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Other IDs

ResearcherID: M-4899-2013

Keywords

Computational biology, genome, exome, transcriptome, population genetics, precision medicine

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Employment (4)

Regeneron Genetics Center LLC: Tarrytown, NY, US

2019-12-01 to present | Senior Manager (Founder and Special Populations)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Weill Cornell Medicine: New York, New York, US

2016-02-02 to 2019-11-30 | Assistant Professor (Genetic Medicine)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Weill Cornell Medical College: NY, NY, US

2013-07-25 to 2016-02-01 | Instructor (Genetic Medicine)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Weill Cornell Medical College: NY, NY, US

2010-07-01 to 2013-06-31 | Postdoctoral Associate (Genetic Medicine)
Employment
Source: Self-asserted source
JL Rodriguez-Flores

Education and qualifications (2)

University of California San Diego: La Jolla, CA, US

2009-07-01 | PhD (Bioinformatics and Systems Biology)
Education
Source: Self-asserted source
JL Rodriguez-Flores

Massachusetts Institute of Technology: Cambridge, MA, US

1998-07-01 | BS (Biology)
Education
Source: Self-asserted source
JL Rodriguez-Flores

Professional activities (3)

Society for Advancement of Chicanos and Native Americans in Science: Santa Cruz, California, US

2024-01-14 to present | Professional Member
Membership
Source: Self-asserted source
JL Rodriguez-Flores

Society for Molecular Biology & Evolution: Lawrence, KS, US

2014 to present
Membership
Source: Self-asserted source
JL Rodriguez-Flores

American Society of Human Genetics: Bethesda, Maryland, US

2007 to present
Membership
Source: Self-asserted source
JL Rodriguez-Flores

Works (44)

Cysteine-Altering NOTCH3 Variants Are Associated with an Increased Risk of Autoimmune Diseases

Journal of Clinical Medicine
2023-09-29 | Journal article
DOI: 10.3390/jcm12196278
Contributors: Emily Rieder; Jiang Li; Juan L. Rodriguez-Flores; Muhammad Taimur Malik; Vida Abedi; Ramin Zand
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Supplementary Table S8 from Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers

2023-04-04 | Preprint
DOI: 10.1158/2643-3230.22543185.v1
Contributors: Julie E. Feusier; Sasi Arunachalam; Tsewang Tashi; Monika J. Baker; Chad VanSant-Webb; Amber Ferdig; Bryan E. Welm; Juan L. Rodriguez-Flores; Christopher Ours; Lynn B. Jorde et al.
Source: check_circle
Crossref

The QChip1 knowledgebase and microarray for precision medicine in Qatar.

NPJ genomic medicine
2022-01-19 | Journal article
DOI: 10.1038/s41525-021-00270-0
PMID: 35046417
PMC: PMC8770564
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes

Nature Communications
2021-10-12 | Journal article
DOI: 10.1038/s41467-021-25287-y
Contributors: Rozaimi Mohamad Razali; Juan Rodriguez-Flores; Mohammadmersad Ghorbani; Haroon Naeem; Waleed Aamer; Elbay Aliyev; Ali Jubran; Said I. Ismail; Wadha Al-Muftah; Radja Badji et al.
Source: check_circle
Crossref

Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers

Blood Cancer Discovery
2021-05-01 | Journal article
DOI: 10.1158/2643-3230.BCD-20-0094
Contributors: Julie E. Feusier; Sasi Arunachalam; Tsewang Tashi; Monika J. Baker; Chad VanSant-Webb; Amber Ferdig; Bryan E. Welm; Juan L. Rodriguez-Flores; Christopher Ours; Lynn B. Jorde et al.
Source: check_circle
Crossref

Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population.

Scientific reports
2021-01-13 | Journal article
DOI: 10.1038/s41598-020-80040-7
PMID: 33441698
PMC: PMC7806807
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Genome diversity in Ukraine.

