Personal information

Computational biology, genome, exome, transcriptome, population genetics, precision medicine

Activities

Employment (4)

Regeneron Genetics Center LLC: Tarrytown, NY, US

2019-12-01 to present | Senior Manager (Founder and Special Populations)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Weill Cornell Medicine: New York, New York, US

2016-02-02 to 2019-11-30 | Assistant Professor (Genetic Medicine)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Weill Cornell Medical College: NY, NY, US

2013-07-25 to 2016-02-01 | Instructor (Genetic Medicine)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Weill Cornell Medical College: NY, NY, US

2010-07-01 to 2013-06-31 | Postdoctoral Associate (Genetic Medicine)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Education and qualifications (2)

University of California San Diego: La Jolla, CA, US

2009-07-01 | PhD (Bioinformatics and Systems Biology)
Education
Source: Self-asserted source
JL Rodriguez-Flores

Massachusetts Institute of Technology: Cambridge, MA, US

1998-07-01 | BS (Biology)
Education
Source: Self-asserted source
JL Rodriguez-Flores

Professional activities (3)

Society for Advancement of Chicanos and Native Americans in Science: Santa Cruz, California, US

2024-01-14 to present | Professional Member
Membership
Source: Self-asserted source
JL Rodriguez-Flores

Society for Molecular Biology & Evolution: Lawrence, KS, US

2014 to present
Membership
Source: Self-asserted source
JL Rodriguez-Flores

American Society of Human Genetics: Bethesda, Maryland, US

2007 to present
Membership
Source: Self-asserted source
JL Rodriguez-Flores

Works (44)

Cysteine-Altering NOTCH3 Variants Are Associated with an Increased Risk of Autoimmune Diseases

Journal of Clinical Medicine
2023-09-29 | Journal article
Contributors: Emily Rieder; Jiang Li; Juan L. Rodriguez-Flores; Muhammad Taimur Malik; Vida Abedi; Ramin Zand
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Supplementary Table S8 from Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers

2023-04-04 | Preprint
Contributors: Julie E. Feusier; Sasi Arunachalam; Tsewang Tashi; Monika J. Baker; Chad VanSant-Webb; Amber Ferdig; Bryan E. Welm; Juan L. Rodriguez-Flores; Christopher Ours; Lynn B. Jorde et al.
Source: check_circle
Crossref

The QChip1 knowledgebase and microarray for precision medicine in Qatar.

NPJ genomic medicine
2022-01-19 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes

Nature Communications
2021-10-12 | Journal article
Contributors: Rozaimi Mohamad Razali; Juan Rodriguez-Flores; Mohammadmersad Ghorbani; Haroon Naeem; Waleed Aamer; Elbay Aliyev; Ali Jubran; Said I. Ismail; Wadha Al-Muftah; Radja Badji et al.
Source: check_circle
Crossref

Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers

Blood Cancer Discovery
2021-05-01 | Journal article
Contributors: Julie E. Feusier; Sasi Arunachalam; Tsewang Tashi; Monika J. Baker; Chad VanSant-Webb; Amber Ferdig; Bryan E. Welm; Juan L. Rodriguez-Flores; Christopher Ours; Lynn B. Jorde et al.
Source: check_circle
Crossref

Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population.

Scientific reports
2021-01-13 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Genome diversity in Ukraine.

GigaScience
2021-01-01 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation

Genes
2019-01 | Journal article | Author
Contributors: Sofia Kolchanova; Sergei Kliver; Aleksei Komissarov; Pavel Dobrinin; Gaik Tamazian; Kirill Grigorev; Walter W. Wolfsberger; Audrey J. Majeske; Jafet Velez-Valentin; Ricardo Valentin de la Rosa et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population.

PloS one
2018-09-13 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Point-of-care whole-exome sequencing of idiopathic male infertility.

Genetics in medicine : official journal of the American College of Medical Genetics
2018-04-12 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population.

