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Biography

Alexandra Nunes is an Assistant Professor at the Department of Medical Sciences, University of Aveiro (UA) and Principal Investigator at Institute for Biomedicine (iBiMED) - Aveiro. During her career she has been teaching courses related to biochemistry, molecular biology, molecular biomedicine in both undergraduate and graduate levels. Alexandra Nunes started her undergraduate studies at the University of Aveiro, in Biochemistry and Food Chemistry which she concluded in 1996, and in 2000 concluded her Master Degree in Natural Products and Food Stuff in the same institution. She developed her PhD in Chemistry, in the Chemistry Department of University of Aveiro from 2000 to 2004. She is specialist in metabolic profiling, spectroscopic techniques and multivariate analysis of spectroscopic signals. Alexandra Nunes is interested in the application of spectroscopic techniques to the analysis of complex matrices, she uses multivariate analysis to the interpretation of spectroscopic signals for the analysis of biological samples. She applies FTIR spectroscopy as a screening tool to discriminate biologic samples with different age and age-related pathologies with particular interest in protein aggregation profile. She is putting a lot of effort in the identification of biomarkers of aging and age-related diseases as well as cancer biomarkers to be used in early diagnosis. Alexandra Nunes has been involved in 5 research projects has graduated 1 PhD student and 10 master students. Within these projects and other parallel research activities, she has published >50 papers, 8 books chapters (scopus h index=18). Actually, and she manages a research group with 10 people, including of 3 PhD student, 5 MSc students and 6 BSc students.

Activities

Employment (1)

Universidade de Aveiro: Aveiro, Aveiro, PT

2007 to present | Professor Auxiliar (Departamento de Ciências Médicas)
Employment
Source: Self-asserted source
Alexandra Nunes

Education and qualifications (1)

Universidade de Aveiro: Aveiro, Aveiro, PT

2004-10-15 | PhD in Chemistry (Departamento de Química)
Education
Source: Self-asserted source
Alexandra Nunes

Works (50 of 92)

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Page 1 of 2

Impaired Extracellular Proteostasis in Patients with Heart Failure

Archives of Medical Research
2023-04 | Journal article
Contributors: Marisol Gouveia; Manuel Teixeira; Cristine Schmidt; Mário Lopes; Dário Trindade; Sandra Magalhães; Ana Gabriela Henriques; Alexandra Nunes; Mário Santos; Sandra Vieira et al.
Source: check_circle
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Age-Related Fourier-Transform Infrared Spectroscopic Changes in Protein Conformation in an Aging Model of Human Dermal Fibroblasts

Spectroscopy Journal
2023-04-24 | Journal article
Contributors: Cláudia Martins; Idália Almeida; Sandra Rebelo; Sandra Magalhães; Alexandra Nunes
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FTIR spectroscopy confirms age-related changes in protein conformation in a new independent dataset of human plasma samples

Medical Research Archives
2022 | Journal article
Part of ISSN: 2375-1916
Part of ISSN: 2375-1924
Source: Self-asserted source
Alexandra Nunes
grade
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Development and validation of the clinical report form for nodular thyroid pathologies

Archives of Endocrinology and Metabolism
2022-12-05 | Journal article
Contributors: Vanessa Neto; Sara Esteves-Ferreira; Isabel Inácio; Márcia Alves; Rosa Dantas; Teresa Azevedo; Joana Guimarães; Maria Teresa Herdeiro; Alexandra Nunes
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The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence

International Journal of Molecular Sciences
2022-05-23 | Journal article
Contributors: Sandra Magalhães; Idália Almeida; Cátia D. Pereira; Sandra Rebelo; Brian J. Goodfellow; Alexandra Nunes
Source: check_circle
Crossref

Proteostasis Response to Protein Misfolding in Controlled Hypertension

Cells
2022-05-19 | Journal article
Contributors: Manuel Teixeira; Dário Trindade; Marisol Gouveia; Roberta Eller-Borges; Sandra Magalhães; Ana Duarte; Miriam Ferreira; Maria I. Simões; Maria Conceição; Alexandra Nunes et al.
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Crossref
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Metabolic Profile Characterization of Different Thyroid Nodules Using FTIR Spectroscopy: A Review

Metabolites
2022-01-08 | Journal article
Contributors: Vanessa Neto; Sara Esteves-Ferreira; Isabel Inácio; Márcia Alves; Rosa Dantas; Idália Almeida; Joana Guimarães; Teresa Azevedo; Alexandra Nunes
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Cell culture studies: a promising approach to the metabolomic study of human aging