GigaScience
2021-01-01 | Journal article
DOI: 10.1093/gigascience/giaa159
PMID: 33438729
PMC: PMC7804371
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation

Genes
2019-01 | Journal article | Author
DOI: 10.3390/genes10010054
Contributors: Sofia Kolchanova; Sergei Kliver; Aleksei Komissarov; Pavel Dobrinin; Gaik Tamazian; Kirill Grigorev; Walter W. Wolfsberger; Audrey J. Majeske; Jafet Velez-Valentin; Ricardo Valentin de la Rosa et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population.

PloS one
2018-09-13 | Journal article
DOI: 10.1371/journal.pone.0199837
PMID: 30212457
PMC: PMC6136697
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Point-of-care whole-exome sequencing of idiopathic male infertility.

Genetics in medicine : official journal of the American College of Medical Genetics
2018-04-12 | Journal article
DOI: 10.1038/gim.2018.10
PMID: 29790874
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population.

Nature communications
2018-01-23 | Journal article
DOI: 10.1038/s41467-017-01972-9
PMID: 29362361
PMC: PMC5780481
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores
grade
Preferred source (of 3)‎

Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder.

PloS one
2017-01-13 | Journal article
DOI: 10.1371/journal.pone.0169994
PMID: 28085938
PMC: PMC5234816
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations

Genome Research
2016 | Journal article
DOI: 10.1101/gr.191478.115
EID:

2-s2.0-84956909090
Contributors: Rodriguez-Flores, J.L.; Fakhro, K.; Agosto-Perez, F.; Ramstetter, M.D.; Arbiza, L.; Vincent, T.L.; Robay, A.; Malek, J.A.; Suhre, K.; Chouchane, L. et al.
Source: Self-asserted source
JL Rodriguez-Flores via Scopus - Elsevier

Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population.

PloS one
2016-08-23 | Journal article
DOI: 10.1371/journal.pone.0161910
PMID: 27551721
PMC: PMC4995036
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

The Qatar genome: a population-specific tool for precision medicine in the Middle East.

Human genome variation
2016-06-30 | Journal article
DOI: 10.1038/hgv.2016.16
PMID: 27408750
PMC: PMC4927697
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores

Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.

Nature genetics
2016-04-25 | Journal article
DOI: 10.1038/ng.3559
PMID: 27111036
PMC: PMC4884158
Contributors: JL Rodriguez-Flores
Source: Self-asserted source
JL Rodriguez-Flores
grade
Preferred source (of 2)‎

Copy number variations in the genome of the Qatari population.

2015 | Journal article
DOI: 10.1186/s12864-015-1991-5
PMID: 26490036
PMC: PMC4618522
Contributors: Fakhro KA; Yousri NA; Rodriguez-Flores JL; Robay A; Staudt MR; Agosto-Perez F; Salit J; Malek JA; Suhre K; Jayyousi A et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

A global reference for human genetic variation.

2015-10 | Journal article
DOI: 10.1038/nature15393
PMID: 26432245
Contributors: 1000 Genomes Project Consortium; Auton A; Brooks LD; Durbin RM; Garrison EP; Kang HM; Korbel JO; Marchini JL; McCarthy S; McVean GA et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.

2014 | Journal article
DOI: 10.1186/gb-2014-15-6-r88
PMID: 24980144
PMC: PMC4197830
Contributors: Colonna V; Ayub Q; Chen Y; Pagani L; Luisi P; Pybus M; Garrison E; Xue Y; Tyler-Smith C; 1000 Genomes Project Consortium et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.

2014 | Journal article
DOI: 10.1038/ncomms4934
PMID: 25653097
PMC: PMC4338501
Contributors: Delaneau O; Marchini J; 1000 Genomes Project Consortium; 1000 Genomes Project Consortium
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations.

