Personal information

drug discovery, medicinal chemistry, fragments
United Kingdom

Biography

Paul is currently Head of The Drug Discovery Unit. His current role is to develop translational research at Dundee, by bringing together his and other’s experience of Drug Discovery in the Pharma/Biotech sector with basic academic research to de-risk novel targets for drug discovery and new treatments for diseases such as TB and cancer.

Previously Paul worked within the BioPharma industry (GSK, Astex Therapeutics) for 23 years, gaining experience across a range of therapeutic areas. He played a significant part in seven compounds entering pre-clinical development, two of which are now in Phase II clinical trials. Paul obtained his BSc and PhD in Chemistry from the University of Birmingham. Paul has published around 50 papers and he is an inventor on over 35 patent applications.

Activities

Employment (4)

University of Dundee: Dundee, Dundee, GB

2006-03-16 to present | Head of Drug Discovery Unit (Drug Discovery Unit)
Employment
Source: Self-asserted source
Paul G Wyatt

Astex Pharmaceuticals European office: Cambridge, Cambridgeshire, GB

2001-10-01 to 2006-03-15 | Project Leader, Group Leader (Medicinal Chemistry)
Employment
Source: Self-asserted source
Paul G Wyatt

Glaxo, GlaxoWellcome, GlaxoSmithKline: Greenford, Stevenage, GB

1991-01 to 2001-09 (Medicinal Chemistry)
Employment
Source: Self-asserted source
Paul G Wyatt

Beecham, SmithKlineBeecham: Epsom, GB

1983-11-07 to 1990-12-31 (Antivirals, Medicinal Chemistry)
Employment
Source: Self-asserted source
Paul G Wyatt

Education and qualifications (2)

University of Birmingham: Birmingham, GB

1980-09 to 1983-10 | PhD (Chemistry)
Education
Source: Self-asserted source
Paul G Wyatt

University of Birmingham: Birmigham, GB

1977-09 to 1980-06 | BSc (Chemistry)
Education
Source: Self-asserted source
Paul G Wyatt

Works (50 of 51)

Items per page:
Page 1 of 2

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

Antimicrobial Agents and Chemotherapy
2013 | Journal article
DOI:

10.1128/AAC.02398-12

Contributors: De Rycker, M.; Hallyburton, I.; Thomas, J.; Campbell, L.; Wyllie, S.; Joshi, D.; Cameron, S.; Gilbert, I.H.; Wyatt, P.G.; Frearson, J.A. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

De Novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

ACS Chemical Biology
2013 | Journal article
DOI:

10.1021/cb300729y

Contributors: Urich, R.; Wishart, G.; Kiczun, M.; Richters, A.; Tidten-Luksch, N.; Rauh, D.; Sherborne, B.; Wyatt, P.G.; Brenk, R.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

PLoS Neglected Tropical Diseases
2013 | Journal article
DOI:

10.1371/journal.pntd.0002492

Contributors: Pizarro, J.C.; Hills, T.; Senisterra, G.; Wernimont, A.K.; Mackenzie, C.; Norcross, N.R.; Ferguson, M.A.J.; Wyatt, P.G.; Gilbert, I.H.; Hui, R.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Fragment-based hit identification: Thinking in 3D

Drug Discovery Today
2013 | Journal article
DOI:

10.1016/j.drudis.2013.07.011

Contributors: Morley, A.D.; Pugliese, A.; Birchall, K.; Bower, J.; Brennan, P.; Brown, N.; Chapman, T.; Drysdale, M.; Gilbert, I.H.; Hoelder, S. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

From on-target to off-target activity: Identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

ChemMedChem
2013 | Journal article
DOI:

10.1002/cmdc.201300072

Contributors: Woodland, A.; Grimaldi, R.; Luksch, T.; Cleghorn, L.A.T.; Ojo, K.K.; VanVoorhis, W.C.; Brenk, R.; Frearson, J.A.; Gilbert, I.H.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Structure-activity relationship studies of pyrrolone antimalarial agents