Current Metabolomics and Systems Biology
2021 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2610554

Contributors: Ana Rocha; Sandra Magalhães; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Fourier-transform infraredspectroscopy as a discriminatory tool for Myotonic Dystrophy type 1metabolism: a pilot study

International Journal of Environmental Researchand Public Health
2021 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2610491

Contributors: Mateus, Tiago; Almeida Idália; Adriana Costa; Diana VIegas; Magalhaes, Sandra; Martins, Filipa; Herdeiro, Maria Teresa; Nunes, Alexandra; Rebelo, Sandra
Source: check_circle
CIÊNCIAVITAE

Lipids:Biomarkers of Healthy Aging

Biogerontology
2021 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2610436

Contributors: Almeida Idália; Magalhaes, Sandra; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Metabolic alterations in myotonic dystrophy type 1 and their correlation with lipin

International Journal of Environmental Research and Public Health
2021 | Journal article
EID:

2-s2.0-85100612398

Part of ISSN: 16604601 16617827
Contributors: Mateus, T.; Martins, F.; Nunes, A.; Herdeiro, M.T.; Rebelo, S.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
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Two novelmolecular approaches towards deciphering Myotonic Dystrophy Type 1

16th International Congress of Neuromuscular Diseases
2021 | Conference abstract
SOURCE-WORK-ID:

cv-prod-id-2610514

SOURCE-WORK-ID:

cv-prod-id-2610529

SOURCE-WORK-ID:

cv-prod-id-2618928

Contributors: Adriana Costa; Diana Viegas; Tiago Mateus; Ana Basílio; Idália ALmeida; Odete da Cruz e Silva; Nunes, Alexandra; Sandra Rebelo
Source: Self-asserted source
Alexandra Nunes

FTIR spectroscopy in biomedical research: how to get the most out of its potential

Applied Spectroscopy Reviews
2021-11-26 | Journal article
Contributors: Sandra Magalhães; Brian J. Goodfellow; Alexandra Nunes
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Crossref
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FTIR Spectroscopy as a Tool to Study Age-Related Changes in Cardiac and Skeletal Muscle of Female C57BL/6J Mice

Molecules
2021-10-23 | Journal article
Contributors: Sandra Magalhães; Idália Almeida; Filipa Martins; Fátima Camões; Ana R. Soares; Brian J. Goodfellow; Sandra Rebelo; Alexandra Nunes
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Crossref
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Lipids: biomarkers of healthy aging

Biogerontology
2021-06 | Journal article
Contributors: I. Almeida; S. Magalhães; A. Nunes
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Crossref
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Effect of exercise training on amyloid-like protein aggregates among patients with heart failure

European Journal of Preventive Cardiology
2021-05-01 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2668729

Contributors: Gouveia, M; Schmidt, C; Teixeira, M; Magalhaes, S; Nunes, A; Lopes, M; Vitorino, R; et al.
Source: check_circle
CIÊNCIAVITAE

Fourier-Transform Infrared Spectroscopy as a Discriminatory Tool for Myotonic Dystrophy Type 1 Metabolism: A Pilot Study

International Journal of Environmental Research and Public Health
2021-04 | Journal article | Author
Contributors: Mateus T.; Idália Almeida; Adriana Costa; Diana Viegas; Sandra Magalhães; Filipa Martins; Herdeiro MT; Odete A. B. da Cruz e Silva; Carla Fraga; Ivânia Alves et al.
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Multidisciplinary Digital Publishing Institute
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Metabolismo do sistema digestivo. Metabolismo do Pâncreas Exócrino e sua regulação

Bioquímica fisiológica: integração do metabolismo na especialização dos órgãos
2020 | Book chapter
SOURCE-WORK-ID:

cv-prod-id-323062

Part of ISBN: 9789723618082
Contributors: Nunes, Alexandra; Magalhaes, Sandra; Neuparth, M. J.
Source: check_circle
CIÊNCIAVITAE

Metabolismo do sistema digestivo.A interação entre o metabolismo do estômago e a sua função

Bioquímica fisiológica: integração do metabolismo na especialização dos órgãos.
2020 | Book chapter
SOURCE-WORK-ID:

cv-prod-id-323134

Part of ISBN: 9789723618082
Contributors: Magalhães, S.; Nunes, Alexandra; Fortuna, M.
Source: check_circle
CIÊNCIAVITAE