2014-01 | Journal article
DOI: 10.1016/j.amjcard.2013.09.021
PMID: 24239320
PMC: PMC3943837
Contributors: Abou Ziki MD; Strulovici-Barel Y; Hackett NR; Rodriguez-Flores JL; Mezey JG; Salit J; Radisch S; Hollmann C; Chouchane L; Malek J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Reconstructing Native American Migrations from Whole-Genome and Whole-Exome Data

PLoS Genet
2013 | Journal article
DOI: 10.1371/journal.pgen.1004023
Contributors: Simon Gravel; Fouad Zakharia; Andres Moreno-Estrada; Jake K. Byrnes; Marina Muzzio; Juan L. Rodriguez-Flores; Eimear E. Kenny; Christopher R. Gignoux; Brian K. Maples; Wilfried Guiblet et al.
Source: Self-asserted source
JL Rodriguez-Flores via Crossref Metadata Search

Exome Sequencing Identifies Potential Risk Variants for Mendelian Disorders at High Prevalence in Qatar.

2013-10 | Journal article
DOI: 10.1002/humu.22460
PMID: 24123366
Contributors: Rodriguez-Flores JL; Fakhro K; Hackett NR; Salit J; Fuller J; Agosto-Perez F; Gharbiah M; Malek JA; Zirie M; Jayyousi A et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Integrative annotation of variants from 1092 humans: application to cancer genomics.

2013-10 | Journal article
DOI: 10.1126/science.1235587
PMID: 24092746
Contributors: Khurana E; Fu Y; Colonna V; Mu XJ; Kang HM; Lappalainen T; Sboner A; Lochovsky L; Chen J; Harmanci A et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.

PloS one
2012 | Journal article
EID:

2-s2.0-84876451303
Contributors: Rodriguez-Flores, J.L.; Fuller, J.; Hackett, N.R.; Salit, J.; Malek, J.A.; Al-Dous, E.; Chouchane, L.; Zirie, M.; Jayoussi, A.; Mahmoud, M.A. et al.
Source: Self-asserted source
JL Rodriguez-Flores via Scopus - Elsevier

An integrated map of genetic variation from 1,092 human genomes.

2012-11 | Journal article
DOI: 10.1038/nature11632
PMID: 23128226
PMC: PMC3498066
Contributors: 1000 Genomes Project Consortium; Abecasis GR; Auton A; Brooks LD; DePristo MA; Durbin RM; Handsaker RE; Kang HM; Marth GT; McVean GA
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.

2012 | Journal article
DOI: 10.1371/journal.pone.0047614
PMID: 23139751
PMC: PMC3490971
Contributors: Rodriguez-Flores JL; Fuller J; Hackett NR; Salit J; Malek JA; Al-Dous E; Chouchane L; Zirie M; Jayoussi A; Mahmoud MA et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations.

2012 | Journal article
DOI: 10.1186/1471-2156-13-49
PMID: 22734698
PMC: PMC3512499
Contributors: Omberg L; Salit J; Hackett N; Fuller J; Matthew R; Chouchane L; Rodriguez-Flores JL; Bustamante C; Crystal RG; Mezey JG
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

RNA-Seq quantification of the human small airway epithelium transcriptome.

2012 | Journal article
DOI: 10.1186/1471-2164-13-82
PMID: 22375630
PMC: PMC3337229
Contributors: Hackett NR; Butler MW; Shaykhiev R; Salit J; Omberg L; Rodriguez-Flores JL; Mezey JG; Strulovici-Barel Y; Wang G; Didon L et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.

2011-01 | Journal article
DOI: 10.1038/ajh.2010.186
PMID: 20814407
Contributors: Chen Y; Zhang K; Wen G; Rao F; Sanchez AP; Wang L; Rodriguez-Flores JL; Mahata M; Mahata SK; Waalen J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.

2010-11 | Journal article
DOI: 10.1007/s10571-010-9535-7
PMID: 20571875
PMC: PMC3008933
Contributors: Rao F; Zhang K; Zhang L; Rana BK; Wessel J; Fung MM; Rodriguez-Flores JL; Taupenot L; Ziegler MG; O'Connor DT
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.

2010-04 | Journal article
DOI: 10.1016/j.jacc.2009.11.064
PMID: 20359597
PMC: PMC2889490
Contributors: Zhang K; Rao F; Wang L; Rana BK; Ghosh S; Mahata M; Salem RM; Rodriguez-Flores JL; Fung MM; Waalen J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.