ChemMedChem
2013 | Journal article
DOI:

10.1002/cmdc.201300177

Contributors: Murugesan, D.; Kaiser, M.; White, K.L.; Norval, S.; Riley, J.; Wyatt, P.G.; Charman, S.A.; Read, K.D.; Yeates, C.; Gilbert, I.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Chemical proteomic analysis reveals the drugability of the kinome of trypanosoma brucei

ACS Chemical Biology
2012 | Journal article
DOI:

10.1021/cb300326z

Contributors: Urbaniak, M.D.; Mathieson, T.; Bantscheff, M.; Eberhard, D.; Grimaldi, R.; Miranda-Saavedra, D.; Wyatt, P.; Ferguson, M.A.J.; Frearson, J.; Drewes, G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Design, synthesis and biological evaluation of Trypanosoma brucei Trypanothione Synthetase inhibitors

ChemMedChem
2012 | Journal article
DOI:

10.1002/cmdc.201100420

Contributors: Spinks, D.; Torrie, L.S.; Thompson, S.; Harrison, J.R.; Frearson, J.A.; Read, K.D.; Fairlamb, A.H.; Wyatt, P.G.; Gilbert, I.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Discovery of a novel class of orally active trypanocidal N-Myristoyltransferase inhibitors

Journal of Medicinal Chemistry
2012 | Journal article
DOI:

10.1021/jm201091t

Contributors: Brand, S.; Cleghorn, L.A.T.; McElroy, S.P.; Robinson, D.A.; Smith, V.C.; Hallyburton, I.; Harrison, J.R.; Norcross, N.R.; Spinks, D.; Bayliss, T. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Quinol derivatives as potential trypanocidal agents

Bioorganic and Medicinal Chemistry
2012 | Journal article
DOI:

10.1016/j.bmc.2011.12.018

Contributors: Capes, A.; Patterson, S.; Wyllie, S.; Hallyburton, I.; Collie, I.T.; McCarroll, A.J.; Stevens, M.F.G.; Frearson, J.A.; Wyatt, P.G.; Fairlamb, A.H. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism

Journal of Biological Chemistry
2011 | Journal article
DOI:

10.1074/jbc.M110.214833

Contributors: König, J.; Wyllie, S.; Wells, G.; Stevens, M.F.; Wyatt, P.G.; Fairlamb, A.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase1

ChemMedChem
2011 | Journal article
DOI:

10.1002/cmdc.201000450

Contributors: Spinks, D.; Ong, H.B.; Mpamhanga, C.P.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Read, K.D.; Frearson, J.A.; Wyatt, P.G.; Brenk, R. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: Discovery, synthesis, and characterization of their binding mode by protein crystallography

Journal of Medicinal Chemistry
2011 | Journal article
DOI:

10.1021/jm200312v

Contributors: Patterson, S.; Alphey, M.S.; Jones, D.C.; Shanks, E.J.; Street, I.P.; Frearson, J.A.; Wyatt, P.G.; Gilbert, I.H.; Fairlamb, A.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

ChemMedChem
2011 | Journal article
DOI:

10.1002/cmdc.201100344

Contributors: Cleghorn, L.A.T.; Woodland, A.; Collie, I.T.; Torrie, L.S.; Norcross, N.; Luksch, T.; Mpamhanga, C.; Walker, R.G.; Mottram, J.C.; Brenk, R. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

ChemMedChem
2011 | Journal article
DOI:

10.1002/cmdc.201100278

Contributors: Smith, V.C.; Cleghorn, L.A.T.; Woodland, A.; Spinks, D.; Hallyburton, I.; Collie, I.T.; YiMok, N.; Norval, S.; Brenk, R.; Fairlamb, A.H. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Progress in neglected disease drug discovery

Current Topics in Medicinal Chemistry
2011 | Journal article
DOI:

10.2174/156802611795429149

Contributors: Hopkins, A.L.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Target validation: Linking target and chemical properties to desired product profile

Current Topics in Medicinal Chemistry
2011 | Journal article
DOI:

10.2174/156802611795429185

Contributors: Wyatt, P.G.; Gilbert, I.H.; Read, K.D.; Fairlamb, A.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Drug discovery in academia: The third way?