Nature communications
2018-01-23 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores
grade
Preferred source (of 3)‎

Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder.

PloS one
2017-01-13 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations

Genome Research
2016 | Journal article
EID:

2-s2.0-84956909090

Contributors: Rodriguez-Flores, J.L.; Fakhro, K.; Agosto-Perez, F.; Ramstetter, M.D.; Arbiza, L.; Vincent, T.L.; Robay, A.; Malek, J.A.; Suhre, K.; Chouchane, L. et al.
Source: Self-asserted source
JL Rodriguez-Flores via Scopus - Elsevier

Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population.

PloS one
2016-08-23 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

The Qatar genome: a population-specific tool for precision medicine in the Middle East.

Human genome variation
2016-06-30 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.

Nature genetics
2016-04-25 | Journal article
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores
grade
Preferred source (of 2)‎

Copy number variations in the genome of the Qatari population.

2015 | Journal article
Contributors: Fakhro KA; Yousri NA; Rodriguez-Flores JL; Robay A; Staudt MR; Agosto-Perez F; Salit J; Malek JA; Suhre K; Jayyousi A et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

A global reference for human genetic variation.

2015-10 | Journal article
Contributors: 1000 Genomes Project Consortium; Auton A; Brooks LD; Durbin RM; Garrison EP; Kang HM; Korbel JO; Marchini JL; McCarthy S; McVean GA et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.

2014 | Journal article
Contributors: Colonna V; Ayub Q; Chen Y; Pagani L; Luisi P; Pybus M; Garrison E; Xue Y; Tyler-Smith C; 1000 Genomes Project Consortium et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.

2014 | Journal article
Contributors: Delaneau O; Marchini J; 1000 Genomes Project Consortium; 1000 Genomes Project Consortium
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations.

2014-01 | Journal article
Contributors: Abou Ziki MD; Strulovici-Barel Y; Hackett NR; Rodriguez-Flores JL; Mezey JG; Salit J; Radisch S; Hollmann C; Chouchane L; Malek J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Reconstructing Native American Migrations from Whole-Genome and Whole-Exome Data

PLoS Genet
2013 | Journal article
Contributors: Simon Gravel; Fouad Zakharia; Andres Moreno-Estrada; Jake K. Byrnes; Marina Muzzio; Juan L. Rodriguez-Flores; Eimear E. Kenny; Christopher R. Gignoux; Brian K. Maples; Wilfried Guiblet et al.
Source: Self-asserted source
JL Rodriguez-Flores via Crossref Metadata Search

Exome Sequencing Identifies Potential Risk Variants for Mendelian Disorders at High Prevalence in Qatar.

2013-10 | Journal article
Contributors: Rodriguez-Flores JL; Fakhro K; Hackett NR; Salit J; Fuller J; Agosto-Perez F; Gharbiah M; Malek JA; Zirie M; Jayyousi A et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Integrative annotation of variants from 1092 humans: application to cancer genomics.

2013-10 | Journal article
Contributors: Khurana E; Fu Y; Colonna V; Mu XJ; Kang HM; Lappalainen T; Sboner A; Lochovsky L; Chen J; Harmanci A et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.

PloS one
2012 | Journal article
EID:

2-s2.0-84876451303

Contributors: Rodriguez-Flores, J.L.; Fuller, J.; Hackett, N.R.; Salit, J.; Malek, J.A.; Al-Dous, E.; Chouchane, L.; Zirie, M.; Jayoussi, A.; Mahmoud, M.A. et al.
Source: Self-asserted source
JL Rodriguez-Flores via Scopus - Elsevier

An integrated map of genetic variation from 1,092 human genomes.

2012-11 | Journal article
Contributors: 1000 Genomes Project Consortium; Abecasis GR; Auton A; Brooks LD; DePristo MA; Durbin RM; Handsaker RE; Kang HM; Marth GT; McVean GA
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.