Monitoring plasma protein aggregation during aging using conformation-specific antibodies and FTIR spectroscopy

Clinica Chimica Acta
2020 | Journal article
EID:

2-s2.0-85076750431

Part of ISSN: 18733492 00098981
Contributors: Magalhães, S.; Trindade, D.; Martins, T.; Martins Rosa, I.; Delgadillo, I.; Goodfellow, B.J.; da Cruz e Silva, O.A.B.; Henriques, A.G.; Nunes, A.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
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Potential of FTIR spectroscopy applied to exosomes for Alzheimer's disease discrimination: A pilot study

Journal of Alzheimer's Disease
2020 | Journal article
EID:

2-s2.0-85082021433

Part of ISSN: 18758908 13872877
Contributors: Soares Martins, T.; Magalhães, S.; Rosa, I.M.; Vogelgsang, J.; Wiltfang, J.; Delgadillo, I.; Catita, J.; Da Cruz Silva, O.A.B.E.; Nunes, A.; Henriques, A.G.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
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Regular Exercise Participation Contributes to Better Proteostasis, Inflammatory Profile, and Vasoactive Profile in Patients with Hypertension

American Journal of Hypertension
2020 | Journal article
EID:

2-s2.0-85080849442

Part of ISSN: 19417225 08957061
Contributors: Teixeira, M.; Gouveia, M.; Duarte, A.; Ferreira, M.; Simões, M.I.; Conceição, M.; Silva, G.; Magalhães, S.; Ferreira, R.; Nunes, A. et al.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
grade
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Investigation of spectroscopic and proteomic alterations underlying prostate carcinogenesis

Journal of Proteomics
2020-08 | Journal article
SOURCE-WORK-ID:

cv-prod-id-1273726

EID:

2-s2.0-85087310840

Contributors: Felgueiras, Juliana; Silva, Joana Vieira; Nunes, Alexandra; Fernandes, Inês; Patrício, António; Maia, Nuno; Pelech, Steven; Fardilha, Margarida
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CIÊNCIAVITAE
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Study aging by fibroblasts metabolome

Current Molecular Medicine
2020-08 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2385558

Contributors: Rocha, Ana; Magalhães, Sandra; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Lipid profiles of extracellular vesicles are distinct forAlzheimer's disease cases

Alzheimer's Association International Conference
2020-07 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-2533784

SOURCE-WORK-ID:

cv-prod-id-2533861

Contributors: Soares Martins, T.; Magalhaes, S.; Martins Rosa, I; da Cruz e Silva, O.A.B.; Nunes, Alexandra; Henriques, A.G.
Source: Self-asserted source
Alexandra Nunes

ATR-FTIR spectroscopy detects changes in lipid profile during aging

V Postgrad symposium in Biomedicine
2019 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1273446

Contributors: Almeida, I.; Magalhaes, S.; Martins, T.; Martins Rosa, I.; Delgadillo, I.; da Cruz e Silva, O.A.B.; Henriques, A.G.; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Fourier Transform Infrared Spectroscopy of extracellular vesicles as a diagnostic tool for Alzheimer's disease

5th GEIVEX Symposium
2019 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1272725

Contributors: Soares Martins, T; Magalhães, S.; Martins Rosa, I; Vogelgsang, J.; Wiltfang, J.; Delgadillo, I.; Catita, J.; et al.
Source: check_circle
CIÊNCIAVITAE

FTIR spectroscopy reveals changes in protein aggregation profile in plasma from middle to old age

V Postgrad Symposium in Biomedicine
2019 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1273488

Contributors: Magalhães, S.; Trindade, D.; Martins, T.; Martins Rosa, I.; Delgadillo, I.; Goodfellow, B.J.; da Cruz e Silva, O.A.B.; Henriques, A.G.; Nunes, Alexandra
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CIÊNCIAVITAE

Monitoring plasma protein aggregation during ageing using FTIR spectroscopy

Jornadas do CICECO
2019 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1273556

Contributors: Magalhaes, S.; Trindade, D.; Martins, T.; Martins Rosa, I.; Delgadillo, I.; Goodfellow, B.J.; da Cruz e Silva, O.A.B.; Henriques, A.G.; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Proteostasis, inflammatory and vasoactive biomarkers in patients with hypertension: effect of exercise training

