article
DOI: 10.1016/j.neurobiolaging.2022.07.009
PMID: 35977442
PMC: PMC9548409
Contributors: Matthew Bracher-Smith; Leonenko G; Baker E; Crawford K; Graham AC; Salih DA; Howell BW; Hardy J; Valentina Escott-Price
Source: Self-asserted source
Brian Howell

GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development

Stroke
2022-03 | Journal article
DOI: 10.1161/STROKEAHA.121.036940
Contributors: Miriam Sartages; Mar García-Colomer; Cristina Iglesias; Brian W. Howell; Manuel Macía; Patricia Peña; Celia M. Pombo; Juan Zalvide
Source: check_circle
Crossref

Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.

Cellular and molecular gastroenterology and hepatology
2021-10-06 | Journal article
DOI: 10.1016/j.jcmgh.2021.09.018
PMID: 34624527
PMC: PMC8688184
Contributors: Kurhe Y; Caputo M; Cansby E; Xia Y; Kumari S; Anand SK; Howell BW; Marschall HU; Margit Mahlapuu
Source: Self-asserted source
Brian Howell

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2021-09-13 | Journal article
DOI: 10.1523/jneurosci.0523-21.2021
PMID: 34518307
PMC: PMC8549536
Contributors: Tohru Matsuki; Iio A; Ueda M; Yumi Tsuneura; Howell BW; Nakayama A
Source: Self-asserted source
Brian Howell

Identification of the kinase STK25 as an upstream activator of LATS signaling

Nature Communications
2019-04-04 | Journal article
DOI: 10.1038/s41467-019-09597-w
Contributors: Sanghee Lim; Nicole Hermance; Tenny Mudianto; Hatim M. Mustaly; Ian Paolo Morelos Mauricio; Marc A. Vittoria; Ryan J. Quinton; Brian W. Howell; Hauke Cornils; Amity L. Manning et al.
Source: check_circle
Crossref

Ethanol Exposure Transiently Elevates but Persistently Inhibits Tyrosine Kinase Activity and Impairs the Growth of the Nascent Apical Dendrite.

Molecular neurobiology
2019-01-23 | Journal article
DOI: 10.1007/s12035-019-1473-x
PMID: 30674037
PMC: PMC6615985
Contributors: Wang D; Enck J; Howell BW; Eric Olson
Source: Self-asserted source
Brian Howell

Synaptic structural protein dysfunction leads to altered excitation inhibition ratios in models of autism spectrum disorder.

Pharmacological research
2018-11-19 | Journal article
DOI: 10.1016/j.phrs.2018.11.019
PMID: 30465851
Contributors: Howell BW; Smith KM
Source: Self-asserted source
Brian Howell

Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway.

Frontiers in cellular neuroscience
2018-08-03 | Journal article
DOI: 10.3389/fncel.2018.00228
PMID: 30127721
PMC: PMC6088185
Contributors: Dairaghi L; Flannery E; Paolo Giacobini; Aybike Saglam; Hassan Saadi; Stephanie Constantin; Filippo Casoni; Howell BW; Wray S
Source: Self-asserted source
Brian Howell

STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology
2018-06 | Journal article
DOI: 10.1161/atvbaha.118.311241
Part of ISSN: 1079-5642
Contributors: Emmelie Cansby; Elin Magnusson; Esther Nuñez-Durán; Manoj Amrutkar; Matteo Pedrelli; Paolo Parini; Jenny Hoffmann; Marcus Ståhlman; Brian W. Howell; Hanns-Ulrich Marschall et al.
Source: Self-asserted source
Brian Howell via Crossref Metadata Search

STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue

Journal of Endocrinology
2018-05 | Journal article
DOI: 10.1530/joe-18-0182
Part of ISSN: 0022-0795
Contributors: Silva Sütt; Emelie Cansby; Alexandra Paul; Manoj Amrutkar; Esther Nunez Duran; Nagaraj M Kulkarni; Marcus Ståhlman; Jan Borén; Jurga Laurencikiene; Brian W Howell et al.
Source: Self-asserted source
Brian Howell via Crossref Metadata Search

The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression

Journal of Neurochemistry
2017-07 | Journal article
DOI: 10.1111/jnc.14045
Contributors: Dawn B. Lammert; Frank A. Middleton; Jen Pan; Eric C. Olson; Brian W. Howell
Source: check_circle
Crossref