2012 | Journal article
Contributors: Rodriguez-Flores JL; Fuller J; Hackett NR; Salit J; Malek JA; Al-Dous E; Chouchane L; Zirie M; Jayoussi A; Mahmoud MA et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations.

2012 | Journal article
Contributors: Omberg L; Salit J; Hackett N; Fuller J; Matthew R; Chouchane L; Rodriguez-Flores JL; Bustamante C; Crystal RG; Mezey JG
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

RNA-Seq quantification of the human small airway epithelium transcriptome.

2012 | Journal article
Contributors: Hackett NR; Butler MW; Shaykhiev R; Salit J; Omberg L; Rodriguez-Flores JL; Mezey JG; Strulovici-Barel Y; Wang G; Didon L et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.

2011-01 | Journal article
Contributors: Chen Y; Zhang K; Wen G; Rao F; Sanchez AP; Wang L; Rodriguez-Flores JL; Mahata M; Mahata SK; Waalen J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.

2010-11 | Journal article
Contributors: Rao F; Zhang K; Zhang L; Rana BK; Wessel J; Fung MM; Rodriguez-Flores JL; Taupenot L; Ziegler MG; O'Connor DT
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.

2010-04 | Journal article
Contributors: Zhang K; Rao F; Wang L; Rana BK; Ghosh S; Mahata M; Salem RM; Rodriguez-Flores JL; Fung MM; Waalen J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.

2010-04 | Journal article
Contributors: Rodríguez-Flores JL; Zhang K; Kang SW; Wen G; Ghosh S; Friese RS; Mahata SK; Subramaniam S; Hamilton BA; O'Connor DT
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.

2010-04 | Journal article
Contributors: Zhang K; Zhang L; Rao F; Brar B; Rodriguez-Flores JL; Taupenot L; O'Connor DT
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells.

2010-03 | Journal article
Contributors: Courel M; Soler-Jover A; Rodriguez-Flores JL; Mahata SK; Elias S; Montero-Hadjadje M; Anouar Y; Giuly RJ; O'Connor DT; Taupenot L
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.

2010-01 | Journal article
Contributors: Chen Y; Wen G; Rao F; Zhang K; Wang L; Rodriguez-Flores JL; Sanchez AP; Mahata M; Taupenot L; Sun P et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.

2009-09 | Journal article
Contributors: Wang L; Rao F; Zhang K; Mahata M; Rodriguez-Flores JL; Fung MM; Waalen J; Cockburn MG; Hamilton BA; Mahata SK et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides.

2009-08 | Journal article
Contributors: Biswas N; Rodriguez-Flores JL; Courel M; Gayen JR; Vaingankar SM; Mahata M; Torpey JW; Taupenot L; O'Connor DT; Mahata SK
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B.

2009-02 | Journal article
Contributors: Zhang K; Rao F; Rana BK; Gayen JR; Calegari F; King A; Rosa P; Huttner WB; Stridsberg M; Mahata M et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Adrenergic polymorphism and the human stress response.

2008-12 | Journal article
Contributors: Rao F; Zhang L; Wessel J; Zhang K; Wen G; Kennedy BP; Rana BK; Das M; Rodriguez-Flores JL; Smith DW et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

2008-10 | Journal article
Contributors: Chen Y; Rao F; Rodriguez-Flores JL; Mahata M; Fung MM; Stridsberg M; Vaingankar SM; Wen G; Salem RM; Das M et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.

2008-07 | Journal article
Contributors: Chen Y; Rao F; Rodriguez-Flores JL; Mahapatra NR; Mahata M; Wen G; Salem RM; Shih PA; Das M; Schork NJ et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

2007-09 | Journal article
Contributors: Zhang L; Rao F; Zhang K; Khandrika S; Das M; Vaingankar SM; Bao X; Rana BK; Smith DW; Wessel J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.

2007-08 | Journal article
Contributors: Rao F; Zhang L; Wessel J; Zhang K; Wen G; Kennedy BP; Rana BK; Das M; Rodriguez-Flores JL; Smith DW et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central