Expert Opinion on Drug Discovery
2010 | Journal article
DOI:

10.1517/17460441.2010.506508

Contributors: Frearson, J.; Wyatt, P.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Nature
2010 | Journal article
DOI:

10.1038/nature08893

Contributors: Frearson, J.A.; Brand, S.; McElroy, S.P.; Cleghorn, L.A.T.; Smid, O.; Stojanovski, L.; Price, H.P.; Guther, M.L.S.; Torrie, L.S.; Robinson, D.A. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei

Journal of Biological Chemistry
2010 | Journal article
DOI:

10.1074/jbc.M109.074591

Contributors: Ma, J.; Benz, C.; Grimaldi, R.; Stockdale, C.; Wyatt, P.; Frearson, J.; Hammarton, T.C.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Chemical validation of trypanothione synthetase: A potential drug target for human trypanosomiasis

Journal of Biological Chemistry
2009 | Journal article
DOI:

10.1074/jbc.M109.045336

Contributors: Torrie, L.S.; Wyllie, S.; Spinks, D.; Oza, S.L.; Thompson, S.; Harrison, J.R.; Gilbert, I.H.; Wyatt, P.G.; Fairlamb, A.H.; Frearson, J.A.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity

Journal of Medicinal Chemistry
2009 | Journal article
DOI:

10.1021/jm800984v

Contributors: Howard, S.; Berdini, V.; Boulstridge, J.A.; Carr, M.G.; Cross, D.M.; Curry, J.; Devine, L.A.; Early, T.R.; Fazal, L.; Gill, A.L. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

ChemMedChem
2009 | Journal article
DOI:

10.1002/cmdc.200900262

Contributors: Spinks, D.; Shanks, E.J.; Cleghorn, L.A.T.; McElroy, S.; Jones, D.; James, D.; Fairlamb, A.H.; Frearson, J.A.; Wyatt, P.G.; Gilbert, I.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

One scaffold, three binding modes: Novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening

Journal of Medicinal Chemistry
2009 | Journal article
DOI:

10.1021/jm900414x

Contributors: Mpamhanga, C.P.; Spinks, D.; Tulloch, L.B.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Fairlamb, A.H.; Wyatt, P.G.; Frearson, J.A.; Hunter, W.N. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Synthesis and evaluation of 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl) piperidine (BTCP) analogues as inhibitors of trypanothione reductase

ChemMedChem
2009 | Journal article
DOI:

10.1002/cmdc.200900098

Contributors: Patterson, S.; Jones, D.C.; Shanks, E.J.; Frearson, J.A.; Gilbert, I.H.; Wyatt, P.G.; Fairlamb, A.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

The emerging academic drug-discovery sector

Future Medicinal Chemistry
2009 | Journal article
DOI:

10.4155/fmc.09.78

Contributors: Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

Journal of Medicinal Chemistry
2008 | Journal article
DOI:

10.1021/jm800382h

Contributors: Wyatt, P.G.; Woodhead, A.J.; Berdini, V.; Boulstridge, J.A.; Carr, M.G.; Cross, D.M.; Davis, D.J.; Devine, L.A.; Early, T.R.; Feltell, R.E. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases

ChemMedChem
2008 | Journal article
DOI:

10.1002/cmdc.200700139

Contributors: Brenk, R.; Schipani, A.; James, D.; Krasowski, A.; Gilbert, I.H.; Frearson, J.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Identification of inhibitors of protein kinase B using fragment-based lead discovery

Journal of Medicinal Chemistry
2007 | Journal article
DOI:

10.1021/jm070091b

Contributors: Saxty, G.; Woodhead, S.J.; Berdini, V.; Davies, T.G.; Verdonk, M.L.; Wyatt, P.G.; Boyle, R.G.; Barford, D.; Downham, R.; Garrett, M.D. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Target assessment for antiparasitic drug discovery

Trends in Parasitology
2007 | Journal article
DOI:

10.1016/j.pt.2007.08.019

Contributors: Frearson, J.A.; Wyatt, P.G.; Gilbert, I.H.; Fairlamb, A.H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Bioorganic and Medicinal Chemistry
2006 | Journal article
DOI:

10.1016/j.bmc.2005.09.055

Contributors: Collins, I.; Caldwell, J.; Fonseca, T.; Donald, A.; Bavetsias, V.; Hunter, L.-J.K.; Garrett, M.D.; Rowlands, M.G.; Aherne, G.W.; Davies, T.G. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR

Bioorganic and Medicinal Chemistry Letters
2005 | Journal article
DOI:

10.1016/j.bmcl.2005.03.045

Contributors: Wyatt, P.G.; Allen, M.J.; Borthwick, A.D.; Davies, D.E.; Exall, A.M.; Hatley, R.J.D.; Irving, W.R.; Livermore, D.G.; Miller, N.D.; Nerozzi, F. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

2,5-Diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics

Journal of Medicinal Chemistry
2005 | Journal article
DOI:

10.1021/jm050557v

Contributors: Borthwick, A.D.; Davies, D.E.; Exall, A.M.; Livermore, D.G.; Sollis, S.L.; Nerozzi, F.; Allen, M.J.; Perren, M.; Shabbir, S.S.; Woollard, P.M. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Detection of ligands from a dynamic combinatorial library by X-ray crystallography

Angewandte Chemie - International Edition
2003 | Journal article
DOI:

10.1002/anie.200351951

Contributors: Congreve, M.S.; Davis, D.J.; Devine, L.; Granata, C.; O'Reilly, M.; Wyatt, P.G.; Jhoti, H.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

A novel and efficient regiospecific preparation of arenesulfonamide derivatives of 3,5-diamino-1,2,4-triazole

Synthesis
2002 | Journal article
Contributors: Chibale, K.; Dauvergne, J.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Identification of potent and selective oxytocin antagonists. Part 1: Indole and benzofuran derivatives

Bioorganic and Medicinal Chemistry Letters
2002 | Journal article
DOI:

10.1016/S0960-894X(02)00159-2

Contributors: Wyatt, P.G.; Allen, M.J.; Chilcott, J.; Foster, A.; Livermore, D.G.; Mordaunt, J.E.; Scicinski, J.; Woollard, P.M.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives

Bioorganic and Medicinal Chemistry Letters
2002 | Journal article
DOI:

10.1016/S0960-894X(02)00160-9

Contributors: Wyatt, P.G.; Allen, M.J.; Chilcott, J.; Gardner, C.J.; Livermore, D.G.; Mordaunt, J.E.; Nerozzi, F.; Patel, M.; Perren, M.J.; Weingarten, G.G. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides

Bioorganic and Medicinal Chemistry Letters
2001 | Journal article
DOI:

10.1016/S0960-894X(01)00019-1

Contributors: Wyatt, P.G.; Coomber, B.A.; Evans, D.N.; Jack, T.I.; Fulton, H.E.; Wonacott, A.J.; Colman, P.; Varghese, J.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Structure-activity relationship investigations of a potent and selective benzodiazepine oxytocin antagonist

Bioorganic and Medicinal Chemistry Letters
2001 | Journal article
DOI:

10.1016/S0960-894X(01)00202-5

Contributors: Wyatt, P.G.; Allen, M.J.; Chilcott, J.; Hickin, G.; Miller, N.D.; Woollard, P.M.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino- 4H-pyran-6-carboxamides

Journal of Medicinal Chemistry
1998 | Journal article
DOI:

10.1021/jm970374b

Contributors: Smith, P.W.; Sollis, S.L.; Howes, P.D.; Cherry, P.C.; Starkey, I.D.; Cobley, K.N.; Weston, H.; Scicinski, J.; Merritt, A.; Whittington, A. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

A short high yielding synthesis of the potent anti-VZV carbocyclic nucleoside analogue carba-BVDU

Nucleosides and Nucleotides
1995 | Journal article
Contributors: Wyatt, P.G.; Anslow, A.S.; Coomber, B.A.; Cousins, R.P.C.; Evans, D.N.; Gilbert, V.S.; Humber, D.C.; Paternoster, I.L.; Sollis, S.L.; Tapolczay, D.J. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Approaches to carbocyclic analogues of the potent neuraminidase inhibitor 4-guanidino-Neu5Ac2en. X-ray molecular structure of N-[(1S,2S,6R)-2-azido-6- benzyloxymethyl-4-formylcyclohex-3-enyl]acetamide

Journal of the Chemical Society, Perkin Transactions 1
1995 | Journal article
Contributors: Chandler, M.; Conroy, R.; Cooper, A.W.J.; Lamont, R.B.; Scicinski, J.J.; Smart, J.E.; Storer, R.; Weir, N.G.; Wilson, R.D.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Benzophenone derivatives: A novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase

Journal of Medicinal Chemistry
1995 | Journal article
Contributors: Wyatt, P.G.; Bethell, R.C.; Cammack, N.; Charon, D.; Dodic, N.; Dumaitre, B.; Evans, D.N.; Green, D.V.S.; Hopewell, P.L.; Humber, D.C. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Synthesis and structure activity relationships of a series of penicillin- derived pseudosymmetric inhibitors of HIV-1 proteinase

Antiviral Chemistry and Chemotherapy
1994 | Journal article
Contributors: Humber, D.C.; Bamford, M.J.; Bethell, R.C.; Cammack, N.; Orr, D.C.; Storer, R.; Weingarten, G.G.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Synthesis, oral bioavailability and in vivo activity of acetal derivatives of the selective antiherpesvirus agent 9-(3-hydroxypropoxy) guanine (BRL 44385)

Antiviral Chemistry and Chemotherapy
1994 | Journal article
Contributors: Harnden, M.R.; Ashton, R.J.; Boyd, M.R.; Jennings, L.J.; Sutton, D.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

A series of penicillin derived C2-symmetric inhibitors of HIV-1 proteinase: Synthesis, mode of interaction, and structure-activity relationships

Journal of Medicinal Chemistry
1993 | Journal article
Contributors: Humber, D.C.; Bamford, M.J.; Bethell, R.C.; Cammack, N.; Cobley, K.; Evans, D.N.; Gray, N.M.; Hann, M.M.; Orr, D.C.; Saunders, J. et al.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy]purines

Journal of Medicinal Chemistry
1990 | Journal article
Contributors: Harnden, M.R.; Wyatt, P.G.; Boyd, M.R.; Sutton, D.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Synthesis of 9-hydroxypurines: Intermediates to novel antiviral acyclonucleosides

Tetrahedron Letters
1990 | Journal article
DOI:

10.1016/0040-4039(90)80104-T

Contributors: Harnden, M.R.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Analogues of the antiviral acyclonucleoside 9-(4-hydroxy-3-hydroxymethylbutyl)guanine. Part 1. Substitutions on C-2′ of the acyclic N-9 substituent

Journal of the Chemical Society, Perkin Transactions 1
1988 | Journal article
Contributors: Harnden, M.R.; Parkin, A.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier

Synthesis of 9-(3-hydroxypropoxy)guanine, a novel antiviral acyclonucleoside

Tetrahedron Letters
1988 | Journal article
Contributors: Harnden, M.R.; Parkin, A.; Wyatt, P.G.
Source: Self-asserted source
Paul G Wyatt via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (1 review for 1 publication/grant)

Review activity for Journal of medicinal chemistry. (1)