2010-04 | Journal article
DOI: 10.1007/s00335-010-9253-y
PMID: 20204374
PMC: PMC2844968
Contributors: Rodríguez-Flores JL; Zhang K; Kang SW; Wen G; Ghosh S; Friese RS; Mahata SK; Subramaniam S; Hamilton BA; O'Connor DT
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.

2010-04 | Journal article
DOI: 10.1161/CIRCGENETICS.109.904813
PMID: 20124442
PMC: PMC3064953
Contributors: Zhang K; Zhang L; Rao F; Brar B; Rodriguez-Flores JL; Taupenot L; O'Connor DT
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells.

2010-03 | Journal article
DOI: 10.1074/jbc.M109.064196
PMID: 20061385
PMC: PMC2843166
Contributors: Courel M; Soler-Jover A; Rodriguez-Flores JL; Mahata SK; Elias S; Montero-Hadjadje M; Anouar Y; Giuly RJ; O'Connor DT; Taupenot L
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.

2010-01 | Journal article
DOI: 10.1097/HJH.0b013e328332bc87
PMID: 20009769
PMC: PMC2860271
Contributors: Chen Y; Wen G; Rao F; Zhang K; Wang L; Rodriguez-Flores JL; Sanchez AP; Mahata M; Taupenot L; Sun P et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.

2009-09 | Journal article
DOI: 10.1016/j.jacc.2009.05.035
PMID: 19712806
PMC: PMC2792636
Contributors: Wang L; Rao F; Zhang K; Mahata M; Rodriguez-Flores JL; Fung MM; Waalen J; Cockburn MG; Hamilton BA; Mahata SK et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides.

2009-08 | Journal article
DOI: 10.1210/en.2008-1613
PMID: 19372204
PMC: PMC2717865
Contributors: Biswas N; Rodriguez-Flores JL; Courel M; Gayen JR; Vaingankar SM; Mahata M; Torpey JW; Taupenot L; O'Connor DT; Mahata SK
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B.

2009-02 | Journal article
DOI: 10.1161/CIRCGENETICS.108.785659
PMID: 20011129
PMC: PMC2792940
Contributors: Zhang K; Rao F; Rana BK; Gayen JR; Calegari F; King A; Rosa P; Huttner WB; Stridsberg M; Mahata M et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Adrenergic polymorphism and the human stress response.

2008-12 | Journal article
DOI: 10.1196/annals.1410.085
PMID: 19120120
PMC: PMC2743085
Contributors: Rao F; Zhang L; Wessel J; Zhang K; Wen G; Kennedy BP; Rana BK; Das M; Rodriguez-Flores JL; Smith DW et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

2008-10 | Journal article
DOI: 10.1016/j.jacc.2008.07.047
PMID: 19017515
PMC: PMC2659417
Contributors: Chen Y; Rao F; Rodriguez-Flores JL; Mahata M; Fung MM; Stridsberg M; Vaingankar SM; Wen G; Salem RM; Das M et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.

2008-07 | Journal article
DOI: 10.1038/ki.2008.113
PMID: 18432188
PMC: PMC2576285
Contributors: Chen Y; Rao F; Rodriguez-Flores JL; Mahapatra NR; Mahata M; Wen G; Salem RM; Shih PA; Das M; Schork NJ et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

2007-09 | Journal article
DOI: 10.1172/JCI31093
PMID: 17717598
PMC: PMC1950457
Contributors: Zhang L; Rao F; Zhang K; Khandrika S; Das M; Vaingankar SM; Bao X; Rana BK; Smith DW; Wessel J et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.

2007-08 | Journal article
DOI: 10.1161/CIRCULATIONAHA.106.682302
PMID: 17698732
Contributors: Rao F; Zhang L; Wessel J; Zhang K; Wen G; Kennedy BP; Rana BK; Das M; Rodriguez-Flores JL; Smith DW et al.
Source: Self-asserted source
JL Rodriguez-Flores via Europe PubMed Central
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