Personal information

Biography

Lúcio José de Lara Santos, MD, PhD, is senior surgeon, Professor of Surgical Oncology, former
director of the Digestive Pathology Unit, currently the coordinator of the Experimental Pathology
and Therapeutics Group and member of the PIO’s Surgical Oncology Department. He also serves
as Adviser of Oncology for ONCOCIR - Education and Care in Oncology, Angola.
Prof. Santos received MD degrees from both Agostinho Neto University, Angola, and Nova
University, Lisboa, Portugal. He received his PhD in Surgery and Oncobiology from Porto
University, Porto, Portugal. He served a fellowship in General Surgery at the Portuguese Institute
of Oncology and received specialized training in esophageal surgery at Leiden Academy and in
liver surgery at Hôpital Paul Brousse in Villejuif, France, and The University of Texas MD Anderson
Cancer Center in Houston, Texas.
Prof. Santos’ research interests include surgical oncology and carcinogenesis, working in Portugal
and Angola. As a Consultant Surgical Oncologist and General Surgeon in the Portuguese Institute
of Oncology (Digestive Pathology and Breast Cancer Unit), Prof. de Lara Santos conducts
research in experimental pathology and oncology, including gastrointestinal, breast cancer, and
cancers related to infections. He has extensive experience in organizing oncology facilities such as
chemotherapy, radiation therapy, and surgical oncology services, and in standardizing procedures
and teaching of general medicine, surgery, and oncology.
Additionally, Prof. de Lara Santos is the author or coauthor of nearly 60 peer-reviewed publications
in journals including Nature Communications, Annals of Oncology, BMC Cancer, British Journal of
Cancer, and Molecular Oncology.

Activities

Funding (23)

Circulating Tumour Cells glycosylation for improved esophageal cancer care: a step towards precision oncology

2017 to 2020 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

NORTE-45-2015-02

Source: check_circle
CIÊNCIAVITAE

Towards a single therapy with a synergistic drug combination against triple negative breast cancer and neuroblastoma by nucleolin-mediated multicellular targeting

2015 to 2019 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

ENMed/0005/2015

Source: check_circle
CIÊNCIAVITAE

Photodynamic Therapy With LUZ11 in Advanced Head and Neck Cancer

2014 to present | Contract
N/A (N/A, PT)
GRANT_NUMBER: NCT02070432
Source: check_circle
CIÊNCIAVITAE

A double-blind, randomised, placebo controlled Phase I li study of nintedanib plus best supportive care (BSC) versus placebo plus BSC in patients with colorectal cancer refractory to standard therapies

2014 to 2017 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

LUME COLON 1

Source: check_circle
CIÊNCIAVITAE

Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells.

2013-06 to 2015 | Contract
Universidade do Algarve Faculdade de Ciências e Tecnologia (Faro, PT)
Source: check_circle
CIÊNCIAVITAE

Phase II trial of the addition of Lapatinib to Capecitabine versus Capecitabine alone as radio-sensitizers in KRAS wild type resectable rectal cancer

2013 to present | Contract
N/A (N/A, PT)
GRANT_NUMBER: 2013-001203-36)
Source: check_circle
CIÊNCIAVITAE

A multi-center, randomized, open-label, mechanism of action trial on the biological effects of the therapeutic cancer vaccine Stimuvax® (L BLP25) in rectal cancer subjects undergoing neoadjuvant chemoradiotherapy.

2012 to 2017 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

EMR 63325-013 SPRINT

Source: check_circle
CIÊNCIAVITAE

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled Study of Rilotumumab (AMG 102) with Epirubicin, Cisplatin, and Capecitabine (ECX) as First-line Therapy in Advanced MET- Positive Gastric or Gastroesophageal Junction Adenocarcinoma

2012 to 2015 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

RILOMET-1

Source: check_circle
CIÊNCIAVITAE

IOERT - O efeito da blindagem nas distribuições de dose em Radioterapia Intra-operatória com electrões: um estudo por simulação Monte Carlo

2012 to 2015 | Contract
N/A (N/A, PT)
Source: check_circle
CIÊNCIAVITAE

Phase III clinical trial for evaluation of prophylactic treatment with minocycline versus reactive treatment of dermatological toxicity secondary to cetuximab in patients with metastatic colorectal cancer.