EuroPrevent
2019 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1272890

Contributors: Teixeira, M.; Gouveia, M.; Duarte, A.; Ferreira, M.; Simões, M.I.; Conceição, M.; Silva, G.; et al.
Source: check_circle
CIÊNCIAVITAE

A multi-omic analysis reveals that human OPTN proteinopathy induces lipid metabolism defects in a yeast model system

2019-04-19 | Interactive resource
SOURCE-WORK-ID:

cv-prod-id-1273768

Contributors: Bean, D.M.; Hnatova, S.; Mulleder, M.; Magalhães, S.; Nightingale, D.J.H.; Lilley, K.S.; Ralser, M.; et al.
Source: check_circle
CIÊNCIAVITAE

Understanding Prostate Cancer Cells Metabolome: A Spectroscopic Approach

Current Metabolomics
2019-01-22 | Journal article
SOURCE-WORK-ID:

cv-prod-id-422108

Part of ISSN: 2213-235X
Contributors: Santos, Francisco; Magalhães, Sandra; Henriques, Magda Carvalho; Silva, Beatriz; Valença, Isabel; Ribeiro, Daniela; Fardilha, Margarida; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Aging and proteins: What does proteostasis have to do with age?

Current Molecular Medicine
2018 | Journal article
EID:

2-s2.0-85054426278

Part of ISSN: 18755666 15665240
Contributors: Magalhães, S.; Goodfellow, B.J.; Nunes, A.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
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ATR-FTIR spectroscopy detects age-related changes in human plasma: preliminary data.

Ciência 2018
2018 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-318656

Contributors: Magalhaes, Sandra; Martins, Tânia; Rosa, Ilka; Ana Gabriela Henriques; Odete da Cruz e Silva; Delgadillo, Ivonne; Goodfellow, B.J.; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Discrimination between tumoral and normal prostate cells by FTIR spectroscopy

Jornadas do CICECO
2018 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1272685

Contributors: Santos, F.; Magalhaes, S.; Henriques, M.C.; Silva, B.; Valença, I.; Ribeiro, D.; Fardilha, M.; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Identification of protein aggregation in Saccharomyces cerevisiae using FTIR and NMR spectroscopy

Jornadas CICICO 2018
2018 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-318689

Contributors: Magalhaes, Sandra; Graça, Ana Luísa; Tavares, Joana; Santos, Manuel S.; Delgadillo, Ivonne; Goodfellow, B.J.; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Raman Spectroscopy Applied to Health Sciences

Raman Spectroscopy
2018 | Book chapter
SOURCE-WORK-ID:

cv-prod-id-322912

Contributors: Nunes, Alexandra; Magalhães, Sandra
Source: check_circle
CIÊNCIAVITAE

Understanding prostate cancer biology using metabolomics and proteomics approaches: potentials in the improvement of the diagnosis, prognosis and identification of new therapeutic targets.

Eur J Cancer
2018 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-321659

SOURCE-WORK-ID:

cv-prod-id-318782

Contributors: Felgueiras, J.; Vieira Silva J.; Nunes, Alexandra; Patrício, A.; Pelech S.; Fardilha, M.
Source: Self-asserted source
Alexandra Nunes

Unravelling an age-related metabolomic profile of human plasma: a spectroscopic approach (preliminary data).

IV PostGraduate Symposium in Biomedicine
2018 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-318649

Contributors: Magalhaes, Sandra; Martins, Tânia; Rosa, Ilka; Ana Gabriela Henriques; Odete da Cruz e Silva; Delgadillo, Ivonne; Goodfellow, B.J.; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Saccharomyces cerevisiae as a Model to Confirm the Ability of FTIR to Evaluate the Presence of Protein Aggregates

Spectral Analysis Review
2018-12-18 | Journal article
SOURCE-WORK-ID:

cv-prod-id-271861

Contributors: Magalhães, Sandra; Graça, Ana; Tavares, Joana; Santos, Manuel A. S.; Delgadillo, Ivonne; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE
grade
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Spectroscopic Features of Cancer Cells: FTIR Spectroscopy as a Tool for Early Diagnosis

Current Metabolomics
2018-07-16 | Journal article
SOURCE-WORK-ID:

cv-prod-id-318187

Part of ISSN: 2213-235X
Contributors: Santos, Francisco; Magalhaes, Sandra; Henriques, Magda Carvalho; Fardilha, Margarida; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Biological Predictors of Aging and Potential of FTIR to Study Age-related Diseases and Aging Metabolic Fingerprint