RELN mutations in autism spectrum disorder

Frontiers in Cellular Neuroscience
2016 | Journal article
DOI: 10.3389/fncel.2016.00084
EID:

2-s2.0-84963762448
Contributors: Lammert, D.B.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Genetic disruption of protein kinase STK25 ameliorates metabolic defects in a diet-induced type 2 diabetes model

Diabetes
2015 | Journal article
DOI: 10.2337/db15-0060
EID:

2-s2.0-84953371016
Contributors: Amrutkar, M.; Cansby, E.; Chursa, U.; Nuñez-Durán, E.; Chanclón, B.; Ståhlman, M.; Fridén, V.; Mannerås-Holm, L.; Wickman, A.; Smith, U. et al.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Novel Disabled-1-expressing neurons identified in adult brain and spinal cord

European Journal of Neuroscience
2014 | Journal article
DOI: 10.1111/ejn.12416
EID:

2-s2.0-84894054626
Contributors: Abadesco, A.D.; Cilluffo, M.; Yvone, G.M.; Carpenter, E.M.; Howell, B.W.; Phelps, P.E.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Transient downregulation of dab1 protein levels during development leads to behavioral and structural deficits: Relevance for psychiatric disorders

Neuropsychopharmacology
2014 | Journal article
DOI: 10.1038/npp.2013.226
EID:

2-s2.0-84892673576
Contributors: Teixeira, C.M.; Masachs, N.; Muhaisen, A.; Bosch, C.; Pérez-Martínez, J.; Howell, B.; Soriano, E.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration

Neural Development
2013 | Journal article
DOI: 10.1186/1749-8104-8-21
EID:

2-s2.0-84887323459
Contributors: Matsuki, T.; Chen, J.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice

GLIA
2013 | Journal article
DOI: 10.1002/glia.22519
EID:

2-s2.0-84880700004
Contributors: Brunne, B.; Franco, S.; Bouché, E.; Herz, J.; Howell, B.W.; Pahle, J.; Müller, U.; May, P.; Frotscher, M.; Bock, H.H.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus

Journal of Neuroscience
2012 | Journal article
DOI: 10.1523/JNEUROSCI.1857-12.2012
EID:

2-s2.0-84865466013
Contributors: Teixeira, C.M.; Kron, M.M.; Masachs, N.; Zhang, H.; Lagace, D.C.; Martinez, A.; Reillo, I.; Duan, X.; Bosch, C.; Pujadas, L. et al.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Identification of Stk25 as a genetic modifier of tau phosphorylation in Dab1-mutant mice

PLoS ONE
2012 | Journal article
DOI: 10.1371/journal.pone.0031152
EID:

2-s2.0-84857066225
Contributors: Matsuki, T.; Zaka, M.; Guerreiro, R.; van der Brug, M.P.; Cooper, J.A.; Cookson, M.R.; Hardy, J.A.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

Neuroscience
2010 | Journal article
DOI: 10.1016/j.neuroscience.2010.04.078
EID:

2-s2.0-77953810503
Contributors: Lee, K.J.; Moussa, C.E.H.; Lee, Y.; Sung, Y.; Howell, B.W.; Turner, R.S.; Pak, D.T.S.; Hoe, H.S.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Reelin and Stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment

Cell
2010 | Journal article
DOI: 10.1016/j.cell.2010.10.029
EID:

2-s2.0-79251476231
Contributors: Matsuki, T.; Matthews, R.T.; Cooper, J.A.; Van Der Brug, M.P.; Cookson, M.R.; Hardy, J.A.; Olson, E.C.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Interaction of Reelin with amyloid precursor protein promotes neurite outgrowth

Journal of Neuroscience
2009 | Journal article
DOI: 10.1523/JNEUROSCI.4872-08.2009
EID:

2-s2.0-67049167155
Contributors: Hoe, H.-S.; Kea, J.L.; Carney, R.S.E.; Lee, J.; Markova, A.; Lee, J.-Y.; Howell, B.W.; Hyman, B.T.; Pak, D.T.S.; Bu, G. et al.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

Molecular Brain
2009 | Journal article
DOI: 10.1186/1756-6606-2-23
EID:

2-s2.0-69049112930
Contributors: Lai, C.; Xie, C.; Shim, H.; Chandran, J.; Howell, B.W.; Cai, H.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

A genetic interaction between the APP and Dab1 genes influences brain development