2011 to present | Contract
N/A (N/A, PT)
GRANT_NUMBER: GEOS-01-2011
Source: check_circle
CIÊNCIAVITAE

A randomized, open-label, multicenter Phase lllb study comparing two trastuzumab dosing regimens, each in combination with cisplatin/capecitabine chemotherapy, as first-line therapy in patients with HER2-positive metastatic gastric or gastro-esophageal junction adenocarcinoma who have not received p

2011 to 2016 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

HELOISE

Source: check_circle
CIÊNCIAVITAE

Colorectal anastomosis proteced by a biodegradable drain fixed to the anastomosis by a circular stapler: A Multi-Center Randomized Controlled Trial

2011 to 2014 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

C-Seal Trial

Source: check_circle
CIÊNCIAVITAE

Ganitumab in Locally Advanced Unresectable Adenocarcinma of the Pancreas

2011 to 2012 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

NCT01318642

Source: check_circle
CIÊNCIAVITAE

REVEAL: Randomized Evaluation of the Effects of Anacetrapib Through Lipid-modification (REVEAL)

2010 to 2019 | Contract
N/A (N/A, PT)
GRANT_NUMBER: REVEAL
Source: check_circle
CIÊNCIAVITAE

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled, Trial of AMG 479 or Placebo in Combination with Gemcitabine as First-line Therapy for Metastatic Adenocarcinoma of the Pancreas.

2010 to 2016 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

GAMMA

Source: check_circle
CIÊNCIAVITAE

Biomarcadores para avaliação de efectividade terapêutica no carcinoma colorectal

2010 to 2015 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

Projecto DO IT. PPS 5

Source: check_circle
CIÊNCIAVITAE

ToGA Study - A Study of Herceptin (Trastuzumab) in Combination With Chemotherapy Compared With Chemotherapy Alone in Patients With HER2-Positive Advanced Gastric Cancer

2009 to 2014 | Contract
N/A (N/A, PT)
GRANT_NUMBER: ToGA
Source: check_circle
CIÊNCIAVITAE

Detecção precoce do cancro utilizando novos marcadores serológicos com base em modificações Pós-Translacionais de Glicoproteinas, O-PTM-Biomarkers

2007 to present | Contract
N/A (N/A, PT)
GRANT_NUMBER: PIC/IC/82716/2007
Source: check_circle
CIÊNCIAVITAE

Study Of FOLFIRI Chemotherapy With Or Without Sunitinib In Patients With Metastatic Colorectal Cancer.

2007 to 2010 | Contract
N/A (N/A, PT)
GRANT_NUMBER: 2007-000325-21
Source: check_circle
CIÊNCIAVITAE

Comparison of Treatment Effect of Chemotherapy With Panitumumab to Chemotherapy Alone

2006 to 2018 | Contract
N/A (N/A, PT)
GRANT_NUMBER: 20050181
Source: check_circle
CIÊNCIAVITAE

Evaluation of the Efficacy of Xaliproden (SR57746A) in Preventing the Neurotoxicity of Oxaliplatin / 5FU/LV Chemotherapy

2006 to 2016 | Contract
N/A (N/A, PT)
GRANT_NUMBER: EFC5505
Source: check_circle
CIÊNCIAVITAE

An International Phase 2 Study Of SU011248 In Patients With Advanced / Metastatic Gastric Cancer Failing Chemotherapy

2005 to 2014 | Contract
N/A (N/A, PT)
GRANT_NUMBER: A6181054
Source: check_circle
CIÊNCIAVITAE

A Randomized, Three Arm Multinational Phase Ili Study to lnvestigate Bevacizumab (q3w or q2w) in Combination With Either lntermittent Capecitabine Plus Oxaliplatin (XELOX) (q3w) or Fluorouracil/ Leucovor in With Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 Regimen Alone as Adjuvant Chemotherapy in Colon C

2004 to 2012 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

AVANT

Source: check_circle
CIÊNCIAVITAE

Peer review (4 reviews for 3 publications/grants)

Review activity for Cancer immunology and immunotherapy. (1)
Review activity for Clinical epigenetics (2)
Review activity for Journal of cancer metastasis and treatment. (1)