Current Metabolomics
2017-06 | Journal article
Contributors: Ana Graça; Sandra Magalhães; Alexandra Nunes
Source: Self-asserted source
Alexandra Nunes via Crossref Metadata Search
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Transform Infrared Spectroscopy Applied to the Study of Unicellular Models

Current Metabolomics
2017-05-02 | Journal article
SOURCE-WORK-ID:

cv-prod-id-271863

Contributors: Sandra Magalhães; Alexandra Nunes
Source: check_circle
CIÊNCIAVITAE
grade
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FTIR and Raman Spectroscopy Applied to Dementia Diagnosis Through Analysis of Biological Fluids

Journal of Alzheimer's Disease
2016 | Journal article
EID:

2-s2.0-84971500954

Part of ISSN: 18758908 13872877
Contributors: Lopes, J.; Correia, M.; Martins, I.; Henriques, A.G.; Delgadillo, I.; Da Cruz E Silva, O.; Nunes, A.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
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FTIR Spectroscopy - A Potential Tool to Identify Metabolic Changes in Dementia Patients

Alzheimer’s & Neurodegenerative Diseases
2016 | Journal article
Contributors: Alexandra Nunes; iBiMED University of Aveiro
Source: Self-asserted source
Alexandra Nunes via Crossref Metadata Search
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Identification of metabolic changes in dementia patients using FTIR.

1st International Electronic Conference on Metabolomics
2016 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-318788

Contributors: Correia, Marta; Lopes, Jéssica; Silva, Rafaela; Rosa, Ilka; Ana Gabriela Henriques; Delgadillo, Ivonne; Odete da Cruz e Silva; Nunes, Alexandra
Source: check_circle
CIÊNCIAVITAE

Composition of food grade Atlantic salts regarding triacylglycerides, polysaccharides and protein

Journal of Food Composition and Analysis
2015 | Journal article
EID:

2-s2.0-84924585495

Part of ISSN: 08891575
Contributors: Silva, I.; Nunes, A.; Rocha, S.M.; Coimbra, M.A.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
grade
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Evaluation of the potential of mid-infrared spectroscopy to assess the microbiological quality of ham

2015 | Journal article
DOI:

10.1111/jfs.12176

EID:

2-s2.0-84920913636

Contributors: Moreirinha, C.; Nunes, A.; Barros, A.; Almeida, A.; Delgadillo, I.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
grade
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Oxidative stress markers: Can they be used to evaluate human sperm quality?,Oksidatif stres belirteçleri: İnsanlarda sperm kalitesini değerlendirmek için kullanılabilir mi?

Turk Uroloji Dergisi
2015 | Journal article
EID:

2-s2.0-84945200059

Part of ISSN: 13084631 13005804
Contributors: Cruz, D.F.; Lume, C.; Silva, J.V.; Nunes, A.; Castro, I.; Silva, R.; Silva, V.; Ferreira, R.; Fardilha, M.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
grade
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Valuation of brewers spent yeast polysaccharides: A structural characterization approach

2015 | Journal article
DOI:

10.1016/j.carbpol.2014.03.010

EID:

2-s2.0-84910683948

Contributors: Pinto, M.; Coelho, E.; Nunes, A.; Brandão, T.; Coimbra, M.A.
Source: Self-asserted source
Alexandra Nunes via Scopus - Elsevier
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2

Peer review (47 reviews for 20 publications/grants)

Review activity for Analysis & sensing. (1)
Review activity for Analytical sciences. (1)
Review activity for Antioxidants. (2)
Review activity for Applied sciences. (1)
Review activity for Biogerontology. (3)
Review activity for Biogerontology. (3)
Review activity for Biomolecules. (3)
Review activity for Cancers. (2)
Review activity for Communications biology. (1)
Review activity for Diagnostics. (2)
Review activity for International journal of molecular sciences. (4)
Review activity for Journal of food measurement and characterization. (2)
Review activity for Journal of personalized medicine. (1)
Review activity for Journal of the science of food and agriculture. (1)
Review activity for Metabolites. (10)
Review activity for Molecules. (5)
Review activity for npj aging and mechanisms of disease. (1)
Review activity for PloS one. (2)
Review activity for RSC advances (1)
Review activity for Thyroid. (1)