Molecular and Cellular Neuroscience
2008 | Journal article
DOI: 10.1016/j.mcn.2007.09.008
EID:

2-s2.0-37349015897
Contributors: Pramatarova, A.; Chen, K.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Function of non-visual arrestins in signaling and endocytosis of the gastrin-releasing peptide receptor (GRP receptor)

Biochemical Pharmacology
2008 | Journal article
DOI: 10.1016/j.bcp.2007.11.022
EID:

2-s2.0-38949130471
Contributors: Schumann, M.; Nakagawa, T.; Mantey, S.A.; Howell, B.; Jensen, R.T.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

Journal of Cell Science
2008 | Journal article
DOI: 10.1242/jcs.027334
EID:

2-s2.0-46749093398
Contributors: Matsuki, T.; Pramatarova, A.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity

Human Molecular Genetics
2007 | Journal article
DOI: 10.1093/hmg/ddm109
EID:

2-s2.0-34447309577
Contributors: Palazzolo, I.; Burnett, B.G.; Young, J.E.; Brenne, P.L.; La Spada, A.R.; Fischbeck, K.H.; Howell, B.W.; Pennuto, M.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin

Proceedings of the National Academy of Sciences of the United States of America
2007 | Journal article
DOI: 10.1073/pnas.0611391104
EID:

2-s2.0-34347273437
Contributors: Andrade, N.; Komnenovic, V.; Blake, S.M.; Jossin, Y.; Howell, B.; Goffinet, A.; Schneider, W.J.; Nimpf, J.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

DAB1 and reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

Journal of Biological Chemistry
2006 | Journal article
DOI: 10.1074/jbc.M602162200
EID:

2-s2.0-33845925306
Contributors: Hoe, H.-S.; Tran, T.S.; Matsuoka, Y.; Howell, B.W.; Rebeck, G.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model

Molecular and Cellular Biology
2006 | Journal article
DOI: 10.1128/MCB.26.4.1510-1517.2006
EID:

2-s2.0-32044468963
Contributors: Pramatarova, A.; Ochalski, P.G.; Lee, C.-H.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity

Experimental Cell Research
2005 | Journal article
DOI: 10.1016/j.yexcr.2005.02.029
EID:

2-s2.0-19544380210
Contributors: Dey, N.; Howell, B.W.; De, P.K.; Durden, D.L.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting

Brain
2005 | Journal article
DOI: 10.1093/brain/awh378
EID:

2-s2.0-13544251405
Contributors: Verbeek, D.S.; Knight, M.A.; Harmison, G.G.; Fischbeck, K.H.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Interaction between Dab1 and CrkII is promoted by Reelin signalling

Journal of Cell Science
2004 | Journal article
DOI: 10.1242/jcs.01320
EID:

2-s2.0-5444247800
Contributors: Chen, K.; Ochalski, P.G.; Tran, T.S.; Sahir, N.; Schubert, M.; Pramatarova, A.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Receptor Clustering Is Involved in Reelin Signaling

Molecular and Cellular Biology
2004 | Journal article
DOI: 10.1128/MCB.24.3.1378-1386.2004
EID:

2-s2.0-9144264158
Contributors: Strasser, V.; Fasching, D.; Hauser, C.; Mayer, H.; Bock, H.H.; Hiesberger, T.; Herz, J.; Weeber, E.J.; Sweatt, J.D.; Pramatarova, A. et al.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Genetic modulation of tau phosphorylation in the mouse

Journal of Neuroscience
2003 | Journal article
EID:

2-s2.0-0037223014
Contributors: Brich, J.; Shie, F.-S.; Howell, B.W.; Li, R.; Tus, K.; Wakeland, E.K.; Jin, L.-W.; Mumby, M.; Churchill, G.; Herz, J. et al.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Nckβ interacts with tyrosine-phosphorylated Disabled 1 and redistributes in Reelin-stimulated neurons

Molecular and Cellular Biology
2003 | Journal article
DOI: 10.1128/MCB.23.20.7210-7221.2003
EID:

2-s2.0-0141640850
Contributors: Pramatarova, A.; Ochalski, P.G.; Chen, K.; Gropman, A.; Myers, S.; Min, K.-T.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Androgens regulate the mammalian homologues of invertebrate sex: Determination genes tra-2 and fox-1

Biochemical and Biophysical Research Communications
2001 | Journal article
DOI: 10.1006/bbrc.2001.4617
EID:

2-s2.0-0034806008
Contributors: Lieberman, A.P.; Friedlich, D.L.; Harmison, G.; Howell, B.W.; Jordan, C.L.; Breedlove, S.Marc; Fischbeck, K.H.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Disabled-1 functions cell autonomously during radial migration and cortical layering of pyramidal neurons

Journal of Neuroscience
2001 | Journal article
EID:

2-s2.0-0035890195
Contributors: Hammond, V.; Howell, B.; Godinho, L.; Tan, S.-S.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

The LDL receptor gene family: Signaling functions during development

Current Opinion in Neurobiology
2001 | Journal article
DOI: 10.1016/S0959-4388(00)00176-8
EID:

2-s2.0-0035252879
Contributors: Howell, B.W.; Herz, J.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development

Current Biology
2000 | Journal article
DOI: 10.1016/S0960-9822(00)00608-4
EID:

2-s2.0-0343878232
Contributors: Howell, B.W.; Herrick, T.M.; Hildebrand, J.D.; Zhang, Y.; Cooper, J.A.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of Disabled-1 and modulates tau phosphorylation

Neuron
1999 | Journal article
DOI: 10.1016/S0896-6273(00)80861-2
EID:

2-s2.0-0033213319
Contributors: Hiesberger, T.; Trommsdorff, M.; Howell, B.W.; Goffinet, A.; Mumby, M.C.; Cooper, J.A.; Herz, J.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Erratum: Reelin-induced tyrosine phosphorylation of Disabled 1 during neuronal positioning (Gene and Development (1999) 13 (643-648))

Genes and Development
1999 | Journal article
EID:

2-s2.0-0033564578
Contributors: Howell, B.W.; Herrick, T.M.; Cooper, J.A.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Lipoprotein receptors: Signaling functions in the brain?

Cell
1999 | Journal article
DOI: 10.1016/S0092-8674(00)80778-3
EID:

2-s2.0-0032998127
Contributors: Cooper, J.A.; Howell, B.W.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning

Genes and Development
1999 | Journal article
EID:

2-s2.0-0033559054
Contributors: Howell, B.W.; Herrick, T.M.; Cooper, J.A.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

Molecular and Cellular Biology
1999 | Journal article
EID:

2-s2.0-0033066680
Contributors: Howell, B.W.; Lanier, L.M.; Frank, R.; Gertler, F.B.; Cooper, J.A.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Thyroid hormone regulates reelin and dab1 expression during brain development

Journal of Neuroscience
1999 | Journal article
EID:

2-s2.0-0033566884
Contributors: Alvarez-Dolado, M.; Ruiz, M.; Del Río, J.A.; Alcántara, S.; Burgaya, F.; Sheldon, M.; Nakajima, K.; Bernal, J.; Howell, B.W.; Curran, T. et al.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Cerebellar abnormalities in the disabled (mdab1-1) mouse

Journal of Comparative Neurology
1998 | Journal article
DOI: 10.1002/(SICI)1096-9861(19981214)402:2<238::AID-CNE8>3.0.CO;2-H
EID:

2-s2.0-0032517739
Contributors: Gallagher, E.; Howell, B.W.; Soriano, P.; Cooper, J.A.; Hawkes, R.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Mouse disabled (mDab1): A Src binding protein implicated in neuronal development

EMBO Journal
1997 | Journal article
DOI: 10.1093/emboj/16.1.121
EID:

2-s2.0-0031035703
Contributors: Howell, B.W.; Gertler, F.B.; Cooper, J.A.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Neuronal position in the developing brain is regulated by mouse disabled-1

Nature
1997 | Journal article
DOI: 10.1038/39607
EID:

2-s2.0-0030704354
Contributors: Howell, B.W.; Hawkes, R.; Soriano, P.; Cooper, J.A.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier

Scrambler and yotari disrupt the disabled gene and produce a reeler- like phenotype in mice

Nature
1997 | Journal article
DOI: 10.1038/39601
EID:

2-s2.0-0030717493
Contributors: Sheldon, M.; Rice, D.S.; D'Arcangelo, G.; Yoneshima, H.; Nakajima, K.; Mikoshiba, K.; Howell, B.W.; Cooper, J.A.; Goldowitz, D.; Curran, T.
Source: Self-asserted source
Brian Howell via Scopus - Elsevier
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